Those who accept the necessity of mereological universalism face what has come to be known as the ‘junk argument’ due to Bohn [2009], which proceeds from the incompatibility of junk with universalism and the possibility of junk, to conclude that mereological universalism isn't metaphysically necessary. Most attention has focused on ; however, recent authors have cast doubt on . This paper undertakes a defence of premise against three main objections. The first is a new objection to the effect that Bohn's (...) defence of that premise presupposes far too much. I show that one can defend premise from a much weaker set of assumptions. The second objection, due to Contessa [2012], is that those who accept unrestricted composition should only accept the existence of binary sums rather than infinitary fusions. I argue that this conception of unrestricted composition is problematic: it is in conflict with an intuitive remainder principle. The final objection is .. (shrink)

Filosofische ponering van de subjectiviteit van elke interpretatie.

Three remarks, which are sometimes made about Freud's distiction between Ego and Id are discussed: 1. This distinction would have no analogy in other psychological concepts. 2. The essence of the "I" would be misjudged here. 3. It would be the rest of an atomising psychology, not yet arriving at the modern views of totality. Although the common parlance concerning psychic "parts" has indeed analogies in the old atomistic-psychological conceptions, these instances, as well as the conflicting drives are and have (...) been always considered in psychoanalysis as expressions of which the person himself is the subject. Especially the concept "Id" must be looked at as equivalent to the biological total, to the concept: Person-Stern. The concept I or Ego, as a special structure of "figure" within this whole, means no split-off part, but is equivalent to what is called elsewhere "durchstrukturiertes Unterganze". Freud entitles a certain intern organisation with the word "Ich". He that thinks the essence of "the" I herewith misjudged, confuses word and concept -- the word I contains a lot of equivocations. That there are conflicts within the person is a basic matter of fact, which is not to be pushed aside in favour of totalitarian dogmatics, this conflict must be expressed in our terminology in some way or other. Terms, by way of comparison borrowed from material situations cannot always be avoided, and need not give any inconvenience, provided reflecting over the import of the terms is practised sufficiently. (shrink)

I felt happy but a little apprehensive when I received the suggestion from the editors of Science in Context to write a comment on my book Categories of Medieval Culture quite a few years after its first publication and translation. It is always difficult to comment on one's own work, for in such a case there is seldom the necessary degree of “distance” between the author and the commentator. I offer this paper rather as a short account of the direction (...) of my thoughts. (shrink)

Regulated secretory proteins are stored within specialized vesicles known as secretory granules. It is not known how proteins are sorted into these organelles. Regulated proteins may possess targeting signals which interact with specific sorting receptors in the lumen of the trans‐Golgi network (TGN) prior to their aggregation to form the characteristic dense‐core of the granule. Alternatively, sorting may occur as the result of specific aggregation of regulated proteins in the TGN. Aggregates may be directed to secretory granules by interaction of (...) a targeting signal on the surface with a sorting receptor. Novel targeting signals which confer on regulated proteins a tendency to aggregate under certain conditions, and in so doing cause them to be incorporated into secretory granules, have been implicated. Specific targeting signals may also play a role in directing membrane proteins to secretory granules. (shrink)