Background The use of lengthy, detailed, and complex informed consent forms is of paramount concern in biomedical research as it may not truly promote the rights and interests of research participants. The extent of information in ICFs has been the subject of debates for decades; however, no clear guidance is given. Thus, the objective of this study was to determine the perspectives of research participants about the type and extent of information they need when they are invited to participate in (...) biomedical research. Methods This multi-center, cross-sectional, descriptive survey was conducted at 54 study sites in seven Asia-Pacific countries. A modified Likert-scale questionnaire was used to determine the importance of each element in the ICF among research participants of a biomedical study, with an anchored rating scale from 1 to 5. Results Of the 2484 questionnaires distributed, 2113 were returned. The majority of respondents considered most elements required in the ICF to be ‘moderately important’ to ‘very important’ for their decision making. Major foreseeable risk, direct benefit, and common adverse effects of the intervention were considered to be of most concerned elements in the ICF. Conclusions Research participants would like to be informed of the ICF elements required by ethical guidelines and regulations; however, the importance of each element varied, e.g., risk and benefit associated with research participants were considered to be more important than the general nature or technical details of research. Using a participant-oriented approach by providing more details of the participant-interested elements while avoiding unnecessarily lengthy details of other less important elements would enhance the quality of the ICF. (shrink)

Virtual screening is the most critical process in drug discovery, and it relies on machine learning to facilitate the screening process. It enables the discovery of molecules that bind to a specific protein to form a drug. Despite its benefits, virtual screening generates enormous data and suffers from drawbacks such as high dimensions and imbalance. This paper tackles data imbalance and aims to improve virtual screening accuracy, especially for a minority dataset. For a dataset identified without considering the data’s imbalanced (...) nature, most classification methods tend to have high predictive accuracy for the majority category. However, the accuracy was significantly poor for the minority category. The paper proposes a K-mean algorithm coupled with Synthetic Minority Oversampling Technique to overcome the problem of imbalanced datasets. The proposed algorithm is named as KSMOTE. Using KSMOTE, minority data can be identified at high accuracy and can be detected at high precision. A large set of experiments were implemented on Apache Spark using numeric PaDEL and fingerprint descriptors. The proposed solution was compared to both no-sampling method and SMOTE on the same datasets. Experimental results showed that the proposed solution outperformed other methods. (shrink)

Islam and the Rule of Justice: Image and Reality in Muslim Law and Culture. By Lawrence Rosen. Chicago: University of Chicago Press, 2018. Pp. xi + 279. $105 ; $35.

Necessary and sufficient conditions ofinvariance on four-vectors under the Poincaré group E(3, 1) and its subgroups are exploited. As an example the Euclidean group in three dimensions and its subgroups are explicitly considered. Their invariant “potentials” are systematically derived.

Israel has always mattered to American Christians. They are among the strongest supporters of the State of Israel in the United States. The paper argues that the support that was extended by American Christians in general and the Christian Right in particular, to Israel and the Jewish people is the continuation of a long tradition in conservative American Christians rooted mainly in their theological doctrine. However, the study shows that the Christian Right is ambivalent in its view on Jews. On (...) the one hand, Jews are considered to be God’s chosen people and to have a special Biblical status and role. On the other hand, the Christian Right is allegedly anti-Semitic, as it views Jews as a condemned nation for their rejection of Christ as the Messiah, the reason for which they are unsaved and need to be converted to Christianity. Interestingly, both views, love and hatred of Jews, are based on the Biblical teachings and grounded in conservative Protestant theology; their paradoxical views on Jews are not a new phenomenon among conservative American Christians. Nevertheless, the study found that the support of the American Christians of the establishment of the State of Israel goes beyond theological doctrines or values. In fact, the humanitarian considerations of the liberal Christian and secular organizations in particular, were significant in contributing to the establishment of the Jewish state. (shrink)

In this article, I offer a new analysis of knowledge: knowledge, I claim, is normal belief. I begin with what I take to be the conceptual truth that knowledge is epistemically justified, or permissible, belief. I then argue that this in turn is simply doxastically normal belief, first clarifying what is meant by this claim, and then providing reasons to think that normal belief, so understood, must be true and safe from error, making it a good candidate for knowledge.

Some objections to the idea that disputed territories should be auctioned.

This article examines the new conceptualizing and thinking about privacy. It discusses older theories of privacy and explains why they became obsolete. It suggests that the reconceptualization of privacy was influenced by the developments in information technologies, radical changes in the relation between the sexes, and the intrusion of intimacy into the public realm. It describes the normative problems associated with privacy and differentiates the three dimensions of privacy: decisional privacy, informational privacy, and local privacy.

This paper owes its inspiration to a remark made by Professor M. Rostovtzeff; in a note in his Social and Economic History of the Roman Empire on the widespread social unrest of the first two centuries A.D., having cited other literary authorities such as Dio Chrysostom, Aelius Aristides, etc., he writes: ‘The social problem as such, the cleavage between the poor and the rich, occupies a prominent place in the dialogues of Lucian; he was fully aware of the importance of (...) the problem.’ No one, as far as I know, has attempted to collect and discuss the main passages in Lucian on this topic, and the latest writer on this aspect of Lucian reaches a conclusion quite opposed to Rostovtzeff and one which I believe to be wholly misleading. The aim of this paper is to collect and discuss the main references in Lucian to the social problem interpreting them in the light of Lucian's life and background, and the social and economic conditions of his age. In particular I shall stress the importance of the Cynic tradition as it bears on Lucian's attitude, but shall endeavour to show that this tradition is firmly rooted in practical politics and actual participation in social revolutionary movements and goes far beyond the repetition of mere ethical cliches generally ascribed to it. (shrink)

The argument rests on earlier work questioning the Russellian separation of levels and arguing that Russellian levels should be taken to include the levels of particle and aggregate, and generality and detail. That earlier work argues from the non-separation of particle and aggregate that predictability is limited and that physics cannot come to an end. This leads to a view of the world as flux. Identifiable objects demanding explanation can only be temporary entities emerging from flux and explanation can only (...) be local and historical. This precludes explanation of totality and leads us to reject Leibniz’s question. Baldwin’s argument from possible worlds theory that a null world is possible is examined and questioned. Koon’s combination of the kalam argument with the grim reaper paradox is not queried but a way is found of circumventing it. It is noted in passing that the argument does not have the anti-theistic implications which may appear. (shrink)

(1973). Walter Charleton's early life 1620–1659, and relationship to natural philosophy in mid-seventeenth century England. Annals of Science: Vol. 30, No. 3, pp. 311-340.

This article examines Moltmann’s analysis of intensional transitive verbs , and argues that the analysis fails because the key notion it employs, ‘variable satisfier’, is inconsistent.

"This title was first published in 2003.Developments in genetic science are opening up new possibilities for human beings; both the creation and the shaping of human life are now possible in the laboratory. As these techniques develop, questions are increasingly asked about how far everything that is scientifically possible should - morally, legally and socially - be pursued. Whilst much attention and policy-making has focussed on the development of regulation of technologies affecting human reproduction, regulation where plants and animals are (...) concerned is much more limited. In this book, developments in genetics are addressed in the broad sense by an international range of contributors. This includes not only issues such as eugenics and the modification of the human embryo, but also the genetic modification of plants and animals in the pursuit of commerce, agriculture and biomedical research. This book is published in association with the Society for Applied Philosophy"--Provided by publisher. (shrink)

Face transplantation—or, more properly, facial allograft transplantation —generates much public interest and academic debate. In this paper, we suggest that it is up to opponents of FAT to make the case for its impermissibility. We allow that there is a number of apparently strong arguments that might be deployed against FAT. However, all but one of these turn out not to be compelling after examination. The remaining argument is not so easily dismissed—but its central point is fairly workaday and certainly (...) does not tell us anything about FAT in particular. Therefore, qua argument about facial transplant surgery, it fails to hit its target. Overall, we conclude that a compelling case against FAT remains to be made. (shrink)

A distinction is made in formal semantics between "stage-level predicates," predicates that describe the general state of a noun, and "individual-level predicates," predicates that specify the specific properties of a noun. Fernald investigates various contexts in which this distinction is traditionally said to come into play. His aim is to show that the effects displayed are not uniform, and that the differences between the analyses proposed in the literature arise from the authors considering different subsets of data that they take (...) to exemplyify the "core" meaning of the stage/individual distinction. Fernald presents alternatives and extensions that shed light on the limitations of previous theories, as well as making original observations about important aspects of the topic, including coercion, and perceptual reports vs. other phenomena. (shrink)