Prominent tuberculosis (TB) actors are invoking solidarity to motivate and justify collective action to address TB, including through intensified development and implementation (D&I) of technologies such as drugs and diagnostics. We characterize the ethical challenges associated with D&I of new TB technologies by drawing on stakeholder perspectives from 23 key informant interviews and we articulate the ethical implications of solidarity for TB technology D&I. The fundamental ethical issue facing TB technological D&I is a failure within and beyond the TB community (...) to stand in solidarity with persons with TB in addressing the complex sociopolitical contexts of technological D&I. The failure in solidarity relates to two further ethical challenges raised by respondents: skewed power dynamics that hinder D&I and uncertainties around weighing risks and benefits associated with new technologies. Respondents identified advocacy and participatory research practices as necessary to address such challenges and to motivate sustained collective action to accelerate toward TB elimination. We present the first empirical examination of bioethical accounts of solidarity in public and global health. Our study suggests that solidarity allows us better to understand and address the ethical challenges that arrest the D&I of new TB technologies. Solidarity lends credence to policies and practices that address the relational nature of illness and health through collective action. (shrink)

ObjectiveTo identify the ethical challenges associated with the development and implementation of new tuberculosis drugs and diagnostics.MethodsTwenty-three semi-structured qualitative interviews conducted between December 2015 and September 2016 with programme administrators, healthcare workers, advocates, policymakers, and funders based in the Americas, Europe, and Africa. Interviews were analysed using thematic analysis.ResultsDivergent interests and responsibilities, coupled with power imbalances, are a primary source of ethical challenges; the uncertain risk profiles of new drugs present an additional one. Although this challenge can be partially mitigated (...) through stringent pharmacovigilance, respondents highlighted that high-burden countries tend to lack the resources to facilitate safe implementation. Increased advocacy and community engagement are considered an ethical imperative for future TB development and implementation.ConclusionsThis project helps identify some of the ethical challenges of new TB technologies. It demonstrates that investigating ethical challenges through qualitative research is one way to apprehend the difficulty of implementing new TB technologies. Addressing this difficulty will require that those in positions of power reconsider their interests in relation to disempowered communities.Policy implicationsEfforts to build consensus regarding what values should underpin the global governance of TB research, prevention, and care are essential to facilitate the ethical implementation of new TB technologies. (shrink)

Neuronal remodeling is a conserved mechanism that eliminates unwanted neurites and can include the loss of cell bodies. In these processes, a key role for glial cells in events from synaptic pruning to neuron elimination has been clearly identified in the last decades. Signals sent from dying neurons or neurites to be removed are received by appropriate glial cells. After receiving these signals, glial cells infiltrate degenerating sites and then, engulf and clear neuronal debris through phagocytic mechanisms. There are few (...) identified or proposed signals and receptors involved in neuron‐glia crosstalk, which induces the transformation of glial cells to phagocytes during neuronal remodeling in Drosophila. Many of these signaling pathways are conserved in mammals. Here, we particularly emphasize the role of Orion, a recently identified neuronal CX3C chemokine‐like secreted protein, which induces astrocyte infiltration and engulfment during mushroom body neuronal remodeling. Although, chemokine signaling was not described previously in insects we propose that chemokine‐like involvement in neuron/glial cell interaction is an evolutionarily ancient mechanism. (shrink)

Ana‐Carolina Gutiérrez‐Xivillé präsentiert eine neue Lesart zu Kants Grundlegung zur Metaphysik der Sitten. Während ältere Studien die kantische Ethik als bloße Ausarbeitung von bereits in den 1760er Jahren vorliegenden Begriffen lesen, zeigt diese Studie eine Neubestimmung des Freiheitsbegriffs und bietet eine gewandelte Sicht auf das Verhältnis zwischen „Moralvermögen“, „moralischem Gefühl“ und „Moralprinzip“. Gutiérrez‐Xivillé betrachtet die Texte weder isoliert noch monolithisch. Ihre aus einem analytischen und einem exegetischen Moment bestehende Methode erfasst Kants bekannte Schriften ebenso wie in jüngerer Zeit neu edierte, (...) wenig erforschte Materialien. Dabei offenbaren sich strukturelle Brüche, die wegweisend von einer frühen Moralkonzeption in eine spätere überleiten. Die Ethik Kants erweist sich als Ergebnis eines allmählichen Heranreifens über mehrere Stationen hinweg. (shrink)

In her recent book Gillian Brock argues that states’ legitimacy depends on their being part of a just state system that protects human rights. Here I discuss some practical limitations raised by Brock’s legitimacy framework: mainly, (1) the problematic real-world implications of such an account, and (2) the epistemic challenges that judgements inspired by this account would have to face, were we to proceed solely on the basis of it.

Vardanyan’s Theorems [36, 37] state that $\mathsf {QPL}(\mathsf {PA})$ —the quantified provability logic of Peano Arithmetic—is $\Pi ^0_2$ complete, and in particular that this already holds when the language is restricted to a single unary predicate. Moreover, Visser and de Jonge [38] generalized this result to conclude that it is impossible to computably axiomatize the quantified provability logic of a wide class of theories. However, the proof of this fact cannot be performed in a strictly positive signature. The system $\mathsf (...) {QRC_1}$ was previously introduced by the authors [1] as a candidate first-order provability logic. Here we generalize the previously available Kripke soundness and completeness proofs, obtaining constant domain completeness. Then we show that $\mathsf {QRC_1}$ is indeed complete with respect to arithmetical semantics. This is achieved via a Solovay-type construction applied to constant domain Kripke models. As corollaries, we see that $\mathsf {QRC_1}$ is the strictly positive fragment of $\mathsf {QGL}$ and a fragment of $\mathsf {QPL}(\mathsf {PA})$. (shrink)

A patent is a property granted to any new shape, configuration or arrangement of elements, of any device, tool, instrument, mechanism or other object or part thereof, that allows for a better or different operation, use or manufacture of the object that incorporates it or that provides it with some utility, advantage or technical effect that it did not have before. As a document, a patent really is a title that recognizes the right to exploit the patented invention exclusively, preventing (...) others from making, selling or using it without the consent of the owner. The fact of making a patent is motivated by the fact of promoting creativity, hindering competition in the market as only one person holds the patent, thus protecting the initial investment and fighting against plagiarism. Patents are available to the public for dissemination and general knowledge. It is generally recognized in the specialized literature that patents can be used as an indicator to calculate the results generated by research and development activities, being a very useful indicator to measure various social, economic or technological aspects. For this reason, it is of relevant interest to have tools or systems that allow us to obtain the patents developed in a specific period of time and to carry out analyses of various economic and social factors. These analyses can serve to obtain a social perspective of society’s progress in the technological field, and this is why an analysis of patents is of our interest. This paper proposes a platform specifically designed to obtain knowledge about patents as an indicator of Spanish social, economic or technological aspects. For this purpose, the platform retrieves, analyses and visualizes functionalities that represent data on the landscape of patents obtained from the Spanish Patent and Trademark Office as a particular case of study. (shrink)

El discurso primordialista sobre el origen de las identidades sociales etno-nacionales sigue latiendo en algunos enfoques históricos, antropológicos, políticos y jurídicos de las sociedades modernas, camuflado en otras formas iusnaturalistas y biologicistas de concebir los atributos culturales, étnicos, religiosos, conductuales, e incluso económicos de los pueblos. Este artículo pretende presentar, por el contrario, la construcción de las identidades nacionales desde el punto de vista modernista y analizar su papel como discurso que pretende reforzar estructuras de poder, producidas porque tienen utilidad (...) estratégica para el logro de bienes materiales o políticos, formalmente en nombre del grupo, pero de hecho solamente con objeto de dar ventaja a los líderes o las élites. Cuando llevan aparejado un carácter político, las identidades nacionales, culturales y étnicas son susceptibles de provocar conflictos violentos, la naturalización de la violencia y la deshumanización de otros grupos tienen lugar a menudo cuando de conflictos etno-nacionalistas se trata. (shrink)

Cet article est un premier essai d’étude historique sur les relations de genre dans les sociétés indigènes du Chaco, en Amérique du Sud. Le traitement de cette question nécessitant de travailler à partir de contextes sociaux, temporels et spatiaux concrets, nous avons situé l’analyse dans un secteur de la « frontière » chaquéenne placé sous la juridiction argentine, à des moments immédiatement antérieurs et postérieurs à la campagne militaire engagée pour soumettre les populations indigènes entre 1884 et 1911. Nous travaillons (...) ainsi depuis un front de colonisation interne pour repérer les changements que cette situation a provoqués sur les relations, les rôles sociaux et les identités des hommes et des femmes autochtones. L’analyse repose sur des sources issues de deux moments différents du processus de colonisation : le moment initial, à partir des missions franciscaines établies sur les bords du fleuve Bermejo pour évangéliser les Matacos ; puis l’apogée du processus, lorsque les Matacos furent incorporés comme brassiers salariés dans les raffineries sucrières. (shrink)

Este trabajo es el ganador de la III Olimpiada de Filosofía que organiza FICUM en la modalidad de secundaria. Ana Timonet presentó su particular respuesta a la pregunta por el camino de la felicidad.

Estudos recentes vêm revisando a composição da literatura que, ao longo do século XVIII serviu como base às ciências em território britânico. Segundo esses estudos, os seiscentistas de fala inglesa dedicaram-se a duas linhagens de texto, originadas em concepções de ciência muito distintas. Uma dessas linhagens tinha como fonte principal a antiga “literatura do segredo” que incluía desde velhos e sigilosos manuais de ofício até os milenares e proibidos tratados de hermética, literatura antes reservada a poucos. Diferente dessa, a outra (...) ]inhagem de textos surgia como um direto da proposta baconiana para a nova ciência: um saber elaborado por muitos e ao alcance de todos. Exemplos conhecidos dessa linhagem são os livros de divulgação utilizados pelos comenianos ingleses ou mesmo os relatórios, atas e memórias das sociedades científicas, geradores dos primeiros embriões de periódicos dedicados às ciências. Todavia, sob essa aparente contraposição das duas linhagens, há indícios de um profícuo diálogo - expresso sobretudo na correspondência e diários pensadores da época. (shrink)

Towards the middle of the 18th century, Pierre-Louis Moreau de Maupertuis proposed the “principle of least action” as a fundamental law of physics and as a proof of the existence of God. Samuel König and other contemporary authors criticized Maupertuis’ work. There ensued a fierce discussion concerning this subject, in which Leonhard Euler, the king Frédéric II of Prussia and Voltaire took part. This paper discusses that debate, emphasizing its extrascientific features and analyzing the interests that motivated the actions of (...) the people involved in that episode. RESUMO: Em meados do século XVIII, Pierre-Louis Moreau de Maupertuis propôs o “princípio de ação mínima”, que seria uma lei fundamental da física, além de constituir uma prova da existência de Deus. O trabalho de Maupertuis foi criticado por Samuel König e outros autores da época. Ocorreu uma violenta discussão a respeito desse assunto, da qual participaram Leonhard Euler, o rei Frédéric II da Prússia e Voltaire. Este artigo estuda o debate ocorrido, enfatizando especialmente os aspectos extracientíficos e analisando os interesses que motivaram as ações das pessoas envolvidas nesse episódio. (shrink)

This article examines the NEET (Not in Education, Employment, or Training) youth in Romania, employing the secondary analysis of quantitative data and focusing on the socio-economic, cultural and systemic factors contributing to this phenomenon. The analysis highlights how economic instability, poverty and limited access to education exacerbate the challenges faced by this demographic group. Gender disparities, driven by traditional roles and labour market discrimination, further limit opportunities for young women. Additionally, structural deficiencies in the labour market, such as job shortages (...) and mismatches between skills and demand, hinder employment prospects. Cultural expectations and societal norms also play a significant role in influencing youth participation in education and employment. Young citizens of Romania, particularly women and members of the Roma community, face significant barriers to employment, with low wages, poor working conditions and inadequate investment in education and vocational training contributing to high NEET youth rates. Patriarchal norms, especially within the Roma community, further exacerbate cycles of poverty and marginalisation by limiting educational and economic opportunities. (shrink)

En el actual contexto de un nihilismo que suele afirmarse como horizonte insuperable de nuestro tiempo, urge mostrar que no es así. Nada mejor que mirar la experiencia de hombres que han sabido recorrer hasta el fondo el camino del nihilismo y redescubrir su humanidad. Giuseppe Capograssi es uno de ellos. La vida y obra de este genial filósofo del Derecho del siglo XX están traspasadas por la conciencia de que la dependencia, la tristeza y la melancolía son la misma (...) estructura del yo, el terreno abonado en el que, gracias a un encuentro, puede florecer la esperanza. (shrink)

Monsters, argues Haraway, are sites of confusion and hybridity, entities that defy easy categorization and, as a consequence, hold promise, pleasure, and peril. Haraway adds that monsters are also not accidental or innocent: their creation requires sustained work, their existence has effects. Thus, to understand how Frankenstein came to be in Lilliput, the theme of this special edition, it is crucial to examine how monsters are constructed and how they do things in the world.In this article I propose to start, (...) if modestly, that examination. To do so I draw upon ethnographic data generated at two conferences held in 2005 to investigate some of the processes through which the monster of “nano”—this elusive and emergent entity—was brought to life by social scientists and humanities scholars. My initial goal is to explore how nano was defined, framed, and analyzed at these meetings—on the ethics and history of nano, respectively—and how these different ways of constituting and enacting nano have shaped subsequent understandings of, and interactions with, nano. The article next examines the stances and stakes of those who, through their involvement, became nano practitioners, and the ways in which nano was disciplined through their practices. (shrink)

Democratic alternation in power involves uncontrolled policy experiments. One party is elected on one policy platform that it then implements. Things may go well or badly. When another party is elected in its place, it implements a different policy. In imposing policies on the whole community, parties in effect conduct non-randomized trials without control groups. In this paper, we endorse the general idea of policy experimentation but we also argue that it can be done better by deploying in policymaking randomized (...) controlled trials. We focus primarily on the democratic benefits of using randomized trials in policymaking and on how they can enhance the democratic legitimacy of policy. We argue that randomized trials resonate well with three key democratic principles: non-arbitrariness, revisability and public justification. Randomized trials’ contribution to non-arbitrariness and revisability is not unique; other types of evidence can advance these democratic principles as well. But through their peculiar democratic scrutability, randomized trials are well-equipped to contribute to the public justifiability of policy. (shrink)

In 1877 Louis Paul Cailletet in France and Raoul Pictet in Switzerland liquefied oxygen in the form of a mist. The liquefaction of the first of the so-called permanent gases heralded the birth of low-temperature research and is often described in the literature as having started a ‘race’ for attaining progressively lower temperatures. In fact, between 1877 and 1908, when helium, the last of the permanent gases, was liquefied, there were many priority disputes—something quite characteristic of the emergence of a (...) new research field. This paper examines Cailletet’s path to the liquefaction of oxygen, as well as a debate between him and the Polish physicist Zygmunt Wróblewski over the latter’s contribution to the liquefaction of gases. (shrink)

The Platonic myth in Book X of The Republic tells us how the choice of “destinies” is carried out by human souls about to be born. The revenant Er, in his particular nekia, returns to life to tell all he has seen and heard: that what life bring us is related to the good or bad choice of our future life trough a draw carried out under the eyes of Necessity and her three daughters: Lachesis, Clotho and Atropo, who weave (...) the destiny of men (The Republic, Book X, 617e): Theintelligible character of this choice has the burden of a determinism ab origine without possibility of rewriting it, making our fate an inalterable journey. Kant could say the same in KrV, although it is true that the doctrine of the “intelligible character” only appears specifically in 1781, in the light of the Third Antinomies, in the“Dialectic” of the Critique of Pure Reason. Anyway, its long shadow appears in other texts (as in Religion Within Limits of Reason Alone of 1793)– that each one of voluntary acts of men: “it is predetermined, well before it occurs, in the empirical character of man” (KrV, A 553 / B 581) would suppose that this intelligiblecharacter would have to be understood together with the problem of freedom and decision. That threshold pointed out by Kant will be trespassed by Schelling, who will form a concept of freedom of a metaphysical character (libertas ex) which will send us to an origin, beyond all times, in which the de-cision, as ex-cision, restructures and sets in order our time. Cut or beginning, it is a wound without stitches which implies the proper opening of being into existence. (shrink)

National membership in itself aggravates global inequality, and plural membership does all the more so. A key mechanism by which that occurs are double taxation agreements that have the effect of favoring the global rich at the expense of the global poor. One egalitarian solution is a levy on multiple citizenship; another is redesigning double taxation agreements along prioritarian lines. Revising the OECD Model Tax Convention could be a feasible strategy for implementing such reforms.

In online communication, writers incorporate into fictional representation imaginaries that arise from the interaction between various artistic manifestations. This paper explores the work of two spanish authors, Patricia Esteban Erlés and Albert Soloviev in order to study the social impact and ethical aspects of hypermedial short stories in the virtual space, since their works function as vehicles for social criticism. At the same time, the paper addresses fundamental questions associated with the understanding and interpretation of hybrid narrative microtexts.

El presente trabajo trata de abordar la forma testimonial de Ernst Jünger de dar cuenta de la historia con el propósito, en primer lugar, de indagar en el sentido que tiene para el autor alemán la experiencia de la catástrofe, la guerra y el dolor y, en segundo lugar, de explicar los elementos constitutivos de su particular concepto de historia.

In Croatia, the subject of medical ethics, or bioethics, was introduced into the curriculum in the early 1990s at the medical schools of the University of Rijeka and the University of Zagreb. Today, bioethics education has become a basic part of undergraduate medical education not only in Rijeka and Zagreb but also in Osijek.