Descartes is often thought to bifurcate sensory experience into two distinct cognitive components: the sensing of secondary qualities and the more or less intellectual perceiving of primary qualities. A closer examination of his analysis of sensory perception in the Sixth Replies and his treatment of sensory processing in the Dioptrics and Treatise on Man teIls a different story. I argue that Descartes offers a unified cognitive account of sensory experience according to which the senses and intellect operate together to produce (...) a fundamentally imagistic representation of the world in both its primary and secondary quality aspects. At stake here is not only our understanding of the cognitive structure of sensory experience but the relation of sense and intellect more generally in the Cartesian mind. The deep bifurcation in the Cartesian mind is not between the sensory perception of primary and secondary qualities but between sensory perception and purely intellectual perception. (shrink)

According to the doctrine of double effect(DDE), there is a morally significantdifference between harm that is intended andharm that is merely foreseen and not intended.It is not difficult to explain why it is bad tointend harm as an end (you have a ``badattitude'' toward that harm) but it is hard toexplain why it is bad to intend harm as a meansto some good end. If you intend harm as a meansto some good end, you need not have a ``badattitude'' toward (...) it. I distinguish two ways inwhich you can treat something that is yourchosen means to your ends. You can pursue yourends directly, and treat X as a mere means thatyou pursue for the sake of your end. Or you canpursue your ends indirectly, and treat X as a``plan-relative end'' that you pursue for its ownsake. I argue that much of the time we pursueour ends indirectly, and treat our means asplan-relative ends. There are significantanalogies between intending harm as an end, andintending harm as a plan-relative end. So,under certain circumstances, it is morallyworse to intend harm as a means or an end thanto foresee bringing about the same amount of harm. (shrink)

This paper explores two questions central to understanding the nature of formulaic sequences: (1) What are they for? and (2) What determines how many there are? The “Communicative Impact” model draws into a single account how language is shaped by cognitive processing on the one hand and socio-interactional function on the other: Formulaic sequences play a range of coordinated roles in neutralizing unanticipated perturbations in the cognitive management of language, so the speaker's socio-interactional goals can still be achieved. One role (...) involves compensatory actions to sustain fluency. However, these actions are themselves context-sensitive, so the balance of types of formulaic sequence will vary according to situation. The model applies equally to temporary cognitive pressure and chronic problems such as dementia and limited linguistic competency in a foreign language. (shrink)

Standpoint theory is an explicitly political as well as social epistemology. Its central insight is that epistemic advantage may accrue to those who are oppressed by structures of domination and discounted as knowers. Feminist standpoint theorists hold that gender is one dimension of social differentiation that can make such a difference. In response to two longstanding objections I argue that epistemically consequential standpoints need not be conceptualized in essentialist terms, and that they do not confer automatic or comprehensive epistemic privilege (...) on those who occupy them. Standpoint theory is best construed as conceptual framework for investigating the ways in which socially situated experience and interests make a contingent difference to what we know (well), and to the resources we have for determining which knowledge claims we can trust. I illustrate the advantages of this account in terms of two examples drawn from archaeological sources. (shrink)

When radiocarbon dating techniques were applied to archaeological material in the 1950s they were hailed as a revolution. At last archaeologists could construct absolute chronologies anchored in temporal data backed by immutable laws of physics. This would make it possible to mobilize archaeological data across regions and time-periods on a global scale, rendering obsolete the local and relative chronologies on which archaeologists had long relied. As profound as the impact of 14C dating has been, it has had a long and (...) tortuous history now described as proceeding through three revolutions, each of which addresses distinct challenges of capturing, processing and packaging radiogenic data for use in resolving chronological puzzles with which archaeologists has long wrestled. In practice, mobilizing radiogenic data for archaeological use is a hard-won achievement; it involves multiple transformations that, at each step of the way, depend upon a diverse array of technical expertise and background knowledge. I focus on strategies of triangulation and traceability that establish the integrity of these data and their relevance as anchors for evidential reasoning in archaeology. (shrink)

In this article I argue for a model of Deweyan 'critical pragmatism' as a therapeutic alternative to traditional models of deliberative democracy that have been crippled by their inheritance of the threadbare liberal/communitarian debate. By orienting my discussion here with respect to the most serious radical democratic challenges to deliberative democracy, I hope to show how Deweyan critical pragmatism may help us develop new approaches to the theory and practice of deliberation that are both more attuned to power relations than (...) traditional models and make more inventive use of everyday life to pursue more meaningful deliberative opportunities for citizens. (shrink)

Jennifer Lackey argues that knowing that p is not sufficient for being epistemically properly positioned to assert that p. Where that knowledge is entirely second-hand and the subject is an expert, the subject is not properly positioned to make such an assertion—since experts are held to higher epistemic standards. We reject Lackey’s argument. In particular, we argue that the division of labour in science makes isolated, second-hand assertions by experts both inevitable and frequent.

We explore our role as researchers and witnesses in the context of an emerging partnership with the Penelakut Tribe, the aim of which is to locate the unmarked graves of children who died while attending the notorious Kuper Island Indian Residential School on their territory (southwest British Columbia). This relationship is in the process of taking shape, so we focus on understanding conditions for developing trust, and the interactional expertise necessary to work well together, with a good heart. We suggest (...) that, in some respects, this may be usefully understood as a practice of witnessing on several dimensions. (shrink)

Hume’s discussion of pride and sympathy in the _Treatise_ shows direct engagement with Malebranche’s discussion of ‘imitation’ in the _Search_. For Malebranche, imitation—both of passions and belief—and our tendency to judge ourselves by comparison, generate the passion of pride or grandeur, which plays a useful social role. However, as both cause and effect of the admiration of others, grandeur is ungrounded and thus imaginary. Hume disagrees. He invokes the principle of sympathy to explain how the evaluations of others can support (...) pride by indicating, without constituting, grounds for pride. Hume’s argument depends on his underappreciated claim that sympathy can communicate the evaluative opinions as well as the passions of others. Working with the Malebranchean inventory of principles—sympathy and comparison—Hume refines their characterization, thereby redeeming the human tendency to feel pride and humility by characterizing it as corrigible and subject to social regulation. (shrink)

According to orthodox representationalism, perceptual states have constitutive veridicality or accuracy conditions. In defense of this view, several philosophers—most notably Tyler Burge—employ a realist strategy that turns on the purported explanatory ineliminability of representational posits in perceptual science. I argue that Burge’s version of the realist strategy fails as a defense of orthodox representationalism. However, it may vindicate a different kind of representationalism.

The question of bias in methodology and terminology is a problem that faces researchers east, west, north and south; however, it faces Third World intellectuals with special keenness. For although they write in a cultural environment that has its own specific conceptual and cultural paradigms, they nevertheless encounter a foreign paradigm which attempts to impose itself upon their society and upon their very imagination and thoughts. When the term “developmental psychology” for instance is used in the West Arab scholars also (...) say “developmental psychology”, when “applied psychology” is mentioned they hurry to use the same term etc. Why not establish a new science with its own mechanisms, methodologies and points of reference to deal with epistemological biases and open up the gate of ijtihad with respect to them? This collection of papers aims to discover some of the biases latent in our terminology, methodologies, research tools, and conceptual principles, and to propose alternative ones marked by a greater degree of independence and neutrality. This is not to belittle the human value of the West’s creative contributions but to emphasize the danger of making it the ultimate point of reference and then trying to continuously play “catch up” with it. (shrink)

Philosophers tend to focus on the metaphysics of functions: establishing unifying theories employing general criteria for being a function, avoiding spooky backward causation, distinguishing functions from accidents, and correctly representing the functional structure of the world. We show that there is a need for localized, practice-sensitive accounts of the epistemology of functions—accounts that explain the identification, justification, and explanatory applications of function attributions in particular scientific contexts—and that this need is best met alongside a plurality of unifying metaphysical theories of (...) functions. Our argument begins with the observation that unifying theories assume that (i) functions are discovered or justified by criteria for being a function and (ii) criteria identified in a theory are generally applicable across target systems. We then draw on examples from cognitive science and ecology to show that function ascriptions are sometimes presupposed or assigned based on highly contextual epistemic factors not described in unifying metaphysical theories. (shrink)

How do archaeologists make effective use of physical traces and material culture as repositories of evidence? Material Evidence is a collection of 19 essays that take a resolutely case-based approach to this question, exploring key instances of exemplary practice, instructive failures, and innovative developments in the use of archaeological data as evidence. The goal is to bring to the surface the wisdom of practice, teasing out norms of archaeological reasoning from evidence. -/- Archaeologists make compelling use of an enormously diverse (...) range of material evidence, from garbage dumps to monuments, from finely crafted artifacts rich with cultural significance to the inadvertent transformation of landscapes over the long term. Each contributor to Material Evidence identifies a particular type of evidence with which they grapple and considers, with reference to concrete examples, how archaeologists construct evidential claims, critically assess them, and bring them to bear on pivotal questions about the cultural past. -/- Historians, cultural anthropologists, philosophers, and science studies scholars are increasingly interested in working with material "things" as objects of inquiry and as evidence – and they acknowledge on all sides just how challenging this is. One of the central messages of the book is that close analysis of archaeological best practice can yield constructive guidelines for practice that have much to offer practitioners within archaeology and well beyond. (shrink)

The last year has seen major advances in the study of Alzheimer's disease (AD).† Four mutations involving amino acid substitutions in axons 16 and 17 of the amyloid precursor protein (APP) gene, have been identified which co‐segregate with the disease in some families multiply affected by early onset Alzheimer's disease. These mutations are strongly suggestive of a causative role for the amyloid preursor protein in Alzheimer's disease. Despite their rarity, these mutations are important because they represent the first known cause (...) of Alzheimer's disease. Processing of APP must be central to the pathogenesis of the disease although the precise effects of these amino acid substitutions are not understood. Work is now being undertaken to characterise the processing pathways of APP and to identify other causes of AD. The development of models of AD using the APP mutations offers the possibility of identifying drug targets and developing more effective treatments than are presently available. (shrink)

In 2013, there were an estimated 50,000 individuals involved in downloading and sharing indecent images of children in the United Kingdom. This poses challenges for limited police resources. We argue that police officers can make most effective use of limited resources by prioritizing those offenders who pose the greatest risk of contact offending, by nature of demonstrable pedophilia, hebephilia or dual offending status and thus, those at highest risk must be dealt with first. What is currently lacking is a clear (...) idea of the potential scale of the problem in socio-economic terms and why, therefore, it is so important that evidence-based approaches to offender detection and investigation continue to be a top priority for funders and policy makers. A systematic literature review was undertaken to address two related questions. First, what is the scale of the problem in the UK, in terms of the number of pedophilic and hebephilic individuals who pose a risk of contact offending against a child? Second, what is the potential socio-economic burden generated by the national IIOC suspect pool if left unattended to by targeted police action? Applying population estimates of pedophilia and hebephilia to the male population, we estimate there are between 2,365–5,991 males with paedophila and 12,218–30,952 males with hebephilia who are likely contact offenders. Applying average prevalence and incidence based costing methods to a conservative estimate of one victim per offender, the combined socio-economic burden from these persons could amount to £236-£597 million increasing to £2.9-£7.3 billion. Applying the same costs to CEOP estimate of 50,000 IIOC offenders we estimate that between 6,000 and 27,500 dual offenders could have already committed past contact offenses, contributing an economic burden of between £97–£445 million increasing to £1.2–£5.4 billion. Future contact offenses could contribute a further burden of £16–£18.6 million increasing to £198–£227 million. Drawing upon these findings, we argue for the benefits of a research-informed prioritization approach to target IIOC offenders. (shrink)

The most striking region of structural differentiation of a eukaryotic chromosome is the kinetochore. This chromosomal domain plays an integral role in the stability and propagation of genetic material to the progeny cells during cell division. The DNA component of this structure, which we refer to as the centromere, has been localized to a small region of 220–250 base pairs within the chromosomes from the yeast Saccharomyces cerevisiae. The centromere DNA (CEN) is organized in a unique structure in the cell (...) nucleus and is required for chromosome stability during both mitotic and meiotic cell cycles. The centromeres from one chromosome can stabilize small circular minichromosomes or other yeast chromosomes. The centromeres may therefore interact with the same components of the segregation apparatus regardless of the chromosome in which they reside. The CEN DNA does not encode any regulatory RNAs or proteins, but rather is a cis‐acting element that provides genetic stability to adjacent DNA sequences. (shrink)

This paper examines the outcomes of Preserving the Past Together, a workshop series designed to build the capacity of local heritage managers to engage in collaborative and community-based approaches to archaeology and historic preservation. Over the past two decades practitioners of these approaches have demonstrated the interpretive, methodological, and ethical value of integrating Indigenous perspectives and methods into the process and practice of heritage management and archaeology. Despite these benefits, few professional resources exist to support the development of collaborative relationships (...) between local heritage managers and Tribal nations. Filling this need, Preserving the Past Together’s interactive workshops and keynote lectures involved participants in a discussion of the central themes in collaborative and Indigenous approaches to archaeology today, highlighting the local challenges and opportunities that exist for archaeologists, heritage managers, and Tribal nations to work together to care for the past. This paper presents an overview of the event series’ goals, the strategies it used to foster collaboration among the diverse stakeholders of the Salish Sea, and the next steps the project’s co-directors are taking to further support communication and collaboration between stewards and stakeholders in the Pacific Northwest. (shrink)

This volume brings together essential writings by the unjustly neglected nineteenth-century philosopher Frances Power Cobbe (1822-1904). A prominent ethicist, feminist, champion of animal welfare, and critic of Darwinism and atheism, Cobbe was well known and highly regarded in the Victorian era. This collection of her work introduces contemporary readers to Cobbe and shows how her thought developed over time, beginning in 1855 with her Essay on Intuitive Morals, in which she set out her duty-based moral theory, arguing that morality and (...) religion are indissolubly connected. This work provided the framework within which she addressed many theoretical and practical issues in her prolific publishing career. In the 1860s and early 1870s, she gave an account of human duties to animals; articulated a duty-based form of feminism; defended a unique type of dualism in the philosophy of mind; and argued against evolutionary ethics. Cobbe put her philosophical views into practice, campaigning for women's rights and for first the regulation and later the abolition of vivisection. In turn her political experiences led her to revise her ethical theory. From the 1870s onwards she increasingly emphasized the moral role of the emotions, especially sympathy, and she theorized a gradual historical progression in sympathy. Moving into the 1880s, Cobbe combatted secularism, agnosticism, and atheism, arguing that religion is necessary not only for morality but also for meaningful life and culture. -/- Shedding light on Cobbe's philosophical perspective and its applications, this volume demonstrates the range, systematicity and philosophical character of her work and makes her core ethical theory and its central applications and developments available for teaching and scholarship. (shrink)

Advancements in fetal assessment and therapeutic intervention in medical practice and clinical research call for corresponding progress in regulatory and ethical guidance. In “A new ethical framewo...

What does ‘communism’ mean in Walter Benjamin’s writing? It has been used in some quarters to claim that Benjamin has a quasi-Marxist theory of communist society. This paper will argue instead that Benjamin’s communism is framed by his distinctive conception of experience and that it is understandable only through that conception. Benjamin’s image of ‘communist society’ refers to a specific type of experience rather than a type of social organization. The paper discusses the conceptual background of that image and also (...) points out a number of the difficulties that Benjamin’s conception of collective experience faces given its genesis in a model of individual experience. (shrink)

Alzheimer’s disease is an insidious onset neurodegenerative syndrome without effective treatment or cure. It is rapidly becoming a global health crisis that is overwhelming healthcare, society, and individuals. The clinical nature of neurocognitive decline creates significant challenges in bidirectional communication between caregivers and persons with Alzheimer’s disease that can negatively impact quality-of-life. This paper sought to understand how and to what extent would awareness training about the levels of consciousness in AD influence the quality-of-life interactions in the caregiver-patient dyad. A (...) literature review of multiple databases was conducted utilizing a transdisciplinary approach. The sum of findings indicates a positive relationship between enhanced caregiver awareness and training, positive interactions, and improved QOL measures among patients and caregivers. A multidirectional relationship was found among healthcare policies, training and education resources, caregivers, and persons with AD. Specifically, the current lack of policy and inadequate training and educational resources has various detrimental effects on patients and caregivers, while improvements in training and education of caregivers yields positive outcomes in communication and QOL. Furthermore, evidence of preserved consciousness in persons with AD was demonstrated from multiple disciplines, including neurobiological, psychological, and biopsychosocial models. The literature further revealed several methods to access the preserved consciousness in persons with AD and related dementias, including sensory, emotional, and cognitive stimulations. The evidence from the literature suggests a reframed approach to our understanding and treatment of persons with AD is not only warranted, but crucial to address the needs of those affected by AD. (shrink)

Studies in Stoicism contains six unpublished and seven republished essays, the latter incorporating additions and changes which Brunt wished to be made. The papers have been integrated and arranged in chronological order by subject matter, with an accessible lecture to the Oxford Philological Society serving as Brunt's own introduction.

Antimicrobial resistance (AMR) has become one of the defining challenges of the twenty-first century. Food production and farming are a key if troubling component of that challenge. Livestock production accounts for well over half of annual global consumption of antimicrobials, though the contribution of the sector to drug resistance is less clear. As a result, there is an injunction to act in advance of incontrovertible evidence for change. In this paper we engage with the role of market actors in the (...) precautionary regulation of farming practices and AMR threats. The paper takes the UK poultry sector as exemplary of an audit-led process that has, in recent years, achieved impressive reductions in antimicrobial use. Using qualitative interview data with farmers and veterinarians we chart the changing practices that have accompanied this reduction in treatments. We use this analysis to raise some cautions around audit-led systems of regulation. Audits can lock farms and animals into particular versions of farming and animal health; they can elevate harmful compensatory practices (including disinfectant uses); and they can reproduce an actuarial approach to an issue that does not fit the conventions of risk management. The paper presents the considerable successes that have been achieved over a short period of time in a livestock sector, while generating notes of caution concerning the audit-led management of livestock-related AMR threats. (shrink)

This volume features a distinguished, international group of scholars and practitioners who provide a comparative account of ethics regulations across four Western democracies: the United States, the United Kingdom, Canada, and Italy. They situate conflict-of-interest regulations within a broader discourse involving democratic theory; identify the structural, political, economic, and cultural factors that have contributed to the development of these regulations over time; and assess the extent to which these efforts have succeeded or failed across and within different branches and systems (...) of government. Collectively, they provide an invaluable survey of the development, function, and impact of conflict-of-interest regimes in public life. (shrink)

This interdisciplinary volume of contributed essays focuses on issues of gender in the British novel of the eighteenth and nineteenth centuries, particularly Hardy and Trollope. Approaching the topic from a variety of backgrounds the contributors reinvigorate the law-and-literature movement by displaying a range of ways in which literature and law can illuminate one another, and in which the conversation between them can illuminate deeper human issues with which both disciplines are concerned.

Fluorescence imaging has become an indispensable tool in cell and molecular biology. GFP‐like fluorescent proteins have revolutionized fluorescence microscopy, giving experimenters exquisite control over the localization and specificity of tagged constructs. However, these systems present certain drawbacks and as such, alternative systems based on a fluorogenic interaction between a chromophore and a protein have been developed. While these systems are initially designed as fluorescent labels, they also present new opportunities for the development of novel labeling and detection strategies. This review (...) focuses on new labeling protocols, actuation methods, and biosensors based on fluorogenic protein systems. (shrink)

Despite the increasing focus on rationing, and rationing decisions in the NHS, little attention has been given to patient's perceptions of rationing and the potential impact this might have on people's use of services. Drawing on the qualitative findings of a study conducted in the North West of England which was concerned with the pattern and processes of primary care help seeking, this paper sets out to examine perceptions and experiences of rationing in primary care and the potential impact this (...) has on people's use of services. In relation to primary care services people had experienced rationing by deterrence, dilution and delay. There was some evidence that perceptions of rationing impacted on help seeking and the use of primary care services. The implications for understanding the way in which perceptions of rationing might influence the formulation of demand and help seeking by people using primary care services are discussed. (shrink)

What did Leibniz have to contribute to the philosophy of mind? To judge from textbooks in the philosophy of mind, and even Leibniz commentaries, the answer is: not much. That may be because Leibniz’s philosophy of mind looks roughly like a Cartesian philosophy of mind. Like Descartes and his followers, Leibniz claims that the mind is immaterial and immortal; that it is a thinking thing ; that it is a different kind of thing from body and obeys its own laws; (...) and that it comes stocked with innate truth-tracking intellectual ideas and an epistemically troubling habit of forming confused sensory ideas on the occasion of external corporeal events. Nothing is new. Of course, Leibniz adds unconscious perceptions to the mind in the form of his famous petites perceptions, and he offers a unique solution to the problem of mind-body interaction in the form of his infamous pre-established harmony. In the overall scheme of things, however, these look like minor alterations in a philosophy of mind that the Cartesians had been advocating for some fifty years. Or so it appears. (shrink)