BackgroundThere is increasing need for peer reviewers as the scientific literature grows. Formal education in biostatistics and research methodology during residency training is lacking. In this pilot study, we addressed these issues by evaluating a novel method of teaching residents about biostatistics and research methodology using peer review of standardized manuscripts. We hypothesized that mentored peer review would improve resident knowledge and perception of these concepts more than non-mentored peer review, while improving review quality.MethodsA partially blinded, randomized, controlled multi-center study (...) was performed. Seventy-eight neurology residents from nine US neurology programs were randomized to receive mentoring from a local faculty member or not. Within a year, residents reviewed a baseline manuscript and four subsequent manuscripts, all with introduced errors designed to teach fundamental review concepts. In the mentored group, mentors discussed completed reviews with residents. Primary outcome measure was change in knowledge score between pre- and post-tests, measuring epidemiology and biostatistics knowledge. Secondary outcome measures included level of confidence in the use and interpretation of statistical concepts before and after intervention, and RQI score for baseline and final manuscripts.ResultsSixty-four residents (82%) completed initial review with gradual decline in completion on subsequent reviews. Change in primary outcome, the difference between pre- and post-test knowledge scores, did not differ between mentored (−8.5%) and non-mentored (−13.9%) residents (p = 0.48). Significant differences in secondary outcomes (using 5-point Likert scale, 5 = strongly agree) included mentored residents reporting enhanced understanding of research methodology (3.69 vs 2.61; p = 0.001), understanding of manuscripts (3.73 vs 2.87; p = 0.006), and application of study results to clinical practice (3.65 vs 2.78; p = 0.005) compared to non-mentored residents. There was no difference between groups in level of interest in peer review (3.00 vs 3.09; p = 0.72) or the quality of manuscript review assessed by the Review Quality Instrument (RQI) (3.25 vs 3.06; p = 0.50).ConclusionsWe used mentored peer review of standardized manuscripts to teach biostatistics and research methodology and introduce the peer review process to residents. Though knowledge level did not change, mentored residents had enhanced perception in their abilities to understand research methodology and manuscripts and apply study results to clinical practice. (shrink)

A hypnotic induction produces different patterns of spontaneous experiences across individuals. The magnitude and characteristics of these responses covary moderately with hypnotic suggestibility, but also differ within levels of hypnotic suggestibility. This study sought to identify discrete phenomenological profiles in response to a hypnotic induction and assess whether experiential variability among highly suggestible individuals matches the phenomenological profiles predicted by dissociative typological models of high hypnotic suggestibility. Phenomenological state scores indexed in reference to a resting epoch during hypnosis were submitted (...) to a latent profile analysis. The profiles in the derived four-class solution differed in multiple experiential dimensions and hypnotic suggestibility. Highly suggestible individuals were distributed across two classes that exhibited response patterns suggesting an inward attention subtype and a dissociative subtype. These results provide support for dissociative typological models of high hypnotic suggestibility and indicate that highly suggestible individuals do not display a uniform response to a hypnotic induction. (shrink)

Researchers have long suspected that grapheme-color synaesthesia is useful, but research on its utility has so far focused primarily on episodic memory and perceptual discrimination. Here we ask whether it can be harnessed during rule-based Category learning. Participants learned through trial and error to classify grapheme pairs that were organized into categories on the basis of their associated synaesthetic colors. The performance of synaesthetes was similar to non-synaesthetes viewing graphemes that were physically colored in the same way. Specifically, synaesthetes learned (...) to categorize stimuli effectively, they were able to transfer this learning to novel stimuli, and they falsely recognized grapheme-pair foils, all like non-synaesthetes viewing colored graphemes. These findings demonstrate that synaesthesia can be exploited when learning the kind of material taught in many classroom settings. (shrink)

Globally, chronic disease and conditions such as diabetes, cardiovascular disease, depression and cancer are the leading causes of morbidity and mortality. Why, then, are public health efforts and programs aimed at preventing chronic disease so difficult to implement and maintain? Also, why is primary care—the key medical specialty for helping persons with chronic disease manage their illnesses—in decline? Public health suffers from its often being socially controversial, personally intrusive, irritating to many powerful corporate interests, and structurally designed to be largely (...) invisible and, as a result, taken for granted. Primary care struggles from low reimbursements, relative to specialists, excessive paperwork and time demands that are unattractive to medical students. Our paper concludes with a discussion of why the need for more aggressive public health and redesigned primary care is great, will grow substantially in the near future, and yet will continue to struggle with funding and public popularity. (shrink)

Sudden infant death syndrome (SIDS) has been mainly described from a risk perspective, with a focus on endogenous, exogenous, and temporal risk factors that can interact to facilitate lethal outcomes. Here we discuss the limitations that this risk-based paradigm may have, using two of the major risk factors for SIDS, prone sleep position and bed-sharing, as examples. Based on a multipronged theoretical model encompassing evolutionary theory, developmental biology, and cultural mismatch theory, we conceptualize the vulnerability to SIDS as an imbalance (...) between current physiologic-regulatory demands and current protective abilities on the part of the infant. From this understanding, SIDS appears as a developmental condition in which competencies relevant to self-protection fail to develop appropriately in the future victims. Since all of the protective resources in question are bound to emerge during normal infant development, we contend that SIDS may reflect an evolutionary mismatch situation—a constellation in which certain modern developmental influences may overextend the child’s adaptive (evolutionary) repertoire. We thus argue that SIDS may be better understood if the focus on risk factors is complemented by a deeper appreciation of the protective resources that human infants acquire during their normal development. We extensively analyze this evolutionary-developmental theory against the body of epidemiological and experimental evidence in SIDS research and thereby also address the as-of-yet unresolved question of why breastfeeding may be protective against SIDS. (shrink)

Michael Smith attempts to solve the moral problem by arguing that our moral beliefs constitute a rational constraint on our desires. In particular, Smith defends the ‘practicality requirement’, which says that rational agents who believe that an action is right must have some desire to perform that action. We clarify and examine Smith’s argument. We argue that, for the argument to be sound, it must make two crucial assumptions about the rational agent in question: that facts about her desires are (...) transparent to her, and that she believes that she is rational. We conclude that if Smith has solved the moral problem then he has done so only for a restricted class of subjects—those who satisfy these two assumptions. (shrink)

In both law and ethics, precedent shapes the deliberation of novel issues. Despite the interconnection between new and old decisions, few research ethics boards have an explicit mechanism for archiving issue-based research ethics decisions to inform future decisions. With the intent of promoting expediency, consistency, and accountability in REB decision-making, Sunnybrook Health Sciences Centre implemented a “decision bank”: a formal mechanism for systematically capturing institutional REB decisions. We describe the development of the decision bank, its implementation, and the lessons we (...) have learned from both. The decision bank, which is categorized by general issue themes such as consent, study design, and privacy, is still in the early implementation phase, but it provides a much-needed method to address the paucity of formal mechanisms and literature in a biomedical field otherwise inundated with evidence-based information. (shrink)

The vegetation eaten by animals on large areas of several continents is deficient in phosphate and deleterious effects on physiology, particularly reproduction, ensue. Records on bone chewing behaviour by both pastoral andwild game animals extend over two centuries. In laboratory investigation of this apt behaviour it has been shown that the appetite for bones is innate and specific and cued predominantly by olfactory stimuli. It is suppressed by rapidly increasing the plasma phosphate concentration to normal but not influenced by increasing (...) the phosphate concentration in cerebrospinal fluid. The central organization of this genetically programmed behaviour appears to differ from systems subserving thirst and sodium appetite. (shrink)

We make two suggestions with regard to Depue & Collins's target article. First, regarding the functioning of MOC13, we provide data indicating that, contrary to D&C's apparent position, this structure is not necessary for instrumental conditioning. Second, we suggest that D&C's approach would be advanced by reference to formal computational theory, in particular the work of Grossberg. We suggest that an integration of Grossberg 's and D&C's models can provide a more complete account of extraversion.

Change is one of experience's most evident data. The man who has finished reading is different from the same man before he started; the book he has read was once a tree. But if the fact is clear, it hides a very profound problem. Examining change, we see from experience that things do not come to be out of nothing; other things turn into them. The principle of sufficient reason confirms this, since a pure negation can never be a sufficient (...) reason for anything. But if this is true, then neither can the negation of an attribute provide a sufficient reason for its emergence in an already existing thing; this would be tantamount to saying that the attribute came from nothing. Nor, if the thing really changes, can we say simply that an external agent "pours in" some of its perfection, since then it would not change, but only receive a metaphysical coat of paint. And so, we seem to have forced ourselves into a dilemma: things must be what they are, and yet they must themselves be in some sense what they are not. If we deny the first part there is nothing to change; if the second, change is unintelligible, and hence impossible. (shrink)

We conducted a case study on how unreliable and/or unrepresentative stimuli in psycholinguistics research may impact the generalizability of experimental findings. Using the domain of lexical ambiguity as a foil, we analyzed 2033 unique words (6481 tokens) from 214 studies. Specifically, we examined how often studies agreed on the ambiguity types assigned to a word (i.e., homonymy, polysemy, and monosemy), and how well the words represented the populations underlying each ambiguity type. We observed far from perfect agreement in terms of (...) how words are assigned to ambiguity types. We also observed that coverage of the populations is relatively poor and biased, leading to the use of a narrower set of words and associated properties. This raises concerns about the degree to which prior theoretical claims have strong empirical support, and offers targeted directions to improve research practices that are relevant to a broad set of domains. (shrink)

Regular polysemes are sets of ambiguous words that all share the same relationship between their meanings, such as CHICKEN and LOBSTER both referring to an animal or its meat. To probe how a context embedding model, here exemplified by BERT, represents regular polysemy, we analyzed whether its embeddings support answering sense analogy questions similar to “is the mapping be- tween CHICKEN (as an animal) and CHICKEN (as a meat) the same as that which maps between LOBSTER (as an animal) to (...) LOBSTER (as a meat)?” We found that (1) the model was sensitive to the shared structure within a regularity type; (2) the shared structure varies across regularity types, potentially reflective of a “regularity continuum;” (3) some high-order latent structure may be shared across regularity types, suggestive of a similar la- tent structure across types; and (4) there is equivocal ev- idence that the aforementioned effects are explained by meaning overlap. (shrink)

In his commentary on our article on phenomenological subtypes of highly suggestible individuals , Kumar argues that methodological differences between our studies and previous research on highly suggestible subtypes temper our ability to link the two and that it is unclear whether the existence of phenomenological subtypes has implications for hypnotherapy. Although we agree that it is premature to make conclusive statements about highly suggestible subtypes, we argue that convergent findings across studies with different methodologies are especially salient because they (...) are unlikely to result from a common set of methodological artifacts. In addition, we describe a number of implications that research on phenomenological subtypes has for hypnotherapy. (shrink)

El artículo apunta a desarrollar una reflexión sobre el tema de las memorias del conflicto político armado y/o de la guerra, que podría contribuir a potenciar políticamente los esfuerzos y las iniciativas de muchas organizaciones de víctimas en el país. En las propuestas que viene haciendo la geopolítica crítica en el marco de discusiones del pensamiento social contemporáneo, específicamente en lo referente a la importancia del espacio en los procesos sociales y políticos —lo que, de paso, cuestiona la concepción estadocéntrica (...) del poder—, se le confiere una enorme fuerza política a otros espacios y lugares, más cercanos a los sujetos que, como las víctimas, habitan lugares y espacios más micro y cotidianos. (shrink)

J. Anthony Blair is a prominent international figure in argumentation studies. He is among the originators of informal logic, an author of textbooks on the informal logic approach to argument analysis and evaluation and on critical thinking, and a founder and editor of the journal Informal Logic. Blair is widely recognized among the leaders in the field for contributing formative ideas to the argumentation literature of the last few decades. This selection of key works provides insights into the (...) history of the field of argumentation theory and various related disciplines. It illuminates the central debates and presents core ideas in four main areas: Critical Thinking, Informal Logic, Argument Theory and Logic, Dialectic and Rhetoric. (shrink)

Various social animal species have been noted to inhibit aggressive attacks when a conspecific displays submission cues. Blair (1993) has suggested that humans possess a functionally similar mechanism which mediates the suppression of aggression in the context of distress cues. He has suggested that this mechanism is a prerequisite for the development of the moral/conventional distinction; the consistently observed distinction in subject's judgments between moral and conventional transgressions. Psychopaths may lack this violence inhibitor. A causal model is developed showing (...) how the lack of this mechanism would explain the core behavioural symptoms associated with the psychopathic disorder. A prediction of such a causal model would be that psychopaths should fail to make the moral/conventional distinction. This prediction was confirmed. The implication of this finding for other theories of morality is discussed. (shrink)

Psychopaths continue to be demonised by the media and estimates suggest that a disturbing percentage of the population has psychopathic tendencies. This timely and controversial new book summarises what we already know about psychopathy and antisocial behavior and puts forward a new case for its cause - with far-reaching implications. Presents the scientific facts of psychopathy and antisocial behavior. Addresses key questions, such as: What is psychopathy? Are there psychopaths amongst us? What is wrong with psychopaths? Is psychopathy due to (...) nature or nurture? And can we treat psychopaths? Reveals the authors' ground-breaking research into whether an underlying abnormality in brain development leaves psychopaths with an inability to feel emotion or fear. The resulting theory could lead to early diagnosis and revolutionize the way society, the media and the state both views and contends with the psychopaths in our midst. (shrink)

Empathy is a lay term that is becoming increasingly viewed as a unitary function within the field of cognitive neuroscience. In this paper, a selective review of the empathy literature is provided. It is argued from this literature that empathy is not a unitary system but rather a loose collection of partially dissociable neurocognitive systems. In particular, three main divisions can be made: cognitive empathy , motor empathy, and emotional empathy. The two main psychiatric disorders associated with empathic dysfunction are (...) considered: autism and psychopathy. It is argued that individuals with autism show difficulties with cognitive and motor empathy but less clear difficulties with respect to emotional empathy. In contrast, individuals with psychopathy show clear difficulties with a specific form of emotional empathy but no indications of impairment with cognitive and motor empathy. (shrink)

Table of Contents: Illustrations Acknowledgments Conventions Introduction 3 Ch. 1 Kinds of Natural Philosophy 14 Ch. 2 Methods of Bookishness 49 Ch. 3 Modes of Argument 82 Ch. 4 Bodin’s Philosophy of Nature 116 Ch. 5 Theatrical Metaphors 153 Ch. 6 The Reception of the Theatrum 180 Epilogue: The Legacies of the Theatrum 225 Notes 233 Bibliography 331 Index 369.