Background: Although convolutional neural networks (CNNs) achieve high diagnostic accuracy for detecting Alzheimer’s disease (AD) dementia based on magnetic resonance imaging (MRI) scans, they are not yet applied in clinical routine. One important reason for this is a lack of model comprehensibility. Recently developed visualization methods for deriving CNN relevance maps may help to fill this gap as they allow the visualization of key input image features that drive the decision of the model. We investigated whether models with higher accuracy (...) also rely more on discriminative brain regions predefined by prior knowledge. Methods: We trained a CNN for the detection of AD in N = 663 T1-weighted MRI scans of patients with dementia and amnestic mild cognitive impairment (MCI) and verified the accuracy of the models via cross-validation and in three independent samples including in total N = 1655 cases. We evaluated the association of relevance scores and hippocampus volume to validate the clinical utility of this approach. To improve model comprehensibility, we implemented an interactive visualization of 3D CNN relevance maps, thereby allowing intuitive model inspection. Results: Across the three independent datasets, group separation showed high accuracy for AD dementia versus controls (AUC ≥ 0.91) and moderate accuracy for amnestic MCI versus controls (AUC ≈ 0.74). Relevance maps indicated that hippocampal atrophy was considered the most informative factor for AD detection, with additional contributions from atrophy in other cortical and subcortical regions. Relevance scores within the hippocampus were highly correlated with hippocampal volumes (Pearson’s r ≈ −0.86, p < 0.001). Conclusion: The relevance maps highlighted atrophy in regions that we had hypothesized a priori. This strengthens the comprehensibility of the CNN models, which were trained in a purely data-driven manner based on the scans and diagnosis labels. The high hippocampus relevance scores as well as the high performance achieved in independent samples support the validity of the CNN models in the detection of AD-related MRI abnormalities. The presented data-driven and hypothesis-free CNN modeling approach might provide a useful tool to automatically derive discriminative features for complex diagnostic tasks where clear clinical criteria are still missing, for instance for the differential diagnosis between various types of dementia. (shrink)

Background Physician-assisted suicide (PAS) and voluntary euthanasia remain highly debated topics in society, drawing attention due to their ethical, legal, and emotional complexities. Within this debate, the loss of a loved one through suicide may shape the attitudes of survivors, resulting in more or less favorable attitudes towards this topic. Aims This study aims to explore and compare the attitudes towards PAS and voluntary euthanasia in a population of suicide loss survivors and the general population, while also considering socio-demographic factors. (...) Methods A total of 529 participants, 168 of whom were survivors of suicide loss, completed an online questionnaire on their attitudes (NOBAS) and opinions (open response format) towards PAS and voluntary euthanasia, as well as regarding their legalization in Germany. The analysis consisted of both quantitative and qualitative components. Results The entire sample showed positive attitudes towards PAS and voluntary euthanasia in terminally ill persons. Participants were more divided in their attitudes towards PAS in the case of a mental health disorder. Individuals without experienced suicide loss were more liberal regarding legalization in Germany and were more likely to understand the wish for PAS. Survivors of suicide loss were mainly concerned about the consequences for relatives. However, differences between both groups are small. Discussion The experience of a loss by suicide influences attitudes towards PAS and voluntary euthanasia. Both groups showed an accepting attitude towards PAS and voluntary euthanasia, but also expressed concerns and fears regarding easy accessibility and consequences for grieving relatives. (shrink)

This volume addresses the interdependencies between visual technologies and epistemology with regard to our perception of the medical body. It explores the relationships between the imagination, the body, and concrete forms of visual representations: Ranging from the Renaissance paradigm of anatomy, to Foucault's "birth of the clinic" and the institutionalised construction of a "medical gaze"; from "visual" archives of madness, psychiatric art collections, the politicisation and economisation of the body, to the post-human in mass media representations. Contributions to this volume (...) investigate medical bodies as historical, technological, and political constructs, constituted where knowledge formation and visual cultures intersect. Contributors are: Axel Fliethmann, Michael Hau, Birgit Lang, Carolyn Lau, Heikki Lempa, Stefanie Lenk, Joanna Madloch, Barry Murnane, Jill Redner, Claudia Stein, Elizabeth Stephens, Corinna Wagner, and Christiane Weller. (shrink)

In this article we present a new experimental paradigm: comparative visual search. Each half of a display contains simple geometrical objects of three different colors and forms. The two display halves are identical except for one object mismatched in either color or form. The subject's task is to find this mismatch. We illustrate the potential of this paradigm for investigating the underlying complex processes of perception and cognition by means of an eye‐tracking study. Three possible search strategies are outlined, discussed, (...) and reexamined on the basis of experimental results. Each strategy is characterized by the way it partitions the field of objects into “chunks.” These strategies are: (i) Stimulus‐wise scanning with minimization of total scan path length (a “traveling salesman” strategy), (ii) scanning of the objects in fixed‐size areas (a “searchlight” strategy), and (iii) scanning of object sets based on variably sized clusters defined by object density and heterogeneity (a “clustering” strategy). To elucidate the processes underlying comparative visual search, we introduce besides object density a new entropy‐based measure for object heterogeneity. The effects of local density and entropy on several basic and derived eye‐movement variables clearly rule out the traveling salesman strategy, but are most compatible with the clustering strategy. (shrink)

Frege believes (1) that his definition of number is (partly) arbitrary; (2) that it "makes" numbers of certain extensions; (3) that without such a definition we cannot even think or understand arithmetical propositions. this position is part of a view according to which mathematics in general involves the free construction of objects, their properties, and the very contents of mathematical propositions. frege tries to avoid excess subjectivism by the kantian device of treating alternative systems of arithmetic (e.g.) as different appearances (...) of a single realm of unstructured truths. (shrink)

Suppose that several individuals who have separately assessed prior probability distributions over a set of possible states of the world wish to pool their individual distributions into a single group distribution, while taking into account jointly perceived new evidence. They have the option of first updating their individual priors and then pooling the resulting posteriors or first pooling their priors and then updating the resulting group prior. If the pooling method that they employ is such that they arrive at the (...) same final distribution in both cases, the method is said to be externally Bayesian, a property first studied by Madansky . We show that a pooling method for discrete distributions is externally Bayesian if and only if it commutes with Jeffrey conditioning, parameterized in terms of certain ratios of new to old odds, as in Wagner , rather than in terms of the posterior probabilities of members of the disjoint family of events on which such conditioning originates. (shrink)

Taking his critique of totalitarianizing conceptions of community as a starting point, this text examines Jean-Luc Nancy's work of an ‘ontology of plural singular being’ for its political implications. It argues that while at first this ontology seems to advocate a negative or an anti-politics only, it can also be read as a ‘theory of communicative praxis’ that suggests a certain ethos – in the form of a certain use of symbols (which is expressed only inaptly by the word ‘style’) (...) that would render the ontological plurality of singulars perceptible and practically effective. Finally, some recent texts by Nancy even sidestep the ontology of being-with and face the question of what politics, faced with demands of justice, could be and what a democratic politics could provide. Both of these aspects in Nancy's work, however, still remain to be spelled out more politically. (shrink)

A meta-analysis and an experiment show that the degree of compression of the in-depth dimension of visual space relative to the frontal dimension increases quickly as a function of the distance between the stimulus and the observer at first, but the rate of change slows beyond 7 m from the observer, reaching an apparent asymptote of about 50 %. In addition, the compression of visual space is greater for monocular and reduced cue conditions. The pattern of compression of the in-depth (...) dimension as a function of distance is similar to the ratio of in-depth to frontal visual angles of stimuli, but is not as extreme as this ratio would suggest, implying that observers are incapable of fully ignoring size information provided by cues to depth. Size and distance judgments may be described by an Affine transformation of physical space; however, the compression parameter in this model changes as a function of distance from the observer and other experimental conditions. (shrink)

Handeln, Personsein, Menschenwürde und zahlreiche Fragen der Angewandten Ethik – das ist das weite Spektrum dieser Festschrift und auch des Denkens von Ralf Stoecker, dem sie gewidmet ist. Ganz in seinem Geiste laden die Beiträge des Bandes dazu ein, zusammen zu denken und zusammenzudenken, was – möglicherweise – zusammengehört.

In philosophy, the criteria for personhood (PH) at a specific point in time (synchronic), and the necessary and sufficient conditions of personal identity (PI) over time (diachronic) are traditionally separated. Hence, the transition between both timescales of a person's life remains largely unclear. Personal habits reflect a decision-making (DM) process that binds together synchronic and diachronic timescales. Despite the fact that the actualization of habits takes place synchronically, they presuppose, for the possibility of their generation, time in a diachronic sense. (...) The acquisition of habits therefore rests upon PI over time; that is, the temporal extension of personal decisions is the necessary condition for the possible development of habits. Conceptually, habits can thus be seen as a bridge between synchronic and diachronic timescales of a person's life. In order to investigate the empirical mediation of this temporal linkage, we draw upon the neuronal mechanisms underlying DM; in particular on the distinction between internally and externally guided DM. Externally guided DM relies on external criteria at a specific point in time (synchronic); on a neural level, this has been associated with lateral frontal and parietal brain regions. In contrast, internally guided DM is based on the person's own preferences that involve a more longitudinal and thus diachronic timescale, which has been associated with the brain's intrinsic activity. Habits can be considered to reflect a balance between internally and externally guided DM, which implicates a particular temporal balance between diachronic and synchronic elements, thus linking two different timescales. Based on such evidence, we suggest a habit-based neurophilosophical approach of PH and PI by focusing on the empirically-based linkage between the synchronic and diachronic elements of habits. By doing so, we propose to link together what philosophically has been described and analyzed separately as PH and PI. (shrink)

Although children learn more when teachers gesture, it is not clear how gesture supports learning. Here, we sought to investigate the nature of the memory processes that underlie the observed benefits of gesture on lasting learning. We hypothesized that instruction with gesture might create memory representations that are particularly resistant to interference. We investigated this possibility in a classroom study with 402 second‐ and third‐grade children. Participants received classroom‐level instruction in mathematical equivalence using videos with or without accompanying gesture. After (...) instruction, children solved problems that were either visually similar to the problems that were taught, and consistent with an operational interpretation of the equal sign (interference), or visually distinct from equivalence problems and without an equal sign (control) in order to assess the role of gesture in resisting interference after learning. Gesture facilitated learning, but the effects of gesture and interference varied depending on type of problem being solved and the strategies that children used to solve problems prior to instruction. Some children benefitted from gesture, while others did not. These findings have implications for understanding the mechanisms underlying the beneficial effect of gesture on mathematical learning, revealing that gesture does not work via a general mechanism like enhancing attention or engagement that would apply to children with all forms of prior knowledge. (shrink)

A pesquisa procura não só conceituar e expor a estética de Hegel, mas também elucidar seu pensamento referente à questão. Em suas palavras, estética seria o belo artístico, criado pelo homem. Nesse sentido, a ascendência da arte está na precisão que o homem tem de objetivar seu espírito, morfosiando o mundo e também se transformando. Assim, nas páginas que se seguem há uma exposição do conceito vulgar de estética em contraponto a visão hegeliana, para tanto, o filósofo cita a ascensão (...) e declínio do conceito de arte e estética buscando contextualizá-la enquanto função na história do homem. (shrink)

El presente trabajo busca exponer las premisas y la fundamentación teológica que subyace a la moral de Pedro Abelardo, con el fin de mostrar cómo en el sistema filosófico de dicho autor, conocido por su racionalismo, hay una justificación que extralimita dicho sistema. Para ello, se expondrá la terminología clave de su moral, la aplicación práctica de dichos conceptos, y una serie de objeciones tanto teológicas como filosóficas.

We show that if p is a real type which is almost internal in a formula φ in a simple theory, then there is a type p' interalgebraic with a finite tuple of realizations of p, which is generated over φ. Moreover, the group of elementary permutations of p' over all realizations of φ is type-definable.

A decision problem in which the values of the decision variables must sum to a fixed positive real number s is called an "allocation problem," and the problem of aggregating the allocations of n experts the "allocation aggregation problem." Under two simple axiomatic restrictions on aggregation, the only acceptable allocation aggregation method is based on weighted arithmetic averaging (Lehrer and Wagner, Rational Consensus in Science and Society, 1981). In this note it is demonstrated that when the values assigned to (...) the variables are restricted to a finite set (as is always the case in practice), the aforementioned axioms allow only dictatorial aggregation. (shrink)

This book examines the many ethical issues that are encountered in the Pediatric Intensive Care Unit. It supports pediatricians, nurses, residents, and other providers in their daily management of critically ill children with the dilemmas that arise. It begins by examining the evolution of pediatric critical care, and who is now impacted by this advancing medical technology. Subsequent chapters explore specific ethical concerns and controversies that are commonly encountered. These topics include how to conduct end-of-life discussions with families facing a (...) myriad of challenging choices. It goes on to explore the concept of futility, and what that does and does not mean in the pediatric ICU setting. Controversial subjects such as children as organ donors, particularly using donation after cardiac death, in addition to issues surrounding the declaration of brain death are covered. Additional chapters address resource allocation, and also analyze the use of long-term technology in chronically critically ill children. Chapters include case examples with guidance on how to work through similar difficulties and decision-making. While this book is specifically targeted for care providers at the ICU bedside, it is also of benefit to medical students, students in bioethics, practicing ethical consultants and families who are dealing with critically ill children. (shrink)

"One might say that where Religion becomes artificial, it is reserved for Art to save the spirit of religion." With these words Richard Wagner began "Religion and Art" (1880), one of his most passionate essays. That passion made Wagner himself a central icon in the growing cult of art. Wagner felt that he lived in an age of spiritual crisis. "It can but rouse our apprehension, to see the progress of the art-of-war departing from the springs of (...) moral force, and turning more and more to the mechanical," he wrote. In response to the frightening progress of dynamite and steel, Wagner adopted the role of the Tone Poet Seer, who reveals the inexpressible in concert halls and cleanses souls in waves of symhonic revelation. "Religion and Art" is the pivot of the works collected here. Also included are his defining essays "Public and Popularity" and "The Public in Time and Space"; his papers relating to the creation of the Bayreuth School; his complaint against publishers, "On Poetry and Composition" (1879); his article on the first production of Parsifal (1882); and other works that speak his mind about strengthening the spirit through music. These works participated in the duel between Wagner and Nietzsche that ensued after the breakup of their friendship in 1878. Nietzsche publicly called Wagner an incurable romantic, emphasizing how sick he thought both Wagner and his art were. Here Wagner counterattacks with arch innuendo and sarcasm. This edition includes the complete volume 6 of the 1897 translation of Wagner's works commissioned by the London Wagner Society. William Ashton Ellis is one of the most important translators of nineteenth-century musicology. In addition to his monumental translation of Wagner's prose works, he translated Wagner's correspondence with Franz Lizst, Mathilde Wesendonck, and Wagner's own family. Ellis died in 1919. (shrink)

Abraham Newman has written a thoughtful and provocative book about the protection of privacy and how it has evolved in two dramatically different ways in the European Union and the United States over the past 50 years.

Aristotle's Rhetoric presents a number of problems for interpreters. It contains criticisms of sophists, yet seems to teach sophistical techniques of persuasion. It is unclear to some readers whether the book is an elaboration of a rational discourse or not. And its diversity of material has led some to view it as a collection of texts rather than as a unified book. In his commentary Arnhart argues that Aristotle's Rhetoric is a coherent account of public speech as a kind of (...) rational discourse less rigorous than scientific demonstration but more rational than sophistry. (shrink)

Elaborating on the substantial parallels between Molina’s and Kant’s attempts to reconcile human freedom with divine foreknowledge and natural causal determinism respectively, my aim is to establish a proper historical connection as well. Leibniz is shown to be the crucial mediator in two respects: (i) Kant knew Molina’s account of divine knowledge in general in its Leibnizian version through Baumgarten’s Metaphysica. In this work, scientia media plays no role in the explication as to how God knows absolute future contingents. (ii) (...) In the Critique of Practical Reason Kant resorted to doctrines similar to Molina’s in his criticism of Leibniz’s alternative explication which drew on complete concepts of monads. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

In his new book, Rossi emphasizes the prominent role of enlightened religion in the political project of establishing perpetual peace. My paper discusses Rossi’s stance on the question as to whether Kant, in his later years, moved to an immanentist conception of the highest good. Kant’s own position in this regard can arguably be better described as comprehensive, according to which an immanent and a transcendent conception of the highest good are upheld as realizable side by side. Rossi’s account looks (...) perfectly consistent with such a view. One of the reasons for such a comprehensive reading is that “immanent” and “secular” do not coincide in Kant in the first place. Seen in this comprehensive way, and while a version of the highest good ought to be realized immanently, we cannot be certain that this will indeed happen. If it does indeed happen, the immortality postulate, which Kant never abandoned, renders it rational to believe that the immanent version of the highest good is merely a step towards its transcendent realization. Affinities of Rossi’s approach to the suggestion that Kant subscribes to a political theology based on what has been called “Molinism minimally defined” will also be explored. (shrink)