An exciting development in the field of assisted reproductive technologies is In Vitro Gametogenesis (IVG) that enables production of functional gametes from stem cells in the laboratory. Currently, development of this technology is still at an early stage and has demonstrated to work only in rodents. Upon critically examining the ethical dimensions of various possible IVG applications in human fertility treatment from a Sunni Islamic perspective, together with benefit-harm (maslahah-mafsadah) assessment; it is concluded that utilization of IVG, once its efficacy (...) and safety are guaranteed, could be permissible by strictly adhering to Islamic ethical principles related to marriage, biological/genetic relatedness, sexual intercourse, and moral status of the embryo/fetus versus that of the gamete. As a result, IVG will be acceptable for treating primary infertility, age-related infertility, and preventing genetic diseases. However, it will be unacceptable for application in posthumous reproduction, donor gametes, genetic enhancement, and procreation in same-sex couples. (shrink)

Orthodox economics operates within a hypothesized world of perfect competition in which perfect consumers and firms act to bring about supposedly optimal outcomes. The discrepancies between this model and the reality it claims to address are then attributed to particular imperfections in reality itself. Most heterodox economists seize on this fact and insist that the world is characterized by imperfect competition. But this only ties them to the notion of perfect competition, which remains as their point of departure and base (...) of comparison. There is no imperfection without perfection. In Capitalism, Anwar Shaikh takes a different approach. He demonstrates that most of the central propositions of economic analysis can be derived without any reference to standard devices such as hyperrationality, optimization, perfect competition, perfect information, representative agents, or so-called rational expectations. This perspective allows him to look afresh at virtually all the elements of economic analysis: the laws of demand and supply, the determination of wage and profit rates, technological change, relative prices, interest rates, bond and equity prices, exchange rates, terms and balance of trade, growth, unemployment, inflation, and long booms culminating in recurrent general crises. In every case, Shaikh's innovative theory is applied to modern empirical patterns and contrasted with neoclassical, Keynesian, and Post-Keynesian approaches to the same issues. Shaikh's object of analysis is the economics of capitalism, and he explores the subject in this expansive light. This is how the classical economists, as well as Keynes and Kalecki, approached the issue. Anyone interested in capitalism and economics in general can gain a wealth of knowledge from this ground-breaking text. (shrink)

Irecall vividly my initial excitement at the accomplishments of the Human Genome Project. That excitement was short-lived and diminished steadily over the next decade as I came to realize that the HGP was just another nail to be hit by the metaphoric hammer of genome-sequencing technology. To this day, I see this trend in many other spheres of public health and biomedical science. I take responsibility for using this same approach of "hammer" and "nail" in my own research program, where (...) I use complex systems modeling to address pressing public health issues, such as adverse birth outcomes, food insecurity, and the opioid epidemic. But I am slowly yet surely shifting my ways by explicitly and slowly... (shrink)

Present era can be categorized due to its speed of changes. Pakistani society got affected by worst kind of terrorism and extremism in last fifteen years. The root causes of prevailing security environment in Pakistan are multifaceted, complex and are derived from structural, as well as micro-level conditions. Objective of this research is to highlight the gaps in security doctrine of Pakistan. Both qualitative and quantitative methodology in the format of Knowledge Attitude and Practice is selected. Primary question of this (...) research was to find the gaps in national internal security policy of Pakistan. This primary question is further sub divided into ten sub questions. Implementation modalities and the impediments of National Internal Security Policy 2014 are also discussed. This research finds out that national internal security policy 2014 was a vibrant document and right step in the domain of policy formulation but demanded non-pragmatic results from security operators. Majority of its drawbacks are removed in in its later version of 2018-23. Survey and questionnaire based analysis is also made part of this article along with recommendations as submitted by respondents. (shrink)

Codes of ethics in journalism in the light of Koran and Hadith (Islamic traditions).

During the late 1960s, the long post-war economic boom which had characterised the advanced capitalist countries began to fade away. In its wake came an equally long era of stagnation, decline, and political and economic turbulence. Unemployment, inflation, falling profitability, business failures and bankruptcies were the new order of the day, and it became commonplace to see fearful headlines about the possible collapse of the global financial system or even of accumulation itself.

Motivated by the social and environmental challenges resulting from the COVID‐19 pandemic, this research examines the influence of the “big five” personality traits; extroversion, agreeableness, openness, conscientiousness, and neuroticism on sustainable social responsibility with a mediating role of bricolage. We collected empirical evidence from 245 family‐owned SMEs. The results indicate that the personality traits do not directly influence sustainable social responsibility, although the traits (except extroversion) influence bricolage. Moreover, we found that open, conscious, and agreeable personalities indirectly contribute to sustainable (...) social responsibility, with bricolage as a mediator. Our findings encourage enterprises to focus on those personality traits during crises (especially COVID‐19) that empower people to effectively manage existing resources (e.g., bricolage) and protect their stakeholders. Family‐owned SMEs need to assign resource utilization tasks to family members having personalities of openness, conscientiousness, and neuroticism because these kinds of people have high capacities for bricolage. (shrink)

Greek philosophy; Syriac schools; Ancient Near East; history.

In this paper we critically review recent developments in policies, practices and philosophies pertaining to the mediation between science and the public within the EU and the UK, focusing in particular on the current paradigm of Public Understanding of Science and Technology (PEST) which seeks to depart from the science information-transmission associated with previous paradigms, and enact a deliberative democracy model. We first outline the features of the current crisis in democracy and discuss deliberative democracy as a response to this (...) crisis. We then map out and critically review the broad outlines of recent policy developments in public-science mediation in the EU and UK contexts, focusing on the shift towards the deliberative-democratic model. We conclude with some critical thoughts on the complex interrelationships between democracy, equality, science and informal pedagogies in public-science mediations. We argue that science and democracy operate within distinct value-spheres that are not necessarily consonant with each other. We also problematize the now common dismissal of information-transmission of science as inimical to democratic engagement, and argue for a reassessment of the role and importance of informal science learning for the lay public, provided within the framework of a deliberative democracy that is not reducible to consensus building or the mere expression of opinions rooted in social and cultural givens. This, we argue, can be delivered by a model of PEST that is creative and experimental, with both educational and democratic functions. (shrink)

The fight to find effective, long-lasting treatments for cancer has led many researchers to consider protein degrading entities. Recent developments in PROteolysis TArgeting Chimeras (PROTACs) have signified their potential as possible cancer therapies. PROTACs are small molecule, protein degraders that function by hijacking the built-in Ubiquitin-Proteasome pathway. This review mainly focuses on the general design and functioning of PROTACs as well as current advancements in the development of PROTACs as anticancer therapies. Particular emphasis is given to PROTACs designed against various (...) types of Leukemia/Blood malignancies. (shrink)

This essay is to invite a new form of theorizing Baldwin’s intellectual archive beyond a work of protest or as being contributory to Queer writing. I argue that Baldwin’s thought often in the form of the polemic is a form of non-violent resistance. Baldwin’s contestation against whiteness and the methods of Black erasure in general and Black male annihilation in particular is why he is challenging the complexity of protest. In pushing against traditional or what has become traditional ways of (...) analyzing Black thought, my essay highlights why figures like Baldwin are read in fragmentation. Hence, my insistence on Baldwin being categorized as a Gender/Genre theorist more so than a Queer theorist. Because his writings are on the erasure of Black Male existence within and outside of heteronormative spaces. (shrink)

In a fiercely competitive business landscape, the optimization of supply chain management (SCM) strategies and the integration of robust corporate digital competencies stand as pivotal determinants for sustained success across various industries, including the fast-moving consumer goods (FMCG) sector. The study investigates the dynamic interplay between SCM strategies, corporate digital competencies, and operational performance. Through a hypothesis testing research design, the examination sought to determine the influence of these variables. The study revealed strong support for the hypothesis that SCM strategies (...) significantly impact corporate digital competencies and, in turn, operational performance. The results indicated a direct positive relationship between SCM strategies and operational performance while corporate digital competencies indirectly influenced operational performance through their mediation between SCM strategies and operational effectiveness. The findings underscored the integral role of corporate digital competencies in enhancing the efficacy of SCM strategies, amplifying operational performance, and driving customer-centric value. These implications stress the imperative for businesses to strategically align their SCM processes with digital competencies to effectively navigate market complexities and ensure long-term competitiveness. (shrink)

The aim of this article is to trace some lines of thinking towards a conceptualization of the uniqueness of the creative work of museums, the mode of creativeness that belongs exclusively to museums, or at least that museums are capable of by virtue of the types of materials and forms as well as activities unique to what will be referred to as museography. This is linked to the question of what it is that constitutes the uniqueness of museum work as (...) a professional field. The article characterizes the uniqueness of museum professional knowledge primarily in terms of a mode of creativeness, or bricolage in Levi-Strauss’s sense, mediated through the museographic form, and applied to the chance assemblies of materials to generate museum-specific modes of engaging questions—across science, culture, and society—particularly through creating unique temporal arrangements, or durations, that provoke thought, learning, and engagement on museographic terms. Museography’s originality, it is argued, consists in a bricolage that works through the museum’s unique material and form to create learning resources and encounters, museographic assemblages that depart from a conception of linear time as the space of evolutionary narrative to facilitate the experience of Bergsonian durations. (shrink)

Integrating artificial intelligence (AI) into healthcare can potentially revolutionize how clinical decisions are made. Advancements in AI-driven Clinical Decision Support Systems (AI_CDSS) are enh...

This book provides an alternative foundation for the measurement of the production of nations, and applies it to the US economy for the postwar period. The patterns which result are significantly different from those derived within conventional systems of national accounts. Conventional national accounts seriously distort basic economic aggregates, because they classify military, bureaucratic and financial activities as creation of new wealth, when in fact they should be classified as forms of social consumption which, like personal consumption, actually use up (...) social wealth in the performance of their functions. The difference between the two approaches has an impact not only on basic aggregate economic measures, but also on the very understanding of the observed patterns of growth and stagnation. In a world of burgeoning militaries, bureaucracies, and sales forces, such matters can assume great importance at the levels of both theory and policy. (shrink)

There is growing interest for implementing tools to monitor cognitive performance in naturalistic work and everyday life settings. The emerging field of research, known as neuroergonomics, promotes the use of wearable and portable brain monitoring sensors such as functional near infrared spectroscopy (fNIRS) to investigate cortical activity in a variety of human tasks out of the laboratory. The objective of this study was to implement an on-line passive fNIRS-based brain computer interface to discriminate two levels of working memory load during (...) highly ecological aircraft piloting tasks. Twenty eight recruited pilots were equally split into two groups (flight simulator vs. real aircraft). In both cases, identical approaches and experimental stimuli were used (serial memorization task, consisting in repeating series of pre-recorded air traffic control instructions, easy vs. hard). The results show pilots in the real flight condition committed more errors and had higher anterior prefrontal cortex activation than pilots in the simulator, when completing cognitively demanding tasks. Nevertheless, evaluation of single trial working memory load classification showed high accuracy (>76%) across both experimental conditions. The contributions here are two-fold. First, we demonstrate the feasibility of passively monitoring cognitive load in a realistic and complex situation (live piloting of an aircraft). In addition, the differences in performance and brain activity between the two experimental conditions underscore the need for ecologically-valid investigations. (shrink)

Kameron Carter’s reading of Black life as matter, as the imaginary, and as an innovation of possibilities enmeshes Black theology, Black womanist/feminist thought, Black Diaspora and Black American Studies, Philosophy, and Queer of Color Critique to reveal how the project of the western world erases Black physical and intellectual legacy. A project that is anti-black, anti-other, anti-difference that erases the legacy of the physical and intellectual aspects of Black contributions to the western world. His book is an invitation to think (...) through what Black ontology would look like outside of white western constructions of religion and social scripts. Carter’s radical shift from being beyond the long durée of enslavement, colonization, segregation, and its afterlives scripts an (anti)blackening because of the western project of erasure works to undo such a project. The book is working against the social ontology of being a fragmented object that is plasticized, fetishized, and dissolved into a state of non-being. It is a project that disrupts and decolonizes previously constructed (anti)blackening architecture by creating a blueprint that asks for Black matter as an incomplete project because it must include imagination and innovation. (shrink)

New concepts of Muhammadiyah in teaching Islamic values for socio-economic and political development in Indonesia.

Ethics; philosophy, Modern; globalization; economic aspects.

Shyness affects and influences the performance of the learners at school and college level. There are different correlates and reasons of shyness. Zimbardo states that Shyness is a vague concept which has many interpretations and definitions. One definition which is very renowned is that “The person, male or female, who is nervous, worried, and uncomfortable in the gathering or presence of others, is called shy”. The objectives of this research study were as: to investigate the relationship of schooling system with (...) shyness to investigate the relationship of residential locality with shyness to check relationship of Socio- Economic status with shyness To rank the correlates of shyness. Overall 252 students from graduation of Indus group of Colleges from Rawalpindi and Islamabad were the population of the study and 42 students were selected through simple random sampling technique as a sample for the study. The researcher got the data with the help of personal visits to the colleges. Questionnaire for measuring shyness was used by the researcher for this research study1. Another self developed questionnaire or instrument was used to know the correlates of shyness. Chisquare test of independence was used for data analysis. The results of the study showed that shyness depended upon these correlates of shyness as residential locality Schooling system socio-economic status of the learners. Shyness depends upon above mentioned correlates. In order to remove this problem of shyness, some steps should be taken as learners or students may not be blamed or punished without any reason. Learners should be encouraged and motivated. (shrink)

The present study was conducted in Quetta district Balochistan province so as to determine the perception of the respondents about causes and consequences of child labor in Balochistan province. The sample size was 100 family units selected by using the simple random sampling. Somehow of the respondents fall in the age categories of 41 to 50 years, followed by 30% of the family units who were in the age categories of 50 and above years. More than half 52% of the (...) respondents were illiterates and the other of the respondents had primary level of education. The result is further expressed that the other 20% of the male respondents were of the view that the retail trade, cycling repairing and carpet business important child labor route respectively. While 20% of the female respondents revealed that they are cycling repairing and carpet business important child labor route respectively at Quetta district. Children are the assets of any nation without their contribution in the developmental process can be null and void, therefore it should be recommended that government must take stern action against the child labor at grass-root level to eliminate the child labor in the community or society. (shrink)

This article is a discourse analysis based on a theory of figures of speech advocated by Orecchionni that analyzes implicit not only as a mark of literality but also as trope of illocutionary type not lexical, lexical, metaphorical or semantic. It considers also the explicit information of the novel through four levels of competency: linguistic, encyclopedic, logical and pragmatic rhetorical and analyzes the romantic statement according to the maxims of quantity, quality, relation or relevance and modality. This study shows, through (...) verbal interactions of « Douane de mer » that the story is the heiress of the mnemonic representation than of historical representation. It sheds light on the dual role played by implicit as a mediator in relation to historical reality or an opaque screen over the truth of the world. (shrink)

The aim of this paper is to evaluate on how good traditional house design is able to give residential satisfaction levels and could contribute towards habitability in Shibam, Yemen. House design in this study is a subject dealing with efficient space-function design of the house layout which shows cultural aspects of the community. Houses in Shibam typify the traditional architecture which reflects to the structure of family, and social and cultural realms. The houses comprises mid and high-rise mud brick house (...) types, considered as one of the earliest high-rise house type built in the world. Today, the city of Shibam with mid and high-rises mud brick house types is recognized as one of the heritage sites under UNESCO’s World Heritage Lists. The literature study is conducted to understand the definitions of the title, which is important to identify the measurable factors for the research analysis. The study finds that diwan, dining area, bedrooms, bathrooms, corridor and storage, courtyard and balcony, and the composition of the rooms’ layout are important measurable checklist’s factors under category of space planning and function. There are two types of the research analyses which are qualitative and quantitative analysis. The qualitative analysis is a study by the researcher based on the researcher’s observation on the house design during the site visit while the quantitative analysis is from the respondents’ answers (300 respondents) on their satisfaction level from the research questionnaires. With high average scores of 94% in qualitative and 90% in quantitative analysis on satisfactory level, it shows that both results of qualitative and quantitative analysis support the research assumption. In that light, within the ambit of this study, the house design in Shibam can and does serve as a reference. (shrink)

History and criticism on the work of Sir Muhammad Iqbal, 1877-1938.