A central task of comparative constitutional law scholarship is categorization and classification of constitutions. Recent scholarship, no doubt informed by the populist tide, has sought to develop the concept of a mixed constitution. Broadly speaking, a mixed constitution is a constitution that integrates liberal and illiberal elements, elements that are usually separate and not found under the same constitution. The study of “mixed constitutions” encompasses both descriptive and normative aspects. First, an attempt to ascertain what, exactly, makes a constitution “mixed.” (...) Second, an attempt to analyze either the desirability of such a system or an attempt to figure out how to harness mixed constitutions in the service of particular normative goals, for example the protection of human rights. This article has two goals. First, an inquiry into the descriptive aspect of mixed constitutions. My aim is to show that given the seeming consensus of what constitutes a mixed constitution, the category itself might encompass many more constitutions than is often acknowledged, to the point that many constitutions are likely to be mixed to a certain extent. My second goal is to demonstrate that given this definitional consensus, what makes a constitution mixed is not necessarily because the constitution itself is mixed, but because sub-constitutional norms shape our constitutional understanding. Put differently, the meaning of a constitution is not determined exclusively through an analysis of the constitution, but also by shifts in sub-constitutional understandings. If this is correct, then it turns out that the universe of mixed constitutions is much larger than thought, which casts doubt on the utility of the category of mixed constitutions. (shrink)

Industrial drug design methodology has undergone remarkable changes in the recent history. Up to the 1970s, the screening of large numbers of randomly selected substances in biological test system was often a crucial step in the development of novel drugs. From the early 1980s, such ‘blind’ screening was increasingly rejected by many pharmaceutical researchers and gave way to ‘rational drug design’, a method that grounds the design of new drugs on a detailed mechanistic understanding of the drug action. Surprisingly, however, (...) the chance-based method of random screening returned to center stage of industrial drug development in the 1990s in the form of ‘high-throughput screening’ (HTS). I will argue in this paper that this to-and-fro in the prominence of random screening comes with fundamental changes in the epistemic significance of chance experiments in pharmaceutical development. While up to the 1970s, random screening used to be chosen as an empirical search strategy primarily because suffi- cient knowledge of the mechanistic basis of drug action was lacking, it has turned with high-throughput screening into an experimental method that employs chance variation and testing to illuminate this mechanistic basis. As a consequence, research into the underlying mechanisms of drug action and the development of new drugs have become closely integrated. The rise of HTS therefore not only shows how chance experiments have assumed a new epistemic role in drug development. It also allows for a detailed study of the much debated emergence of a new relationship between scientific understanding and the development of technological artifacts. (shrink)

This teaching resource introduces undergraduate students to Chapter 2 of John Stuart Mill's Utilitarianism. John Stuart Mill was an English philosopher and well-known proponent of utilitarianism. This chapter is Mill's attempt to answer 'What is good?' and the implications of our answer for determining which actions are morally right. Mill thinks that, ultimately, happiness is the only thing that is good, and right actions are those which maximise happiness. In providing his answer, he considers and replies to several objections, including (...) that this account is 'worthy of swine', and that it is impossible to always be certain which actions will produce the most happiness over the long-term. This piece introduces summarises the main arguments and guides readers through the chapter, outlining the key concepts and exploring the wider implications of Mill's version of utilitarianism. (shrink)

In this paper I aim to defend one version at least of Hume’s dictum: roughly, the idea that possibility is determined by ontology through something like independent variation. My defence is broadly pragmatic, in the sense that adherence to something like Hume’s dictum delivers at least three benefits. The first benefit is that, through Hume’s dictum, a physical theory’s ontology delimits a range of possibilities, that I call kinematical possibilities, which serves as a sufficiently permissive notion of possibility to sustain (...) something like an intensional semantics for its claims, and a sufficiently demanding notion of supervenience to sustain plausible claims of inter-theoretic reduction and theoretical equivalence. The second benefit is that Hume’s dictum allows us to work backwards from a range of kinematical possibilities to an ontology. This is especially useful when aiming to glean an interpretation of a physical theory, since often we are more confident that we have arrived at the right space of possibilities than that we have arrived at the right ontology. The third benefit is that Hume’s dictum —- at least the version I aim to defend here —- may be applied to physical theories more or less as we find them, and therefore we can practice something resembling ontology without having to force our theories into some Procrustean bed, such as a first-order language. (shrink)

The clinical concept of projective identification encompasses both unconscious fantasies of putting aspects of oneself into another person, as well as interpersonal processes aimed at evoking a corresponding response in another person, all for purposes of defensive evacuation, control and/or communication.1 In thinking about this complex situation, we need to consider its interpersonal dimensions as well as the intrapsychic processes that take place in each party. Louise Braddock's paper is thought provoking, far-reaching, and important in its use of concepts from (...) analytic philosophy to attempt to bring clarity on both fronts. Her account makes use of two crucial philosophical notions... (shrink)

Epistemology and Relativism Epistemology is, roughly, the philosophical theory of knowledge, its nature and scope. What is the status of epistemological claims? Relativists regard the status of epistemological claims as, in some way, relative— that is to say, that the truths which epistemological claims aspire to are … Continue reading Epistemology and Relativism →.

According to a common view, the activity of justifying is epistemologically irrelevant: being justified in believing as one does never requires the ability to justify one’s belief. This view runs into trouble regarding the epistemic basing relation, the relation between a person’s belief and the reasons for which the person holds it. The view must appeal to basing relations as part of its account of what it is for a person to be justified in believing as she does, but the (...) view prevents basing relations from doing the needed work. In place of the common view, I propose an account of basing relations which links them to the person’s commitments and hence to her justificatory activity. If this proposal is correct, then positive justificatory status, too, will be conceptually linked to the ability to succeed in the activity of justifying. (shrink)

In defending the fundamentality of the open systems view for quantum theory, Cuffaro and Hartmann (2024) articulate an account of frameworks in physics. They argue that the general quantum theory of open systems is a more fundamental framework than standard quantum theory. In this chapter, we articulate an account of frameworks using the examples of quantum field theory and statistical mechanics. We argue that what makes frameworks useful in physics is the combination of generality and abstractness of frameworks. In particular, (...) their abstractness makes them poor targets for metaphysical analysis; the more concrete levels of theories or models are the appropriate target for ontological fundamentality claims. (shrink)

"[An] important essay by a philosopher who more convincingly than any other I can think of demonstrates the continuing significance of his vocation in the life of our culture."—Karsten Harries, _The New York Times Book Review_ With _The Presence of Myth_, Kolakowski demonstrates that no matter how hard man strives for purely rational thought, there has always been-and always will be-a reservoir of mythical images that lend "being" and "consciousness" a specifically human meaning. "Kolakowski undertakes a philosophy of culture which (...) extends to all realms of human intercourse—intellectual, artistic, scientific, and emotional.... [His] book has real significance for today, and may well become a classic in the philosophy of culture."—_Anglican Theological Review_. (shrink)

Bacterial chemotaxis is often considered to be a textbook example of the rudimentary semiotic process. As such, it gives an excellent opportunity to better understand both semiosis and biology. Our study reviews this phenomenon in the light of up-to-date scientific knowledge to answer the most basic semiotic questions: what is the sign? What types of signs are there? What is the meaning understood on the molecular level, and by what means can it grow with time? As a case study, the (...) bacterial chemotaxis toward glucose in E. coli species is chosen, and the semiotic framework of Charles Sanders Peirce applied. The analyses provide us with the following results: the sign, in its ultimate nature, is a general process. Bacterial chemotaxis can be understood in terms of Peircean type, symbol, and argument. The meaning on the molecular level is entirely pragmatic and, in this case, reduced to a bacterial response to glucose. A sign can grow through sign generalization, the emergence of different sign categories, the integration of these categories in functional cycles, and the introduction of contextuality. The sign of bacterial chemotaxis extends from the cell signaling pathways up to the population level. The presented results advance our knowledge of sign processing in the context of semiotic evolution. (shrink)

In the twentieth century, economic modernization projects were often part of a broader programme of social engineering, which did not avoid – and in many cases assumed – the use of violence. The author analyses the relationship between definitions of modernity developed by the classic authors of modernization theory during the 1950s and 1960s, tries to look for their roots in Marx’s writings on colonialism, and shows the consequences of the radical version of such projects, using the example of the (...) Chinese modernization programme implemented by Mao. In conclusion, Leszczyński assumes that a clear relationship can be traced between socio-economic modernization programmes and political violence in the twentieth century. (shrink)

This article seeks to reconsider the meaning of the phrase al-shayṭān al-rajīm. It surveys the controversy surrounding the meaning of rajīm in this context and argues two points: first, that by the time the phrase was employed in the Qurʾan its original meaning had been forgotten, and second, that the original meaning of the term was related to Satan’s role as a heavenly accuser.

Michel Foucault's genealogies, due to their reliance on Nietzschean accounts of the violent origins of human culture, present a problematic description of the emergence of patterns of resistance and domination. By creating a parallel fiction of emergence that replaces Nietzschean originary violence with Richard Dawkins's account of the centrality of cultural transmission in human survival we can release emergence from the unitary Foucauldian drama. It is then possible to reconstruct Foucault's genealogies, anchoring the will to knowledge in an active agent (...) dedicated to the transgression of sociocultural limits. (shrink)

Drug development regularly has to deal with complex circumstances on two levels: the local level of pharmacological intervention on specific target proteins, and the systems level of the effects of pharmacological intervention on the organism. Different development strategies in the recent history of early drug development can be understood as competing attempts at coming to grips with these multi-level complexities. Both rational drug design and high-throughput screening concentrate on the local level, while traditional empirical search strategies as well as recent (...) systems biology approaches focus on the systems level. The analysis of these strategies reveals serious obstacles to integrating the study of interventive and systems complexity in a systematic, methodical way. Due to some fairly general properties of biological networks and the available options for pharmaceutical intervention, drug development is captured in an obstinate methodological dilemma. It is argued that at least in typical cases, drug development therefore remains dependent on coincidence, serendipity or plain luck to bridge the gap between development methodology and actual therapeutic success. (shrink)

La insistencia de Ibn Hazm en la interpretación literal del Corán y la Sunna ha llevado frecuentemente a los investigadores modernos a concluir que él es un pensador conservador o dogmático. En realidad, no es ninguna de las dos cosas. El zahirismo de Ibn Hazm enfatiza el alcance limitado de la ley religiosa islámica, e intenta reducir las pretensiones de los juristas musulmanes de hablar en nombre de la ley de Dios. Esta metodología le lleva a apoyar el racionalismo, el (...) individualismo y el anticlericalismo. Ibn Hazm argumenta con consistencia a favor de estos principios en sus trabajos sobre teoría legal islámica, entre los que se incluye el texto al-Nubdha al-kafiya fi usul ahkam al-din que traducimos aquí. Esta propuesta implica socavar todo el sistema del madhhab, lo que explica la reacción negativa que recibió del sistema religioso establecido. En lugar del madhhab, Ibn Hazm intenta hacer valer la responsabilidad individual de cada musulmán en la obediencia a la ley de Dios, tal y como se revela claramente en el texto sagrado del Islam. (shrink)