The proteasome is a proteolytic complex that is known to degrade proteins marked by the attachment of ubiquitin. Recently, it has become apparent that the proteasome has non-proteolytic roles. Several studies have implicated the proteasome in the regulation of transcription. A new study now shows that the proteasome facilitates the interaction of a histone acetyltransferase complex with transcriptional activators at active promoters.1 Bioessays 28:235–239, 2006. © 2006 Wiley Periodicals, Inc.

We sought to evaluate whether health care professionals’ viewpoints differed on the role of ethics committees and hospitals in the resolution of clinical ethical dilemmas based on practice location. We conducted a survey study from December 21, 2013 to March 15, 2014 of health care professionals at six hospitals. The survey consisted of eight clinical ethics cases followed by statements on whether there was a role for the ethics committee or hospital in their resolution, what that role might be and (...) case specific queries. Respondents used a 5-point Likert scale to express their degree of agreement with the premises posed. We used the ANOVA test to evaluate whether respondent views significantly varied based on practice location. 240 health care professionals completed the survey. Only three individual queries of 32 showed any significant response variations across practice locations. Overall, viewpoints did not vary across practice locations within question categories on whether the ethics committee or hospital had a role in case resolution, what that role might be and case specific queries. In this multicenter survey study, the viewpoints of health care professionals on the role of ethics committees or hospitals in the resolution of clinical ethics cases varied little based on practice location. (shrink)

Encyclopeadic work on the religious and philosophical terms in Hinduism ; includes Sanskrit text of Viṣṇudaśāvatārarahasyadarśikā and Parāśaktigāyatryaṣṭakam with Hindi explanation.

This short book edited by J. N. Mohanty consists of eight essays written by Ganeswar Misra from 1969 to 1984. These essays were originally published in various journals and books in India. Misra, a student of A. J. Ayer, was greatly influenced by the philosophical style of his mentor. These essays capture the philosophical views of an Indian intellectual who rebelled against the narrow Vedantic interpretation of Indian philosophy popularized by Radhakrishnan and Dasgupta.

"--Brian Greene, Columbia University "This book includes material that is intellectually innovative and comes as a surprise even to specialists in the field.

Interesante y muy bien lograda aproximación al universo teórico construido por Ricardo Guastini, filósofo del derecho italiano.

Context: Immunity includes cognitive concepts: the organism is thought to specifically recognize foreign materials and develop a memory of these encounters. Vaccines are thought to work by enhancing this immunological memory. Lymphocytes are key cells and specific antibodies are key molecules in immune recognition. Antibodies are blood proteins called “immunoglobulins.” Spontaneously formed immunoglobulins are seen as “natural” antibodies to dietary components and commensal bacteria. Immune cognition is used simply as a didactic metaphor. Problem: Do the cognitive aspects of immunology stem (...) from the activities of cells and molecules, or are they ascribed by the immunologist operating as a human observer? (1) An immense variety of immunoglobulins may bind to the same antigen with different binding energies. It is the immunologist who arbitrates the boundary between those that are specific (and declared antibodies) and those that are not. Specific antibodies serve as functional labels pasted onto natural immunoglobulins, as if they were recognizing elements. Is this “arbitration” the true cognitive event ascribed to immunoglobulins and lymphocytes? (2) A major impasse exists between progress in experimental immunology and its translation into clinical results. A proper understanding of immunological activity demands a wider view of an organism’s biology and, also, of the interference of human observers in delineating experimental realities, such as the specificity of immune recognition. Maturana’s biology of cognition and language provides one such approach. Method: Use of Maturana’s biology of cognition and language concepts to describe immunological activity. Results: A whole new understanding of immunological activity is suggested. Implications: A major change in the way of seeing is proposed that may eventually help the translation of this knowledge into clinical results. Furthermore, the immune system may also become a proper model for cognitive analyses. (shrink)

Эта книга поможет пролить свет на метафизическое осмысление философии истории, подведет к более глубокому пониманию сущности добра и зла, предложенному известным русским философом и мыслителем Н. Ф. Федоровым.

Contributed articles on Indic philosophy, Vedic grammer, and classical Sanskrit literature; includes some on the life of Kr̥ṣṇa Mādho Jha, Sanskrit scholar.

These three Ciceronian references, each used only once, have given rise to a most confusing variety of interpretations. In this article I hope to show, as far as the evidence will allow, who these poets were and what sort of poetry Cicero probably had in mind.οί νєώτєροι.

An important part of successful socialization of young people is the transfer of socio-cultural heritage to previous generations. Knowledge of artistic and cultural values, monuments of material and spiritual culture become the basis for the affirmation in the minds of students possessing high moral values ​​in the Ukrainian people; promote the development of moral feelings and behaviors ; form a cultural approach to Christian values.

Throughout history, the nature of the UGCC is at the center of the attention of researchers. Until now, they are divided into "Westerners" - supporters of Romanization of the church, that is, its purely Catholic nature, and "Byzantines" - those who defend its eastern rite. In addition, the study of the history of the Ukrainian Greek Catholic Church can be divided into two groups: negativist works and apologetic works. The first group is primarily represented by the works of Ukrainian Soviet (...) historians of the postwar period, which have very well-known names: "Unia: the path of betrayal and disgrace", "UniCity - an instrument of clerical anti-communism", "Uniate Church - enemy of the Ukrainian people", "The reactionary role of the union in the history of Ukrainian people "etc. Of course, the significance of such ideologically exacerbated "research" as a scientific development is doubtful. They have, if not scientific, but rather a journalistic character. (shrink)

Purpose of the article is to establish the role of egoism in the life of a person faced with a disability situation, as a moment of self-determination in an existential crisis. I set the task to evaluate the influence of egoism and find out its significance in the prospect of the person’s further existence in the conditions of disability using the philosophical anthropology based on the meta-anthropology principle. Theoretical basis. Based on the fact that the role of egoism is perceived (...) by public opinion as a vice and entails the absorption by a person of the benefits intended for others, I find them inappropriate for a person in a situation of disability. Taking into account the concepts of ego of altruism and altruistic egoism, which partially justify the positive influence of egoism, are only a product of the symbiotic interaction of altruism and egoism. The combination of egoism with altruism cannot reveal the essence of the crisis for a person in a disability situation. In a situation of disability, a person cannot synthesize altruism, as part of the egoism symbiosis. Methodological system in the study of the positive role of egoism, the modern theory of meta-anthropology by Nazip Khamitov is used. The theory that divides the being of a person into various types is able to most fully structure the concept of egoism in the being of a person who has disability. Originality. I made an attempt to prove the positive role of egoism in a situation related to the body transformation into new conditions. The analysis of evidence of the need for the egoism development, as a function capable of actualizing a person in the formed crisis circumstances is carried out. A theory about the need for egoism to get a person out of the existential crisis situation in which he stays due to a disability situation was proposed. Conclusions. I show that taking care of oneself is a balancing factor for a person, as opposing a fatally unfair situation in which a person has received disability. Rational egoism is able to bring a person out of ultimate being and allow him to transform into a new, changed reality. (shrink)

Sobre dialéctica recoge las principales aportaciones –inéditas en su mayor parte– de Manuel Sacristán Luzón (1925-1985) en torno a esta debatida noción, entre las que se incluye el importante prólogo que escribió en 1964 para su traducción castellana del Anti-Dühring, prólogo que Javier Muguerza ha caracterizado como “el texto filosófico más significativo de Sacristán –el que más me impactó cuando lo leí y prolongó más duraderamente dicho impacto” y del que Gregorio Morán escribió que “otro tanto ocurrió con su soberbio (...) prólogo al Anti-Dühring…; fue un texto capital en la formación marxista de una generación”. Como señaló Sacristán, y tal como reflejan los distintos textos que configuran este volumen, la dialéctica es una visión global del mundo, no un método, y una hipótesis de estas características no se aplica: se realiza, se concreta, y para ello hay que trabajar de verdad y verazmente. Miguel Candel Sanmartín, Manuel Monleón Pradas y Félix Ovejero Lucas son los autores del prólogo, nota final y epílogo del volumen. Antoni Domènech ha traducido para esta edición la “Loa a la dialéctica” de Brecht. Manuel Sacristán Luzón (Madrid, 1925-Barcelona, 1985) estudió Derecho y Filosofía y Letras en la Universidad de Barcelona y cursó estudios de lógica y epistemología en el Instituto de Lógica Matemática e Investigación de Fundamentos de la Universidad de Münster (Westfalia, Alemania) entre 1954 y 1956. Sacristán se doctoró en Filosofía en 1959 con una tesis sobre Las ideas gnoseológicas de Heidegger y en 1964, dos años después de que le fuera negada la cátedra de lógica de la Universidad de Valencia, publicó Introducción a la lógica y al análisis formal, uno de los textos que más contribuyeron a la presencia y consolidación de la lógica formal en la cultura científica y filosófica española. Profesor de “Fundamentos de Filosofía” y de “Metodología de las ciencias sociales” en la Universidad de Barcelona, impartió durante el curso 1982-1983 dos seminarios de postgrado en la UNAM de México. Miembro del comité central del PCE y del PSUC, entre 1965 y 1970 formó parte del comité ejecutivo del PSUC. En su faceta de filósofo marxista, destaca la sensatez y originalidad con que siempre trató el complejo, y en ocasiones oscuro, tema de la dialéctica y su concepción del marxismo como una tradición de política revolucionaria. De uno de los escritos aquí recogidos, Félix Ovejero Lucas señaló en 1985: “Apenas veinte páginas tenía la introducción de Manuel Sacristán a la edición castellana del Anti-Dühring, de Engels; veinte páginas que enseñaron a varias generaciones de marxistas mucho más acerca de lo que significaba ser marxista que la marabunta editorial de unos años más tarde”. (shrink)

Three essays on the nature of the philosophical task. The author's view is that the primary focus of philosophy should be critical.

Open peer commentary on the target article “Who Conceives of Society?” by Ernst von Glasersfeld. Excerpt: In the face of modern neuroscience we should give up on constructivism, even more so on radical constructivism, and stick to the physical and psychological reality given in science and daily life, even if it is the brain’s illusion from associative networks. The illusion of constructivism may hurt!