Intercellular communication (IC) is mediated by gap junctions (GJs) and hemichannels, which consist of proteins. This has been particularly well documented for the connexin (Cx) family. Initially, Cxs were thought to be the only proteins capable of GJ formation in vertebrates. About 10 years ago, however, a new GJ‐forming protein family related to invertebrate innexins (Inxs) was discovered in vertebrates, and named the pannexin (Panx) family. Panxs, which are structurally similar to Cxs, but evolutionarily distinct, have been shown to be (...) co‐expressed with Cxs in vertebrates. Both protein families show distinct properties and have their own particular function. Identification of the mechanisms that control Panx channel gating is a major challenge for future work. In this review, we focus on the specific properties and role of Panxs in normal and pathological conditions. (shrink)

This is a volume of philosophical studies, centred on problems of personal identity and extending to related topics in the philosophy of mind and moral philosophy.

A survey of democratic institutions and republics reveals the aristocratic origins of democracy.

A discussion of egoism and altruism as related both to ethical theory and moral psychology. Williams considers and rejects various arguments for and against the existence of egoistic motives and the rationality of someone motivated by self-interest. He ultimately attempts to give a more Humean defense of altruism, as opposed to the more Kantian defenses found in Thomas Nagel, for example.

Can we make progress exploring consciousness? Or is it forever beyond human reach? In science we never know the ultimate outcome of the journey. We can only take whatever steps our current knowledge affords. This paper explores today's evidence from the viewpoint of Global Workspace theory. First, we ask what kind of evidence has the most direct bearing on the question. The answer given here is ‘contrastive analysis’ -- a set of paired comparisons between similar conscious and unconscious processes. This (...) body of evidence is already quite large, and constrains any possible theory . Because it involves both conscious and unconscious events, it deals directly with our own subjective experience, as anyone can tell by trying the demonstrations in this article. (shrink)

No detailed description available for "Natural and Conventional Meaning".

Autistic-spectrum conditions and psychotic-spectrum conditions (mainly schizophrenia, bipolar disorder, and major depression) represent two major suites of disorders of human cognition, affect, and behavior that involve altered development and function of the social brain. We describe evidence that a large set of phenotypic traits exhibit diametrically opposite phenotypes in autistic-spectrum versus psychotic-spectrum conditions, with a focus on schizophrenia. This suite of traits is inter-correlated, in that autism involves a general pattern of constrained overgrowth, whereas schizophrenia involves undergrowth. These disorders also (...) exhibit diametric patterns for traits related to social brain development, including aspects of gaze, agency, social cognition, local versus global processing, language, and behavior. Social cognition is thus underdeveloped in autistic-spectrum conditions and hyper-developed on the psychotic spectrum.;>We propose and evaluate a novel hypothesis that may help to explain these diametric phenotypes: that the development of these two sets of conditions is mediated in part by alterations of genomic imprinting. Evidence regarding the genetic, physiological, neurological, and psychological underpinnings of psychotic-spectrum conditions supports the hypothesis that the etiologies of these conditions involve biases towards increased relative effects from imprinted genes with maternal expression, which engender a general pattern of undergrowth. By contrast, autistic-spectrum conditions appear to involve increased relative bias towards effects of paternally expressed genes, which mediate overgrowth. This hypothesis provides a simple yet comprehensive theory, grounded in evolutionary biology and genetics, for understanding the causes and phenotypes of autistic-spectrum and psychotic-spectrum conditions. (shrink)

When “divided attention” methods were discovered in the 1950s their implications for conscious experience were not widely appreciated. Yet when people process competing streams of sensory input they show both selective processesandclear contrasts between conscious and unconscious events. This paper suggests that the term “attention” may be best applied to theselection and maintenanceof conscious contents and distinguished from consciousness itself. This is consistent with common usage. The operational criteria for selective attention, defined in this way, are entirely different from those (...) used to assess consciousness. To illustrate the scientific usefulness of the distinction it is applied to Posner's brain model of visual attention. It seems that features that are often attributed to attention—like limited capacity—may more accurately be viewed as properties of consciousness. (shrink)

In the last decade, careful studies of the living brain have opened the way for human consciousness to return to the heights it held before the behavioristic coup of 1913. This is illustrated by seven cases: the discovery of widespread brain activation during conscious perception; high levels of regional brain metabolism in the resting state of consciousness, dropping drastically in unconscious states; the brain correlates of inner speech; visual imagery; fringe consciousness; executive functions of the self; and volition. Other papers (...) in this issue expand on many of these points. . In the past, evidence based on subjective reports was often neglected . It is still true that brain evidence has greater credibility than subjective reports, no matter how reliable. What is new is increasing convergence between subjective experiences and brain observations. For that reason it is no longer rare to see the word 'consciousness' and 'subjectivity' in major science journals. No one so far has discovered a gulf dividing mind and brain. On the contrary, the new evidence supports the central role of consciousness as it was regarded over more than two millenia of written thought. In a sense this was predictable. Nature is full of unexpected convergences -- between fruit fly genes and the human body, between the arc of a tennis ball and the orbit of Mars, and between consciousness and the brain. These convergences show once again the remarkable unity of the observable universe. (shrink)

According to orthodox views of philosophical methodology, when philosophers appeal to intuitions, they treat them as evidence for their contents. Call this “descriptive evidentialism.” Descriptive evidentialism is assumed both by those who defend the epistemic status of intuitions and by those, including many experimental philosophers, who criticize it. This article shows, however, that the idea that philosophers treat intuitions as evidence struggles to account for the way philosophers treat intuitions in a variety of philosophical contexts. In particular, it cannot account (...) for philosophers' treatment of a priori intuitions, for nonpropositional uses of intuition, and for philosophers' failure to use intuition to exclude the counterintuitive. The article concludes that alternatives to descriptive evidentialism (some of which are sketched) must be developed, and that much of the recent debate between traditionalists and skeptics from, for example, experimental philosophy is probably based on a false presupposition. (shrink)

This study investigated the relations of cheating on an exam and using a false excuse to avoid taking an exam as scheduled to various forms of minor deviance. College students completed measures of cheating, false excuse making, and minor deviance. A factor analysis identified clusters of deviance behaviors. Cheaters scored higher than noncheaters on measures of unreliability and risky driving behaviors, and false excuse makers scored higher than other students on measures of substance use, risky driving, illegal behaviors, and personal (...) unreliability. In addition, men scored higher than women on substance abuse and illegal behaviors factors. Results are interpreted in terms of personological theories of honesty and reliability. (shrink)

_Explores Schelling’s Essay on Human Freedom, focusing on the themes of freedom, evil, and love, and the relationship between his ideas and those of Plato and Kant._.

Collingwood’s account of re-enactment is often misunderstood as providing methodological guidance to historians. Williams’s chapter is perceptive in seeing through this erroneous interpretation. Williams is however very critical of Collingwood’s account of the relationship between philosophy and history. He reads Collingwood’s account of absolute presuppositions as embracing a form of ‘radical historicism’ and argues that, like many other philosophers who reject foundationalism, Collingwood tends to use the word ‘we’ in an evasive way, both in an inclusive sense “as implying universalistic (...) preconditions on interpretation and intelligibility” and in a contrastive sense “under which ‘we’ here and now are distinct from others elsewhere and elsewhen, who lived in others and different intelligible human formations”. William’s chapter appropriately introduces this volume since the question concerning the nature of absolute presuppositions, and in what sense they can be said to be constitutive of the forms of inquiry which they make possible, is a central concern of this collection and is discussed by several contributors. (shrink)

In his recent address to the Aristotelian Society, Aurel Kolnai suggests that games exhibit what he calls a “genuine paradoxy.” I do not believe that he has shown this to be the case, even on the most permissive interpretation of what it means to be a paradox. Kolnai has, however, called attention to an aspect of games which invites further investigation, and I should like to advance the following considerations not so much as a criticism of Kolnai as an attempt (...) to take the investigation along a path which Kolnai has indicated, but which he has not himself, in my opinion, followed. It is not that Kolnai does not say many interesting, indeed penetrating, things about games, for he does. That Kolnai's inquiry is an important contribution to the philosophy of games is not in question. What is questionable is whether paradox has very much to do with that contribution. (shrink)

Reveals comedy's contributions to the philosophical enterprise.

The scholastic philosopher is interested in definition for a different reason than the lexicographer and linguist. The philosopher is trying to learn things. Fe defines, after investigating reality, in an attempt to describe reality clearly and to sum up some aspect of his understanding of reality. Hence, we find our scholastic philosophers adopting as a main feature of their method this insistence on defining, on precise and detailed explanation of their definitions, and on proving that their definitions da correctly express (...) what a nature or activity is. A dictionary of the language of scholastic philosophy fitted to the needs of beginners and of undergraduate students of the subject is not available in English. (shrink)