Many philosophers accept derivative blameworthiness for ignorant conduct – the idea that the blameworthiness for one’s ignorance can ‘transfer’ to blameworthiness for one’s subsequent ignorant conduct. In this chapter we ask the question what it actually means that blameworthiness would transfer, and explore four distinct views and their merits. On views (I) and (II), one’s overall degree of blameworthiness is determined by factors relevant to one’s ignorance and/or one’s subsequent conduct, and transfer only involves an increase in (...) scope. On views (III) and (IV), one’s overall degree of blameworthiness is determined by factors relevant to one’s ignorance as well as one’s subsequent conduct, and transfer might not only entail an increase in scope, but also in degree. (shrink)

Knowledge transfer across different contexts has become an increasingly prevalent feature of current science. As such, it is a relevant topic also for history and philosophy of science. This special issue presents a set of papers that study knowledge transfer in various disciplines. The contributions approach the topic from either an integrated history and philosophy of science perspective, 2) a systematic philosophical perspective, or 3) a historical perspective. This overview article is organized in three sections. The introduction provides (...) some background and context of the topic. The second section specifies the three components of knowledge transfer, i.e., knowledge, context, and the transfer process. It motivates our take on this topic and then outlines the central ideas of each paper. The third section reflects on the kinds of methods used to study processes of knowledge transfer. The article concludes by highlighting some of the features of such processes, some of the main challenges and obstacles that those processes involve, and possible ways of dealing with them. (shrink)

Many ethical systems hold that agents earn merit and demerit through their good and bad deeds. Some of these ethical systems also accept merit transference, allowing merit to be transferred, in certain circumstances, from one agent to another. In this article, I argue that there is a previously unrecognized paradox for merit transference involving a phenomenon I call “merit inflation”. With a particular focus on Buddhist ethics, I then look at the options available for resolving this paradox. I conclude that (...) merit inflation poses a serious challenge for any ethical system that broadly permits the transfer of merit. (shrink)

Our folk epistemology says that if someone knows that P and tells you that P, then, given the absence of defeaters, if you believe what they tell you, you will come to know that P as well. A speaker's knowledge that P is then, for the most part, enough for a hearer to come to know that P. But there are counterexamples to this principle: testimonial knowledge does not always transfer from the speaker to the hearer. Why should that (...) be so? Because testimonial knowledge arises through the flow of information--from conclusive grounds--from the speaker through the speaker's assertion to the hearer's state of comprehension as of the speaker's assertion. A speaker's belief can be based on conclusive grounds, but the speaker's assertion may fail to provide conclusive grounds to the hearer. Then the hearer won't acquire knowledge, even from a knowledgeable speaker. Knowledge from testimony then works more like knowledge through perception. But wait, you say, that can't be so because testimony involves free will but perception does not. The essay ends with a broadly Hume inspired reply to this objection. (shrink)

Technology transfer is the movement of technical and organizational skills, knowledge, and methods from one individual or organization to another for economic purposes. This process usually involves a group that possesses specialized technical skills and technology that transfers it to a target group of receptors who do not possess those skills, and who cannot create that technology themselves.

International transfers of human biological material (biospecimens) and data are increasing, and commentators are starting to raise concerns about how donor wishes are protected in such circumstances. These exchanges are generally made under contractual material transfer agreements (MTAs). This paper asks what role, if any, should research ethics committees (RECs) play in ensuring legal and ethical conduct in such exchanges. It is recommended that RECs should play a more active role in the future development of best practice MTAs involving (...) exchange of biospecimens and data and in monitoring compliance. (shrink)

In a recent BioEssays paper [W. F. Martin, BioEssays 2017, 39, 1700115], William Martin sharply criticizes evolutionary interpretations that involve lateral gene transfer into eukaryotic genomes. Most published examples of LGTs in eukaryotes, he suggests, are in fact contaminants, ancestral genes that have been lost from other extant lineages, or the result of artefactual phylogenetic inferences. Martin argues that, except for transfers that occurred from endosymbiotic organelles, eukaryote LGT is insignificant. Here, in reviewing this field, we seek to correct (...) some of the misconceptions presented therein with regard to the evidence for LGT in eukaryotes. A recent paper dismisses claims of lateral gene transfer into eukaryotic genomes. We counter the arguments made in that paper and discuss the extensive evidence for LGT in eukaryotes. (shrink)

The construal of the self is related to individuals' cognition, emotion and behavior. The aim of this study was to investigate shame in the context of interdependent-self and independent-self culture. 163 Chinese and 196 American college undergraduates completed a questionnaire about their reaction to 3 different scenarios about shameful events involving 5 different persons including self, mother, boy/girl friend, best friend and classmate. The participants reported the intensity of shame they felt in each of the situation and how close they (...) were related to other people in the scenarios. The results demonstrated that there is a significant difference between Chinese and American participants on the levels of shame across all the scenarios, as well as for the persons involved in the scenario. It was also found that the intensity of shame was reduced as the relationship between the participants and the persons involved in the shameful events becomes remote in social distance. A significant correlation was found between closeness of relationship and intensity of shame felt. Implications for understanding cultural differences to emotions and future studies are discussed. (shrink)

Harvesting human embryonic stem (hES) cells is a highly controversial field of research because it rests on the destruction of human embryos. Altering the procedure of nuclear transfer (NT) is suggested to generate hES cell lines without ethical obstacles by claiming that no embryo would be involved. While discussing the nature of an embryo and related central questions concerning their moral status and the respect they deserve, this paper argues that the entity created by somatic cell nuclear (...) class='Hi'>transfer (SCNT) or altered nuclear transfer (ANT) is an embryo and has the same moral status as a natural embryo. Respect for the embryo is expressed by the ethical principles of proportionality, probability and subsidiarity. This paper argues that the human embryo should only be taken for research with high ranking goals, which are proven in animal experimentation and for which there are no alternatives. This makes ANT obsolete and shows that SCNT to produce hES cells is premature at the present time. (shrink)

Individuals sometimes pass their duties on to collectives, which is one way in which collectives can come to have duties. The collective discharges its duties by acting through its members, which involves distributing duties back out to individuals. Individuals put duties in and get (transformed) duties out. In this paper we consider whether (and if so, to what extent) this general account can make sense of states' duties. Do some of the duties we typically take states to have come from (...) individuals having passed on certain individual duties? There are complications: states can discharge their duties by contracting fulfilment out to non-members; states seem able to dissolve the duties of non-members; and some of states' duties are not derived in this way. We demonstrate that these complicate, but do not undermine, the general account and its application to states. And the application has an interesting upshot: by asking which individuals robustly participate in this process of duty transfer-and-transformation with a given state, we can begin to get a grip on who counts as a member of that state. (shrink)

This paper argues that the type of conscience claims made in last decade’s spate of cases involving pharmacists’ objections to filling birth control prescriptions and cases such as Ms. Means and Mercy Health Partners of Michigan, and even the Affordable Care Act and the Little Sisters of the Poor, as different as they appear to be from each other, share a common element that ties them together and makes them fundamentally different in kind from traditional claims of conscience about which (...) a practical consensus emerged in the 1980s and 1990s. This difference in kind is profoundly significant; so much so, we contend, that it puts them at odds with the normative basis for protecting conscience claims in United States health care settings in the first place, making them illegitimate. Finally, we argue that, given the illegitimacy of these contemporary claims of conscience, physicians and other health professionals must honor their well-established standing obligations to provide informed consent and refer or transfer care even if the service requested or needed is at odds with their own core moral beliefs—a requirement that is in line with the aforementioned practical consensus on traditional claims of conscience. (shrink)

More and more areas of medicine involve subjects donating tissues to another — blood, organs, bone marrow, sperm, ova and embryos can all be transferred from one person to another. Within the technical frameworks of biomedicine, such fragments are generally treated as detachable things, severed from social identity once they are removed from a particular body. However an abundant anthropological and sociological literature has found that, for donors and patients, human tissues are not impersonal. They retain some of the values (...) of personhood and identity, and their incorporation often has complex effects on embodied identity. This article draws on feminist philosophy of the body to think through the implications of some of these practices. Specifically, it draws on the idea of intercorporeality, wherein the body image is always the effect of embodied social relations. While this approach is highly productive for considering the stakes involved in tissue transfer, it is argued that the concept of body image has been too preoccupied with the register of the visual at the expense of introceptive data and health/illness events. Empirical data around organ transplant and sperm donation are used to demonstrate that the transfer of biological fragments involves a profound kind of intercorporeality, producing identifications and disidentifications between donors and recipients that play out simultaneously at the immunological, psychic and social levels. (shrink)

‘Creative destruction’ is one of the most important analytical tools, taking into consideration both the economic and sociological characteristics of capitalist society. According to Schumpeter, in the long term, evolution gives rise to economic development resulting from batches of innovative solutions, leading to improvements in the standard of living. The innovation activity of firms is based on supply-side factors, hence it is large enterprises that excel in innovation since they strive to achieve a monopoly market position and above-average profits. Schumpeter (...) attempts to combine two elements: the spread of monopolies and the continuation of economic development, both occurring through innovation, which is far more important than price competition. The Schumpeterian ‘creative destruction’ permeates the main aspects of macroeconomic activity, not only in the long term, but also in the area of economic fluctuations, structural changes, or the functioning of markets. As a result, it becomes a factor determining changes in the economic order. The purpose of this paper is to analyse the role of territories in the process of creating and using knowledge and its impact on the economic efficiency of the companies which function within their boundaries. Regional cooperation increases the involvement of business entities in innovation activities, which translates into higher competitiveness of firms. Moreover, the awareness of the necessity of cooperation and use of innovation capital tends to grow. (shrink)

In this paper we start from the assumption that in a metaphor, or an analogy, some terms belonging to one domain (source domain) are used to refer to objects other than their conventional referents belonging to a possibly different domain (target domain). We describe a formalism, which is based on the First Order Predicate Calculus, for representing the knowledge structure associated with a domain and then develop a theory of Constrained Semantic Transference [CST] which allows the terms and the structural (...) relationships of the source domain to be transferred coherently across to the target domain. We show how metaphors and analogies can be characterized in CST in such a way that many of their cognitive properties con be explained.We then propose a theory of Approximate Semantic Transference [AST] which is a computational version of CST and is derived from it by replacing the coherency requirement with approximate coherency. We show how AST can be used as a basis for designing models of cognitive processes involved in comprehending metaphors and analogies. (shrink)

How do professionals working in pre-implantation genetic diagnosis reflect upon their decision making with regard to ethical challenges arising in everyday practice? Two focus group discussions were held with staff of reproductive genetic clinics: one in Utrecht with PGD-professionals from Dutch PGD-centres and one in Prague with PGD-professionals working in centres in different European countries. Both meetings consisted of two parts, exploring participants’ views regarding treatment requests for conditions that may not fulfill traditional indications criteria for PGD, and treatment and (...) transfer requests involving welfare-of-the-child considerations. There was general support for the view that people who come for PGD will have their own good reasons to consider the condition they wish to avoid as serious. But whereas PGD-professionals in the international group tended to stress the applicants’ legal right to eventually have the treatment they want, participants in the Dutch group sketched a picture of shared decision-making, where professionals would go ahead with treatment in cases where they are able to understand the reasonableness of the request in the light of the couple’s reproductive history or family experience. In the international focus group there was little support for guidance stating that welfare-of-the child considerations should be taken into account. This was different in the Dutch focus group, where shared decision-making also had the role of reassuring professionals that applicants had adequately considered possible implications for the welfare of the child. (shrink)

Hegel, in his work _Philosophy of Right_, defines ownership through three elements: acquisition by occupation, use, and transfer. To own something involves mere acquisition and encompasses its appropriate use and potential transfer to others. Subsequently, the final aspect mentioned was the concept of infinite judgement. The acts of owning and transferring to others are diametrically opposed, and Hegel’s unique logic forcibly connects these opposing concepts. This form of infinite judgement was advocated by the young Hegel during the era (...) of _Phenomenology of Spirit_. There, he stated, “Spirit is a bone”. However, when he later wrote _Science of Logic_ or _Encyclopedia_, the formulation of infinite judgement changed to “Spirit is not something that is bone”. This shift was influenced by Kant. In _Logic_, the discourse advances into syllogism, inferential theory, leading to “Spirit is a bone for such-and-such reasons”. In essence, Hegel binarily connected spirit and bone in his youth and introduced a mediating term in this connection later in his life, establishing inferential links. However, the notion of forcibly connecting opposing concepts remains. Therefore, the statement “Ownership is transfer” represents an infinite judgement while simultaneously signifying syllogism that “I truly own this object if I can transfer it to others”. This contributes to the reasoning that “I and objects can be connected through the intermediary of others”, progressing to the inference that “I and others can be connected through objects”, thereby laying the foundation for society. (shrink)

In this paper, we study a stability transfer theorem in d-tame metric abstract elementary classes, in a similar way as in 2, but using superstability-like assumptions which involves a new independence notion instead of ℵ0-locality.

Technology transfer is a multi-level process of communication involving a variety of senders and receivers of ideas and materials. As a response to market failure, or as an effort to accelerate market-driven social change, technology transfer may combine public and private aparatus or rely solely on public institutional mechanisms to identify, develop, and deliver innovations and information. Technology transfer institutions include universities, government ministries, research institutes, and what may be termed the ‘project sector’. Four farm- and village-level (...) change models are considered: traditional community development, adoption-diffusion, training and Visit Extension, and Farming Systems Research. The challenges to technology transfer efforts center on developing indigenous capacity to generate and adapt agricultural technology to local conditions. This is the primary objective of technology transfer in agriculture and the basis for advancing rural development. (shrink)

In this paper, I will argue that heterologous embryo transfer (HET) is malum in se because it involves a disordered use of a woman’s gestative faculty. Against most HET opponents, I will argue for and defend the distinction between the generative faculty or procreation and the gestative faculty or gestation, grounded in St. Thomas Aquinas’s explanation for how faculties are distinguished. Against the advocates of HET, I will argue that a thorough analysis of the gestative faculty and its natural (...) object will help us to demonstrate why HET constitutes a disordered (and therefore illicit) use of a woman’s gestative faculty. (shrink)

During evolution, the genomes of eukaryotic cells have undergone major restructuring to meet the new regulatory challenges associated with compartmentalization of the genetic material in the nucleus and the organelles acquired by endosymbiosis (mitochondria and plastids). Restructuring involved the loss of dispensable or redundant genes and the massive translocation of genes from the ancestral organelles to the nucleus. Genomics and bioinformatic data suggest that the process of DNA transfer from organelles to the nucleus still continues, providing raw material (...) for evolutionary tinkering in the nuclear genome. Recent reconstruction of these events in the laboratory has provided a unique tool to observe genome evolution in real time and to study the molecular mechanisms by which plastid genes are converted into functional nuclear genes. Here, we summarize current knowledge about plastid‐to‐nuclear gene transfer in the context of genome evolution and discuss new insights gained from experiments that recapitulate endosymbiotic gene transfer in the laboratory. BioEssays 30:556–566, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Two key research issues in the field of causal learning are how people acquire causal knowledge when observing data that are presented sequentially, and the level of abstraction at which learning takes place. Does sequential causal learning solely involve the acquisition of specific cause-effect links, or do learners also acquire knowledge about abstract causal constraints? Recent empirical studies have revealed that experience with one set of causal cues can dramatically alter subsequent learning and performance with entirely different cues, suggesting that (...) learning involves abstract transfer, and such transfer effects involve sequential presentation of distinct sets of causal cues. It has been demonstrated that pre-training can modulate classic causal learning phenomena such as forward and backward blocking. To account for these effects, we propose a Bayesian theory of sequential causal learning. The theory assumes that humans are able to consider and use several alternative causal generative models, each instantiating a different causal integration rule. Model selection is used to decide which integration rule to use in a given learning environment in order to infer causal knowledge from sequential data. Detailed computer simulations demonstrate that humans rely on the abstract characteristics of outcome variables to select a causal integration rule, which in turn alters causal learning in a variety of blocking and overshadowing paradigms. When the nature of the outcome variable is ambiguous, humans select the model that yields the best fit with the recent environment, and then apply it to subsequent learning tasks. Based on sequential patterns of cue-outcome co-occurrence, the theory can account for a range of phenomena in sequential causal learning, including various blocking effects, primacy effects in some experimental conditions, and apparently abstract transfer of causal knowledge. (shrink)

ABSTRACTPsychotherapy is a mental health activity where therapists assist clients through verbal interaction. The phenomenon of transference, where clients superimpose their past experiences onto present life situations, occurs frequently in psychotherapy, and may have varied effects on treatment outcome depending on how it is managed or “worked through.” While previous work has linked transference to metaphor based on their theoretical similarity, this article explores the relationship on the basis of actual psychotherapy talk between a therapist–client dyad at a Chinese university (...) counseling center. It combines clinical and discourse analytic observations to the model working through transference as an interactional process of constructing a “PRESENT IS PAST” conceptual metaphor, and suggests that the process involves guiding the client to move from an awareness of correspondences at the conceptual level, to the transferential level (between feelings,.. (shrink)

A remarkable event occurred at the December 3, 2004, meeting of the U. S. President’s Council on Bioethics. Council member William Hurlbut, a physician and Consulting Professor in the Program in Human Biology at Stanford University, formally unveiled a proposal that he claimed would solve the ethical problems surrounding the extraction of stem cells from human embryos. The proposal would involve the creation of genetically defective embryos that “never rise to the level of integrated organismal existence essential to be designated (...) human life with potential,” and therefore could be used as morally acceptable sources of stem cells for research and therapy. The aim of this essay is to show that Hurlbut’s proposal does not solve the ethical problems associated with human embryonic stem cell research. Two major reasons are presented. First, the proposal, which involves modification of a somatic cell nucleus, suffers from an ethical problem that is common to all types of human genetic engineering: since the procedure is not foolproof, there will be failures. In the case of the procedure Hurlbut proposes, some normal (albeit cloned) embryos will be produced. Second, the embryo engineered in the manner described is, at least in the early stages of its development, fully human despite its genetic defect. This essay also will show how a reasonable person might mistakenly view the proposal as legitimate if he or she makes the error of conflating genetic determinism with Aristotelian teleology. Finally, it will argue that ethical clarity can be achieved by seeing the embryo as a holistic entity possessing emergent properties that cannot simply be spelled out by genes. (shrink)

An article by Mark Repenshek and a letter by Edward Delaquil published recently in The National Catholic Bioethics Quarterly underscore the urgent need for further moral and magisterial clarification regarding a number of highly complex and difficult bioethical issues. These involve ex utero therapeutic genomic interventions, the practice of in vitro fertilization and embryo transfer, and the ongoing debate over the morality of embryo adoption to help resolve the “absurd” fate of countless, cryopreserved human embryos. This essay critiques and (...) argues against the use of therapeutic IVF, helps clarify why embryo transfer and embryo adoption do not violate the sacred bond of marriage, and uses key magisterial passages from both Donum vitae and the Catechism of the Catholic Church to defend the practice of embryo transfer. National Catholic Bioethics Quarterly 14.2 : 227–234. (shrink)

The introduction of new medical technologies into a developing country is usually greeted with enthusiasm as the possible benefits become an object of great anticipation and provide new hope for therapy or relief. The prompt utilization of new discoveries and inventions by a medical practitioner serves as a positive indicator of high standing in the professional community. But the transfer of medical technology also involves a transfer of concomitant values. There is a danger that, in the process of (...) adopting a particular technology, the user takes for granted the general utility and desirability of the implements and procedures under consideration without recognizing the socio‐cultural peculiarities of the adopting country. A sensitivity to the social conditions and cultural traditions is important so that the emergence of new values can be examined critically and the transfer of necessary technology can be effected smoothly. In the Philippines, efforts to boost patronage of transplant technology appear to have overlooked this need for socio‐cultural sensitivity. Legislative fiat cannot be used to override deep‐seated values. There is a need to be more sensitive to the possible confrontation of values that the transfer of technology brings in order to avoid the erosion of indigenous socio‐cultural values and minimize the intrusiveness of beneficial medical technology. (shrink)

Background: Sharing of tissue samples for research and disease surveillance purposes has become increasingly important. While it is clear that this is an area of intense, international controversy, there is an absence of data about what researchers themselves and those involved in the transfer of samples think about these issues, particularly in developing countries. Methods: A survey was carried out in a number of Asian countries and in Egypt to explore what researchers and others involved in research, (...) storage and transfer of human tissue samples thought about some of the issues related to sharing of such samples. Results: The results demonstrated broad agreement with the positions taken by developing countries in the current debate, favoring quite severe restrictions on the use of samples by developed countries. Conclusions: It is recommended that an international agreement is developed on what conditions should be attached to any sharing of human tissue samples across borders. (shrink)

Reasoning about underlying causal relations drives responsibility judgments: agents are held responsible for the outcomes they cause through their behaviors. Two main causal reasoning approaches exist: dependence theories emphasize statistical relations between causes and effects, while transference theories emphasize mechanical transmission of energy. Recently, pluralistic or hybrid models, combining both approaches, have emerged as promising psychological frameworks. In this paper, we focus on causal reasoning as involved in third-party judgements of responsibility and on related judgments of intention and control. (...) In particular, we used a novel visual paradigm to investigate the combined effects of two well-known causal manipulations, namely omission and pre-emption, on these evaluations. Our findings support the view that people apply a pluralistic causal reasoning when evaluating individual responsibility for negative outcomes. In particular, we observed diminished responsibility when dependence, transference, or both fail, compared to when these mechanisms are upheld. Responsibility judgement involves a cognitive hybrid of multiple aspects of causal reasoning. However, important differences exist at the interindividual level, with most people weighting transference more than dependence. (shrink)

Universities have long been involved in knowledge transfer activities. Yet the last 30 years have seen major changes in the governance of university–industry interactions. Knowledge transfer has become a strategic issue: as a source of funding for university research and (rightly or wrongly) as a policy tool for economic development. Universities vary enormously in the extent to which they promote and succeed in commercializing academic research. The identification of clear-cut models of governance for university–industry interactions and knowledge (...) transfer processes is not straightforward. The purpose of this article is to critically discuss university knowledge transfer models and review the recent developments in the literature on research collaborations, intellectual property rights and spin-offs, those forms of knowledge transfer that are more formalized and have been institutionalized in recent years. The article also addresses the role played by university knowledge transfer organizations in promoting commercialization of research results. (shrink)

The transfer of children from primary school to secondary school has long been seen as a problematic area. The National Curriculum was depicted as offering a solution to some of the transfer problems by providing for curriculum continuity across the primary-secondary divide. This paper reports the results of a study of curriculum continuity in one subject, history, now that a National Curriculum has been in place for several years. It reports that teachers continue to see problems with the (...) transfer and that secondary school teachers still incline to a ‘fresh start’ approach to year 7 pupils. There is also some evidence of a lack of curriculum consistency within the secondary schools involved in the research, there are differences between primary and secondary schools in the range of teaching and learning methods employed, there is some decline in pupils’ ratings of their experience of secondary education across year 7 and there are signs of some gender differences in these ratings. The conclusion is that there is a case for saying that the new arrangements have not alleviated the problems associated with the transfer. (shrink)

Recent advances in automation technology have increased the opportunity for collaboration between humans and multiple autonomous systems such as robots and self-driving cars. In research on autonomous system collaboration, the trust users have in autonomous systems is an important topic. Previous research suggests that the trust built by observing a task can be transferred to other tasks. However, such research did not focus on trust in multiple different devices but in one device or several of the same devices. Thus, we (...) do not know how trust changes in an environment involving the operation of multiple different devices such as a construction site. We investigated whether trust can be transferred among multiple different devices, and investigated the effect of two factors: the similarity among multiple devices and the agency attributed to each device, on trust transfer among multiple devices. We found that the trust a user has in a device can be transferred to other devices and that attributing different agencies to each device can clarify the distinction among devices, preventing trust from transferring. (shrink)

The scientific life in mid-seventeenth-century Europe was characterised by numerous academies of sciences and scientific associations whose aim was to propagate the development of the sciences, art and literature. Some have called it “the new Age of Academies all over Europe”. These institutions brought together not only educated professionals but also a large number of amateur scientists. They called for the deliberate abandonment of verbal dispute in favour of visual demonstration/experimentation, and for the creation of paid scientific professionals who would (...) devote their full time to the enterprise. These scientists conducted numerous experiments, the results of which were demonstrated at academic sessions. Franciszek Bieliński became Grand Marshal of the Crown in 1742. During the many years of his public service, he aimed to improve the well-being of Warsaw inhabitants, especially by paving the streets and creating a modern sewerage system. In the light of recent scholarly studies, Franciszek Bieliński is perceived as a figure of very wide horizons, striving to join the Parisian academic scientific discourse in order to transfer knowledge and technology to Poland. Bieliński exchanged letters with the eminent member and three-time president of the Paris Academy of Sciences, Henri Louis Duhamel du Monceau, who among numerous other projects tested new methods of horticulture, agriculture and forestry. The article aims to discuss the scientific research undertaken by Bieliński in regards to technology transfer in the area of agriculture, on the basis of unanalysed documents. Recently found correspondence shows that Grand Marshal Bieliński was involved in experimental research supervised by Duhamel du Monceau, under the aegis of the Paris Academy of Sciences. It pertained to modern agricultural crops and the application of new technologies. The agricultural experiments that Bieliński carried out on his private lands in Otwock over many years focused on improving and increasing agricultural production in accordance with the instructions given by Duhamel du Monceau. An interesting research finding was the detailed description of one of the earliest transfers of advanced technology in the field of agricultural machinery. Reports of the work conducted in Poland, which were sent to Duhamel du Monceau, proved to be so useful and important that the latter mentioned these in the proceedings of the Paris Academy of Sciences. (shrink)

One of the major puzzles in evolutionary theory is how communication and information transfer are possible when the interests of those involved conflict. Perfect information transfer seems inevitable if there are physical constraints, which limit the signal repertoire of an individual, effectively making bluffing an impossibility. This, I argue, is incorrect. Unfakeable signals by no means guarantee information transfer. I demonstrate the existence of a so-called pooling equilibrium and discuss why the traditional argument for perfect information (...) transfer does not hold in all cases. Additionally, I demonstrate that deception is possible at equilibrium despite the fact that signals are impossible to fake. (shrink)

Contemporary legal and political discourse includes three different models of minority groups. The outsider group model is applied to groups defined by status that experience political and economic disadvantages, plausibly attributable to that status, which are regarded as unjust. The adversity group model is applied to groups defined by their relationship to a discrete decision or event that imposes disproportionate losses on the group, which are regarded as unjust. And the transfer group model is applied to groups defined by (...) a shared interest that are differentially advantaged in obtaining benefits from the political system, which are regarded as unjust. This paper argues that with respect to a number of contestable policy questions involving minority groups - such as affirmative action and the NIMBY syndrome - proponents of the group employ the outsider group model, opponents apply the transfer group model, and centrist politicians and judges prefer the adversity group model. It further argues that the model adopted in doubtful cases will have a strong influence on our preferences for different constitutional structures. One who inclines toward the outsider group model will favor a Rawlsian constitution with strong judicial enforcement of a bill of rights; one who favors the adversity group model will prefer a liberal constitution with few deviations from majority rule; and one who gravitates toward the transfer group model will be drawn to a Madisonian constitution that seeks to frustrate group demands in favor of consideration of diffuse majority interests. Der Beitrag beschreibt drei verschiedene Modelle, die in der gegenwärtigen juristischen und politischen Diskussion benutzt werden, wenn es darum geht, mit Bezug auf Minderheitsgruppen zu argumentieren. Das "Außenseiter-Modell" definiert eine Gruppe durch ihren Status und durch die politischen und wirtschaftlichen Nachteile, die die Gruppe offensichtlich aufgrund dieses Status erleidet und die als ungerecht angesehen werden. Das "Sonderopfer-Modell" definiert eine Gruppe durch ihre Relation auf eine konkrete Entscheidung oder einen konkreten Vorfall , der dieser Gruppe unverhältnismäßig hohe Verluste auferlegt, die als ungerecht angesehen werden. Das "Transfer-Modell" schließlich definiert eine Gruppe durch ein gemeinsames Interesse und durch das ausgeprägte Vermögen, vom politischen System Vergünstigungen zu erlangen, die als ungerecht betrachtet werden. Der vorliegende Beitrag zeigt, daß eine Reihe von strittigen Fragen der Politik, die einen Bezug zu Minderheitsgruppen aufweisen - z.B. "affirmative action" und das "NIMBY-Syndrome" -, in der Weise behandelt werden, daß Fürsprecher einer solchen Gruppe das "Außenseiter-Modell" gebrauchen, Gegner der Gruppe das "Transfer-Modell" anwenden und Politiker der Mitte und Richter das "Sonderopfer-Modell" bevorzugen. Darüber hinaus wird gezeigt, daß das Modell, das sich jemand angesichts umstrittener Sachverhalte zu eigen macht, einen starken Einfluß auf seine Vorlieben für bestimmte Verfassungsstrukturen ausübt. Wer dem "Außenseiter-Modell" zuneigt, wird für eine Rawls'sche Verfassung mit strikter, gerichtlich gewährleisteter Durchsetzung eines Grundrechtskatalogs eintreten; wer das "Sonderopfer-Modell" befürwortet, wird eine liberale Verfassung mit nur wenigen Abweichungen vom Mehrheitsprinzip vorziehen; wer zum "Transfer-Modell" tendiert, wird sich zu einer Madison'schen Verfassung hingezogen fühlen, die danach trachtet, Forderungen einzelner Gruppen zugunsten der Berücksichtigung diffuser Mehrheitsinteressen zu durchkreuzen. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Kennedy Institute of Ethics Journal 10.2 (2000) 171-174 [Access article in PDF] Bioethics Inside the Beltway The Oversight of Human Gene Transfer Research LeRoy Walters Jesse Gelsinger's death last September in a gene transfer study being conducted at the University of Pennsylvania has helped to spark a national debate. In part, this debate parallels the broader discussion of how human subjects research should be reviewed and regulated (...) in the United States. However, human gene transfer research is one of a handful of biomedical technologies that seem to deserve special attention, at least in the early years of their development.The major participants in the national debate on human gene transfer include the National Institutes of Health (NIH), the Food and Drug Administration (FDA), the National Bioethics Advisory Commission, members of Congress, biotechnology and pharmaceutical companies, disease-oriented advocacy groups, reporters, and academics. At the December 1999 meeting of the NIH Recombinant DNA Advisory Committee (RAC), the protocol that involved Jesse Gelsinger was a central focus of discussion, but other topics emerged as well. One ad hoc panel reviewed adverse events that had occurred in other research protocols using adenovirus vectors, while a second proposed changes in the general system for reporting adverse events to NIH and the RAC.During the first several months of the year 2000, the United States Congress also became involved in the human gene transfer debate. In February, Senator Bill Frist (R-TN) convened a hearing to which Jesse Gelsinger's father, representatives of NIH and FDA, and several other witnesses were invited. At approximately the same time, the House Commerce Committee and its Subcommittee on Oversight and Investigations initiated their own inquiries, asking the Office of Inspector General at the Department of Health and Human Services to review the oversight roles of NIH and FDA. In March and April, the House committee also wrote directly to the NIH Director, the FDA Commissioner, and the President of the University of Pennsylvania, requesting extensive documentation on gene transfer, in general, and the trial in which Jesse Gelsinger was involved, in particular. Congressman Henry Waxman (D-CA) and Senator Edward Kennedy (D-MA) have also raised questions and proposed solutions in multiple letters to the NIH Director and the Secretary of Health and Human Services. [End Page 171]The major general questions that have emerged from this discussion are the following:(1) What kinds of information about adverse events should be reported by researchers or sponsors during the course of human gene transfer trials?(2) To what group or groups should adverse-event information be reported? How often and in what ways should the information be analyzed?(3) Should the information about adverse events remain confidential, or should it be discussed publicly?(4) How can the disclosure and consent process in gene transfer trials be improved?(5) Which federal agency should have primary responsibility for overseeing human gene transfer research, and how can it best fulfill its oversight role?How these questions are answered will have immediate relevance to the field of human gene transfer research as it enters into its next phase. At the same time, the models that are created for this important cutting-edge field also may be useful in other complex or controversial arenas of biomedical research, for example, xenotransplantation or human embryonic stem-cell research. In addition, the lessons learned from this one important area of human subjects research may suggest ways to improve protections for all the volunteers who make clinical research--and medical progress--possible.In the remainder of this article, I will turn from reporting, in as objective a way as possible, on the status of the public policy debate about human gene transfer research to suggesting measures for improving the current oversight system for such research. My initial general recommendation is that we should not expect a single regulatory agency to be solely responsible for a field as large and dynamic as human gene transfer research. Rather, there should be some helpful redundancy or, to change the metaphor, checks and balances in the public oversight of this field. Thus, an... (shrink)

This paper uses autocatalytic networks to model discontinuous cultural transitions involving cross-domain transfer, using as an illustrative example, artworks inspired by the oldest-known uncontested example of figurative art: the carving of the Hohlenstein-Stadel Löwenmensch, or lion-human. Autocatalytic networks provide a general modeling setting in which nodes are not just passive transmitters of activation; they actively galvanize, or “catalyze” the synthesis of novel nodes from existing ones This makes them uniquely suited to model how new structure grows out of earlier (...) structure, i.e., cumulative, generative network growth. They have been used to model the origin and early evolution of biological life, and the emergence of cognitive structures capable of undergoing cultural evolution. We conducted a study in which six individual creators and one group generated music, prose, poetry, and visual art inspired by the Hohlenstein-Stadel Löwenmensch, and answered questions about the process. The data revealed four through-lines by which they expressed the Löwenmensch in an alternative art form: lion-human hybrid, subtracting from the whole to reveal the form within, deterioration, and waiting to be found with a story to tell. Autocatalytic networks were used to model how these four spontaneously derived through-lines form a cultural lineage from Löwenmensch to artist to audience. We used the resulting data from three creators to model the cross-domain transfer from inspirational source to creative product. These four spontaneously-generated threads of cultural continuity formed the backbone of this Löwenmensch-inspired cultural lineage, enabling culture to evolve even in the face of discontinuity at the level conventional categories or domains. We know of no other theory of cultural evolution that accommodates cross-domain transfer or other forms of discontinuity. The approach paves the way for a broad scientific framework for the origins of evolutionary processes. (shrink)

Prism Adaptation is a useful method to study the mechanisms of sensorimotor adaptation. After-effects following adaptation to the prismatic deviation constitute the probe that adaptive mechanisms occurred, and current evidence suggests an involvement of the cerebellum at this level. Whether after-effects are transferable to another task is of great interest both for understanding the nature of sensorimotor transformations and for clinical purposes. However, the processes of transfer and their underlying neural substrates remain poorly understood. Transfer from throwing to (...) pointing is known to occur only in individuals who had previously reached a good level of expertise in throwing, not in novices. The aim of this study was to ascertain whether anodal stimulation of the cerebellum could boost after-effects transfer from throwing to pointing in novice participants. Healthy participants received anodal or sham transcranial direction current stimulation of the right cerebellum during a PA procedure involving a throwing task and were tested for transfer on a pointing task. Terminal errors and kinematic parameters were in the dependent variables for statistical analyses. Results showed that active stimulation had no significant beneficial effects on error reduction or throwing after-effects. Moreover, the overall magnitude of transfer to pointing did not change. Interestingly, we found a significant effect of the stimulation on the longitudinal evolution of pointing errors and on pointing kinematic parameters during transfer assessment. These results provide new insights on the implication of the cerebellum in transfer and on the possibility to use anodal tDCS to enhance cerebellar contribution during PA in further investigations. From a network approach, we suggest that cerebellum is part of a more complex circuitry responsible for the development of transfer which is likely embracing the primary motor cortex due to its role in motor memories consolidation. This paves the way for further work entailing multiple-sites stimulation to explore the role of M1-cerebellum dynamic interplay in transfer. (shrink)

In this paper we consider one-to-many matching problems where the preferences of the agents involved are represented by monetary reward functions. We characterize Pareto optimal matchings by means of contractual exchange stability and matchings of maximum total reward by means of compensational exchange stability. To conclude, we show that in going from an initial matching to a matching of maximum total reward, one can always provide a compensation schedule that will be ex-post stable in the sense that there will (...) be no subset of agents who can all by deviation obtain a higher reward. The proof of this result uses the fact that the core of an associated compensation matching game with constraints is nonempty. (shrink)

Gene transcription in eukaryotes is associated with conformational changes of a large area of chromatin adjacent to a gene. This rearrangement may involve the whole loop (topological domain) to which a given gene belongs.Regulatory events associated with activation or inactivation of transcription are found to act through relatively short nucleotide sequences, often located several thousand base pairs apart from gene. These sequences, termed enhancers may act independently on their distance from or orientation with respect to the gene.Both long‐range conformational rearrangements (...) of chromatin and any long distance effects of enhancers may be associated with elastic torsional strain in DNA, arising in transcriptionally active chromatin loops. Enhancer effects, in particular, may be associated with conformational transitions in DNA competing for the energy deposited in the elastic spring of the DNA. (shrink)

Social accounting focuses on value transactions between organizations and their stakeholders; both market ones, where the value perceived by the different stakeholders is identified, and non-markets ones, where transactions are monetized at their fair value. There was long awareness of an emotional value translation, linked to the transfer of different products, services, remunerations, and incentives, regardless of whether they were market or non-market. Yet that emotional value seemed to be anchored in the field of psychology and managed to elude (...) economic science. This study seeks to identify emotional value with consumer surplus and, by extension, of the other stakeholders in a value transfer process. This proposal allows the emotional value to be anchored in the micro-economy and allows it to be objectively calculated using a regression involving three elements: the market price, the fair value interval, and a perceived satisfaction score by the different stakeholders in the form of significant sampling. The result obtained not only allows Social Accounting to be complemented with emotional value, but it also facilitates its incorporation in the strategy to optimize the emotional value. Furthermore, it enables a quantification of the perceived subjective utility, which opens up a research path where some possible lines are clearly identified. (shrink)

Capacities for abstract thinking and problem‐solving are central to human cognition. Processes of abstraction allow the transfer of experiences and knowledge between contexts helping us make informed decisions in new or changing contexts. While we are often inclined to relate such reasoning capacities to individual minds and brains, they may in fact be contingent on human‐specific modes of collaboration, dialogue, and shared attention. In an experimental study, we test the hypothesis that social interaction enhances cognitive processes of rule‐induction, which (...) in turn improves problem‐solving performance. Through three sessions of increasing complexity, individuals and groups were presented with a problem‐solving task requiring them to categorize a set of visual stimuli. To assess the character of participants’ problem representations, after each training session, they were presented with a transfer task involving stimuli that differed in appearance, but shared relations among features with the training set. Besides, we compared participants’ categorization behaviors to simulated agents relying on exemplar learning. We found that groups performed superior to individuals and agents in the training sessions and were more likely to correctly generalize their observations in the transfer phase, especially in the high complexity session, suggesting that groups more effectively induced underlying categorization rules from the stimuli than individuals and agents. Crucially, variation in performance among groups was predicted by semantic diversity in members’ dialogical contributions, suggesting a link between social interaction, cognitive diversity, and abstraction. (shrink)

Copredication occurs when a sentence receives a true reading despite prima facie ascribing categorically incompatible properties to a single entity. For example, ‘The red book is by Tolstoy’ can have a true reading even though it seems that being red is only a property of physical copies, while being by Tolstoy is only a property of informational texts. -/- A tempting strategy for resolving this tension is to claim that at least one of the predicates has a non-standard interpretation, with (...) the salient proposal involving reinterpretation via meaning transfer. For example, in ‘The red book is by Tolstoy’, one could hold that the predicate ‘by Tolstoy’ is reinterpreted (or on the more specific proposal, transferred) to ascribe a property that physical copies can uncontroversially instantiate, such as expresses an informational text by Tolstoy. On this view, the truth of the copredicational sentence is no longer mysterious. Furthermore, such a reinterpretation view can give a straightforward account of a range of puzzling copredicational sentences involving counting an individuation. -/- Despite these substantial virtues, we will argue that reinterpretation approaches to copredication are untenable. In §1 we introduce reinterpretation views of copredication and contrast them with key alternatives. In §2 we argue against a general reinterpretation theory of copredication on which every copredicational sentence contains at least one reinterpreted predicate. We also raise additional problems for the more specific proposal of implementing reinterpretation via meaning transfer. In §3 we argue against more limited appeals to reinterpretation on which only some copredicational sentences contain reinterpretation. In §4 we criticize a series of arguments in favour of reinterpretation theories. The upshot is that reinterpretation theories of copredication, and in particular, meaning transfer-based accounts, should be rejected. (shrink)

Despite the therapeutic potential of human embryonic stem (HES) cells, many people believe that HES cell research should be banned. The reason is that the present method of extracting HES cells involves the destruction of the embryo, which for many is the beginning of a person. This paper examines a number of compromise solutions such as parthenogenesis, the use of defective embryos, genetically creating a "pseudo embryo" that can never form a placenta, and determining embryo death, and argues that none (...) of these proposals are likely to satisfy embryoists, that is, those who regard the embryo as a person. This paper then proposes a method of extracting HES cells, what might be called the Blastocyst Transfer Method, that meets the ethical requirements of embryoists, and it considers some possible concerns regarding this method. It concludes by encouraging future HES cell research to investigate this method. (shrink)

Recent studies of Nyäya’s account of testimony have illustrated its anticipation of contemporary testimonial antireductionism, the position that testimony cannot be reduced to a more fundamental means of knowledge like inference or perception. This paper discusses another relevant but less discussed anticipation of current debate, involving the status of speaker belief in testimonial exchange. Is a speaker’s veridical apprehension of the content of his utterance a necessary condition on testimonial exchange? This was a source of much disputation among Indian epistemologists, (...) particularly Naiyäyikas (adherents of the Nyäya, or “Logic” school) and Mimamsakas(adherents of the Mimamsa, or “Exegete” school). (shrink)

This article presents a cognitive map proposed to be associated with understanding of the “system concept,” one component of the physics principle of Newton's second low. A definition of the concept is followed by the results of a problem‐solving experiment designed to investigate whether or not good problem solvers possess cognitive structures similar to the one proposed. Think‐aloud protocols were collected as subjects solved a series of physics problems involving Newton's second law. Coding schemes were used to analyze these protocols (...) and to develop a quantitative index intended to reflect the extent to which subjects possessed certain components of the proposed structure. This index proved a highly significant predictor of performance on Newton's second law transfer problems contained in a written exam. In contrast, performance on a set of familiar problems in the same written exam was not a good predictor of performance on transfer problems. These results indicate that cognitive structures that connect the equation ΣF = ma and the concept of choosing appropriate systems are at least part of what constitutes understanding of the principle of Newton's second law. Implications for physics education and problem‐solving research are presented. (shrink)

It is shown that (a) both the dispersion relations between the mean frequency θ0 and the mean wave number k 0 are invariant under the Lorentz transformation; and (b) the relativistic Doppler effects on θ 0 and k 0 differ. In the suboptic packet there is anomalous red shift in the mean wave number k' 0 received from a source receding with speed v: k′ 0 changes sign through zero as v goes through the value vg, the mean group velocity (...) in the packet. In the superoptic packet the anomalous red shift is in the mean frequency θ′ 0 which reverses sign through zero as v goes through the value vp, the mean phase velocity in the packet. This last finding indicates a blackout of the superoptic signal when propagated toward a receiver moving away from the source at a speed greater than vp. There is no violation of causality involved, and the final conclusion of the paper is that it is not a fundamental axiom of “special relativity,” as usually believed, to deny that information can be transmitted at speeds greater than c. (shrink)

BackgroundBiobanks have recently been established in several low- and middle-income countries in the Arab region of the Middle East. We aimed to explore the views of biobank managers regarding the challenges, ethical issues, and governance arrangements of their biobanks.MethodsIn-depth semi-structured qualitative interviews were conducted with a purposive sample of eight biobank managers from Egypt, Jordan, and Sudan. Interviews were performed either face-to-face, by phone, or via Zoom and lasted approximately 45–75 min. After verbal consent, interviews were recorded and then transcribed. (...) The authors performed a thematic analysis of the transcripts independently and then integrated the themes via a consensus process.ResultsBiobank managers discussed the main challenges in establishing their biobanks. These included the staff’s lack of experience and training, limited funds, deficit awareness of biobanks, obtaining funding from different sources. Only four reported they were active in distributing biospecimens and health data to researchers. Six biobanks used a broad consent model, one used tiered consent, and another allowed participants to opt-out of being recontacted. Five managers avoided partnerships with pharmaceutical companies due to concerns with unfavorable reactions from the community. Five managers did not have clear policies for returning research results to the donors. Five expressed challenges with sample and data sharing with international collaborators; all five used material transfer agreements. The biobank managers revealed variable governance arrangements and activities with community involving awareness and educational efforts rather than active engagement. Several expressed the importance of transparency with the operations of their biobanks and gaining the trust of their stakeholders.ConclusionManagers of biobanks in LMICs in the Arab Middle East encounter financial, operational, and social challenges toward their sustainability efforts. Discussions with key stakeholders are warranted to manage ethical issues involving informed consent, privacy, data sharing, and the return of results. We recommend that biobank managers in the Arab Middle East form collaborative networks within the region and internationally, develop trusting governance relationships with their stakeholders, and pursue engagement activities with their communities to enhance trust. (shrink)

With the economic and political support of the United States, in July 1947, Turkey signed contracts with the Westinghouse Electric International Company and J.G. White Engineering Corporation to construct its first international civilian airport, Istanbul's Yeşilköy Airport. As this article will argue, the building of Yeşilköy (1949–53), through a partnership with two American engineering firms, is essentially an early Cold War narrative of transnational exchange involving the multidirectional flow of technical knowledge, expertise and resources between the United States and Turkey; (...) the circulation of geopolitically significant (and frequently competing) military, civilian and government actors; and the local and global implications of these transmissions. Yet the Yeşilköy construction narrative also illustrates how post-war technology transfer was a highly political process of constant adaptation, modification and negotiation. Fraught with unforeseen friction and thorny challenges, Yeşilköy exemplifies the complicated American Cold War strategy of creating and maintaining alliances through engineering knowledge, personnel and practices, often with unintended consequences. Moreover, as a case study, Yeşilköy opens a new window into the cautious science diplomacy that occurred along the Iron Curtain, while filling a notable historiographic gap with respect to aviation in early Cold War Turkey. (shrink)