Today Asia is attracting attention in the area of bioethics. In fact, the potential of bioethics is beginning to be discussed seriously at academic centers across Asia. In Japan, this discussion began a decade ago with the publication The book is one of the principal explorations of biomedical ethics involving Japan to date. Tom Beauchamp, an author of one of the book's chapters, compares Japanese and American standards of informed consent and refutes relativistic positions, concluding that.

In Japan, modern biomedical ethics emerged in the early 1980s. One of the main triggers was the nationwide debate on organ transplantation and brain death. A lengthy process of academic, religious, and political discussion concerning organ transplantation, lasting well over a few decades, resulted in the enactment of the Organ Transplantation Law in 1997.1 The defining of death and other bioethical issues, including death with dignity and euthanasia, were also stimulating topics throughout the latter end of the twentieth century. For (...) instance, the death-with-dignity movement, which started around the late 1960s, developed into a hospice/palliative-care movement by the end of the 1980s. (shrink)

BackgroundMost medical schools in Japan have incorporated mandatory courses on medical ethics. To this date, however, there is no established means of evaluating medical ethics education in Japan. This study looks 1) To develop a brief, objective method of evaluation for moral sensitivity and reasoning; 2) To conduct a test battery for the PIT and the DIT on medical students who are either currently in school or who have recently graduated (residents); 3) To investigate changes in moral sensitivity and reasoning (...) between school years among medical students and residents.MethodsQuestionnaire survey: Two questionnaires were employed, the Problem Identification Test (PIT) for evaluation of moral sensitivity and a portion of the Defining Issues Test (DIT) for moral reasoning. Subjects consisted of 559 medical school students and 272 residents who recently graduated from the same medical school located in an urban area of Japan.ResultsPIT results showed an increase in moral sensitivity in 4th and 5th year students followed by a decrease in 6th year students and in residents. No change in moral development stage was observed. However, DIT results described a gradual rising shift in moral decision-making concerning euthanasia between school years. No valid correlation was observed between PIT and DIT questionnaires.ConclusionThis study's questionnaire survey, which incorporates both PIT and DIT, could be used as a brief and objective means of evaluating medical students' moral sensitivity and reasoning in Japan. (shrink)

L’article explore le tai chi, art martial d’origine chinoise aujourd’hui majoritairement suivi pour ses bienfaits sur la santé et ses implications spirituelles. Notre intérêt porte sur le fait que l’entraînement à des « formes », une série de mouvements exécutés en solitaire, souvent lentement, s’observe non seulement dans la plupart des écoles focalisées sur la santé, mais aussi dans une minorité portée sur l’aspect martial. Pour analyser le rôle des formes dans l’apprentissage des techniques de combat, l’article s’appuie sur l’émersiologie, (...) l’étude de l’activation involontaire du corps, permettant la focalisation sur les éléments propices à la transformation du schéma corporel. Cette analyse vise à concilier la dichotomie entre le tai chi comme art martial, de combat, et sa pratique à des fins de santé, apportant une meilleure compréhension de l’évolution historique du tai chi. (shrink)

Compared to institutional and area-based ethics committees, little is known about the structure and activities performed by ethics committees at national medical organizations and societies. This five year follow-up study aimed to determine (1) the creation and function of ethics committees at medical organizations in Japan, and (2) their general strategies to deal with ethical problems. The study sample included the member societies of the Japanese Association of Medical Sciences (n=92 in 1998, n=96 in 2003). Instruments consisted of two sections: (...) (1) the structure, function and activities of ethics committees, and (2) the strategies for dealing with ethical problems. Response rates were 84.4% in 1998 and 64.4% in 2003. Findings showed a significant increase of ethics committees at medical organizations between 1998 (25.6%) and 2003 (50.0%). Members were mostly male, medical doctors in clinical or basic medicine, and members of the organization. The major functions of ethics committees were ethical reviews of research protocols, policy making and ethical reviews of manuscripts submitted for journal publication. Among organizations that did not have an ethics committee, a significant decrease was found in organizations that replied that they had never experienced an ethical problem which needed further investigation (p<0.01). Findings suggested an overall rise in awareness of the importance of ethical issues and also highlighted an increase in recognition of responsibility regarding ethical problems. (shrink)

We examined the ethical justification for a national policy governing public funding for the induced pluripotent stem cell stock project in Japan and argue that the initiation of the iPSC stock project in 2012, when no clinical trial using iPSC-derived products had yet succeeded, was premature and unethical. Our analysis considers a generally accepted justice criterion and shows it fails to justify public funding of the iPSC stock project. We also raise concerns related to the massive amounts of public funding (...) at stake and the absence of evidence supporting claimed success rates. We conclude that the iPSC stock project should be re-considered and deferred until a substantial number of clinical trials using iPSC-derived products are deemed successful. This analysis should benefit others worldwide as they consider their own public funding policies. (shrink)

This is the first book to bring West and East together in a broad investigation of contemporary bioethics. A distinguished international team of experts presents original research addressing issues that emerge from new medical technologies, address global challenges arising from social change, and set the agenda for the future.

In this article, we address the problem of how people understand predicative metaphors such as “The rumor flew through the office,” and argue that predicative metaphors are understood as indirect (or two-stage) categorizations. In the indirect categorization process, the verb (e.g., fly) of a predicative metaphor evokes an intermediate entity, which in turn evokes a metaphoric category of actions or states (e.g., “to spread rapidly and soon disappear”) to be attributed to the target noun (e.g., rumor), rather than directly evoking (...) a metaphoric category as argued by CitationGlucksberg's (2001) categorization theory. We test our argument using two experiments, namely, offline comprehension and online priming. The offline comprehension experiment showed that interpretation of predicative metaphors had greater overlap with words indirectly associated with the verb than those directly associated with the verb. The online priming experiment demonstrated that indirectly associated words were activated during predicative metaphor comprehension, but directly associated words were not. These results provide convergent evidence for our argument, and thus the psychological validity of two-stage categorization as a process of predicative metaphor comprehension was confirmed. (shrink)

Caplan & Waters's arguments for separate working memory subsystems for “interpretive” and “post-interpretive” comprehension processes do not have a solid empirical basis. The likely involvement of a separate phonological loop makes their memory-load data irrelevant to theory evaluation, and the lack of statistical power from nonoptimal experimental designs and analyses unfairly reduces the chances of detecting the relevant interactions.

The author points out that there is an essential difference as well as correspondence between the idea of the absolute in Fichte’s philosophy and that of the emptiness (sunyata) in Mahayana Buddhism. Both ideas treat the origin of the subject which goes beyond the relation of subject and object. In this point they are in agreement. But if we pay attention to the point that the absolute in Fichte’s philosophy is completely closed and therefore includes no negation in itself, it (...) becomes clear that it is, however, different from the Buddhist emptiness which consists in selfaffirmation through selfnegation. According to the author, the consciousness which works as a creator of the world in Fichte’s system remains out of the absolute. In this sense, Fichte’s idea of the absolute is insufficient as a principle of philosophy. Der Verfasser weist darauf hin, dass es zwischen dem Begriff des Absoluten bei Fichte und dem der Leere (sunyata) im Mahayanabuddhismus neben einer Übereinstimmung auch einen wesentlichen Unterschied gibt. Beide Begriffe stimmen darin überein, dass es ihnen um den Ursprung des Subjekts geht, der über die Relation von Subjekt und Objekt hinausgeht. Wenn man aber die Aufmerksamkeit darauf richtet, dass das Absolute bei Fichte als ein in sich Geschlossenes keine Negation in sich enthält, wird deutlich, dass es sich von der buddhistischen Leere unterscheidet, die in Selbstaffirmation durch Selbstnegation besteht. Bei Fichte hingegen bleibt das Bewusstsein als Weltschöpfer noch außer dem Absoluten. In diesem Sinne ist das Fichtesche Absolute als Prinzip der Philosophie unzureichend. (shrink)

Interleukin 5 (IL‐5) is a kind of peptide hormone released from T lymphocytes of mammals infected with microorganisms or parasites. It is an acidic glycoprotein with a molecular mass of 40 to 50 kDa that consists of a homodimer of polypeptides. It controls hematopoiesis so that it increases natural immunity. In the mouse, IL‐5 acts on committed B cells to induce differentiation into Ig‐producing cells and on common progenitors for CD5+ pre‐B cells and CD5+ macrophages to support their survival. The (...) antibodies secreted by CD5+ B cells seem to be responsible for the primary protection against the infection with microorganisms or parasites. It also supports the growth and/or differentiation of eosinophil precursor and mature eosinophils, which can be effective for the removal of parasites in combination with the antibodies against them. Murine IL‐5 receptor (IL‐5R) consists of two different polypeptide chains; αL chain and β chain. The IL‐5R α chain is 60 kDa protein that binds IL‐5 with low affinity. The IL‐5R β chain is a 130 kDa protein which does not bind IL‐5 by itself but is necessary to form the high affinity IL‐5R. The β chain was identified by using one of the anti‐IL‐5R mAb and anti‐IL‐3R mAb as the IL‐3R homologue. This β chain is also used as the β chain of GM‐CSF receptor. This fact suggests that there is a common signaling mechanism among these cytokines and efficient cooperation among them. At the same time, these findings may explain the overlapping role of these cytokines in the development of granulocytes. (shrink)

Informed consent, decision-making styles and the role of patient-physician relationships are imperative aspects of clinical medicine worldwide. We present the case of a 74-year-old woman afflicted with advanced liver cancer whose attending physician, per request of the family, did not inform her of her true diagnosis. In our analysis, we explore the differences in informed-consent styles between patients who hold an "independent" and "interdependent" construal of the self and then highlight the possible implications maintained by this position in the context (...) of international clinical ethics. Finally, we discuss the need to reassess informed-consent styles suitable to the needs of each patient regardless of whether he or she resides in the United States or in Japan. (shrink)

AbstractThe Belmont Report continues to be held in high regard, and most bioethical analyses conducted in recent years have presumed that it affects United States federal regulations. However, the assessments of the report’s creators are sharply divided. Understanding the historic reputation of this monumental report is thus crucial. We first recount the historical context surrounding the creation of this report. Subsequently, we review the process involved in developing ethical guidelines and describe the report’s features. Additionally, we analyze the effect of (...) unfolding events on the subsequent creation of federal regulations, especially on gene therapy clinical trials. Moreover, throughout this paper we evaluate the ethical principles outlined in this report and describe how they overlap with the issue of protecting socially vulnerable groups. Based on the analysis, we conclude that the features of the Belmont Report cannot be considered as having affected the basic sections of the federal regulations for ethical reviews that were made uniform in 1981. Nevertheless, regarding the regulations on gene therapy clinical trials—which were at first expected to be applicable to research involving children—in addition to implementing policies regarding the public review of protocols that passed ethical review, this report’s principles are clearly reflected in the key notes that should have been referred to when the report was created. (shrink)

BackgroundSolitary death (kodokushi) has recently become recognized as a social issue in Japan. The social isolation of older people leads to death without dignity. With the outbreak of COVID-19, efforts to eliminate solitary death need to be adjusted in line with changes in lifestyle and accompanying changes in social structure. Health monitoring services that utilize wearable devices may contribute to this end. Our goals are to outline how wearable devices might be used to (1) detect emergency situations involving solitary older (...) people and swiftly connect them with medical treatment, to (2) reduce the frequency of deaths that remain undiscovered and (3) to reduce social isolation by promoting social interaction. MethodsTheoretical and philosophical approaches were adopted to examine ethical issues surrounding the application of wearable devices and cloud-based information processing systems to prevent solitary death in the world with/after COVID-19.Main body(1) Technology cannot replace social connections; without social support necessary to foster understanding of the benefits of health management through wearable devices among older adults, such devices may remain unused, or not used properly. (2) Maturity of the technology; systems face the difficult task of detecting and responding to a wide range of health conditions and life-threatening events in time to avert avoidable morbidity and mortality. (3) Autonomy and personhood; promoting the voluntary use of wearable devices that are a part of larger efforts to connect isolated individuals to a community or social services might be effective. Legal force should be avoided if possible. There is some concern that landlords may require an older person to sign a contract agreeing to wear a device. The autonomy of solitary older people should be respected. (4) Governance: policies must be developed to limit access to data from wearables and the purposes for which data can be used.ConclusionIf thoughtfully deployed under proper policy constraints, wearable devices offer a way to connect solitary older people to health services and could reduce cases of solitary death while respecting the personhood of the user. (shrink)

Recent metaphor research has revealed that metaphor comprehension involves both categorization and comparison processes. This finding has triggered the following central question: Which property determines the choice between these two processes for metaphor comprehension? Three competing views have been proposed to answer this question: the conventionality view (Bowdle & Gentner, 2005), aptness view (Glucksberg & Haught, 2006b), and interpretive diversity view (Utsumi, 2007); these views, respectively, argue that vehicle conventionality, metaphor aptness, and interpretive diversity determine the choice between the categorization (...) and comparison processes. This article attempts to answer the question regarding which views are plausible by using cognitive modeling and computer simulation based on a semantic space model. In the simulation experiment, categorization and comparison processes are modeled in a semantic space constructed by latent semantic analysis. These two models receive word vectors for the constituent words of a metaphor and compute a vector for the metaphorical meaning. The resulting vectors can be evaluated according to the degree to which they mimic the human interpretation of the same metaphor; the maximum likelihood estimation determines which of the two models better explains the human interpretation. The result of the model selection is then predicted by three metaphor properties (i.e., vehicle conventionality, aptness, and interpretive diversity) to test the three views. The simulation experiment for Japanese metaphors demonstrates that both interpretive diversity and vehicle conventionality affect the choice between the two processes. On the other hand, it is found that metaphor aptness does not affect this choice. This result can be treated as computational evidence supporting the interpretive diversity and conventionality views. (shrink)

The purpose of this paper is to show the plausibility of John Rawls’s treatment of efficiency within the system of justice. While in political philosophy efficiency is often treated as an independent condition for establishing justice, or more precisely, as a necessary condition for establishing justice, Rawls considers efficiency as a non-negligible factor that has normativity in general circumstances. This is similar to the view that efficiency is a presumptive condition for evaluating social arrangements. However, Rawls’s view is salient in (...) a more substantive way. This paper demonstrates the salience of Rawls’s view of efficiency by responding to G. A. Cohen’s Impure Justice Objection to Rawls’s theory of justice. This shows that there is no impure connection between Rawls’s justice and efficiency. Moreover, the combined thesis of Rawls’s justice and efficiency is superior to Cohen’s pluralist theory of justice, making it a fruitful approach. (shrink)

Le réseau Labornet a été créé en Californie en 1991 par des syndicalistes, pour donner un nouveau souffle au mouvement ouvrier. Il est aujourd'hui présent dans une dizaine de pays industrialisés, en Amérique du Nord, en Europe et en Asie. La branche japonaise, Labornet Japan, est née en 2001 avec l'aide des militants coréens. À travers une série d'événements annuels comme la Labor Fiesta ou la campagne Union, Yes !, la diffusion de vidéos sur Union-Tube, le réseau Labornet Japan a (...) su développer une nouvelle culture militante qui dépasse les vieux clivages politiques et syndicaux. En dépit de la multiplication des contrats précaires, il attire de nombreux jeunes vers l'action collective.LaborNet network was established in California in 1991 by trade unionists, to reinvigorate the labor movement. It is currently present in ten countries in North America, Europe and Asia. The Japanese branch, LaborNet Japan, was founded in 2001 with the help of Korean activists. Through a series of annual events like the Fiesta or the Labor Union campaign, Yes!, Dissemination of EU-Tube videos on the network LaborNet Japan has developed a new activist culture that goes beyond the old political divisions and labor. Despite the proliferation of precarious contracts, it attracts many young people to collective action. (shrink)