We argue that the most‐promising area of clinical application of microarrays in the foreseeable future is the diagnostics and monitoring of infectious diseases. Microarrays for the detection and characterization of human pathogens have already found their way into clinical practice in some countries. After discussing the persistent, yet often underestimated, importance of infectious diseases for public health, we consider the technologies that are best suited for the detection and clinical investigation of pathogens. Clinical application of microarray technologies for the detection (...) of mycobacteria, Bacillus anthracis, HIV, hepatitis and influenza viruses, and other major pathogens, as well as the analysis of their drug‐resistance patterns, illustrate our main thesis. BioEssays 30:673–682, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

This paper is about intentional identity, the phenomenon of intentional attitudes having a common focus. I present an argument against an approach to explaining intentional identity, defended by Nathan Salmon, Terence Parsons and others, that involves positing exotic objects. For example, those who adopt this sort of view say that when two astronomers had beliefs about Vulcan, their attitudes had a common focus because there is an exotic object that both of their beliefs were about. I argue that countenancing these (...) exotic objects does not help us explain intentional identity. (shrink)

This paper examines two questions about scientists’ search for knowledge. First, which search strategies generate discoveries effectively? Second, is it advantageous to diversify search strategies? We argue pace Weisberg and Muldoon (2009) that, on the first question, a search strategy that deliberately seeks novel research approaches need not be optimal. On the second question, we argue they have not shown epistemic reasons exist for the division of cognitive labor, identifying the errors that led to their conclusions. Furthermore, we generalize the (...) epistemic landscape model, showing that one should be skeptical about the benefits of social learning in epistemically complex environments. (shrink)

Violent video games (VVGs) are a source of serious and continuing controversy. They are not unique in this respect, though. Other entertainment products have been criticized on moral grounds, from pornography to heavy metal, horror films, and Harry Potter books. Some of these controversies have fizzled out over time and have come to be viewed as cases of moral panic. Others, including moral objections to VVGs, have persisted. The aim of this paper is to determine which, if any, of the (...) concerns raised about VVGs are legitimate. We argue that common moral objections to VVGs are unsuccessful, but that a plausible critique can be developed that captures the insights of these objections while avoiding their pitfalls. Our view suggests that the moral badness of a game depends on how well its internal logic expresses or encourages the players’ objectionable attitudes. This allows us to recognize that some games are morally worse than others—and that it can be morally wrong to design and play some VVGs—but that the moral badness of these games is not necessarily dependent on how violent they are. (shrink)

This essay aims to articulate why the Orthodox have historically, and to the present, opposed cremation. Its primary line of argument is that inhumation is a site of “theophanic encounter”: a manifestation of the Glory of God. This theophanic quality is borne out in the scriptures and the Church’s liturgical experience. In particular, the connections between the funeral service and the entombed Christ on Holy Friday and Saturday properly situate the meaning of the post-mortem body. This intimate connection between the (...) deceased and their body is clear in Orthodoxy’s “hylomorphism,” the soul-body unity, which champions the eschatology of resurrection. Finally, all of the above is concretely experienced in the cult of the saints and their relics, which become vehicles for the divine energies: a theophany of Christ’s ongoing conquest of sin and death. Thus, cremation can only be viewed as a tragic misunderstanding of the dual meaning of “doxa” in Orthodoxy: right-belief and right-glory. (shrink)

We prove the following Main Theorem: $ZF + AD + V = L(R) \Rightarrow DC$ . As a corollary we have that $\operatorname{Con}(ZF + AD) \Rightarrow \operatorname{Con}(ZF + AD + DC)$ . Combined with the result of Woodin that $\operatorname{Con}(ZF + AD) \Rightarrow \operatorname{Con}(ZF + AD + \neg AC^\omega)$ it follows that DC (as well as AC ω ) is independent relative to ZF + AD. It is finally shown (jointly with H. Woodin) that ZF + AD + ¬ DC (...) R , where DC R is DC restricted to reals, implies the consistency of ZF + AD + DC, in fact implies R # (i.e. the sharp of L(R)) exists. (shrink)

The article shows that Kuhn's concept of incommensurability emphasizes mainly the objective dimension of communication. To the thesis about the incommensurability of the meanings of scientific concepts in competing paradigms, we oppose the idea of a three-dimensional space of communicative dimensions. We supplement the objective dimension of communication, within which the environmental evolutionary selection of the best knowledge is carried out, with equal social and temporal horizons.

Physicians have special professional obligations to respond to medical emergencies. A bioterrorism attack would be a medical emergency. Thus, it seems that physicians would have an obligation to respond to a bioterrorist attack. However, the scope of those obligations, and their limits, are vexed topics. General rules may be comforting but the details and nuances of particular situations will always be relevant.

Ame, vie, souffle, qui saurait bien les distinguer exactement?1like heartburn, a pronounced discomfort with the very idea of consciousness followed the early days of experimental psychology. Received wisdom has it that psychologists came to mistrust consciousness for largely behaviorist reasons—they are supposed to have worried about the alleged impossibility of performing quantifiable, repeatable measurements on an essentially private phenomenon.2 But this is a historical distortion, one that obscures some interesting and earlier philosophical concerns about the scientific study of consciousness.Behaviorists rejected (...) the scientific respectability of consciousness, to be sure. But by the... (shrink)

Volume 20, Issue 6, June 2020, Page 30-32.

John Divers and Joseph Melia have argued that Lewis's modal realism is extensionally inadequate. This paper explains why their argument does not succeed.

In simplified form, the argument that I am defending holds that the incompatibility of our freedom with determinism follows from the conjunction of (1) a plausible supervenience claim which says that whether a human agent is free depends only on what happens during the agent’s life and (2) a freedom-cancellation principle of Richard Gale which says that an agent is not free if all of her actions are intentionally brought about by another agent. Improved versions of (1) and (2) are (...) also considered. (shrink)

The term ‘Orthodox Christian medicine’ has become so customary among believers in Russia that the concept behind it is rarely questioned. However, it is worth articulating both for the sake of the profession and for the benefit of patients whether such a phrase is at all meaningful and if so what exactly it stands for. The following analysis, based on a public lecture, draws on the personal experience and reflections of a practicing GP and cardiologist who is also the Chairman (...) of the Society of Orthodox Christian Physicians of Russia. (shrink)

Let Mm k be the simply connected constant curvature space form of dimension m. • Mm 0 is Rm with euclidean metric • Mm k for k > 0 is an m-sphere of radius k−1/2 • Mm k for k < 0 is m dimensional hyperbolic space modelled on the m-ball of radius (−k)−1/2.

So far I have taken prose and poetry where admittedly they exist, in literature, and attempted to discover the difference between them by taking pieces of prose or poetry which have the same or much the same subjects and comparing them with one another. In all these pairs of passages I thought I could detect this difference: that in the poem the subject as rendered in words acquires a life of its own, is a living thing, as it were, living (...) its own life like an animal or plant, is organic, and, in a word, concrete. While the prose, for all its constructive unity, is not self-subsistent, but is descriptive of a given subject, even though that subject is itself created by the writer, as in a novel, and, in a word, is analytic. It is not the greater passion or vividness of the poem, for prose may be vivid, as in Carlyle, and passionate, as in Burke. It is that the poet places himself and places his hearer within the subject itself, and works from within outwards, while the prosaist describes relatively from without. Both of them describe, the poet as well as the prosaist. But the prosaist builds up his subject so as to bring it before your mind. The poet starts with his subject in its integrity, places the hearer's mind within it, and his exposition is the unfolding life of the subject itself. (shrink)

This article analyses how Rousseau's First Discourse and the questions it posed about human progress and the reform of society were debated in the institutional context of the Berlin Academy by Formey and Herder. Despite some important disagreements, Formey and Herder fundamentally shared Rousseau's assumption that erudition could be detrimental both to society and to the individual. In order to limit the socially corrosive effects of the arts and the sciences, and in an attempt to realize their full beneficent potential, (...) they called for their reform through institutional regulation and management by a meritocracy of scholarly experts. Drawing on Hume, Herder in particular developed a positive role for the modern state as an active agent of enlightenment, provided it not only promoted the arts and sciences but also guaranteed freedom and the rule of law to ensure their flourishing. (shrink)

This is the second of two special issues, and the articles are grouped according to two themes: The previous, first issue featured articles that shared the theme Technologies and the Political, while this second issue is focused on the theme of Subjectivities. In this second, somewhat expanded, introduction, the “sky’s the limit.” This introduction canvasses various theoretical and conceptual-empricial perspectives that the articles of both issues touch on and further tries to open many doors through which readers are invited to (...) go on their own rather than give readymade answers. This introduction is written not only to give both an overview of some of the most important conceptual, methodological, and empirical contexts that the two special issues evoke but also to create invitations for many further conversations to be had from here on forward by beginning the interrogating and troubling of the intercourse between “science” and “science fiction”: beause all of this has happened before and will happen again. (shrink)

In this article we prove step by step the main theorem of Smullyan sets. This main theorem says that each element of a Smullyan set is simultaneously satisfiable in a semantic system of model sets and therefore also, for example, in a semantic system of truth sets as well as in a semantic system according to Henkin. After that, we prove the semantical compactness of a propositional logic system as an example of a utilisation of Smullyan sets and its main (...) theorem. (shrink)

In this volume his object is to fully examine his friend's writings and characters and draws upon his own personal recollections to do so.

Democracy as one of the forms of a governance and political process is at the same time a political value. The value’s aspects of democracy are closely connected with the character of democratic political regime, democratic process and democratic political culture of society. in the structure of democratic values one may roughly point out horizontal facet of them and vertical one. Horizontal values include following values: general social domain; the sphere of political institutions; the aspects of political process and procedures; (...) cultural sphere. As a rule, these values are out of doubt, though this fact doesn’t preclude there critic from various opponents of democracy. On the contrary, it’s a hierarchy of democratic values, which is the vertical facet of them is the point at scientific andpolitical debates. This fact also causes various approaches to democracy. The problems of democratic values inseparably linked with the questions about there universal character. Under an analysis of the universal character of democratic values it’s necessary to take into account its socioantropological aspect. The point is about developing essence of the human being under the impact of diverse internal and external factors. (shrink)

We prove that for any computable successor ordinal of the form α = δ + 2k there exists computable torsion-free abelian group that is relatively Δα0 -categorical and not Δα−10 -categorical. Equivalently, for any such α there exists a computable TFAG whose initial segments are uniformly described by Σαc infinitary computable formulae up to automorphism, and there is no syntactically simpler family of formulae that would capture these orbits. As far as we know, the problem of finding such optimal examples (...) of Δα0-categorical TFAGs for arbitrarily large α was first raised by Goncharov at least 10 years ago, but it has resisted solution 315–356]). As a byproduct of the proof, we introduce an effective functor that transforms a 0″-computable worthy labeled tree into a computable TFAG. We expect that this techni... (shrink)