The consequences of experiences and exposures suffered by those living in poverty can last a lifetime and can even be passed on to the next generation. The challenges associated with poverty have been labeled the "social determinants of health" (SDoH), but this is something of a misnomer. A more appropriate label would be the "social determinants of disease." This essay is a broad overview of the processes, including allostatic load and epigenetic aging, that might contribute to prolonging the adverse effects (...) of the social determinants of disease. (shrink)

Excerpt from Cultures and Institutions of Natural History: Essays in the History and Philosophy of Science This volume consists mainly of papers delivered at two meetings cosponsored by the Museo Civico di Storia Naturale in Milan and the California Academy of Sciences in San Francisco. The first, on the Culture of Natural History, was held in Milan, November l4-l 6, I996. The second, on Institutions of Natural History, was held in San Francisco, October 5 - 7, 1998. They followed two (...) earlier conferences on Biology as History (pinna and Ghiselin I996; Ghiselin and Pinna I996) likewise held in Milan and San Francisco. We intend to continue the series of meetings and have publications based on them in commemoration of the Academy's sesquicentennial in 2003. The emphasis here is mainly upon natural history museums and the kind of science that goes on in them. Although the essays were originally written to stand by themselves, when arranged in chronological order they suggest a common theme. To paraphrase Darwin, the culture and institutions of natural history have been, and are being, evolved. They have adapted to local circumstances, diversified, and sometimes even progressed. We may hope that the future holds more than just retrogression and extinction in store. Read as case studies the essays provide valuable insights into not just how, but why, the institutions have come into being and subsequently been transformed. Previous generations had quite different ideas than we do about how a collection of naturalia is supposed to function and how it should be organized. And there were con icting goals and serious disputes about policy, much as there are today. Often, though not always, the institutions turn out to be very different from what had been envisioned by their founders. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.". (shrink)

What is new here is the detailed discussion of several important results in the classical foundations of mathematics and of the relation of logic to mathematics. As regards logical questions, the central thesis of Wittgenstein's later philosophy is well known, both from the earlier posthumous volume and from the writings of his many disciples. In the Investigations the thesis is applied to the "logic of our expressions" in everyday contexts; here he discusses in the same spirit the more specialized language (...) used in talking about the foundations of mathematics. (shrink)

Explores the extraordinary states of expanded consciousness that arise during comas, both positive and negative.

Drawing upon ancient Hindu philosophy, the author explores the human psyche and the importance of personal identity.

O texto investiga algumas dimensões do pensamento de Levinas em relação aos temas da linguagem, justiça, perdão e pluralidade, entre outros, a partir da leitura talmúdica “Envers Autrui”, estabelecendo relações com alguns aspectos da filosofia analítica e do pensamento do Kant e William Galston.

(1986). Reason and Nuclear Deterrence. Canadian Journal of Philosophy: Vol. 16, Supplementary Volume 12: Nuclear Weapons, Deterrence and Disarmament, pp. 129-159.

In her dedicated promotion of feminism and pacifism, especially during the 1930s, Vera Brittain (1893–1970) was strongly influenced by Ber­trand Russell’s writings, especially Marriage and Morals (1929) and Which Way to Peace? (1936). Both were members of the Peace Pledge Union, and she continued as a sponsor after Russell abandoned his pac­ifism soon after the beginning of the Second World War. She admired his political and social activism in the aftermath of that war, endorsing it as much as her family (...) situation allowed; and, as chairman of the Peace News board, Brittain intervened in Russell’s support when a dispute broke out between him and the editor. Although their rela­tionship was personally limited, Russell’s influence on her opinions and actions was profound. (shrink)

Taking religious freedom as illustrative, this essay proposes a theory of the basic freedoms that pacifies the conflict among libertarian, egalitarian, and communitarian sects of liberalism. This theory follows John Rawls’s suggestion that constitutional courts are exemplars of public reason but rejects his partisan construal of public reason in terms that only an egalitarian liberal would recognize. If, as Rawls argues, liberal pluralism is reasonable and if constitutional courts are guardians of public reason, then an ideal constitutional court will guide (...) itself by the theory of the basic freedoms that reconciles liberal pluralism with the rule of public reason. Such a theory will integrate the plurality of liberal sects into an inclusive liberalism that preserves a distinctive role for each in defining and limiting constitutional rights, while refining them of the errors resulting from their hegemonic ambitions. Liberal pluralism is thus preserved, but liberal fragmentation is overcome. Public reason is sought not through an escape from pluralism but in a logical concord among the denominations of liberalism. The way for courts to execute this concord in constitutional cases is to follow the method of reasoning they have already largely adopted. That method is proportionality review. (shrink)

Michael Tooley defends infanticide by analysing ‘A has a right to X’ as roughly synonymous with ‘If A desires X, then others are under a prima facie obligation to refrain from actions that would deprive him [or her] of it.’ An infant who cannot conceive of himself or herself as a continuing subject of experiences cannot desire to continue existing. Hence, on Tooley’s analysis, killing the infant is not impermissible, for it does not go against any of the infant’s desires. (...) However, Tooley’s argument in support of his analysis seems to justify, instead, a slightly more subtle analysis—namely, ‘A has a right to X’ is roughly extensionally equivalent with ‘Unless A expresses his or her desire that not‐X, then others are under a prima facie obligation to refrain from actions that would deprive him or her of X.’ But given this analysis, the infant’s purported lack of any capacity to conceive of himself or herself as a continuing subject of experiences implies that we cannot be released from any duty that we might have not to harm him or her. In short, Tooley’s argument in support of his analysis actually implies that infanticide may well be impermissible. (shrink)

Although retroviral integration requires specific viral DNA sequences, factors which govern the choice of a chromosomal target site within an infected celi are less clear. For example, certain chromosomal regions may be inaccessible to the viral integration machinery, while others may favor integration. A recent paper by Withers‐Ward et al.(1) addresses this issue using a polymerase chain reaction‐based assay capable of identifying single integration events within a large population of infected cells. Their results show that integration can occur into many (...) different chromosomal regions, and that local DNA structure can influence the site of integration within a given region. (shrink)