In a recent paper, Selim Berker develops an abductive argument against practical reasons for belief that exploits an alleged difference between epistemic and practical reasons. According to Berker, epistemic reasons for belief balance to suspension. If I have equally strong epistemic reasons to believe and disbelieve some proposition, I lack sufficient reason either to believe or disbelieve it. Rather, I have decisive reason to suspend judgment. In contrast, practical reasons balance to permission. If I have equally strong practical reasons to (...) φ or ψ, I have sufficient reason to do either. Given this difference, Berker argues that defenders of practical reasons for belief cannot offer a plausible explanation of how practical and epistemic reasons interact in order to yield all-things-considered normative verdicts. In this essay, I defend a non-interactionist “pure” form of pragmatism against Berker’s objection. I outline a pure pragmatist theory, recapitulate why Berker thinks it also falls prey to his objection, and explain why the objection fails to undermine pure pragmatism. Finally, I consider an additional reason Berker’s argument might seem persuasive and show that it depends on conflating Berker’s objection and a separate challenge to pure pragmatism. Once these distinct challenges are disambiguated, it is easier to see why Berker’s objection is not a significant concern for pure pragmatists. (shrink)

This chapter provides empirical evidence about everyday attitudes concerning euthanasia. These attitudes have important implications for some ethical arguments about euthanasia. Two experiments suggested that some different descriptions of euthanasia have modest effects on people’s moral permissibility judgments regarding euthanasia. Experiment 1 (N = 422) used two different types of materials (scenarios and scales) and found that describing euthanasia differently (‘euthanasia’, ‘aid in dying’, and ‘physician assisted suicide’) had modest effects (≈3 % of the total variance) on permissibility judgments. These (...) effects were largely replicated in Experiment 2 (N = 409). However, in Experiment 2, judgments about euthanasia’s moral permissibility were best predicted by the voluntariness of the treatment. Voluntariness was a stronger predictor than some demographic factors and some domain general elements of moral judgments. These results help inform some debates about the moral permissibility of euthanasia (e.g., the slippery slope argument) suggesting that some of the key premises of those arguments are unwarranted. (shrink)

Industrial drug design methodology has undergone remarkable changes in the recent history. Up to the 1970s, the screening of large numbers of randomly selected substances in biological test system was often a crucial step in the development of novel drugs. From the early 1980s, such ‘blind’ screening was increasingly rejected by many pharmaceutical researchers and gave way to ‘rational drug design’, a method that grounds the design of new drugs on a detailed mechanistic understanding of the drug action. Surprisingly, however, (...) the chance-based method of random screening returned to center stage of industrial drug development in the 1990s in the form of ‘high-throughput screening’ (HTS). I will argue in this paper that this to-and-fro in the prominence of random screening comes with fundamental changes in the epistemic significance of chance experiments in pharmaceutical development. While up to the 1970s, random screening used to be chosen as an empirical search strategy primarily because suffi- cient knowledge of the mechanistic basis of drug action was lacking, it has turned with high-throughput screening into an experimental method that employs chance variation and testing to illuminate this mechanistic basis. As a consequence, research into the underlying mechanisms of drug action and the development of new drugs have become closely integrated. The rise of HTS therefore not only shows how chance experiments have assumed a new epistemic role in drug development. It also allows for a detailed study of the much debated emergence of a new relationship between scientific understanding and the development of technological artifacts. (shrink)

Behemoth is traditionally read as supporting Hobbes's science from the treatises, but it also goes beyond the strict limitations of Hobbes's science. Understanding how Hobbes expands his approach requires that we examine how A's confidence in institutional reform is met by B's cynicism. Hobbes shifts from an analysis of general inclinations to an analysis of the particular strategies that skilful sovereigns use to acquire and maintain peace. The result is a theory of the state that relies less on> institutional arrangement, (...) and more on effective statesmanship, than we typically see when considering Hobbes's treatises alone. (shrink)

language="EN"> The eighth annual meeting of the ASSC took place between June 25th and 28th in Antwerp, an extremely beautiful Belgian city, a major European port and the home of the Peter Paul Rubens, 'the prince of painters and painter of princes'. The meeting was held in a University building at the edge of the old town. This part of the city is remarkable both for the elegance of its architecture and for its innumerable short, interlocking, streets with oddly indistinguishable (...) names. The demands on spatial memory were high and some delegates may still be hunting for the conference dinner which took place, magnificently but improbably, in a hotel - the Elzenveld - inside a hospital. (shrink)

We study the lattice of extensions of four-valued Belnap–Dunn logic, called super-Belnap logics by analogy with superintuitionistic logics. We describe the global structure of this lattice by splitting it into several subintervals, and prove some new completeness theorems for super-Belnap logics. The crucial technical tool for this purpose will be the so-called antiaxiomatic (or explosive) part operator. The antiaxiomatic (or explosive) extensions of Belnap–Dunn logic turn out to be of particular interest owing to their connection to graph theory: the lattice (...) of finitary antiaxiomatic extensions of Belnap–Dunn logic is isomorphic to the lattice of upsets in the homomorphism order on finite graphs (with loops allowed). In particular, there is a continuum of finitary super-Belnap logics. Moreover, a non-finitary super-Belnap logic can be constructed with the help of this isomorphism. As algebraic corollaries we obtain the existence of a continuum of antivarieties of De Morgan algebras and the existence of a prevariety of De Morgan algebras which is not a quasivariety. (shrink)

Drug development regularly has to deal with complex circumstances on two levels: the local level of pharmacological intervention on specific target proteins, and the systems level of the effects of pharmacological intervention on the organism. Different development strategies in the recent history of early drug development can be understood as competing attempts at coming to grips with these multi-level complexities. Both rational drug design and high-throughput screening concentrate on the local level, while traditional empirical search strategies as well as recent (...) systems biology approaches focus on the systems level. The analysis of these strategies reveals serious obstacles to integrating the study of interventive and systems complexity in a systematic, methodical way. Due to some fairly general properties of biological networks and the available options for pharmaceutical intervention, drug development is captured in an obstinate methodological dilemma. It is argued that at least in typical cases, drug development therefore remains dependent on coincidence, serendipity or plain luck to bridge the gap between development methodology and actual therapeutic success. (shrink)

This article seeks to reconsider the meaning of the phrase al-shayṭān al-rajīm. It surveys the controversy surrounding the meaning of rajīm in this context and argues two points: first, that by the time the phrase was employed in the Qurʾan its original meaning had been forgotten, and second, that the original meaning of the term was related to Satan’s role as a heavenly accuser.

Michel Foucault's genealogies, due to their reliance on Nietzschean accounts of the violent origins of human culture, present a problematic description of the emergence of patterns of resistance and domination. By creating a parallel fiction of emergence that replaces Nietzschean originary violence with Richard Dawkins's account of the centrality of cultural transmission in human survival we can release emergence from the unitary Foucauldian drama. It is then possible to reconstruct Foucault's genealogies, anchoring the will to knowledge in an active agent (...) dedicated to the transgression of sociocultural limits. (shrink)

The problem of trust in social relationships was central to the emergence of the modern form of civil society and much discussed by social and political philosophers of the early modern period. Over the past few years, in response to the profound changes associated with postmodernity, trust has returned to the attention of political scientists, sociologists, economists, and public policy analysts. In this sequel to his widely admired book, The Idea of Civil Society, Adam Seligman analyzes trust as a (...) fundamental issue of our present social relationships. Setting his discussion in historical and intellectual context, Seligman asks whether trust--which many contemporary critics, from Robert Putnam through Francis Fukuyama, identify as essential in creating a cohesive society--can continue to serve this vital role. Seligman traverses a wide range of examples, from the minutiae of everyday manners to central problems of political and economic life, showing throughout how civility and trust are being displaced in contemporary life by new "external' system constraints inimical to the development of trust. Disturbingly, Seligman shows that trust is losing its unifying power precisely because the individual, long assumed to be the ultimate repository of rights and values, is being reduced to a sum of group identities and an abstract matrix of rules. The irony for Seligman is that, in becoming postmodern, we seem to be moving backward to a premodern condition in which group sanctions rather than trust are the basis of group life. (shrink)

People engage in pure moral inquiry whenever they inquire into the moral features of some act, agent, or state of affairs without inquiring into the non-moral features of that act, agent, or state of affairs. This chapter argues that ordinary people act rationally when they engage in pure moral inquiry, and so any adequate view in metaethics ought to be able to explain this fact. The Puzzle of Pure Moral Motivation is how to provide such an explanation. This chapter argues (...) that each of the standard views in metaethics has trouble providing such an explanation. Discussion of why reveals that a metaethical view can provide such an explanation only if it meets two constraints: it allows ordinary moral inquirers to know the essences of moral properties, and the essence of each moral property makes it rational to care for its own sake whether that property is instantiated. (shrink)

The slightest reflection shows that the conceptual material employed in writing history is that of the period in which a history is written. There is no material available for leading principles and hypotheses save that of the historic present. As culture changes, the conceptions that are dominant in a culture change. Of necessity new standpoints for viewing, appraising and ordering data arise. History is then rewritten.The problem referred to in this passage is well known both from the literature on the (...) subject and the practice of historiography: historical works get old, the development of science—particularly of historical science—determines a new approach to old problems, and, consequently, history is rewritten in a different way. The fact is incontestable. But how should it be interpreted? Why is it so? (shrink)

Bacterial chemotaxis is often considered to be a textbook example of the rudimentary semiotic process. As such, it gives an excellent opportunity to better understand both semiosis and biology. Our study reviews this phenomenon in the light of up-to-date scientific knowledge to answer the most basic semiotic questions: what is the sign? What types of signs are there? What is the meaning understood on the molecular level, and by what means can it grow with time? As a case study, the (...) bacterial chemotaxis toward glucose in E. coli species is chosen, and the semiotic framework of Charles Sanders Peirce applied. The analyses provide us with the following results: the sign, in its ultimate nature, is a general process. Bacterial chemotaxis can be understood in terms of Peircean type, symbol, and argument. The meaning on the molecular level is entirely pragmatic and, in this case, reduced to a bacterial response to glucose. A sign can grow through sign generalization, the emergence of different sign categories, the integration of these categories in functional cycles, and the introduction of contextuality. The sign of bacterial chemotaxis extends from the cell signaling pathways up to the population level. The presented results advance our knowledge of sign processing in the context of semiotic evolution. (shrink)

In the twentieth century, economic modernization projects were often part of a broader programme of social engineering, which did not avoid – and in many cases assumed – the use of violence. The author analyses the relationship between definitions of modernity developed by the classic authors of modernization theory during the 1950s and 1960s, tries to look for their roots in Marx’s writings on colonialism, and shows the consequences of the radical version of such projects, using the example of the (...) Chinese modernization programme implemented by Mao. In conclusion, Leszczyński assumes that a clear relationship can be traced between socio-economic modernization programmes and political violence in the twentieth century. (shrink)

On Limited Divine Knowledge in the structure of Open Theism ‘Open Theism,’ also known as ‘open theology,’ ‘open view’ and ‘openness of God’ is not a new philosophical position, but it has not been presented and analyzed in detail in the Polish philosophy of religion. Open theism is a significant modification of the traditional Christian concept of God, some important aspects of God’s nature and God’s relationship with the world created by Him. Briefly speaking, ‘open theism’ is a philosophical model (...) of God and His activity in the world, made on the basis of analytical philosophy of religion, referring to the biblical image of God, including such issues as God’s omniscience, human freedom, the problem of evil and providence. Sometimes ‘open theism’ is also referred to as ‘free will theism’, because it is concerned with the problem of the freedom of human will and the related question of God’s omniscience. It is this latter issue that seems to be regarded by advocates of ‘open theism’ as the essential point. So someone can get the impression that the central content of this philosophical position is the problem of God’s knowledge (His foreknowledge) and the limitations of this knowledgecharacteristic of ‘open theism’. In the light of a closer analysis, however, it turns out that it is important to define precisely the role of the concept of God’s limited knowledge in the structure of ‘open theism.’ This article aims to reconstruct and present the essential elements of the ‘open theism’ with particular emphasis on the role played in it by the concept of God’s limited foreknowledge, and to clarify the place of individual elements of the structure and their relationships. Keywords: open theism, God’s foreknowledge, free will, concept of God. (shrink)

Sogdian Epigraphy of Central Asia and Semirech’e. By Vladimir A. Livshits, translated by Tom Stableford and edited by Nicholas Sims-Williams. Corpus Inscriptionum Iranicarum, pt. II: Inscriptions of the Seleucid and Parthian periods of Eastern Iran and Central Asia, vol. III: Sogdian IV. London: School of Oriental and African Studies, 2015. Pp. 315. £60.

Decisions are affected by the potential consequences as much as any factor during the decision-making process. This prospective influence represents another flaw overlooked by most experiments that raises questions about the use of certain laboratory paradigms. Lethal force encounters are a prime example of this problem, where negative consequences of slow decisions and wrong decisions should be considered alongside behavior.

The Collegium Phaenomenologicum has met in Umbria, Italy every summer since 1976; only COVID made it pause, and hopefully only temporarily. It has been a forum for deep and broad discussion of the phenomenological tradition; it has also been a place where that tradition has itself been broadened and deepened by generations of thinkers who came to study the classical texts and to do phenomenology. In 2019, over the course of three weeks in July, in three lecture courses, several talks (...) by visiting faculty, twelve text seminars sessions, art workshops, and very many informal talks over dinner, on the terrace, and on long walks through the town of Città di Castello and beyond, the Collegium worked on the question of critical phenomenology. (shrink)

Originally published during the early part of the twentieth century, the Cambridge Manuals of Science and Literature were designed to provide concise introductions to a broad range of topics. They were written by experts for the general reader and combined a comprehensive approach to knowledge with an emphasis on accessibility. Plato: Moral and Political Ideals by Adela Marion Adam, first printed in 1913, deals with the main substance of Plato's philosophy of ethics and politics, set within the context of (...) his intellectual debt to Socrates. (shrink)

Reid's principle of credulity may be interpreted as equivalent to a principle of charity, due to the nature of three beliefs it implies concerning the interlocutors, which are held by the person who attempts to acquire their language: They are telling truth in the sense that they are saying what they really think, perceive, feel, believe; they are veracious in the sense that what they say is objectively true; they use language consistently. This interpretation relies on Reid's straightforward remarks on (...) his principle of credulity and on his view of two related correspondences: One correspondence is between the principle of credulity and the principle of veracity. The other is between these two principles and the principles that create the ‘language of nature’ and guide us in our efforts to unravel it. (shrink)

Rozumienie sztuki w chrześcijaństwie nie jest jednolite. Kościoły różnie podchodzą do tej kwestii, tłumacząc się przestrzeganiem II przykazania dekalogu (Wj 20, 3–4). Ważne tu jest jednak podejście do danego dzieła sztuki: czy patrzymy na nie jako na obraz Boży, czy raczej jako na okno do transcendencji. Spotkanie ze sztuką opiera się na trzech płaszczyznach: na intencji autora, intencji dzieła i intencji odbiorcy. W bogactwie różnorodności ekumenicznej sztuka jest jak symbol, który stał się narzędziem umożliwiającym dostęp do Boga i całej rzeczywistości (...) niedającej się w pełni poznać przez współczesny język werbalny i rozum ludzki. Jej głównym zadaniem jest doprowadzenie aktu myślenia człowieka poprzez podobieństwa do zrozumienia jakiejś rzeczy lepiej i pełniej niż przez rozpoznanie zmysłami. (shrink)