ResumoVersa-se sobre o agenciamento de criadores de pensamento realizado por Deleuze como elemento fundamental de sua filosofia. Coloca-se em foco o processo de minoração da tragédia Ricardo III, de Shakespeare, realizado por Bene via a composição de uma nova peça. Intenta-se evidenciar o caminho percorrido por Bene à luz da perspectiva deleuziana. Para tanto, apresenta-se a importância de se agenciar pensamentos entre a filosofia e outras áreas do conhecimento; realiza-se uma breve análise do núcleo dramático da tragédia shakespeariana; e estuda-se (...) o Ricardo III de Bene e o ensaio de Deleuze, Um manifesto de menos. Como resultado, salienta-se que o processo de agenciamento se trata de um potente método de criação de conceitos.Palavras-chave: Impersonagens. Linhas de variação. Devir minoritário. AbstractIt deals with the agency of thought creators carried out by Deleuze as a fundamental element of his philosophy. The process of lessening Shakespeare's tragedy Ricardo III, carried out by Bene through the composition of a new play, is brought into focus. The aim is to highlight the path taken by Bene in the light of the Deleuzian perspective. To this end, the importance of agencing thoughts between philosophy and other fields of knowledge is presented; a brief analysis of the dramatic core of the Shakespearean tragedy is carried out; and we study Ricardo III, by Bene, and the essay by Deleuze, Um manifesto de menos. As a result, it is emphasized that the agency process is a powerful method of creating concepts.Keywords: Impersonagens. Variation lines. Becoming a minority. (shrink)

Nell'estate del 1886 Nietzche cura a proprie spese, da Sils-Maria, in Engadina, la pubblicazione di Al di là del bene e del male. Tra le recensioni che più entusiasmarono il filosofo tedesco vi fu quella di Joseph Widmann, pubblicata su 'Der Bund' di Berna, il quale paragonò il libro a quei carri che, inalberando bandiera nera come segno di pericolo, trasportavano la dinamite attraverso le quiete valli svizzere passando per il tunnel del San Gottardo. Nietzsche comincia la sua guerra, dopo (...) una guerriglia condotta a colpi di aforismi, contro tutti i pregiudizi morali e filosofici, contro l'illusionismo magico di parole e concetti. Un attacco che diventa più organico e sistematico, e che con la stessa intensità poetica segue il dionisiaco abbraccio alla vita selvaggia dell Zarathustra. (shrink)

Human beings have physical and psychological limits, but also ethical, which are precisely what make their actions human. These ethical limits enable any debate and investigation, in particular, with human beings. Therefore, any investigation would be unfeasi- ble without those limits. We talk about ethical limits, not in the sense of impediment but in the sense of possibility for action; you can only speak of ethical limits if you af rm a truth that is valid for everyone and for all (...) times, regardless of oneself. We are witnessing a true progress as long as a research is carried out for the bene t of human beings. That’s right; you can only speak of progress if it is understood in a growth in humanity. (shrink)

Il prelievo della Biblioteca Palatina fu, nel 1623, ad un secolo circa dall'inizio della Riforma, l'atto non solo simbolico con cui si cercò di vulnerare alla radice la cultura protestante asportando la Biblioteca di Heidelberg, vanto dell'intellettualità riformata e stimata superiore perfino alla Vaticana. In una lettera del 14 luglio 1608 a Janus Gruter, bibliotecario della Palatina, Scaligero era molto esplicito nella comparazione tra le due biblioteche, simbolo delle rispettive confessioni: «Indicem bibliothecae vestrae legi. Locupletior est, et meliorum librorum quam (...) Vaticana» (Lib. VI, Ep. 434). La concreta operazione di prelievo e trasporto dei libri fino a Roma, via Monaco, affidata a Leone Allacci, andò incontro ad una serie di difficoltà, a cominciare dalla imprevista totale indisponibilità di mezzi di trasporto: i «carri» di cui ampiamente si parla nel documento che qui di seguito pubblichiamo. Che fosse così arduo reperirli, ovvero trovare qualcuno che li mettesse a disposizione, era in realtà solo un aspetto - e certo non irrilevante - della più generale ostilità che circondò l'operazione. Ostilità che Allacci stesso bene avverte («Quando passo [per le strade] - scrive - li sento sospirare e dolere intrinsecamente, se bene all'esteriore bisogna che stiano savij»), e che sarà sedata solo dal deciso intervento del conte di Tilly (su di lui ved. oltre), intervenuto direttamente a Heidelberg il 14 gennaio 1623, al fine appunto di sbloccare la situazione. Ma veniamo al documento ed alla sua esemplare vicenda. (shrink)

HOME . ABOUT US . CONTACT US HELP . PUBLISH WITH US . LIBRARIANS Search in or Explore Browse Publications A-Z Browse Subjects A-Z Advanced Search University of Cambridge SIGN IN Register | Why Register? | Sign Out | Got a Voucher? prev abstract next Two Approaches to Reading the Historical Descartes A Devout Catholic? Knowledge of The Mental Thought and Language Descartes as A Natural Philosopher Substance Dualism Notes Two Approaches to Reading the Historical Descartes Author: Desmond M. Clarke (...) DOI: 10.1080/09608780902986680 Publication Frequency: 5 issues per year Published in: British Journal for the History of Philosophy, Volume 17, Issue 3 June 2009 , pages 601 - 616 John Cottingham: Cartesian Reflections: Essays on Descartes's Philosophy (Oxford: Oxford University Press, 2008) 40.00 (hb.). ISBN 978-0-19-922697-9 John Cottingham, in a new collection of essays, asks the question: 'what exactly did Descartes himself chiefly take himself to be doing?' (254). 1 While the question is relatively clear, and while it acknowledges implicitly that Descartes was probably doing a range of different things, the answer that is apparently proposed here emerges only on reading the whole collection. Cottingham distinguishes in Chapter 1 - which is a new, synoptic overview of what is discussed in the other chapters, all of which were previously published - between two approaches to reading Descartes. One is to see him as 'a dummy on which to drape various suspect doctrines (such as “Cartesian dualism”)' (3), which contemporary analytic philosophers have shown to be radically mistaken. Another approach is adopted by historians of ideas 'who make it their life's work to pay meticulous scholarly attention to the philosophical works of past ages' (3). Cottingham does not explicitly criticize either of these approaches, but he hints at situating his own as some kind of Aristotelian middle course between the two. Since the two reference points are dangerously close to straw men or what Cottingham calls 'extreme positions', the proposed middle way may simply combine elements of two approaches, each of which is entirely legitimate. I return to this question at the conclusion. In fact, many of these essays were intended to show (rightly!) that Descartes never held the philosophical positions that are often attributed to him. The interpretation of Karol Wojtyla, later Pope John Paul II, provides a good example of how mistaken one can be: The Cogito ergo sum radically changed the way of doing philosophy … After Descartes, philosophy became a science of pure thought: all that is being- the created world, and even the Creator, is situated within the ambit of the Cogito, as contents of human consciousness. Philosophy is concerned with beings as contained in consciousness, and not as existing independently of it. (257) The only way to address such a caricature is to refer back to what Descartes actually wrote. Cottingham does precisely that, often quoting the original Latin or French texts. However, having shown successfully, by a close reading of the texts, that Descartes did not hold many of the views that are attributed to him, it still remains to say what Descartes did hold or teach about various philosophical problems that retain their perennial interest for us. This is how the question arises, intermittently, about what Descartes thought he was 'chiefly' doing, or what was his primary objective, in the course of an intellectual career that spanned three decades. However, the apparently legitimate desire to bring Descartes' intellectual endeavours into sharp focus may be frustrated by the evidence. His life and work manifestly lack the coherence or unity of purpose that one finds, for example, among many of his French or Dutch contemporaries. It is comparatively easy to 'read' the life of Gisbertus Voetius as that of an unwavering Calvinist theologian, to see Antoine Arnauld as a staunch and consistent theological defender of Port Royal, and even to interpret the obviously fragmentary contents of Pascal's unpublished notebooks (subsequently, the Penses) as an extended search for authentic religious faith, in opposition to what he perceived as the corruption of ecclesial structures. In contrast, Descartes' life reveals features that are difficult to integrate into a coherent pattern. He lived and published during a critical juncture in the Scientific Revolution of the seventeenth century. Although baptized into the Catholic Church soon after his birth in the Loire district of France, he chose to live most of his life in the aggressively Calvinist United Provinces, in which other religious practices were officially (though often ineffectively) banned. Descartes may have adopted the motto from Ovid, at least early in his career: 'bene vixit qui bene latuit' (he lives well who conceals himself well), and he seems genuinely to have wished to avoid theological controversies. However, he engaged in very public controversies with so many of his contemporaries - including Hobbes, Gassendi, the French Jesuits (collectively) and Father Dinet (in particular), Voetius and the University of Utrecht, Regius, Fermat, Roberval, Revius and other theologians at Leiden - that one might conclude that his claimed preference for a quiet life was a disingenuous mask. 2 Descartes published four books during his lifetime, and wrote at least one other that he had intended to publish. The latter was his first major composition, Le Monde, which he suppressed when he heard about Galileo's condemnation by Rome in 1633. This was followed, in 1637, by Descartes' first book (also written in French), which he tried to publish anonymously by withholding his name from the title page: the Discours de la methode pour bien conduire sa raison, & chercher la verit dans les sciences. Plus la dioptrique, les meteors, et la geometrie, qui sont des essais de cete methode. Four years later Descartes published the first edition (in Latin) of Meditationes de prima philosophia, in quibus Dei existentia et animae immortalitas demonstrator, which also included six sets of objections and replies. The Principia philosophiae appeared (in Latin) in Amsterdam in 1644, and was followed five years later by Les Passions de l'Ame (in French). 3 In parallel with these publications, Descartes carried on a very extensive correspondence over a thirty-year period (in both Latin and French), and preserved copies or drafts of his letters with a view to future publication. Given the range and variety of his interests, and the sheer volume of writings, published or otherwise, that have survived from his pen, one may be tempted to engage in a comparative evaluation, as Cottingham does, by selecting one of Descartes' books as his primary contribution to philosophy. Cottingham claims that the Meditations was Descartes''masterpiece' (44), 'the definitive statement of Descartes's philosophy' (45) and the 'definitive statement of his metaphysics' (68). He also describes the Meditations more narrowly as 'his metaphysical masterpiece' (259, 303) and, more broadly, as 'his philosophical masterpiece' (289), and he lists it with the Discours as one of Descartes' two 'masterworks' (280). The Principia offers some competition in this comparative judgement when it is described as 'the canonical presentation of his metaphysical views' (114), while 'the construction of a moral system … was the crowning aim of his philosophy' (231). Having pitched repeatedly for the Meditations as Descartes' primary text, Cottingham claims that its author was 'a devout Catholic' (215), that he was 'a devoutly religious philosopher' (256), and that he could not free himself 'from the influence of the long years of theological study he had dutifully completed at La Flche' (62). Accordingly, the Meditations should be read as 'in essence a work of theodicy' (220); 'what has pride of place in the construction of his philosophical system is … an appeal to God … the nature and existence of the Deity is something that lies at the very heart of his entire philosophical system' (255). Without quite saying so, there are hints here that Descartes was a devout Christian whose primary intellectual contribution was to write a work of metaphysics, in which God is central and in the course of which the author alternates between proving God's existence and contemplating God - the latter a seventeenth-century version of Bonaventure's Journey of the Soul to God. 'Descartes's attraction to a contemplative mode of philosophizing' (305) is reflected, in the Meditations, in 'the language of the soul's coming to rest in adoring contemplation of the light' (306). Cottingham also accepts the overwhelming evidence from Descartes' correspondence that he 'devoted most of his career not to metaphysics but to science' (108), although he quibbles elsewhere with those who adopt the shorthand term 'science' to describe part of what was called 'natural philosophy' in the seventeenth century (282). He also refers to the '(notoriously lame) argument for the essential incorporeality of the thinking self' in one of Descartes' masterworks (60), and he describes the 'strange, seemingly isolated world of his metaphysical meditations' (139), with its 'creaking ontology' (147), when read in isolation from the rest of his work as a natural philosopher. How should we read him, then, in the twenty-first century? A Devout Catholic? That Descartes was a devout Catholic is possible, unlikely and undecidable. He seems not to have studied theology at all while at school at La Flche, although he completed the pre-theology college cycle in the company of Jesuit students who then continued their studies in theology. Descartes consistently attempted to avoid public entanglement with religious and theological controversies, and said so frequently. 4 Given the alignments that prevailed at the time, both in France. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Horatius: The Man and the HourKenneth J. ReckfordTrimalchio’s projected monumentum in Petronius’ Satyricon will include, among other ill-assorted designs, a sundial: horologium in medio, ut quisquis horas inspiciet, velit nolit, nomen meum legat (71). Horace too, I argue, connects his name with the passing hours: more subtly and modestly than Trimalchio, but also more significantly, in a recurrent play of sounds and words.That Roman poets and orators exploited puns (...) on names, especially cognomina, is well known; but although scholars have noted scattered name-puns in Horace’s poetry (some of which will be mentioned here), the important play on Horatius/hora has been ignored, and any argument seeking to restore it to general consciousness must rely on probabilities: somewhat subjective ones, to be sure, yet which carry a certain cumulative conviction. I begin by discussing Satires 2.6, where Horace is most clearly involved in the horae, and then proceed through a wide range of hora references, most notably in Odes 4.6. A code on Vergilius/ver will provide a friendly parallel. I hope in all this to suggest that Horace plays on his own redende Name not just for occasional fun, but as a way of asserting, and sometimes exploring, his personal identity beneath the shifting personae of his life and craft.Hora Quota Est? (Satires 2.6.44)The question hora quota est? is given as an example of small talk, safely “entrusted” to Horace’s “leaky ear”:septimus octavo propior iam fugerit annus ex quo Maecenas me coepit habere suorum in numero, dumtaxat ad hoc, quem tollere raeda vellet iter faciens et cui concredere nugas hoc genus, “hora quota est? Thraex est Gallina Syro par? matutina parum cautos iam frigora mordent”: et quae rimosa bene deponuntur in aure. per totum hoc tempus subiectior in diem et horam invidiae noster....(40–48) [End Page 583]As if he were giving a public interview, Horace carefully and humorously delimits his relationship with Maecenas. He is an occasional, amusing companion, not a privileged insider. In Satires 1.6 he had distinguished his personal and social acceptance within Maecenas’ circle, where true merit is honored, from those political ambitions from which—in the blind, prejudiced world of Roman politics—a freedman’s son must normally be barred. In Satires 2.6 he goes further. He is not (he alleges) really intimate with Maecenas, certainly not to the point of sharing inside information about, e.g., the Dacian threat or plans to resettle veterans in Southern Italy or Sicily. He is nothing like the confidential friend described by Ennius, “with whom he [the great man] often and gladly shares his table, his conversation, and the giving and taking of advice about his affairs” (rerumque suarum consilium) and “to whom he would speak out confidently” (audacter) about great things or small, good things or bad, all “vomited forth” carelessly, yet “safely deposited” (evomeret... tutoque locaret), and “with whom [he would share] many pleasures.” 1We may suspect that Horace played the role of just such a confidential friend to Maecenas, and played it well. 2 We may also suspect that while he regaled that first audience of insiders with the comic narrative of his daily frustrations in Rome, he was also reassuring Maecenas—to everyone’s amusement, as with the earlier “Journey to Brundisium”—that he did not have, precisely, a leaky ear. One resulting and more than simply dramatic irony is that today’s reader must identify with those importunate street people who were teased, baffled, and insulted by Horace’s silence. I want, however, to argue here for a second irony involving the offhand question hora quota est? which may mean a good deal more to Horace, Maecenas, and ourselves than first appears [End Page 584] on the surface—much as Falstaff’s opening question to the Prince, “Now, Hal, what time of day is it, lad?” proves fatally relevant to the affairs of Hal and Hotspur, Falstaff and the King, in Henry IV, Part 1. 3“What time is it?” The Romans did not wear watches. Their sense of time, even with sundials, was very inexact by modern standards. Because they had hours (roughly... (shrink)

We study the process of observation (measurement), within the framework of a “perspectival” (“relational,” “relative state”) version of the modal interpretation of quantum mechanics. We show that if we assume certain features of discreteness and determinism in the operation of the measuring device (which could be a part of the observer's nerve system), this gives rise to classical characteristics of the observed properties, in the first place to spatial localization. We investigate to what extent semi-classical behavior of the object system (...) itself (as opposed to the observational system) is needed for the emergence of classicality. Decoherence is an essential element in the mechanism of observation that we assume, but it turns out that in our approach no environment-induced decoherence on the level of the object system is required for the emergence of classical properties. (shrink)

O termo sujeito na filosofia aristotélico-tomista era empregado no sentido de fundamento, substrato, referindo-se a qualquer substância. Com a Idade Moderna surge Descartes que desencadeará uma verdadeira revoluçáo na concepçáo filosófica de sujeito: o homem passa a ser o fundamento primeiro de toda a realidade, sujeito único, inaugurando-se a filosofia da subjetividade. O sujeito cartesiano primeiro é o ego do cogito ( penso ), em que o homem é concebido apenas como espírito, substância pensante . Entretanto, o caminhar meditativo de (...) Descartes aponta para novos desdobramentos de sua concepçáo de homem e conseqüentemente do sujeito, permitindo-nos falar de uma subjetividade corporal. Por outro lado, a realidade das paixões nos leva também a considerar a existência de um sujeito resultante da uniáo alma-corpo. (shrink)

A tension between cosmopolitanism and nationalism characterizes the career of the poetckert. The German orientalist and mentor to Paul de Lagarde translated remarkable quantities of Sanskrit, Farsi, and Arabic verse, while earning popular acclaim for his Biedermeier celebrations of the German Heimat. The contradiction in these scholarly pursuits can be reconciled by examining the intersection of the local, national, and global in Rckert expected to transform German into a universal language of spiritual reconciliation, thereby transcending Babel and distinguishing the German (...) nation as a chosen people. This article investigates the process of cultural translation through which Rworld poetry” intelligible to a German audience, arguing that cosmopolitanism underlay a German claim to cultural dominance in post-Napoleonic Europe. (shrink)

This second volume of Ordo V , in the Amsterdam edition of the Latin texts of Erasmus, comprises theological treatises presenting the first half of Erasmus’ commentaries on eleven Psalms. The commentaries explain the Psalms, offering the priests and parishioners material for their preaching.

Review of Aleš Havlíček and Filip Karfík , Plato’s Parmenides. Proceedings of the Fourth Symposium Platonicum Pragense, OIKOYMENH, Prague, 2005.

Carrie Figdor presents a critical assessment of how psychological terms are used to describe the non-human biological world. She argues against the anthropocentric attitude which takes human cognition as the standard against which non-human capacities are measured, and offers an alternative basis for naturalistic explanation of the mind.

Divergindo em pontos fundamentais do pensamento filosófico medieval, Descartes, na construção de sua filosofia do homem, terá em pensadores renascentistas sua principal fonte de inspiração, estabelecendo com estes pensadores uma continuidade de idéias, uma comunhão de pensamentos. Não obstante as divergências, mostraremos neste texto como Descartes irá buscar na Escolástica fórmulas e conceitos para melhor expor sua antropologia.

Contemporary political discourse is marked with the language of democracy, and Western countries in particular seek to promote democracy at home and abroad. However, there is a sublimated conflict in general political discourse between a desire to rely on alleged political experts and a desire to assert the supposed common sense of all men. Can the struggle between the democratic and aristocratic values embodied in this conflict be reconciled? The question is perennial, and raises issues that are central to constitutional (...) design. Aristotle, developing in significant ways insights made by his teacher Plato, grapples with it in his Politics. Aristotle's views on these matters are relevant—by way of the American Founders'—to contemporary American politics and modern democracies generally. During the eighteenth century, the Founders, some of whom explicitly reached back to Aristotle's work, also struggled—especially in The Federalist Papers—with these thorny issues of constitutional design. They created the U.S. Constitution in part to address these very same problems and issues. We are living in some ways, then, in the shadow of Aristotle's political theorizing, albeit as transposed by the American Founders. Both Aristotle and some of the American Founders theoretically favor aristocracy over democracy, but concede that in practice a blend of the two has to be integrated into the fundamental structure of political society. We need to reconnect with these important political discussions in order to come to terms with aristocratic and democratic values in our current circumstances. Footnotesa I am grateful to Fred Miller and David Keyt for many helpful suggestions and thoughtful questions throughout the editing process. I would also like to thank Irfan Khawaja for valuable feedback on an earlier version of this essay. (shrink)

The paper deals with the Sartrean concept of lived experience which constitutes a bridge between phenomenology and Marxism, psychology and ontology, individual and society, as well as between philosophy and literary criticism. The notion of lived experience is rooted in psychology, at the same time being embedded in literary criticism and phenomenology. It is interlinked with the notions of facticity, contingency, singularity, intersubjectivity, and body in the Being and Nothingness, and became the theoretical base of Sartre’s essays on Baudelaire, Genet, (...) and especially of that on Flaubert. This lived experience is closely related to the Sartrean phenomenological concept of nature which consists in the non-reflexive conscience of our own presence-at-theworld, including corporeality. (shrink)

Controversies around large-scale development projects offer many cases and insights which may be analyzed through the lenses of corporate social (_ir_)responsibility (CS_I_R) and business ethics studies. In this paper, we confront the CSR narratives and strategies of _WeBuild_ (formerly known as _Salini Impregilo_), an Italian transnational construction company. Starting from the Global Atlas of Environmental Justice (EJAtlas), we collect evidence from NGOs, environmental justice organizations, journalists, scholars, and community leaders on socio-environmental injustices and controversies surrounding 38 large hydropower schemes built (...) by the corporation throughout the last century. As a counter-reporting exercise, we code (un)sustainability discourses from a plurality of sources, looking at their discrepancy under the critical lenses of post-normal science and political ecology, with environmental justice as a normative framework. Our results show how the mismatch of narratives can be interpreted by considering the voluntary, self-reporting, non-binding nature of CSR accounting performed by a corporation wishing to grow in a global competitive market. Contributing to critical perspectives on political CS(I)R, we question the reliability of current CSR mechanisms and instruments, calling for the inclusion of complexity dimensions in and a re-politicization of CS(I)R accounting and ethics. We argue that the fields of post-normal science and political ecology can contribute to these goals. (shrink)

Choreographies of the Living explores the shift from viewing art as an exclusively human undertaking to recognizing it as an activity that all living creatures enact. Carrie Rohman's bioaesthetic framework describes how art-making binds us to other animals in literature, visual art, dance, and performance.

Carrie Jenkins presents a new account of arithmetical knowledge, which manages to respect three key intuitions: a priorism, mind-independence realism, and empiricism. Jenkins argues that arithmetic can be known through the examination of empirically grounded concepts, non-accidentally accurate representations of the mind-independent world.

This book unpicks the conceptual, ideological, and metaphysical tangles that get in the way of understanding romantic love. -/- Written for a general audience, What Love Is And What It Could Be explores different disciplinary perspectives on love, in search of the bigger picture. It presents a "dual-nature" theory: romantic love is simultaneously both a biological phenomenon and a social construct. The key philosophical insight comes in explaining why this a coherent—and indeed a necessary—position to take. -/- The deep motivation (...) behind this work is that we have a collective responsibility to figure out romantic love. It is a formidable and potentially dangerous force, its power underwritten by its twin footholds in our biological natures and in our most treasured social practices. Often we pretend that it is incomprehensible and out of control, but this is a way of abdicating our responsibility to understand love and fix it when it's broken. -/- What Love Is And What It Could Be explains that romantic love is currently broken in multiple interlocking ways, but also that we can change this status quo. Once we understand what love is, we will be able to take control of what it could be. (shrink)

This essay revisits a debate about literary fiction’s ability to depict the consequences of climate change. Philosopher McKenzie Wark’s 2017 essay, ‘On the Obsolescence of the Bourgeois Novel in the Anthropocene’, offers one of many critiques of climate fiction, such as Amitav Ghosh’s influential book, The Great Derangement. But while Ghosh sees a shortcoming in contemporary novels in their lack of representation of major climate events, Wark emphasises the importance of collective action, conversation, and connection, beyond the limits of literature. (...) Since Wark’s intervention, the global School Strike for Climate in 2019 and 2020 brought more participatory post-literary forms to represent climate change. Jean- Luc Nancy’s theory of participation, that there is no mimesis without participation (methexis), sees a tense relation between the two rather than an opposition or conflict. I argue that Wark, by not undervaluing participation, disrupts a hierarchy that privileges the imitator at the expense of the imitation. To explore this relation, I consider how the slogan ‘there is no Planet B’ forms a snapshot of our twenty- first-century mimetic condition, from which no imitative representation will save us. Can Wark expand the vision of another relational kind of femininity in her later writing to support the demand to take part in transformational action against climate catastrophe, beyond mimetic representation carried in the form of the novel? (shrink)

Vascular development entails multiple cell‐fate decisions to specify a diverse array of vascular structures. Notch proteins are signaling receptors that regulate cell‐fate determination in a variety of cell types. The finding that Notch genes are robustly expressed in the vasculature suggests roles for Notch in guiding endothelial and associated mural cells through the myriad of cell‐fate decisions needed to form the vasculature. In fact, mice with defects in genes encoding Notch, Notch ligands, and components of the Notch signaling cascade invariably (...) display vascular defects. Human Notch genes are linked to Alagille's Syndrome, a developmental disorder with vascular defects, and CADASIL, a cerebral arteriopathy. Studies in zebrafish, mice and humans indicate that Notch works in conjunction with other angiogenic pathways to pattern and stabilize the vasculature. Here, we will focus on established functions for Notch in vascular remodeling and arterial/venous specification and more speculative roles in vascular homeostasis and organ‐specific angiogenesis. BioEssays 26:225–234, 2004. © 2004 Wiley Periodicals, Inc. (shrink)