Dispositional essentialism, a plausible view about the natures of (sparse or natural) properties, yields a satisfying explanation of the nature of laws also. The resulting necessitarian conception of laws comes in a weaker version, which allows differences between possible worlds as regards which laws hold in those worlds and a stronger version that does not. The main aim of this paper is to articulate what is involved in accepting the stronger version, most especially the consequence that all possible properties exist (...) in all worlds. I also suggest that there is no particularly strong reason for preferring the weaker to the stronger version. For example, Armstrong's instantiation condition on universals entails that according to strong necessitarianism every property is instantiated in all possible worlds. But first we do not need to accept Armstrong's instantiation condition, in part because his arguments for it are forceful only for a contingentist about laws and properties. Secondly, even if we do accept the condition, the consequence that all properties are instantiated is not itself contradictory, so long as any form of necessitarianism holds. Strong necessitarianism is prima facie counter-intuitive. But for that matter so is weak necessitarianism. Accepting either weak or strong necessitarianism requires denying the force of intuition in this area. And indeed we have every reason to deny the force of intuition and its primary source, imagination, concerning modal facts. (shrink)

Evidence is often taken to be foundational, in that while other propositions may be inferred from our evidence, evidence propositions are themselves not inferred from anything. I argue that this conception is false, since the non-inferential propositions on which beliefs are ultimately founded may be forgotten or undermined in the course of enquiry.

This chapter contains sections titled: Introduction Two Interrelated Problems Lewis's Solution Inductive Paradox Identity versus Counterpart Theory Platonism: The Main Realist Alternative to Lewis An Aristotelian Alternative Leibniz's Account A Combined Account.

The need to find an intrinsic characterization of what makes a relation between events causal arises not only in local theories of causation like Salmon's process theory but also in global approaches like Lewis' counterfactual theory. According to the localist intuition, whether a process connecting two events is causal should depend only on what goes on between the events, not on conditions that hold elsewhere in the world. If such intrinsic characterizations could be found, an identification of the causal relation (...) in the actual world (though not in other possible worlds) with physical processes may be feasible (the a posteriori identification). I consider recent proposals made for intrinsic characterizations of causality and conclude that none of them is able to deliver the intended result. (shrink)

In this paper I argue that we can understand incommensurability in a naturalistic, psychological manner. Cognitive habits can be acquired and so differ between individuals. Drawing on psychological work concerning analogical thinking and thinking with schemata, I argue that incommensurability arises between individuals with different cognitive habits and between groups with different shared cognitive habits.

Previous research has established that goal tracking emerges early in the first year of life and rapidly becomes increasingly sophisticated. However, it has not yet been shown whether young children continue to update their representations of others’ goals over time. The current study investigates this by probing young children’s ability to differentiate between goal directed actions that have been halted because the goal was interrupted, and because the goal was abandoned. To test whether children are sensitive to this distinction, we (...) manipulated the experimenter’s reason for not completing a goal-directed action - his initial goal is either interrupted by an obstacle, or it is abandoned in favour of an alternative. We measure whether children’s helping behaviour is sensitive to the experimenter’s reason for not completing his goal-directed action by recording whether they complete the experimenter’s initial goal or the alternative goal. The results showed that children helped complete the experimenter’s initial goal significantly more often after this goal had been interrupted than after it had been abandoned. These results support the hypothesis that children continue to update their representations of others’ goals over time by the age of two, and specifically that they differentiate between abandoned and interrupted goals. (shrink)

Social and behavioral scientists - that is, students of human nature - nowadays hardly ever use the term ‘human nature’. This reticence reflects both a becoming modesty about the aims of their disciplines and a healthy skepticism about whether there is any one thing really worthy of the label ‘human nature’.

This paper argues that if creatures are to have significant free will, then God's essential omni-benevolence and essential omnipotence cannot logically preclude Him from creating a world containing a moral evil. The paper maintains that this traditional conclusion does not need to rest on reliance on subjunctive conditionals of free will. It can be grounded in several independent ways based on premises that many will accept.

How can it be rational to work on a new theory that does not yet meet the standards for good or acceptable theories? If diversity of approaches is a condition for scientific progress, how can a scientific community achieve such progress when each member does what it is rational to do, namely work on the best theory? These two methodological problems, the problem of pursuit and the problem of diversity, can be solved by taking into account the cognitive risk that (...) is involved in theory choice. I compare this solution to other proposals, in particular T. S. Kuhn's and P. Kitcher's view that the two problems demonstrate the epistemic significance of the scientific community. (shrink)

In this paper I examine two aspects of Hempel’s covering-law models of explanation. These are (i) nomic subsumption and (ii) explication by models. Nomic subsumption is the idea that to explain a fact is to show how it falls under some appropriate law. This conception of explanation Hempel explicates using a pair of models, where, in this context, a model is a template or pattern such that if something fits it, then that thing is an explanation. A range of well-known (...) counter-examples to Hempel’s models has led his successors to seek alternatives. Problems with limited amendments have encouraged some theorists of explanation to abandon nomic subsumption. So, in particular, causal components have come to be regarded as essential, even though Hempel had intended his model to capture causal explanation as well.1 Here I want to examine the prospects for retaining nomic subsumption by rejecting the other feature of Hempel’s approach – explication by models. An examination of the counter-examples will suggest that it is a mistake to imagine that a limited quantity of information about laws and antecedent conditions will be able to provide an actual explanation – other information, about explanations, may be relevant. This in turn leads me to examine what I shall call structural approaches. They are structural because the status of something as an explanation depends on its fitting into a structure of explanations. There are two structural approaches I shall examine. One is holistic – it proposes that we consider explanation hand-in-hand with the concept of law. This account of explanation inherits its holistic nature from the holistic (or sys- tematic) character of laws of nature. The second supervenience view I shall consider is not global as the holistic approach is. Instead it concentrates on the ‘vertical’ structure of explanations, whereby the existence of a nomic explanation at one level reflects explanations on lower levels on which it supervenes. These structural approaches were first proposed in Bird Synthese 120: 1–18, 1999. © 1999 Kluwer Academic Publishers.. (shrink)

This book presents a concise introduction to the epistemology and methodology of the Austrian School of economics as defended by Ludwig von Mises. The author provides an innovative interpretation of Mises’ arguments in favour of the a priori truth of praxeology, the received view of which contributed to the academic marginalisation of the Austrian School. The study puts forward a unique argument that Mises – perhaps unintentionally – defends a form of conventionalism. Chapters in the book include detailed discussions of (...) individualism, historicism, epistemological positions, and essentialism. The author goes on to discuss Mises’ justification of the fundamental axiom and proposes a conventionalist interpretation. By presenting praxeology as a conventionalist research programme, the author aims to reinvigorate the interaction between the Austrian School, mainstream economics, and the philosophy of science. This comprehensive reconstruction is suitable for economists interested in the history and philosophy of their discipline, as well as for philosophers of science. (shrink)

This thesis examines the alethic modal concepts of possibility and necessity. It is argued that one cannot do justice to all our modal talk without possible worlds, i.e., complete ways that a cosmos might have been. I argue that not all of the proposed applications of possible worlds succeed but enough remain to give one good theoretical reason to posit them. The two central problems now are: What feature of reality makes correct alethic modal claims true and What are possible (...) worlds? ;David Lewis makes possible worlds be concretely existing universes. Unfortunately, I show Lewis's account involves set-theoretic, ethical, inductive and probabilistic paradoxes, and commits Lewis to an objectionable form of primitive modality that governs the choice of the counterpart relation. The most promising contemporary alternatives to Lewis's theory have been the worlds of Adams and Plantinga constructed out of Platonic entities such as maximal collections of consistent propositions. However, these approaches fail to provide a satisfactory answer to the question of what makes true modal claims true. I also criticize some alternative accounts. ;Finally, I discuss and combine two historical approaches. The first is an Aristotelian approach that says a non-actual event is possible is to say that some actual substances could have initiated a causal chain that could lead up to the event in question. However, it can be shown that some plausible global possibility claims can be made true on this account only if there is a necessarily existent first cause capable of initiating very different universes. On the other hand, Leibniz made possible worlds be ideas in the mind of an omniscient necessarily existent deity. Leibniz fails to explain what it is that makes these possible worlds possible, but if we were willing to combine his story with the conclusion drawn from the Aristotelian one, we could get the following story: Possible worlds are ideas in the mind of an omniscient deity and what makes them possible is that this deity has the Aristotelian capability of initiating causal chains that can lead to them being actualized. (shrink)

Jennifer Lackey argues that knowing that p is not sufficient for being epistemically properly positioned to assert that p. Where that knowledge is entirely second-hand and the subject is an expert, the subject is not properly positioned to make such an assertion—since experts are held to higher epistemic standards. We reject Lackey’s argument. In particular, we argue that the division of labour in science makes isolated, second-hand assertions by experts both inevitable and frequent.

Readers familiar with Philip Pettit’s work will not be surprised to find that The Birth of Ethics is at once very ambitious – offering nothing less than a basis for a complete naturalistic reconstr...

Twentieth century philosophy of science has been dominated by a view of language with a strong prejudice against psychology, even while empirical psychology has moved away from the nineteenth century philosophical psychology against which the prejudice was originally directed. This legacy is shown to dominate even in recent Kripke‐inspired efforts toward new theories of meaning. Its influence is argued to undermine prospects for making sense of such phenomena as scientific progress. Avoiding this consequence requires that we pursue a psychologically informed (...) theory of meaning. (shrink)

ObjectiveCo-morbid insomnia and sleep apnea is a common and debilitating condition that is more difficult to treat compared to insomnia or sleep apnea-alone. Emerging evidence suggests that cognitive behavioral therapy for insomnia is effective in patients with COMISA, however, those with more severe sleep apnea and evidence of greater objective sleep disturbance may be less responsive to CBTi. Polysomnographic sleep study data has been used to predict treatment response to CBTi in patients with insomnia-alone, but not in patients with COMISA. (...) We used randomized controlled trial data to investigate polysomnographic predictors of insomnia improvement following CBTi, versus control in participants with COMISA.MethodsOne hundred and forty five participants with insomnia and sleep apnea [apnea-hypopnea index ≥ 15] were randomized to CBTi or no-treatment control. Mixed models were used to investigate the effect of pre-treatment AHI, sleep duration, and other traditional, and novel [quantitative electroencephalography ] polysomnographic predictors of between-group changes in Insomnia Severity Index scores from pre-treatment to post-treatment.ResultsCompared to control, CBTi was associated with greater ISI improvement among participants with; higher AHI, less wake after sleep onset, and less N3 sleep. No quantitative electroencephalographic, or other traditional polysomnographic variables predicted between-group ISI change.DiscussionAmong participants with COMISA, higher OSA severity predicted a greater treatment-response to CBTi, versus control. People with COMISA should be treated with CBTi, which is effective even in the presence of severe OSA and objective sleep disturbance. (shrink)

In this reply, I defend my views on Nietzsche's “falsification thesis” and his perspectivism against Maudemarie Clark's recent criticisms, which appeared in The Journal of Nietzsche Studies 49.1. I begin by amplifying my interpretation of Gay Science 110 and 111, which, I argue, show that the falsification thesis is absent from The Gay Science. I then turn to perspectivism and argue that, contrary to Clark's claims, perspectivism never involves the falsification of the views to which it applies. It is therefore (...) unnecessary to apply perspectivism, as Clark does, only to value-imbued viewpoints and not to empirical knowledge or the natural sciences. Perspectivism, as Nietzsche, I believe, makes clear, applies to every aspect of human knowledge. (shrink)

Ann M. Blair -- Lorraine Daston -- Benjamin Elman -- Anthony Grafton -- Jill Kraye -- Peter N. Miller -- Jean-Louis Quantin -- Quentin Skinner.

In lieu of an abstract, here is a brief excerpt of the content:Human Genome Research in an Interdependent WorldAlexander Morgan Capron (bio)This has been the year of agenda-setting conferences for the ambitious ELSI (ethical, legal and social issues) program of the Human Genome Project (HGP). But of the dozen or more major meetings of this sort held across the country, the one held at the National Institutes of Heakh (NIH) in Bethesda, MD, June 2-4, 1991, was distinctive in several respects.1As (...) its name implies, "Human Genome Research in an Interdependent World" was a global look at the issues raised by gene mapping and sequencing. Unlike previous conferences, however, this meeting looked beyond a comparative analysis of clinical and domestic legal issues, and concentrated on topics that may require responses on a truly international level if they are to be successfully resolved.The meeting's organizers gathered an impressive group of more than seventy participants from fifteen countries, including the first significant contingent of Soviet and Japanese scientists, physicians, and philosophers at an ELSI meeting. In addition to talks by the heads of the genome projects in the Soviet Union, Japan, and the United States, the meeting was keynoted by Dr. James Wyngaarden, director general of the Human Genome Organization (HUGO), and I had the honor of serving as its general chairman.The goal of the meeting was to consider an array of issues that scientists, philosophers, and lawyers from around the world suggested might have international significance, with an eye to deciding three things: (1) Does the issue deserve further attention? (2) Is the issue best addressed in an international or domestic context? and (3) Do structures exist to which the issue can be referred for resolution? In the final sessions, the entire group debated proposed resolutions on the various topics and narrowed the list needing further, intensive exploration.To provide an international framework for this process, the conference [End Page 247] established a Global Steering Committee on Ethical and Social Issues in Genome Research, which will coordinate the efforts of several task forces charged with refining the tentative resolutions adopted by the conference participants on June 4. The task forces are expected to be able to complete work on some topics by the time of the steering committee's first meeting, which was described by one participant as a "check point," probably within the coming year; on other topics, the task forces will provide interim reports and arrange to continue their analysis. Several topics—less complex or more embryonic—were referred directly to the steering committee. On all issues, a major objective will be to ascertain what existing or newly created structure or structures are capable of implementing the group's recommendations and then to monitor the issue to ensure that appropriate implementation is occurring.Issues to be Explored by Task ForcesInsurance and EmploymentWhile individuals may derive medically useful information from the expanded range of genetic tests that will flow from the HGP, they could also be harmed if test results become a basis for discrimination. An area of particular concern at the conference in Bethesda was whether genetic information should be used to decide eligibility for employment or the scope and cost of health and life insurance. The complexity of this issue is increased as barriers to worker migration fall (especially in Europe) and as more firms carry on business internationally. Furthermore, questions arise about the limits of required testing and whether individuals may decline to be informed of the results of tests.The task force will not only gather information on practices and legal standards throughout the world—especially in light of the differences among nations with regard to the linkage of employment and various forms of insurance—but will also examine international anti-discrimination laws as a possible means of supplementing domestic statutes and regulations. As a starting point, the Bethesda meeting agreed on a set of principles for the task force to refine.2ForensicsAlthough their legal status is not fully resolved, DNA tests are being used increasingly in judicial proceedings and civil and criminal investigations as a highly probative means to identify people. Most forensic uses of "DNA fingerprints" are domestic, but international cooperation among investigative bodies... (shrink)

Forschungsskandale und Diskussionen über Strukturprobleme der Biomedizin evozieren oft die Forderung nach mehr Verantwortung in der Forschung und der Einhaltung von Prinzipien guter wissenschaftlicher Praxis. Doch was genau ist „gute wissenschaftliche Praxis“ und wie kann die Forschungsgemeinschaft Verantwortung für die Verlässlichkeit von Forschungs- und Publikationsprozessen übernehmen? Die vorliegende Untersuchung beantwortet diese Fragen in Form einer prinzipienbasierten Forschungsethik. Durch Fallstudien über Datenfälschung in der Stammzellenforschung, Datenunterdrückung in der Influenzaforschung und die Kontamination von Zellkulturen in der Krebsforschung wird insbesondere gezeigt, dass wissenschaftliche (...) Selbstkorrektur kein notwendig eintretender Effekt der kollektiven Suche nach Erkenntnis ist. Vielmehr sind die Prävention, Identifikation und Korrektur von Fehlern in Forschungs- und Publikationsprozessen Resultate der intendierten Bemühung um epistemische Integrität im konkreten professionellen Handeln. Prinzipien der guten wissenschaftlichen Praxis - wie Ehrlichkeit, Unvoreingenommenheit, Anerkennung wissenschaftlicher Leistung und Kollegialität - müssen deswegen als handlungsleitende Regeln konkretisiert werden. (shrink)

Globalization and cosmopolitanism, on the one hand, and autarchy and nationalism, on the other, are two extremes between which humankind is destined to balance constantly, due to diversity and the natural confrontation of various cultural and civilizational systems by which it is represented. At the same time, globalization and cosmopolitanism are natural phenomena and are the most important characteristics of social development. That is why we should not put obstacles in the way of their dissemination and rooting in social life, (...) but to aim at deeper understanding of their essence and what is hidden behind them in order, preventing ourselves from rash evaluations and one-sided conclusions, to contribute to the formation of a stable and just global world. (shrink)

An account, based principally on Ferguson's Essay on the History of Civil Society, of his concept of enlightened governance, and of the relation between that concept and his concept of human nature.

Biocentric and ecocentric ethics offer a rich discourse on protecting biotic communities – defending conservation with inherent value tied to life. A problem ar...

Hardt and Negri’s Empire series has inspired twenty years of debate and experimentation across the social sciences and humanities in fields as divergent as international re...

Local differences in chromatin organisation may profoundly affect the activity of eukaryotic genomes. Regulation at the level of DNA packaging requires the targeting of structural proteins and histone‐modifying enzymes to specific sites and their stable or dynamic interaction with the nucleosomal fiber. The “chromodomain”, a domain shared by many regulators of chromatin structure, has long been suspected to serve as a module mediating chromatin interactions in a variety of different protein contexts. However, recent functional analyses of a number of different (...) chromodomains revealed an unexpected diversity of interaction targets, including histones, DNA and even RNA. The chromodomains of today seem to have evolved from a common ancestral fold to fulfill various functions in different molecular contexts. Combining information gained from recent functional and structural studies of chromodomains with a bioinformatic classification of their structure could lead to the definition of sequence motifs with predictive quality for chromodomain function. BioEssays 26:133–140, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

The advent of functional imaging has reinforced the attempts to define dreaming as a sleep state-dependent phenomenon. PET scans revealed major differences between nonREM sleep and REM sleep. However, because dreaming occurs throughout sleep, the common features of the two sleep states, rather than the differences, could help define the prerequisite for the occurrence of dreams. [Hobson et al.; Nielsen; Solms; Revonsuo; Vertes & Eastman].

Ethical discussions have entered into the discourse of the International Whaling Commission. In accordance with the existing approach in international environmental law, countries can legitimately choose not to exploit a resource in the traditional sense. Recognition of this possibility is important because it is commonly suggested that countries must adopt a lethal approach to so-called “sustainable whaling” as there are no other legitimate alternatives. However, the precedent of Antarctica suggests otherwise in international environmental law. Moreover, when the possibilities of the (...) nonlethal utilization of whales via operations such as whale watching are examined, the legitimacy of the nonlethal choices is even stronger. (shrink)