The demonstration that pluripotent stem cells could be generated by somatic cell reprogramming led to wonder if these so-called induced pluripotent stem (iPS) cells would extend our investigation capabilities in the cancer research field. The first iPS cells derived from cancer cells have now revealed the benefits and potential pitfalls of this new model. iPS cells appear to be an innovative approach to decipher the steps of cell transformation as well as to screen the activity and toxicity of anticancer drugs. (...) A better understanding of the impact of reprogramming on cancer cell-specific features as well as improvements in culture conditions to integrate the role of the microenvironment in their behavior may strengthen the epistemic interest of iPS cells as model systems in oncology. (shrink)

Theory-ladenness is the view that observation cannot function in an unbiased way in the testing of theories because observational judgments are affected by the theoretical beliefs of the observer. Its more radical cousin, incommensurability, argues that because there is no theory-neutral language, paradigms, or worldviews, cannot be compared because in different paradigms the meaning of observational terms is different, even when the word used is the same. There are both philosophical and practical components to these problems. I argue, using a (...) procedurally-defined, theory-neutral experiment that paradigms are indeed commensurable. The practical problems of theory ladenness include experimental design, failure to interpret observations correctly, possible experimenter bias, and difficulties in data acquisition. I suggest that there are methods to deal with these problems, although sometimes they cannot be dealt with completely. I believe that the philosophical problems of theory-ladenness have been solved, although the practical problems remain. (shrink)

The missing piece of the puzzle: the discovery of the Higgs boson On July 4, 2012 the CMS and ATLAS collaborations at the large hadron collider jointly announced the discovery of a new elementary particle, which resembled the Higgs boson, the last remaining undiscovered piece of the standard model of elementary particles. Both groups claimed to have observed a five-standard-deviation effect above background, the gold standard for discovery in high-energy physics. In this essay I will briefly discuss the how the (...) CMS collaboration performed the experiment and analyzed the data. I will also show the experimental results. (shrink)

In contrast to the behavioral sciences, the nature and impact of ethical procedures such as informed consent and constraints on the use of deception have been addressed infrequently in the marketing discipline. This article describes an initial investigation into the methodological and ethical practices reported in published marketing research articles since the mid-1970s. Empirical articles appearing in the Journal of Marketing Research and the Journal of Consumer Research between 1975 and 1976, 1989 and 1990, and 1996 and 1997 were coded (...) according to methodological and ethical practices employed and compared with recent trends in the social psychological research literature. The marketing findings revealed an increase over time in laboratory experimentation, the utilization of active deception and debriefing, and the use of university student samples. Although the results suggest that marketing researchers use deception with less frequency and intensity overall than social psychologists, the observed rise in deception procedures in marketing investigations stands in stark contrast to the situation in social psychology, where deception rates have been declining along with a corresponding increase in nonexperimental methodologies and nonstudent samples. The article concludes with a call for greater attention to the ethical, methodological, and disciplinary consequences of the increasing use of deception in marketing research and emphasizes the need for more complete reporting of ethical procedures in published research. (shrink)

_ Source: _Volume 53, Issue 2-4, pp 142 - 169 I offer an explanation of why the fallacy of “accident” is so called. By ‘accident’ here, Aristotle does not mean accidental predication but being _per accidens_. Understood in this way, the fallacy of accident can be analyzed in terms of the rules that Aristotle gives for being _per accidens_. The fallacy of accident lost the original justification for its name in the late Greek period. It became associated with accidental predication (...) and not with being _per accidens_. The fallacy was then solved by construing it syllogistically so that the paralogisms became invalid through not having a universal major premise. This medieval analysis became the dominant approach in the medieval period but has led to confusion over the fallacy of accident in millennia of logic books. I end by considering how to formulate the fallacy of accident more fruitfully in modern terms via Aristotle’s original approach. (shrink)

The history of ideas is an interdisciplinary field that began as an offshoot of the history of philosophy and was transformed by notions of perspective and cultural context drawn from the tradition of historical studies. The result is the practice of intellectual history, which has been carried out between the poles of inquiry commonly known as internalist and externalist, corresponding to mental phenomena and collective behavior in cultural surroundings. These are not opposed but rather complementary methods, and intellectual history may (...) be seen as the inside of cultural history and cultural history as the outside of intellectual history, the intellectual historian's task being to bring the two into alliance. (shrink)

In this article it is argued that there are barriers to effective and non-discriminatory practice when mentoring overseas nurses within the National Health Service (NHS) and the care home sector. These include a lack of awareness about how cultural differences affect mentoring and learning for overseas nurses during their period of supervised practice prior to registration with the UK Nursing and Midwifery Council. These barriers may demonstrate a lack of effective teaching of ethical practice in the context of cultural diversity (...) in health care. This argument is supported by empirical data from a national study. Interviews were undertaken with 93 overseas nurses and 24 national and 13 local managers and mentors from six research sites involving UK health care employers in the NHS and independent sectors in different regions of the UK. The data collected showed that overseas nurses are discriminated against in their learning by poor mentoring practices; equally, from these data, it appears that mentors are ill-equipped by existing mentor preparation programmes to mentor overseas-trained nurses from culturally diverse backgrounds. Recommendations are made for improving mentoring programmes to address mentors’ ability to facilitate learning in a culturally diverse workplace and thereby improve overseas nurses’ experiences of their supervised practice. (shrink)

By analysing how the audience interpreted the many voices of tragic performance, this chapter suggests a new model for understanding tragedy’s relationship to the world of the watching community. Although the idea that the poet expresses his personal opinions through the chorus or his characters is now rightly seen as old-fashioned and naïve, it is still legitimate to ask how the poet uses his heroic characters and their voices to speak to his contemporary audience—using ‘speak to’ in the broadest sense, (...) that is, how the poet engages, provokes, and entertains his diverse and demanding audience, with the ultimate aim of winning the prize for the best production in the tragic competition. This chapter argues that tragedy’s status as a popular art-form—where the multiple voices of tragic performance offer something for everyone in the audience—has important implications for the genre’s place in fifth-century Athenian culture, and that a realization of tragedy’s broad appeal opens up the issue of its relationship to civic discourse in new and revealing ways. (shrink)

The paper explores the much-neglected but crucial topic of the capacity of art to transcend time.

Examines (1) the birth of art-as-beauty in Western art and the concomitant birth of the idea of art itself; (2) the death of art-of-beauty from Manet onwards. Also looks briefly at some major implications for aesthetics (the philosophy of art). Paper includes some relevant reproductions.

In his Parts of Animals, Aristotle distinguishes three modes of the necessary.However, it is not clear just what these three modes are.Nor is it clear how this passage fits with other texts where A...

I. ONCE, SAID AN AUTHOR, WHERE I NEED NOT SAY . .

Critics often situate "Les Liaisons dangereuses" within the tradition of the novel of libertinage. Many consider it to be superior to its predecessors but argue nonetheless that it is part of an established tradition, not the beginning of something new. Malraux demurs. While noting similarities with the novel of libertinage, he contends that Laclos’ novel links up much more significantly with the novel of the future, its descendants including Julien Sorel and even Raskolnikov.

Written by a social development practitioner, this paper applies a Goethean approach to the social sphere. The contention being that the Goethean method and understanding can be extended to working with social development processes; equally, that facilitation of social process is enhanced and deepened through a Goethean sensibility. The bulk of the paper, book ended by two obliquely apposite short stories, follows the process of a collaborative enquiry (facilitated by the author) during which participants reflected on a particular social phenomenon. (...) The paper is an illustration of the value of the Goethean approach not only to the (social) phenomenon itself but to the sensibility of participants and groups which undertake it. It also serves to extend the realm of Goethean application into a sphere which is in desperate need of such sensibility. (shrink)

This line involves a variety of important points.

The several verbal responsions of this couplet to the preceding one are clear, and as mando produces mandata, so testor derives, I think, from testis. Read me teste ‘Idaei…’; ‘with me as witness…’. This reading adds greatly to the humour of the situation, where the hen is charged, in his presence, with caring for the fox. For testis as a witness to the audible cf. fors me sermoni testem dedit.

The scribes of the Latin poets were not, as a rule, in the habit of interpolating exclamatory particles; on the contrary, their tendency was to trivialise. The particle io has MSS authority in two passages in Ovid where distinguished critics reject it. Kenney in the Oxford Text of Ars Amatoria 3.742 prints. labor, io: cara lumina conde manu.

Whitehead’s process metaphysics, as developed in Process and Reality, is harmed by the incoherence of his notion of eternal objects as timeless and essentially unrelated entities, which therefore need a primordial agent as their ontological ground and the source of their relatedness and relevance. Such nontemporal entities undermine what is supposed to be a thoroughly temporalist metaphysics. Eternal objects can be understood solely as functions of Creativity, however, as features of a purely temporal process. A notion of God is not (...) required. Whitehead’s Categoreal Obligations specify the necessary conditions for this process, including how the novelty is possible that is needed to account for temporal change and the increased complexity that value enhancement presupposes and makes possible. Adventures of Ideas, especially through the notions of Art and Peace, develops at the level of human civilization this same secular interpretation of the capacity of entities to fashion novel and progressive outcomes. (shrink)

Innovative, data-driven methods provide more rigorous and systematic evidence for the description and explanation of diachronic semantic processes. The volume systematises, reviews, and promotes a range of empirical research techniques and theoretical perspectives that currently inform work across the discipline of historical semantics. In addition to emphasising the use of new technology, the potential of current theoretical models (e.g. within variationist, sociolinguistic or cognitive frameworks) is explored along the way.

Discusses the gulf between the individual and collective experience, and the way the gulf is bridged in two of Malraux's novels.

Choderlos de Laclos’s novel 'Les Liaisons dangereuses', first published in 1782, is regarded as one of the outstanding works of French literature. This article concerns a well known commentary by the twentieth-century writer André Malraux which, though often mentioned by critics, has seldom been studied in detail. The article argues that, while Malraux endorses the favourable modern assessments of 'Les Liaisons dangereuses', his analysis diverges in important respects from prevailing critical opinion. In particular, he regards the work as the commencement (...) of an important new stage in the French novel rather than, as often argued, the culmination of the existing libertine tradition. (shrink)

IN RECOVERY OF THE MEASURE: INTERPRETATION AND NATURE, Robert Cummings Neville develops a philosophy of nature and theory of interpretation as centerpieces for his projected three-volume Axiology of Thinking. This emerging ontology of value is impressive for both its originality and complexity. Neville's claims about meaning, truth, objectivity, and knowledge are deployed in explicit opposition to the relativism, historicism, and subjectivism currently so popular among philosophers. His critique is formidable because neither polemical nor defensive; it is rather the expression of (...) a coherent metaphysical vision. (shrink)

AN OBVIOUS FEATURE OF OUR EXPERIENCE is the constant perishing of what we value. Persons we love, objects we treasure, ideals we revere, desires that enthrall us, groups to which we pledge allegiance, projects in which we are engaged, systems that command our respect, accomplishments before which we stand in awe, memories we cherish, hopes to which we cling—they all are eventually lost to us. They abate, explode, crumble, die, erode, fade; they are deformed, eviscerated, torn apart, vanquished, made to (...) disappear. They gang always, not merely aft, a-gley. The perishing may be cataclysmic or gradual, the devastation wreaked by hurricane-force winds and pandemic plagues or the unnoticed pressures by which tectonic plates shift and species adapt. So pervasive are these perishings that folk wisdom assigns as deepest truth the observation that of anything it can be said: “this too shall pass away.”. (shrink)

After an initial period of popularity in the 1960s and 1970s, André Malraux’s works on the theory of art, "The Voices of Silence" and "The Metamorphosis of the Gods", lapsed into relative obscurity. A major factor in this fall from grace was the frosty reception given to these works by a number of leading art historians, including E.H. Gombrich, who accused Malraux of an irresponsible approach to art history and of "reckless inaccuracies". This essay examines a representative sample of the (...) art historians' arguments and contends that they reveal serious misreadings of Malraux’s texts and a recurring tendency to confuse matters of interpretation with matters of fact. The article suggests that the charge of irresponsibility might well be levelled at the critics themselves, and that the myth of Malraux as guilty of ‘reckless inaccuracies’ needs to be debunked. (shrink)