Literature on maternal exposures and the risk of epigenetic changes or diseases in the offspring is growing. Paternal contributions are often not considered. However, some animal and epidemiologic studies on various contaminants, nutrition, and lifestyle‐related conditions suggest a paternal influence on the offspring's future health. The phenotypic outcomes may have been attributed to DNA damage or mutations, but increasing evidence shows that the inheritance of environmentally induced functional changes of the genome, and related disorders, are (also) driven by epigenetic components. (...) In this essay we suggest the existence of epigenetic windows of susceptibility to environmental insults during sperm development. Changes in DNA methylation, histone modification, and non‐coding RNAs are viable mechanistic candidates for a non‐genetic transfer of paternal environmental information, from maturing germ cell to zygote. Inclusion of paternal factors in future research will ultimately improve the understanding of transgenerational epigenetic plasticity and health‐related effects in future generations. (shrink)

Bobier argued that hope is necessary for practical deliberation. I will demonstrate that Bobier’s argument for this thesis fails. The problem is that one of its main premisses rests on a sufficient condition for hoping that is subject to counterexamples. I consider two ways to save the argument, but show that they are unsuccessful in doing so.

Idealism and relativism were designed to assess different ethical ideological views. Their relation with attitudes toward a variety of outgroups has not been previously studied. Understanding how concerns over ethical principles and consequences are related to prejudiced attitudes could provide some insight into these constructs and into the nature of prejudice. In two studies totaling 311 participants, participants completed measures on ethical ideologies, right-wing authoritarianism, and attitudes toward various outgroups. The differential predictive validities of ethical ideologies, in comparison to right-wing (...) authoritarianism, on prejudicial attitudes toward dangerous, derogated, and dissident outgroup members were examined. We found that both idealism and relativism contributed to predicting attitudes regarding outgroup members, over and above right-wing authoritarianism. As such, people’s personal moral standards and code of conduct for dealing with interpersonal problems and transgressions can partly explain their negative attitudes toward outgroup members. More research is required to determine the unique influence of ethical ideologies over other constructs previously shown to predict prejudice. (shrink)

Les innombrables interprétations de l’allégorie de la caverne, aussi réduc­trices ou spéculatives, aussi fidèles à la lettre ou à l'esprit du texte soient-elles, paraissent s'effacer les unes les autres, comme balayées par la souplesse d'un texte qui autorise les lectures les plus élémentaires comme les plus raffinées. Cet "étrange tableau" qu'expose Socrate s'insère immé­dia­tement entre deux pôles d'intelligibilité censés en assurer la compréhension : l'image de la ligne au...

La métaphysique est l’affirmation de la priorité de l’Être sur la puissance. En toutes ses variations stratégiques, elle retient la pensée dans la prison de l’égalité à soi. Après la physique qui n’a pu arrêter la pensée à la seule évidence sensible, la métaphysique produit les catégories réflexives d’une présence désormais reconnue jusque dans les fondements mêmes de sa représentation rationnelle. Un même désir, une même sève irrigue tout l’arbre de l’Être. Sous le tronc de la physique, les...

Noncoding RNA has arrived at centre stage in recent years with the discovery of “hidden transcriptomes” in many higher organisms. Over two decades ago, noncoding transcripts were discovered in Drosophila Hox complexes, but their function has remained elusive. Recent studies1-3 have examined the role of these noncoding RNAs in Hox gene regulation, and have generated a fierce debate as to whether the noncoding transcripts are important for silencing or activation. Here we review the evidence, and show that, by taking developmental (...) timing into account, some of these apparently conflicting results can be resolved. We examine current models that explain these data and explore alternative interpretations. BioEssays 30:110–121, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Nous nous plaisons à faire varier nos représentations. Nous jouissons en elles du dépôt stupéfiant de notre activité consciente de délimitation. Toujours nous croyons, comme le réalisme spontané nous y enjoint, que la pensée ne s’éprouve qu’en dehors d’elle-même, absorbée par l’œuvre de re­connaissance de ce qui la précède, de ce qui lui est « donné ». En cette pseudo-évidence, la forme est d’emblée présentée comme ce qui, traçant le contour, fait apparaître du fini, conformément aux conditio...

L'idealisme radical de Jean-Michel Le Lannou conteste l'identification de la pensee et de la representation. Loin de soumettre a la vacuite et la mort, l'abstraction manifeste ses puissances d'exces. Plus rien ne nous oblige a persister dans notre amour du fini. Pourtant, la philosophie s'est longtemps meprise sur elle-meme. D'ou provient une telle mesentente sur le desir du penser? Montrer comment la pensee a pu ainsi se fourvoyer sur elle-meme doit permettre d'entreprendre sa liberation definitive. Les etudes reunies ici s'attachent (...) avec ambition a eclairer ce mouvement insurrectionnel d'une pensee qui refuse de se laisser retenir par la particularite et qui, dans son detachement meme, rejoint l'affirmation substantielle la plus intense. (shrink)

What are the effects of our environment on human development and the next generation? Numerous studies have provided ample evidence that a healthy environment and lifestyle of the mother is important for her offspring. Biological mechanisms underlying these environmental influences have been proposed to involve alterations in the epigenome. Is there enough evidence to suggest a similar contribution from the part of the father? Animal models provide proof of a transgenerational epigenetic effect through the paternal germ line, but can this (...) be translated to humans? To date, literature on fathers is scarce. Human studies do not always incorporate appropriate tools to evaluate paternal influences or epigenetic effects. In reviewing the literature, I stress the need to explore and recognize paternal contributions to offspring's health within the Developmental Origins of Health and Disease hypothesis, and coin this new concept the Paternal Origins of Health and Disease paradigm. A better understanding of preconceptional origins of disease through the totality of paternal exposures, or the paternal exposome, will provide evidence-based public health recommendations for future fathers. A father's hereditary contribution exceeds that of his DNA sequence. The environment can regulate systems such as the sperm epigenome, which is inheritable as well and may steer the genome and health status of his offspring. We here suggest a new concept, the Paternal Origins of Health and Disease, as part of the DOHaD theory. (shrink)

I will argue for a novel variant of the knowledge norm for practical reasoning. In Sect. 2, I will look at current variations of a knowledge norm for practical reasoning and I will provide reasons to doubt these proposals. In Sects. 3 and 4, I develop my own proposal according to which knowledge is the norm of apt practical reasoning. Section 5 considers objections. Finally, Sect. 6 concerns the normativity of my proposed knowledge norm and its significance.

If we supply a missing connection in the master text of English Renaissance poetic theory, we can bring the dilemma posed by political poetry into sharp relief. Sidney’s Defence of Poesie seeks to confirm the supremacy of the poet’s power over human minds by invoking the celebrated three-way distinction between poetry, philosophy, and history in the Poetics. According to Sidney, the proper question to ask of poetry is not “whether it were better to have a particular act truly or falsely (...) set down” but “whether it be better to have it set down as it should be, … for your own use and learning.” On this criterion, the philosopher shows himself too devoted to “knowledge” that “standeth upon the abstract and general,” to the “precept,” to “what should be.” The historian attends too much to “the particular truth of things and not to the general reason of things,” to the “example,” to “what is.” Only the poet “coupleth the general notion with the particular example” in “the speaking picture of poesy,” thus synthesizing through his “imaginative and judging power” the best that the philosophical and historical domains can offer. “Aristotle himself,” concludes Sidney, “plainly determineth this question, saying that poetry … is more philosophical and more studiously serious than history … because poesy dealeth with … the universal consideration, and the history with … the particular.” Yet in mounting his Defence of Poesie, Sidney fails to give due force to a related and equally important distinction drawn from the Poetics. Aristotle ranks poetry below philosophy—and, by implication, history as well—at the crucial juncture where ontology and epistemology meet. He exclusively credits philosophical universals with rational “necessity.” Poetic universals are recognized as having imaginative “likelihood,” but no more than this.1 Under this second three-way distinction, the domain proper to poetry turns out to be neither the realm of historical fact nor that of philosophical truth but some half-region of the truthlike, the verisimilar, disjoint from the plane of knowledge.[…]Milton coped with the questions intrinsic to political poetry during the decade from 1642 to 1652 when he rose to prominence as a pamphleteer on public issued and concurrently pioneered the writing of political sonnets in English. This essay examines the responses he made, in part in his prose but mainly in the composition of seven sonnets. Political poems in a root sense, these sonnets concern themselves with human agency channeled into the functions of the state, with power manifested through governance. After exploratory and uneven beginnings, the group as a whole goes a fair way toward vindicating the enterprise of political poetry and offering one set of criteria for a good political poem. 1. The core distinctions are drawn by Aristotle in chap. 9, secs. 2-4, of the Poetics; also see chap. 1, sec. 1 of the Topics on the distinction between demonstration, based on reasoning from true knowledge, and dialectic, based on reasoning from what is generally accepted as probable. The quotations in this paragraph are from Sidney: A Defence of Poetry, ed. J. A. Van Dorsten , pp. 35, 32, 33, 35. Janel Mueller is professor of English and humanities at the University of Chicago. She has published mainly on poetry and prose of the earlier English Renaissance, culminating in her book The Native Tongue and the Word: Developments in English Prose Style, 1380-1580. An interest in Milton, however, has drawn her more recently to work in the later part of this period. She is writing a book on nature, culture, and gender in Milton’s major poems. (shrink)

Dans le temps même où elle transforme le donné en reflet, la pensée tend à se représenter sous ses actes la présence silencieuse d’un irréfléchi qui résiste à son activité de séparation. Dans sa protestation contre l’emprison­ne­ment de l’évidence, la réflexion peine à se départir de la croyance que son écart n’est que provisoire et qu’il précède une ferme appropriation. Nous ne réfléchirions que pour mieux nous attacher au monde, à la vie et à nous-mêmes. Mais le désir de la (...) réflexion n’est... (shrink)

This article draws on ethnographic field data collected during an investigation of the informed consent process and AIDS clinical trials. It describes the involvement of care providers (physicians, nurse practitioners, physician assistants) during the enlistment, or recruitment, phase of the informed consent process. It shows that sometimes care providers are involved in the receipt, evaluation and distribution of information on clinical trials through their interactions with research professionals and patients. It suggests that the involvement of care providers has the potential (...) to influence the informed consent process. Some of the ethical and practice considerations of this are discussed. (shrink)

The basic hypothesis of this book is that linguistic reference to kinds should be seen as reference to sortal concepts, i.e. cognitive categories for identifying and classifying objects. Viewed that way, kinds serve as the interface between the conceptual system and the grammatical system. Kind-level predicates differ as to whether they presuppose (e.g. to be extinct) or entail (e.g. to invent) the existence of objects, with crucial consequences for the interpretation of indefinite argument noun phrases. Moreover, object reference always involves (...) underlying kind reference, but kind reference does not always involve object reference. This asymmetry, once recognized, proves useful in solving otherwise puzzling problems in semantic composition. (shrink)

The past 20 years have seen dramatic rises in suicide rates in the United States and other countries around the world. These trends have been identified as a public health crisis in urgent need of new solutions and have spurred significant research efforts to improve our understanding of suicide and strategies to prevent it. Unfortunately, despite making significant contributions to the founding of suicidology – through Emile Durkheim’s classic Suicide (1897/1951) – sociology’s role has been less prominent in contemporary efforts (...) to address these tragic trends, though as we will show, sociological theories offer great promise for advancing our understanding of suicide and improving the efficacy of suicide prevention. Here, we review sociological theory and empirical research on suicide. We begin where all sociologists must: with Durkheim. However, we offer a more comprehensive understanding of Durkheim’s insights into suicide than the prior reviews provided by those in other disciplines. In so doing, we reveal the nuance and richness of Durkheim’s insights that have been largely lost in modern suicidology, despite being foundational to all sociological theories of suicide – even those that have moved beyond his model. We proceed to discuss broadly acknowledged limitations to Durkheim’s theory of suicide and review how more recent theoretical efforts have not only addressed those concerns, but have done so by bringing a larger swatch of sociology’s theoretical and empirical toolkit to bare on suicide. Specifically, we review how recent sociological theories of suicide have incorporated insights from social network theories, cultural sociology, sociology of emotions, and sociological social psychology to better theorize how the external social world matters to individual psychological pain and suffering. We conclude by making explicit bridges between sociological and psychological theories of suicide; by noting important limitations in knowledge about suicide – particularly regarding the roles of organizations, inequality, and intersectionality in suicide – that sociology is well situated to help address. (shrink)

Genetic modification of crop plants is frequently described by its proponents as a continuation of the ancient process of domestication. While domestication, crop breeding, and GM all modify the genomes and phenotypes of plants, GM fundamentally differs from domestication in terms of the biological and sociopolitical processes by which change occurs, and the subsequent impacts on agrobiodiversity and seed sovereignty. We review the history of domestication, crop breeding, and GM, and show that crop breeding and GM are continuous with each (...) other in many important ways, but represent a momentous break from domestication because they move plant evolution off of farms and into centralized institutions. The social contexts in which these processes unfold dictate who holds rights to germplasm and agricultural knowledge, shape incentives to effect particular kinds of changes in our crops, and create or constrict biodiversity. Presenting GM as a continuation of domestication puts forward a false equivalency that fundamentally misrepresents how domestication, crop breeding, and GM occur. In doing so, this narrative diminishes public understanding of these important processes and obscures the effects of industrial agriculture on in situ biodiversity and the practice of farming. This misrepresentation is used in public-facing science communication by representatives of the biotechnology industry to silence meaningful debate on GM by convincing the public that it is the continuation of an age-old process that underlies all agricultural societies. (shrink)

It is a popular thought that emotions play an important epistemic role. Thus, a considerable number of philosophers find it compelling to suppose that emotions apprehend the value of objects and events in our surroundings. I refer to this view as the Epistemic View of emotion. In this paper, my concern is with a rivaling picture of emotion, which has so far received much less attention. On this account, emotions do not constitute a form of epistemic access to specific axiological (...) aspects of their objects. Instead it proposes that they are ways of taking a stand or position on the world. I refer to this as the Position-Taking View of emotion. Whilst some authors seem sympathetic to this view, this it has so far not been systematically motivated and elaborated. In this paper, I fill this gap and propose a more adequate account of our emotional engagement with the world than the predominant epistemic paradigm. I start by highlighting the specific way in which emotions are directed at something, which I contrast with the intentionality of perception and other forms of apprehension. I then go on to offer a specific account of the valence of emotion and show how this account and the directedness of emotions makes them intelligible as a way of taking a position on something. (shrink)