First published in 1999. Routledge is an imprint of Taylor & Francis, an informa company.

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be (...) preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

A communication process can be described in terms of a sender transmitting information to a receiver. What happens if one of the two subject roles in this process is virtualised, i.e. substituted by a machine? Is it still appropriate to refer to this as an information transfer even if its source or target is missing? Can information originate from an unknown sender or be transmitted to a (completely) unknown receiver? Before examining these questions and answering them, one has to clarify (...) what is understood by information. As it turns out, different interpretations of this term lead to considerably different answers to the initially raised questions. We consider these questions particularly important since the continuing dissemination of so called information and virtualisation technologies changes the human communication processes fundamentally. These changes are part of the ongoing formation of an information society and may eventually lead to the formation of a new image of man. (shrink)

This volume features the thought and writings of Jonathan Sacks, one of today's leading Jewish public thinkers. It brings together an intellectual portrait, four of his most original and influential philosophical essays, and an interview with him. This volume showcases the work of Sacks, a philosopher who seeks to confront and offer solutions to the numerous problems besetting Judaism and its confrontation with modernity. In addition, the reader will also encounter an important social philosopher and proponent of interfaith dialogue, who (...) articulates how it is possible to cultivate a culture of civility based on the twin notions of the dignity of difference and the ethic of responsibility. Jonathan Sacks has been Chief Rabbi of the United Hebrew Congregations of the Commonwealth from September 1991 to September 2013 and a member of the House of Lords since 2009. (shrink)

The US has found it hard to establish competition in the market for biologics, which are therapeutics derived from living cells. In the case of small-molecule drugs, the emergence of direct competition from generic drugs at the end of the exclusivity period has provided the impetus for price competition, leading to lower spending. In 2010, to spur competition in the biologics market, Congress created a simplified pathway for the US Food and Drug Administration (FDA) to approve comparable versions of biologic (...) drugs called biosimilars. Biosimilar competition in the US has nonetheless remained weaker than in European peer countries. For example, as of August 2020, there were 52 biosimilars available in Germany, and only 15 in the US.1 An important contributor to this “biosimilar gap” has been the fact that biosimilars to biologic blockbusters such as adalimumab (Humira) and etanercept (Enbrel) were only (or will only become) commercially available in the US several years after receiving FDA approval, while they were available in Europe years earlier.2 Through the end of 2021, it took biosimilars a median of 301 days between receiving FDA approval and becoming available for use.3 In one recent study, the median length of time between when a biologic drug was approved and when its first biosimilar was made available to US patients was 21.5 years.4 This paucity of competition has contributed to high US spending on biologics. According to the Department of Health and Human Services, in 2022 41% of US drug expenditures was spent on biologics, which represented 16% of US prescriptions.5. (shrink)

Over-the-counter drugs are ubiquitous in the US. Policymakers have long debated how to modernize the system for making determinations of safety and effectiveness and addressing safety issues with OTC drugs.

The following article is a response to Virginia Aspe’s “The Political Dilemmas of the Transformations of Mexico: A Philosophical Approach”. My aim is to discuss some ideas developed by Aspe Armella, pointing out, from the perspective of the history of Mexican philosophy, both the successes of her approach, as well as some aspects that deserve more debate.

Unlike birds and mammals, reptiles are commonly thought to possess only the most rudimentary means of interacting with their environments, reflexively responding to sensory information to the near exclusion of higher cognitive function. However, reptilian brains, though structurally somewhat different from those of mammals and birds, use many of the same cellular and molecular processes to support complex behaviors in homologous brain regions. Here, the neurological mechanisms supporting reptilian cognition are reviewed, focusing specifically on spatial cognition and the hippocampus. These (...) processes are compared to those seen in mammals and birds within an ecologically and evolutionarily relevant context. By viewing reptilian cognition through an integrative framework, a more robust understanding of reptile cognition is gleaned. Doing so yields a broader view of the evolutionarily conserved molecular and cellular mechanisms that underlie cognitive function and a better understanding of the factors that led to the evolution of complex cognition. (shrink)

The Oxford Handbook of Philosophy of Love offers a wide array of original essays on the nature and value of love. The editors, Christopher Grau and Aaron Smuts, have assembled an esteemed group of thinkers, including both established scholars and younger voices. The volume contains thirty-three essays addressing both issues about love as well as key philosophers who have contributed to the philosophy of love, such as Plato, Kierkegaard, Schopenhauer, and Murdoch. The topics range from central issues about the (...) nature and variety of love, the possibility of its rational justification, and whether it is an emotion, to the significance of love for law, economics, morality, and free will. The volume also contains an introduction to the subject as well as essays on love’s relation to jealousy, biotechnology, religion, knowledge, and several other topics. This wide-ranging handbook will be a key resource for specialists working on the philosophy of love, and a helpful guide for those looking to learn more about the area. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Response to the CommentariesIan Wright, Aaron Sloman, and Luc BeaudoinWe are very grateful for the care with which the commentators have read our paper, and the sympathy with which they treated what we acknowledged to be at best a preliminary attempt to make sense of a range of phenomena involving grief and other emotions in terms of our draft architecture. We are fortunate to have commentators that are (...) so much in sympathy with what we have written.The comments of Castelfranchi and Miceli draw attention to a problem that we expect many readers to bring up, namely that there is a notion of “information processing” that cannot carry the explanatory weight that we attach to our information processing architecture. We believe that there is a concept of “information processing” such as is used by engineers who design software systems to perform such tasks as controlling an aircraft. We claim that within an appropriate system architecture, information processing states can have all the causal powers that we require for states like pain, pleasure, and the like. However this is not obvious, and defending this claim will have to await another occasion.Lloyd helpfully illustrates the relevance of our proposed architecture even to the effects of imagining the death of a loved one. He also makes the useful observation that second-order states can arise when a person who is suffering because events violate some important motivator, discovers that nothing can be done about the cause of the suffering, and then suffers even more because of feeling helpless in that situation. We acknowledge that these are phenomena that the architecture will have to accommodate, and accept the challenge to demonstrate this in due course.We believe that there is enough commonality between the commentators and ourselves to support our view that the research community is on the verge of an important new breakthrough in the study of mind, in which philosophers, psychologists, therapists, brain scientists, and AI researchers can collaborate fruitfully, and from which profound practical and theoretical consequences will follow.Related ArticlesFeature Article: Towards a Design-Based Analysis of Emotional EpisodesCommentary: Commentary by LloydCommentary: Commentary by Miceli and CastelfranchiCommentary: Commentary by BodenResponse: Response to the CommentariesCopyright © 1996 The Johns Hopkins University Press... (shrink)

Wonderful reflections on the history of Western thought.

Professor Beatrice Longuenesse draws our attention to the most important aspect of Kant's Critical Philosophy, namely that it is a system of logic.

Aaron Ridley explores Nietzsche's mature ethical thought as expressed in his masterpiece On the Genealogy of Morals. Taking seriously the use that Nietzsche makes of human types, Ridley arranges his book thematically around the six characters who loom largest in that work—the slave, the priest, the philosopher, the artist, the scientist, and the noble. By elucidating what the Genealogy says about these figures, he achieves a persuasive new assessment of Nietzsche's ethics. Ridley's intellectually supple interpretation reveals Nietzsche's ethical position (...) to be deeper and more interesting than is often supposed: the relation, for instance, between Nietzsche's ideal of the noble and the ascetic or priestly conscience does not emerge as a stark opposition but as a rich interplay between the tensions inherent in each. Equally, he shows that certain under-appreciated confusions in Nietzsche's thought reveal much about the positive aspects of the philosopher's moral vision. The only book devoted entirely to the Genealogy, Nietzsche's Conscience offers a sympathetic but tough-minded critical reading of the philosopher's most important work. Delivered in clear and vigorous language and employing a broadly analytical approach, Ridley's commentary makes Nietzsche's reflections on morality more accessible than they have been hitherto. (shrink)

Abstract: Philosophers interested in Kant's relevance to contemporary debates over the nature of mental content—notably Robert Hanna and Lucy Allais—have argued that Kant ought to be credited with being the original proponent of the existence of ‘nonconceptual content’. However, I think the ‘nonconceptualist’ interpretations that Hanna and Allais give do not show that Kant allowed for nonconceptual content as they construe it. I argue, on the basis of an analysis of certain sections of the A and B editions of the (...) Transcendental Deduction, for a ‘conceptualist’ reading of Kant's Critique of Pure Reason. My contention is that since Kant's notion of empirical intuition makes essential reference to the categories, it must be true for him that no empirical intuition can be given in sensibility independently of the understanding and its categories. (shrink)

How do we know right from wrong? Do we even have moral knowledge? Moral epistemology studies these and related questions about our understanding of virtue and vice. It is one of philosophy’s perennial problems, reaching back to Plato, Aristotle, Aquinas, Locke, Hume and Kant, and has recently been the subject of intense debate as a result of findings in developmental and social psychology. Throughout the book Zimmerman argues that our belief in moral knowledge can survive sceptical challenges. He also draws (...) on a rich range of examples from Plato’s Meno and Dickens’ David Copperfield to Bernard Madoff and Saddam Hussein. (shrink)

Is the procreation asymmetry intuitively supported? According to a recent article in this journal, an experimental study suggests the opposite. Dean Spears (2020) claims that nearly three-quarters of participants report that there is a reason to create a person just because that person’s life would be happy. In reply, I argue that various confounding factors render the study internally invalid. More generally, I show how one might come to adopt the procreation asymmetry for the wrong reasons by misinterpreting one’s intuitions.

The Deed is Everything offers an engaging new interpretation of Nietzsche as committed to an 'expressivist' conception of agency. Aaron Ridley shows that Nietzsche develops highly distinctive accounts of freedom, morality, and selfhood, with a robust commitment to the value of human excellence in all of its forms.

The idea that intentions make the difference between voluntary and non-voluntary behaviors is simple and intuitive. At the same time, we lack an understanding of how voluntary actions actually come about, and the unquestioned appeal to intentions as discrete causes of actions offers little if anything in the way of an answer. We cite evidence suggesting that the origin of actions varies depending on context and effector, and argue that actions emerge from a causal web in the brain, rather than (...) a central origin of intentional action. We argue that this causal web need not be confined to the central nervous system, and that proprioceptive feedback might play a counterintuitive role in the decision process. Finally we argue that the complex and dynamic origins of voluntary action and their interplay with the brain’s propensity to predict the immediate future are better studied using a dynamical systems approach. (shrink)

Readers of Spinoza's philosophy have often been daunted, and sometimes been enchanted, by the geometrical method which he employs in his philosophical masterpiece the Ethics. In Meaning in Spinoza's Method Aaron Garrett examines this method and suggests that its purpose, in Spinoza's view, was not just to present claims and propositions but also in some sense to change the readers and allow them to look at themselves and the world in a different way. His discussion draws not only on (...) Spinoza's works but also on those of the philosophers who influenced Spinoza most strongly, including Hobbes, Descartes, Maimonides and Gersonides. This controversial book will be of interest to historians of philosophy and to anyone interested in the relation between form and content in philosophical works. (shrink)