Purpose: We aimed to find out the distributed functional connectome of white matter in patients with functional dyspepsia.Methods: 20 patients with FD and 24 age- and gender-matched healthy controls were included into the study. The functional connectome of white matter and graph theory were used to these participants. Two-sample t-test was used for the detection the abnormal graph properties in FD. Pearson correlation was used for the relationship between properties and the clinical and neuropshychological information.Results: Patients with FD and healthy (...) controls showed small-world properties in functional connectome of white matter. Compared with healthy controls, the FD group showed decreased global properties. Four pairs of fiber bundles that are connected to the frontal lobe, insula, and thalamus were affected in the FD group. Duration and Pittsburgh Sleep Quality Index positively correlated with the betweenness centrality of white matter regions of interest.Conclusion: FD patients turned to a non-optimized functional organization of WM brain network. Frontal lobe, insula, and thalamus were key regions in brain information exchange of FD. It provided some novel imaging evidences for the mechanism of FD. (shrink)

Some entangled states have nonnegative Wigner representative function. The latter allow being viewed as a distribution function of local hidden variables. It is argued herewith that the interpretation of expectation values using such distribution functions as local hidden variable theory requires restrictions pertaining to the observables under study. The reasoning lead to support the view that violation of Bell’s inequalities that is always possible for entangled states hinges not only on the states involved but also whether the (...) dynamical variables have their values defined even when they cannot be measured. (shrink)

We discuss the profound influence which the Wigner distribution function has had in many areas of physics during its fifty years of existence.

Two-classes of phase-space spin quasi-distribution functions are introduced and discussed. The first class of these distributions is based on the delta function construction. It is shown that such a construction can be carried out for an arbitrary spin s and an arbitrary ordering of the spin operators. The second class of the spin distributions is constructed with the help of the spin coherent states. The connection of the spin coherent states to the Stratonovich formalism is established and discussed. (...) It is shown that the c-number phase-space description of quantum fluctuations provides a simple statistical picture of quantum fluctuations of spinoperators in terms of random directions on a unit sphere. For quantum states of the spin system the statistics of these random orientations is given by non-positive spin quasi-distribution functions. It is shown that the application of these spin quasi-distribution functions to the Einstein-Podolsky-Rosen correlations provide an insight into the quantum theory of measurement. (shrink)

Popper functions allow one to take conditional probabilities as primitive instead of deriving them from unconditional probabilities via the ratio formula P=P/P. A major advantage of this approach is it allows one to condition on events of zero probability. I will show that under plausible symmetry conditions, Popper functions often fail to do what they were supposed to do. For instance, suppose we want to define the Popper function for an isometrically invariant case in two dimensions and hence (...) require the Popper function to be rotationally invariant and defined on pairs of sets from some algebra that contains at least all countable subsets. Then it turns out that the Popper function trivializes for all finite sets: P=1 for all A ) if B is finite. Likewise, Popper functions invariant under all sequence reflections can’t be defined in a way that models a bidirectionally infinite sequence of independent coin tosses. (shrink)

Le contrat social libéral distributif définit une norme d’action communicative pour l’allocation des ressources rares et la redistribution de la richesse privée. Il se compose d’activités qui mettent en œuvre une allocation des ressources Pareto-efficace unanimement préférée à un statu quo hypothétique. Ce statu quo correspond à l’allocation des ressources que l’on obtiendrait en l’absence des activités du contrat social, dans des conditions idéales de communication parfaite. Nous mettons en évidence un ensemble de conditions suffisantes générales sous lesquelles toute allocation (...) du contrat social maximise, au sein de l’ensemble des allocations réalisables, une fonction de bien-être social de Nash bien choisie. Nous montrons également que la correspondance entre les allocations du contrat social libéral et les fonctions de bien-être social de Nash qui les soutiennent est bijective si, et en général seulement si, les préférences distributives des individus sont cardinales. Dans ce dernier cas, la solution coopérative de Nash étendue à un nombre quelconque d’individus définit une norme d’action communicative unique pour l’allocation des ressources et la distribution de la richesse privée. (shrink)

Neuronal activities have recently been reported to exhibit power-law scaling behavior. However, it has not been demonstrated that the power-law component can play an important role in human perceptual functions. Here, we demonstrate that the power spectrum of magnetoencephalograph recordings of brain activity varies in coordination with perception of subthreshold visual stimuli. We observed that perceptual performance could be better explained by modulation of the power-law component than by modulation of the peak power in particular narrow frequency ranges. The (...) results suggest that the brain operates in a state of self-organized criticality, modulating the power spectral exponent of its activity to optimize its internal state for response to external stimuli. (shrink)

Amine acetylation is a diverse topic with importance to the regulation of several physiological processes as well as the metabolism of drugs and environmental chemicals. Arylalkylamine N‐acetyltransferase is widely distributed in several species, where this enzyme plays an important role in the seasonal regulation of reproduction and photoperiodism in vertebrates through the pathway of melatonin formation. In insects, this enzyme is involved in monoamine neurotransmitter inactivation and the formation of catecholamine intermediates necessary for sclerotization of the insect cuticle.

Drawing on Christopher Boorse's Biostatistical Theory (BST), Norman Daniels contends that a genuine health need is one which is necessary to restore normal functioning – a supposedly objective notion which he believes can be read from the natural world without reference to potentially controversial normative categories. But despite his claims to the contrary, this conception of health harbors arbitrary evaluative judgments which make room for intractable disagreement as to which conditions should count as genuine health needs and therefore which needs (...) should be met. I begin by offering a brief summary of Boorse's BST, the theory to which Daniels appeals for providing the conception of health as normal functioning upon which his overall distributive scheme rests. Next, I consider what I call practical objections to Daniels's use of Boorse's theory. Finally I recount Elseljin Kingma's theoretical objection to Boorse's BST and discuss its impact on Daniels's overall theory. Though I conclude that Boorse's view, so weakened, will no longer be able to sustain the judgments which Daniels's theory uses it to reach, in the end, I offer Daniels an olive branch by briefly sketching an alternative strategy for reaching suitably objective conclusions regarding the health and/or disease status of various conditions. (shrink)

Phosphoinositides modulate a plethora of functions including signal transduction and membrane trafficking. PtdInsPs are thought to consist of seven interconvertible species that localize to a specific organelle, to which they recruit a set of cognate effector proteins. Here, in reviewing the literature, we argue that this model needs revision. First, PtdInsPs can carry a variety of acyl chains, greatly boosting their molecular diversity. Second, PtdInsPs are more promiscuous in their localization than is usually acknowledged. Third, PtdInsP interconversion is likely (...) achieved through kinase-phosphatase enzyme complexes that coordinate their activities and channel substrates without affecting bulk substrate population. Additionally, we contend that despite hundreds of PtdInsP effectors, our attention is biased toward few proteins. Lastly, we recognize that PtdInsPs can act to nucleate coincidence detection at the effector level, as in PDK1 and Akt. Overall, better integrated models of PtdInsP regulation and function are not only possible but needed. Phosphoinositides are lipids that control many cellular functions. However, the field of PtdInsP signaling is dominated by several dogmatic notions. Here, we offer an updated glimpse on the current state of the field regarding molecular diversity, localization, organization of modifying enzymes, effector types, and effector organization. (shrink)

Recently, P. D. Finch and R. Groblicki determined all bivariate probability densities with specified margins. We point out that their result follows immediately from the complete solution to the problem of determining all n-dimensional cumulative probability distribution functions with specified one-dimensional margins, which was solved by one of us in 1959.

Language plays a central role in human life. However, the term 'language' as defined in the language sciences of the 20th century and the traditions these have drawn on, have arguably, limited our thinking about what language is and does. The two inter-linked volumes of Thibault's study articulate crucially important aspects of an emerging new perspective shift on language - the Distributed Language view - that is now receiving more and more attention internationally. Rejecting the classical view that the fundamental (...) architecture of language can be localized as a number of inter-related levels of formal linguistic organization that function as the coded inputs and outputs to each other, the distributed language view argues that languaging behaviour is a bio-cultural organisation of process that is embodied, multimodal, and integrated across multiple space-time scales. Thibault argues that we need to think of human languaging as the distinctively human mode of our becoming and being selves in the extended human ecology and the kinds of experiencing that this makes possible. Paradoxically, this also means thinking about language in non-linguistic ways that break the grip of the conventional meta-languages for thinking about human languaging. Thibault's book grounds languaging in process theory: languaging and the forms of experience it actualizes is always an event, not a thing that we 'use'. In taking a distinctively interdisciplinary approach, the book relates dialogical theories of human sense-making to the distributed view of human cognition, to recent thinking about distributed language, to ecological psychology, and to languaging as inter-individual affective dynamics grounded in the subjective lives of selves. In taking this approach, the book considers the coordination of selves in social encounters, the emergent forms of self-reflexivity that characterise these encounters, and the implications for how we think of and live our human sociality, not as something that is mediated by over-arching codes and systems, but as emerging from the endogenous subjectivities of selves when they seek to coordinate with other selves and with the situations, artefacts, social institutions, and technologies that populate the extended human ecology. The two volumes aim to bring our understanding of human languaging closer to human embodiment, experience, and feeling while also showing how languaging enables humans to transcend local circumstances and thus to dialogue with cultural tradition. Volume 1 focuses on the shorter timescales of bodily dynamics in languaging activity. Volume II integrates the shorter timescales of body dynamics to the longer cultural-historical timescales of the linguistic and cultural norms and patterns to which bodily dynamics are integrated. (shrink)

Empirical research has increasingly turned its attention to distributed cognition. Acts of remembering are embedded in a social, interactional context; cognitive labor is divided between a rememberer and external sources. The present article examines the benefits and costs associated with distributed, collaborative, conversational remembering. Further, we examine the consequences of joint acts of remembering on subsequent individual acts of remembering. Here, we focus on influences on memory through social contagion and socially shared retrieval-induced forgetting. Extending beyond a single social interaction, (...) we consider work that tracks the propagation of socially shared retrieval-induced forgetting throughout larger networks made up of several agents. Although much work has focused on how distributing cognition can augment memory, this is not the primary lesson we draw from the conversational remembering literature. Rather, mnemonic convergence between communicators is a boon to sociality. It allows the formation and maintenance of mnemonic communities, rather than expanding capacity or accuracy of memory per se. (shrink)

Quantum distribution functions for spin-1/2 systems are derived for various characteristic functions corresponding to different operator orderings.

A method is given to determine whether or not the distribution functions describing the two spin measurements in the spin-s Einstein-Podolsky-Rosen experiment are compatible with the existence of distributions describing three spin measurements (not all of which can actually be performed). When applied to the spin-1/2 case the method gives the results of Wigner, or of Clauser, Holt, Horne, and Shimony, depending on whether or not the two-spin distributions are assumed to have the forms given by the quantum (...) theory. Generalizations of the conditions of Wigner or of Clauser et al. to the spin-1 case are explicitly calculated. The spin-3/2 case is examined in some simple geometries to show that an apparently monotonic trend toward local realism as s increases from1/2 to1 is, in fact, violated when s increases from1 to3/2. The analysis is based on a novel representation of the modulus squared of a rotation matrix element. The structure of that matrix element responsible for the restoration of local realism in the classical (large s) limit is identified, but a rigorous treatment of the classical limit is not attempted. The higher-spin results are significantly stronger than those given by Mermin's spin-s Bell inequality. (shrink)

Face perception, perhaps the most highly developed visual skill in humans, is mediated by a distributed neural system in humans that is comprised of multiple, bilateral regions. We propose a model for the organization of this system that emphasizes a distinction between the representation of invariant and changeable aspects of faces. The representation of invariant aspects of faces underlies the recognition of individuals, whereas the representation of changeable aspects of faces, such as eye gaze, expression, and lip movement, underlies the (...) perception of information that facilitates social communication. The model is also hierarchical insofar as it is divided into a core system and an extended system. The core system is comprised of occipitotemporal regions in extrastriate visual cortex that mediate the visual analysis of faces. In the core system, the representation of invariant aspects is mediated more by the face-responsive region in the fusiform gyrus, whereas the representation of changeable aspects is mediated more by the face-responsive region in the superior temporal sulcus. The extended system is comprised of regions from neural systems for other cognitive functions that can be recruited to act in concert with the regions in the core system to extract meaning from faces. (shrink)

This paper deals with stochastically globally exponential stability for stochastic impulsive differential systems with discrete delays and infinite distributed delays. By using vector Lyapunov function and average dwell-time condition, we investigate the unstable impulsive dynamics and stable impulsive dynamics of the suggested system, and some novel stability criteria are obtained for SIDSs with DDs and IDDs. Moreover, our results allow the discrete delay term to be coupled with the nondelay term, and the infinite distributed delay term to be coupled with (...) the nondelay term. Finally, two examples are given to verify the effectiveness of our theories. (shrink)

This paper investigates the nonlinear vehicle platoon control problems with external disturbances. The quadratic spacing policy is applied into the platoon control, in which the desired intervehicle distance is a quadratic function in terms of the vehicle’s velocities. Comparing with the general constant time headway policy, the QSP is more suitable to the human driving behaviors and can improve the traffic capacity. Then, a novel platoon control scheme is proposed based on the distributed integrated sliding mode. Since the external disturbances (...) are taken into consideration, the sliding mode method is employed to handle the disturbances. Moreover, the stability and string stability of the proposed platoon control system are strictly analyzed. In final, numerical simulations are provided to verify the proposed approaches. (shrink)

We received several commentaries both challenging and supporting our hypothesis. We thank the commentators for their thoughtful contributions, bringing together alternative hypotheses, complementary explanations, and appropriate corrections to our model. Here, we explain further our hypothesis, using more explicitly the framework of evolutionary social sciences. We first explain what we believe is the ultimate function of fiction in general (i.e., entertainment) and how this hypothesis differs from other evolutionary hypotheses put forward by several commentators. We then turn to the proximate (...) features that make imaginary worlds entertaining and, therefore, culturally successful. We finally explore how these insights may explain the distribution of imaginary worlds across time, space, age, and social classes. (shrink)

The case of ungapped alignment of two literal sequences under constrains is considered. The analysis lead to general formulas for probability mass function and cumulative distribution function for the general case of using an alphabet with a chosen number of letters in the expression of the literal sequences. Formulas for three statistics including mean, mode, and standard deviation were obtained. Distributions are depicted for three important particular cases: alignment on binary sequences, alignment of trinomial series, and alignment of genetic (...) sequences. A particular case when sequences contain each letter of the alphabet at least once in both sequences has also been analyzed and some statistics for this restricted case are given. (shrink)

The international law principle of permanent sovereignty over natural resources posits that governments bear the sovereign rights to manage natural resources on behalf of citizens. That citizens have rights over natural resources at all however detaches from governance realities showcasing citizen marginalization. This necessitates revisiting the issue of what rights citizens actually have over natural resources. Qualitatively investigating this issue reveals rights of citizens over natural resources now embedded in the doctrine of peoples-based permanent sovereignty over natural resources (PPSNR). However, (...) this doctrine appears to be subject to international law limitations and might not be effective within domestic jurisdictions. Alternatively, PPSNR may be domestically driven by common ownership and environmental justice claims. These two drivers may be able to advance distributive justice rights of citizens to returns from natural resources exploitation within domestic jurisdictions. These rights could be actuated through rent distribution practices. This results in functional distributive justice. (shrink)