Ever since its first documented live birth in 2014, the use of uterine transplantation (UTx) for the treatment of absolute uterine factor infertility (UFI) has seen major clinical advances, which include the use of alternative surgical approaches, different donor states, and diverse patient populations. In addition to the thorough research programs that developed the technique, this accomplishment has occurred in large part following a number of ethical frameworks, such as the Montreal Criteria and the Indianapolis Consensus, which paved the way (...) to transition from experimental animal trials to human ones. To date, over 60 uterine transplants have been performed in the world, and at least 18 births have been thus far confirmed. While the procedure remains experimental, the vast knowledge and procedural experience amassed over the last 20 years of rigorous research have hinted at the next step of discovery. In particular, advancing social circumstances have prompted the question regarding the use of this technology in transgender individuals. Though the potential use of uterine transplants in the transgender population has been hypothesized, no in‐depth ethical framework has been developed towards this purpose. Herein, we explore the ethical issues revolving around the use of this technology in this patient population and provide key insights that may advance this cause. (shrink)

Doxastic dualists acknowledge both outright beliefs and credences, and they maintain that neither state is reducible to the other. This gives rise to the ‘Bayesian Challenge’, which is to explain why we need beliefs if we have credences already. On a popular dualist response to the Bayesian Challenge, we need beliefs to simplify our reasoning. I argue that this response fails because credences perform this simplifying function at least as well as beliefs do.

This paper considers contractarianism as a method of justification. The analysis accepts the key tenets of contractarianism: expected utility maximization, unanimity as the criteria of acceptance, and social-scientific uncertainty of modelled agents. In addition to these three features, however, the analysis introduces a fourth feature: a criteria of rational belief formation, viz. Bayesian belief updating. Using a formal model, this paper identifies a decisive objection to contractarian justification. Insofar as contractarian projects approximate the Agreement Model, therefore, they fail to justify (...) their conclusions. Insofar as they fail to approximate the Agreement Model, they must explain which modelling assumption they reject. (shrink)

We examine a contribution L. Susan Stebbing made to the understanding of critical thinking and its relation to formal logic. Stebbing took expertise in formal logic to authorise logical intervention in public debate, specifically in assessing of the validity of everyday reasoning. She held, however, that formal logic is purely the study of logical form. Given the problems of ascertaining logical form in any particular instance, and that logical form does not always track informal validity, it is difficult to see (...) how she could justify her belief in logical interventionism. Her answer to this problem is the contribution we explore here. It involves the view that although the logician’s expertise is not sufficient to assess arguments made in everyday contexts on its own, it nevertheless plays a unique role in giving systematicity and direction to the critique of such arguments, in particular, in public debate. (shrink)

I respond to Vaidman’s recent criticisms of my paper “A New Problem for Quantum Mechanics”.

The percentage of female entrepreneurs is far below the level of males, although it has increased over the past several years. Based on the theory of planned behavior, the purpose of this article is to specify a model in which the relationship among entrepreneurial potential, gender and entrepreneurial intention are explored, by analyzing how perceived behavioral control (PBC) and perceived entrepreneurial skills, as exogenous variables, affect expression of intention for business, and how these are mediated by their entrepreneurial motivations and (...) risk taking propensity. Control variables where also included in this model, such as necessity-driven motives for business, in order to observe whether these are an influential factor. An implementation of Structural Equation Modeling (SEM) was used to analyze data collected from 677 students. Variables within the model were compared by gender using t-Test, and all multivariate analysis were done by each one separately as well in order to better gauge their perceptions. Results showed that mean differences between males and females are not abundant, and come only from intentions, PBC and subjective norm, which are higher in males; and motives for business higher in females. Multivariate analysis shows gender differences at the mediation level and that necessity-driven motives are an influencing factor, more so in males, and it hampers the significance of subjective norm. Finally, the theoretical and practical implications of the results within the framework of entrepreneurship in Spain and future alternatives to improve the entrepreneurial potential are discussed. (shrink)

Building on Nozick's invariantism about objectivity, I propose to define scientific objectivity in terms of counterfactual independence. I will argue that such a counterfactual independence account is (a) able to overcome the decisive shortcomings of Nozick's original invariantism and (b) applicable to three paradigmatic kinds of scientific objectivity (that is, objectivity as replication, objectivity as robustness, and objectivity as Mertonian universalism).

The value of resting electroencephalogram (EEG) in revealing neural constitutes of consciousness (NCC) was examined. We quantified the dynamic repertoire, duration and oscillatory type of EEG microstates in eyes-closed rest in relation to the degree of expression of clinical self-consciousness. For NCC a model was suggested that contrasted normal, severely disturbed state of consciousness and state without consciousness. Patients with disorders of consciousness were used. Results suggested that the repertoire, duration and oscillatory type of EEG microstates in resting condition quantitatively (...) related to the level of consciousness expression in brain-damaged patients and healthy-conscious subjects. Specifically, results demonstrated that (a) decreased number of EEG microstate types was associated with altered states of consciousness, (b) unawareness was associated with the lack of diversity in EEG alpha-rhythmic microstates, and (c) the probability for the occurrence and duration of delta-, theta- and slow-alpha-rhythmic microstates were associated with unawareness, whereas the probability for the occurrence and duration of fast-alpha-rhythmic microstates were associated with consciousness. In conclusion, resting EEG has a potential value in revealing NCC. This work may have implications for clinical care and medical–legal decisions in patients with disorders of consciousness. (shrink)

Maybe you only have 1000 units of some resource, but 10,000 people need the resource or would benefit from it. One question: why do you control the resource? Leave that aside for now. A second question: how should you allocate the resource? If you are a decision-maker in a health system, and if the resource has to do with medicine or public health, we are in the world of the ethics of scarce resource allocation decisions in healthcare. Munthe et al (...) 1 note that the ‘operational norms that guide actual decision making in this area tend to be similar across health systems’ and include principles concerning need, prognosis, equal treatment and cost-effectiveness. Even with just these principles, there are hard questions of how they ought to be specified, operationalised and balanced against each other when they conflict. They do not focus on this. Instead, they identify a concern: paying attention only to these principles in making allocation decisions may lead decision-makers to miss ‘negative dynamics’ that result from their decisions. They aim to rectify this by suggesting a ‘sustainability’ principle that would sit alongside these other ethical principles, serving as a side-constraint that rules out certain allocation choices or as a distinct reason to be weighed in the decision-making calculus (or a reason to save or insure against negative dynamics). I agree that the downstream effects of our allocation decisions matter, …. (shrink)

ObjectiveCo-morbid insomnia and sleep apnea is a common and debilitating condition that is more difficult to treat compared to insomnia or sleep apnea-alone. Emerging evidence suggests that cognitive behavioral therapy for insomnia is effective in patients with COMISA, however, those with more severe sleep apnea and evidence of greater objective sleep disturbance may be less responsive to CBTi. Polysomnographic sleep study data has been used to predict treatment response to CBTi in patients with insomnia-alone, but not in patients with COMISA. (...) We used randomized controlled trial data to investigate polysomnographic predictors of insomnia improvement following CBTi, versus control in participants with COMISA.MethodsOne hundred and forty five participants with insomnia and sleep apnea [apnea-hypopnea index ≥ 15] were randomized to CBTi or no-treatment control. Mixed models were used to investigate the effect of pre-treatment AHI, sleep duration, and other traditional, and novel [quantitative electroencephalography ] polysomnographic predictors of between-group changes in Insomnia Severity Index scores from pre-treatment to post-treatment.ResultsCompared to control, CBTi was associated with greater ISI improvement among participants with; higher AHI, less wake after sleep onset, and less N3 sleep. No quantitative electroencephalographic, or other traditional polysomnographic variables predicted between-group ISI change.DiscussionAmong participants with COMISA, higher OSA severity predicted a greater treatment-response to CBTi, versus control. People with COMISA should be treated with CBTi, which is effective even in the presence of severe OSA and objective sleep disturbance. (shrink)

Dispositions are related to conditionals. Typically a fragile glass will break if struck with force. But possession of the disposition does not entail the corresponding simple (subjunctive or counterfactual) conditional. The phenomena of finks and antidotes show that an object may possess the disposition without the conditional being true. Finks and antidotes may be thought of as exceptions to the straightforward relation between disposition and conditional. The existence of these phenomena are easy to demonstrate at the macro-level. But do they (...) exist at the fundamental level also? While fundamental finkish dispositions may be excluded fairly straightforwardly, the existence of fundamental antidotes is more open. Nonetheless I conclude that the phenomenon is likely to be less widespread than at the macro level and that fundamental antidotes may be eliminable. According to the dispositional essentialist, the laws of nature can be explained by taking natural properties to be essentially dispositional. This account can be extended to show that the existence of finks and antidotes explains ceteris paribus laws. Consequently the existence or otherwise of fundamental finks and antidotes sheds some light on the question of whether fundamental laws may also be ceteris paribus laws. (shrink)

Two sources of possible disagreement in bioethics may be associated with pessimism about what bioethics can achieve. First, pluralism implies that bioethics engages with interlocutors who hold divergent moral beliefs. Pessimists might believe that these disagreements significantly limit the extent to which bioethics can provide normatively robust guidance in relevant areas. Second, the interdisciplinary nature of bioethics suggests that interlocutors may hold divergent views on the nature of bioethics itself—particularly its practicality. Pessimists may suppose that interdisciplinary disagreements could frustrate the (...) goals of bioethics. In this article, I explore how wonder may alleviate the concerns of the first group of pessimists regarding problems associated with pluralism, provided that we are willing to accept some interdisciplinary frustrations. Then, I invite readers of this issue of The Journal of Medicine & Philosophy to test these intuitions by considering the role of wonder in these articles. (shrink)

ZUSAMMENFASSUNGIm Diskurs zum Theodizeeproblem beschäftigen sich die einzelnen Autoren mit sehr unterschiedlichen Ausgangsfragen, und zwar meist ohne diese Tatsache zu reflektieren. Wenn man jedoch ernst nimmt, dass »das Theodizeeproblem« einen Sammelbegriff für sehr unterschiedliche Fragen darstellt, setzt eine sinnvolle Bearbeitung des Theodizeeproblems eine bewusste Benennung der genauen Ausgangsfrage und idealerweise eine sachliche Begründung für die Wahl eben dieser Frage voraus. Davon, ob die Ausgangsfrage im Horizont des Glaubens formuliert wird oder nicht, in existenzieller oder in abstrahierender Perspektive, mit Gott als (...) Adressat oder nicht, anhand eines schöpfungstheologischen, kreuzestheologischen oder eschatologischen Zugangs, unter Zugrundelegung eines traditionell-theistischen oder eines nicht traditionell-theistischen Gottesbegriffs, agnostisch oder atheistisch, logisch oder empirisch, hängt es ab, ob es eine Antwort gibt, welche Antwortmöglichkeiten in den Blick kommen können und welche nicht, welche Bedürfnisse des Fragenden befriedigt werden und welche nicht, kurz: was von der weiteren Problembearbeitung erwartet werden kann und was nicht.SUMMARYIn the discourse on theodicy, individual authors deal with very different initial questions and for the most part fail to reflect upon this very fact. However, if one does recognize the importance of understanding THE problem of evil as an umbrella term for quite distinct issues, a proper treatment of theodicy implies precisely specifying the initial question and, ideally, a factual justification for the choice of this question. Whether the initial question is phrased in the horizon of faith, in an existential or abstract perspective, whether it directly adresses God, whether it is approached by means of creation theology, a theology of the cross or eschatological theology, whether it is based on a traditional theistical idea of god, agnostic or atheistic, logical or empirical, ultimately determines the actual existence of an answer, which possible answers can be brought to the questioner's attention and which of his or her needs can be satisfied in this regard; in short, what can be expected from the treatment of the problem and what cannot. (shrink)

In this paper we define n+1-valued matrix logic Kn+1 whose class of tautologies is non-empty iff n is a prime number. This result amounts to a new definition of a prime number. We prove that if n is prime, then the functional properties of Kn+1 are the same as those of ukasiewicz's n +1-valued matrix logic n+1. In an indirect way, the proof we provide reflects the complexity of the distribution of prime numbers in the natural series. Further, we introduce (...) a generalization K n+1 * of Kn+1 such that the set of tautologies of Kn+1 is not empty iff n is of the form p , where p is prime and is natural. Also in this case we prove the equivalence of functional properties of the introduced logic and those of n+1. In the concluding part, we discuss briefly a partition of the natural series into equivalence classes such that each class contains exactly one prime number. We conjecture that for each prime number the corresponding equivalence class is finite. (shrink)

In this volume his object is to fully examine his friend's writings and characters and draws upon his own personal recollections to do so.

Determinism is a doctrine or assumption best defined in the realm of the natural sciences. In this paper I explain in detail the four senses of determinism, from the most fundamental metaphysical sense, to the most complex epistemic (predictive) sense. I take as a starting point the analysis of determinism offered by Stephen Kellert. Each of these senses is then expounded and commented with a view to explore some of the implications of each of them in theoretical physics. The most (...) important of my tasks in this paper is to differentiate between the metaphysical and epistemic consequences of the deterministic assumption. My objective is to show that determinism as an ontological tenet is capable of withstanding criticism, even though predictive determinism is likely to be false. (shrink)

The authors consider reflexive games that describe the interaction of subjects making decisions based on an awareness structure, i.e., a hierarchy of beliefs about essential parameters, beliefs about beliefs, and so on. It was shown that the language of graphs of reflexive games represents a convenient uniform description method for reflexion effects in bélles-léttres.

I present an argument that encapsulates the view that theory is underdetermined by evidence. I show that if we accept Williamson's equation of evidence and knowledge, then this argument is question-begging. I examine ways of defenders of underdetermination may avoid this criticism. I also relate this argument and my critique to van Fraassen's constructive empiricism.

In "Events and Causality" Mark Steiner argues that though Bertrand Russell was right to claim that the laws of physics do not express causal relations, nevertheless, Russell was wrong to suppose that therefore causality plays no role in physics. I argue that Steiner misses the point of Russell's argument for the first of these claims, and because of this Steiner's argument against the second fails to controvert it. Steiner fails to see that Russell's argument against causation, is in fact an (...) argument against the existence of causal directionality or asymmetry. Steiner gives no reason to suppose physical theory requires this asymmetry after all. (shrink)

James Mill - A Biography is an unchanged, high-quality reprint of the original edition of 1882. Hansebooks is editor of the literature on different topic areas such as research and science, travel and expeditions, cooking and nutrition, medicine, and other genres. As a publisher we focus on the preservation of historical literature. Many works of historical writers and scientists are available today as antiques only. Hansebooks newly publishes these books and contributes to the preservation of literature which has become rare (...) and historical knowledge for the future. (shrink)

Die vom Antaios Verlag herausgegebene Publikation Lieber Chef … (2016) enthält Transkriptionen der Briefe Armin Mohlers sowie ›Paraphrasen‹ der Briefe Ernst Jüngers. Der Aufsatz analysiert, wie die ›Paraphrasen‹ die im Deutschen Literaturarchiv Marbach aufbewahrten Briefe Jüngers im Sinne der Neuen Rechten politisch umschreiben. Durch diese Praxis des Umschreibens gewinnt eine Tradierung an Kohärenz, der zufolge Ernst Jünger heute politisch auf der Seite der Neuen Rechten stehe. Der Blick in die Originalbriefe Jüngers ist indessen aufschlussreich, weil er nicht nur zeigen kann, (...) welcher Aneignungstechniken diese Erzählung bedarf, sondern auch, wo – und wie – Jünger tatsächlich an neurechte Diskurse anschließt. (shrink)

The Rhetorical Fabric of the Traditional Arabic Qaṣīda in Its Formative Stages: A Comparative Study of the Rhetoric in Two Traditional Poems by ʿAlqama l-Faḥl and Bashshār b. Burd. By Ali Ahmad Hussein. Abhandlungen für die Kunde des Morgenlandes, vol. 98. Wiesbaden: Harraaaowitz, 2015. Pp. xv + 292. €78.

This article seeks to disclose the sense(s) of translation by attending to it in the phenomenological key with Edmund Husserl’s The Origin of Geometry. I suggest that the text could be approached through the prism of generative phenomenology, and I investigate it from two different perspectives: xenological and Derridean. Both perspectives are employed toward the same objective: to demonstrate the theoretical relevance of Husserl’s text to the understanding of a complex social phenomenon such as translation. The emphasis on sociality, historicity, (...) and tradition, as these themes transpire in The Origin, brings about a new understanding of translation as a phenomenon of the liminal in-between, with its basic structure defined as the encounter with the alien. Derrida gives this emphasis much attention in his commentary on The Origin. In this commentary, he focuses on the constitution of a communal history, which is not possible without the iteration of the origin, the basic means of which is communication on the general level, while on the level of different socio-cultural worlds translation comes up as the most optimal mode for the encounter with the alien. The encounter takes place in the liminal in-between which points to repeatability as the original sense of translation inscribed in the acts of binding and approximation. (shrink)