Uno dei problemi che affliggono maggiormente lo storico che si occupi del Concilio di Ferrara-Firenze per l'Unione delle Chiese (1438–39) è, notoriamente, la perdurante scarsezza e disorganicità delle fonti, soprattutto occidentali. Nonostante la pubblicazione degli Acta e di altre importanti relazioni, restano infatti molti vuoti che attendono ancora di essere colmati, in primis riguardo agli spostamenti delle varie delegazioni, ed alle attività che furono condotte al di fuori della stretta ufficialità delle sessioni conciliari. Del resto, è emblematico che anche per (...) un evento importante come dovette essere l'arrivo dei Greci a Firenze, con le accoglienze ed i festeggiamenti che furono organizzati per l'occasione, ci si debba rivolgere a quello che rimane sostanzialmente il diario privato di un vinaio fiorentino, Bartolomeo del Corazza, che per giunta ha avuto una tradizione piuttosto fortunosa e non è nemmeno sopravvissuto nella sua interezza. Tutto ciò deve servire da sprone per non abbassare mai la guardia, e soprattutto per non trascurare nessuna possibile fonte d'informazione. (shrink)

In the past decade, the availability of genetically modified animals has enabled the discovery of interesting roles for phosphatidylinositol 3‐kinase‐γ (PI3Kγ) and ‐δ (PI3Kδ) in different cell types orchestrating innate and adaptive immune responses. Therefore, these PI3K isoforms appear to be attractive drug targets for the treatment of diseases caused by unrestrained immune reactions. Currently, pharmacological targeting of PI3Kγ and/or PI3Kδ represents one of the most promising challenges for companies interested in the development of novel safe treatments for inflammatory diseases. (...) In this review we provide a general outline of PI3Kγ‐ and PI3Kδ‐specific functions in distinct subsets of inflammatory cells. We also discuss the therapeutic impact of novel compounds targeting PI3Kγ, PI3Kδ or both, in mouse models of autoimmune disorders (systemic lupus erythematosus (SLE) and rheumatoid arthritis), respiratory diseases (allergic asthma and chronic obstructive pulmonary disease) and cardiovascular dysfunctions (atherosclerosis and myocardial infarction). (shrink)

“Tell me," Wittgenstein once asked a friend, "why do people always say, it was natural for man to assume that the sun went round the earth rather than that the earth was rotating?" His friend replied, "Well, obviously because it just looks as though the Sun is going round the Earth." Wittgenstein replied, "Well, what would it have looked like if it had looked as though the Earth was rotating?” What would it have looked like if we looked at all (...) sciences from the viewpoint of Wittgenstein’s philosophy? Wittgenstein is undoubtedly one of the most influential philosophers of the twentieth century. His complex body of work has been analysed by numerous scholars, from mathematicians and physicists, to philosophers, linguists, and beyond. This volume brings together some of his central perspectives as applied to the modern sciences and studies the influence they may have on the thought processes underlying science and on the world view it engenders. The contributions stem from leading scholars in philosophy, mathematics, physics, economics, psychology and human sciences; all of them have written in an accessible style that demands little specialist knowledge, whilst clearly portraying and discussing the deep issues at hand. (shrink)

Frege’s _Basic Law V_ is inconsistent. The reason often given is that it posits the existence of an injection from the larger collection of first-order concepts to the smaller collection of objects. This article explains what is right and what is wrong with this diagnosis.

The scene in Aristophanes' Frogs where Dionysus rows Charon's boat across the Styx to the accompaniment of the chorus of frogs is, of course, one of the most famous passages of Greek Comedy, and an essential element of the humour of the passage is the ineptitude of Dionysus as a rower. As a large part of the Athenian audience would have served in triremes as rowers, Dionysus' inability to perform this familiar task adequately will have been immediately ridiculous. Aristophanes was (...) thus exploiting an easy source of humour in depicting Dionysus as an unaccomplished rower battling against the difficulties and discomforts of the task. Had so obvious a source of humour been neglected by the playwrights of Athenian Old Comedy till the time of Frogs? We should have been obliged to answer that we had no positive indications to the contrary till the publication in 1968 of Pap. Ox. 2740, but this now furnishes us with grounds to infer that some other Old Comedy, very probably the Taxiarchs of Eupolis, contained a scene where some person was represented as rowing ineptly. (shrink)

Critical study of of the addresses of Sir Muhammad Iqbal, 1877-1938 from philosophical and religious point of view.

Book Information Greek Thought: A Guide to Classical Knowledge. By Jacques Bruschwig and Geoffrey, E. R. Lloyd. MA, Belnap Press. Cambridge. 2000. Pp. xv + 1024. Hardback, US$49.00.

The Central American country of Guatemala committed itself to democratic values and processes in its election of December, 1985. Guatemala, like most other Central American countries, has been through the dictator-constitution-election revolving door many times. For almsot half a century, Guatemala has been afflicted with coups, general-presidents and dictator-presidents. Again, in 1985, Guatemala created a new constitution with provision for democratic presidential elections monitored and declared "democratic" by a score of other nations. The new president, Vinicio Cerezo, and his Minister (...) of Education, Eduardo Meyer Maldonado, emphasized that the elementary school, the only formal educational institution attended by the majority of Guatemalans, must provide those learning experiences required to develop, to nourish and to sustain democracy in Guatemala. (shrink)

At least for those who uphold the rationality of morality, ethics and practical reason are not two distinct topics: an ethically sound agent is one whose practical reason functions as it should. Take, for instance, the greatest historical figures. Aristotle claimed that no virtue of character can exist without practical wisdom—the excellence of practical, deliberative reason. And Kant thought that the categorical imperative, the ultimate moral principle that governs a good will, was at the same time the fundamental principlof practical (...) reasoning because the will simply ispractical reason. Even before any philosophical theory of the connection between acting well and the exercise of a rational power is in view, our moral practices strongly suggest that there is one. For we take it for granted that, in an important range of cases, when an agent fails to act as she should, something has gone awry with the agent and not just with her acts, and, furthermore, that the agent herself may be held responsible for this. In calling an agent who acts unethically "irrational," we are saying these two things. (shrink)

Comparative study of the Mimamsa philosophy of Kumārila Bhaṭṭa and Prabhākaramiśra, 7th century philosophers.

The use of with the future indicative is admittedly rare in post-Homeric Greek. In the passages concerned many deny the usage completely and either omit the particle or resort to emendation, or dismiss the construction as a mere ana-colouthon. In an instructive article in the Classical Quarterly, xl , Moorhouse argues in favour of retaining many of the readings, and it is only his interpretation that is in question here. His main thesis is that in Homeric Greek, where the usage (...) is common enough, κ or with the future means either ‘in that case’ or ‘probably’ . The latter usage, however, he regards as sometimes assuming a tone of dogmatic certainty , and this ‘emphatic future’ came to be the regular and literal meaning of the later idiom, without any irony being involved. (shrink)

The key stakeholders of the Finnish engineering education collaborated during 2006–09 to reform the system of education, to face the challenges of the changing business environment and to create a national strategy for the Finnish engineering education. The work process was carried out using participatory work methods. Impacts of sustainable development (SD) on engineering education were analysed in one of the subprojects. In addition to participatory workshops, the core part of the work on SD consisted of a research with more (...) than 60 interviews and an extensive literature survey. This paper discusses the results of the research and the work process of the Collaboration Group in the subproject of SD. It is suggested that enhancing systematic dialogue among key stakeholders using participatory work methods is crucial in increasing motivation and commitment in incorporating SD in engineering education. Development of the context of learning is essential for improving skills of engineering graduates in some of the key abilities related to SD: systemic- and life-cycle thinking, ethical understanding, collaborative learning and critical reflection skills. This requires changing of the educational paradigm from teacher-centred to learner-centred applying problem- and project-oriented active learning methods. (shrink)