Protein disulfide isomerase (PDI) is one of the most abundant and critical protein folding catalysts in the endoplasmic reticulum of eukaryotic cells. PDI consists of four thioredoxin domains and interacts with a wide range of substrate and partner proteins due to its intrinsic conformational flexibility. PDI plays multifunctional roles in a variety of pathophysiological events, both as an oxidoreductase and a molecular chaperone. Recent studies have revealed that the conformation and activity of PDI can be regulated in multiple ways, including (...) posttranslational modification and substrate/ligand binding. Here, we summarize recent advances in understanding the function and regulation of PDI in different pathological and physiological events. We propose that the multifunctional roles of PDI are regulated by multiple mechanisms. Furthermore, we discuss future directions for the study of PDI, emphasizing how different regulatory modes are linked to the conformational changes and biological functions of PDI in the context of diverse pathophysiologies. (shrink)

Until recently epistemology in the Western sense was never a central issue in Chinese philosophy. Contemporary Chinese neo?Confucian philosophers, however, realize that in order to reconstruct some of the important traditional philosophical insights and make them meaningful in the present time, certain methodological and epistemological considerations are indispensable. The present paper undertakes to examine some of these efforts. Since most neo?Confucian philosophers today have been influenced by Hsiung Shih?li, in one way or another, his epistemological theory is presented first. (...) Then the further development of a neo?Confucian epistemological system in Mou Tsung?san's thought is discussed. Hsiung Shih?li has made an important distinction between what he calls the hsing?ehih and the liang?chih. The former may be translated as the original wisdom and is what we rely upon to grasp ontological reality; the latter may be translated as the measuring wisdom and includes both our commonsensical and scientific ways of understanding which postulate a real, external world. A dialectical relation holds between the two. Mou Tsung?san further develops a comprehensive epistemological system which confirms the basic insights of Hsiung Shih?li. He has attempted a synthesis of the philosophical insights which he learns from Kant in the West and the Confucian tradition in China. (shrink)

According to the revision theory of truth, the binary sequences generated by the paradoxical sentences in revision sequence are always unstable. In this paper, we work backwards, trying to reconstruct the paradoxical sentences from some of their binary sequences. We give a general procedure of constructing paradoxes with specific binary sequences through some typical examples. Particularly, we construct what Herzberger called “unstable statements with unpredictably complicated variations in truth value.” Besides, we also construct those paradoxes with infinitely many finite primary (...) periods but without any infinite primary period, those with an infinite critical point but without any finite primary period, and so on. This is the first formal appearance of these paradoxes. Our construction demonstrates that the binary sequences generated by a paradoxical sentence are something like genes from which we can even rebuild the original sentence itself. (shrink)

This paper gives a definition of self-reference on the basis of the dependence relation given by Leitgeb (2005), and the dependence digraph by Beringer & Schindler (2015). Unlike the usual discussion about self-reference of paradoxes centering around Yablo's paradox and its variants, I focus on the paradoxes of finitary characteristic, which are given again by use of Leitgeb's dependence relation. They are called 'locally finite paradoxes', satisfying that any sentence in these paradoxes can depend on finitely many sentences. I prove (...) that all locally finite paradoxes are self-referential in the sense that there is a directed cycle in their dependence digraphs. This paper also studies the 'circularity dependence' of paradoxes, which was introduced by Hsiung (2014). I prove that the locally finite paradoxes have circularity dependence in the sense that they are paradoxical only in the digraph containing a proper cycle. The proofs of the two results are based directly on König's infinity lemma. In contrast, this paper also shows that Yablo's paradox and its nested variant are non-self-referential, and neither McGee's paradox nor the omega-cycle liar paradox has circularity dependence. (shrink)

The unwinding that Cook, 767–774 2004) proposed is a simple but powerful method of generating new paradoxes from known ones. This paper extends Cook’s unwinding to a larger class of paradoxes and studies further the basic properties of the unwinding. The unwinding we study is a procedure, by which when inputting a Boolean modal net together with a definable digraph, we get a set of sentences in which we have a ‘counterpart’ for each sentence of the Boolean modal net and (...) each point of the digraph. What is more, whenever a sentence of the Boolean modal net says another sentence is necessary, then the counterpart of the first sentence at a point correspondingly says the counterparts of the second one at all accessible points of that point are all true. The output of the procedure is called ‘the unwinding of a Boolean modal net on a definable digraph’. We prove that the unwinding procedure preserves paradoxicality: a Boolean modal net is paradoxical on a definable digraph, iff the unwinding of it on this digraph is also paradoxical. Besides, the dependence digraph for the unwinding of a Boolean modal net on a definable digraph is proved to be isomorphic to the unwinding of the dependence digraph for the Boolean modal net on the previous definable digraph. So the unwinding of a Boolean modal net on a digraph is self-referential, iff the Boolean modal net is self-referential and the digraph is cyclic. Thus, on the one hand, the unwinding of any Boolean modal net on an acyclic digraph is non-self-referential. In particular, the unwinding of any Boolean modal net on \ is non-self-referential. On the other hand, if a Boolean modal net is paradoxical on a locally finite digraph, the unwinding of it on that digraph must be self-referential. Hence, starting from a Boolean modal paradox, the unwinding can output a non-self-referential paradox only if the digraph is not locally finite. (shrink)

Tarski's theorem essentially says that the Liar paradox is paradoxical in the minimal reflexive frame. We generalise this result to the Liar-like paradox $\lambda^\alpha$ for all ordinal $\alpha\geq 1$. The main result is that for any positive integer $n = 2^i(2j+1)$, the paradox $\lambda^n$ is paradoxical in a frame iff this frame contains at least a cycle the depth of which is not divisible by $2^{i+1}$; and for any ordinal $\alpha \geq \omega$, the paradox $\lambda^\alpha$ is paradoxical in a frame (...) iff this frame contains at least an infinite walk which has an arbitrarily large depth. We thus get that $\lambda^n$ has a degree of paradoxicality no more than $\lambda^m$ iff the multiplicity of 2 in the (unique) prime factorisation of $n$ is no more than that in the prime factorisation of $m$; and all tranfinite $\lambda^\alpha$ has the same degree of paradoxcality but has a higher degree of paradoxicality than any $\lambda^n$. (shrink)

This paper aims to explore the relationship between the necessity predicate and the truth predicate by comparing two possible-world interpretations. The first interpretation, proposed by Halbach et al. (J Philos Log 32(2):179–223, 2003), is for the necessity predicate, and the second, proposed by Hsiung (Stud Log 91(2):239–271, 2009), is for the truth predicate. To achieve this goal, we examine the connections and differences between paradoxical sentences that involve either the necessity predicate or the truth predicate. A primary connection is (...) established through two translations that change only one of the predicates to the other while keeping everything else unchanged. We prove that in bijective frames, a set of sentences that contains one of the two semantic predicates has the same paradoxicality as the corresponding set of sentences that contains the other predicate obtained through translation. However, there are substantial differences as well. First, the necessity predicate and the truth predicate, under the two interpretations, cannot be defined by each other. Moreover, for sentences that involve only the truth predicate, their paradoxicality is preserved under the homomorphisms of frames. For sentences containing the necessity predicate, their paradoxicality is preserved under bounded morphisms, but none of these sentences can have their paradoxicality preserved under the extension of frames. Finally, we also show that paradoxical sentences involving the necessity predicate and those involving the truth predicate differ significantly in terms of mirror symmetry, circularity dependence, and frame compactness. (shrink)

This article sets out to undertake a thorough, point-by-point examination of the theory postulated by Campbell (2007), in which an attempt is made to specify the conditions under which corporations may or may not act in socially responsible ways. In order to ensure the overall reliability of our study, and to attempt to provide a new understanding of, and greater insights into, whether corporate social responsibility (CSR) is affected by financial and institutional variables, we empirically investigate a total of 520 (...) financial firms in 34 countries, between the years 2003 and 2005. Our empirical findings are: (i) finns with larger size are more CSR minded, and the financial performance and CSR are not related; (ii) finns would actually act in more socially responsible ways to enhance their competitive advantages when the market competitiveness is more intense; (iii) financial firms in countries with stronger levels of legal enforcement tend to engage in more CSR activities; however, interestingly and rather strikingly, those finns in countries with stronger shareholder rights tend to engage in less CSR activities; and (iv) self-regulation within the financial industry has a significantly positive effect on CSR, with firms being found to act in more socially responsible ways in those countries which have more cooperative employer-employee relations, higher quality management schools, and a better macroeconomic environment. (shrink)

A relativized version of Tarski's T-scheme is introduced as a new principle of the truth predicate. Under the relativized T-scheme, the paradoxical objects, such as the Liar sentence and Jourdain's card sequence, are found to have certain relative contradictoriness. That is, they are contradictory only in some frames in the sense that any valuation admissible for them in these frames will lead to a contradiction. It is proved that for any positive integer n, the n-jump liar sentence is contradictory in (...) and only in those frames containing at least an n-jump odd cycle. In particular, the Liar sentence is contradictory in and only in those frames containing at least an odd cycle. The Liar sentence is also proved to be less contradictory than Jourdain's card sequence: the latter must be contradictory in those frames where the former is so, but not vice versa. Generally, the relative contradictoriness is the common characteristic of the paradoxical objects, but different paradoxical objects may have different relative contradictoriness. (shrink)

It is proved that Yablo’s paradox and the Liar paradox are equiparadoxical, in the sense that their paradoxicality is based upon exactly the same circularity condition—for any frame ${\mathcal{K}}$ , the following are equivalent: (1) Yablo’s sequence leads to a paradox in ${\mathcal{K}}$ ; (2) the Liar sentence leads to a paradox in ${\mathcal{K}}$ ; (3) ${\mathcal{K}}$ contains odd cycles. This result does not conflict with Yablo’s claim that his sequence is non-self-referential. Rather, it gives Yablo’s paradox a new significance: (...) his construction contributes a method by which we can eliminate the self-reference of a paradox without changing its circularity condition. (shrink)

According to the revision theory of truth, the paradoxical sentences have certain revision periods in their valuations with respect to the stages of revision sequences. We find that the revision periods play a key role in characterizing the degrees of paradoxicality for Boolean paradoxes. We prove that a Boolean paradox is paradoxical in a digraph, iff this digraph contains a closed walk whose height is not any revision period of this paradox. And for any finitely many numbers greater than 1, (...) if any of them is not divisible by any other, we can construct a Boolean paradox whose primary revision periods are just these numbers. Consequently, the degrees of Boolean paradoxes form an unbounded dense lattice. The area of Boolean paradoxes is proved to be rich in mathematical structures and properties. (shrink)

A quite popular approach to solving the Causal Exclusion Problem is to adopt a counterfactual theory of causation. In this paper, I distinguish three versions of the Causal Exclusion Argument. I argue that the counterfactualist approach can block the first two exclusion arguments, because the Causal Inheritance Principle and the Upward Causation Principle upon which the two arguments are based respectively are problematic from the perspective of the counterfactual account of causation. However, I attempt to show that the counterfactualist approach (...) is unable to refute a sophisticated version (i.e. the third version) of the exclusion argument in that the Downward Causation Principle, a premise of the third exclusion argument, is actually implied by the counterfactual theory of causation. Therefore, even if other theories of causation might help the non-reductive physicalist to solve the exclusion problem, the counterfactual theory of causation cannot. (shrink)

All the known non-self-referential paradoxes share a reference pattern of Yablo’s paradox in that they all necessarily contain infinitely many sentences, each of which refers to infinitely many sentences. This raises a question: Does the reference pattern of Yablo’s paradox underlie all non-self-referential paradoxes, just as the reference pattern of the liar paradox underlies all finite paradoxes? In this regard, Rabern et al. [J Philos Logic 42(5): 727–765, 2013] prove that every dangerous acyclic digraph contains infinitely many points with an (...) infinite out-degree. Building upon their work, this paper extends Rabern et al.’s result to the first-order arithmetic language with a primitive truth predicate, proving that all reference digraphs for non-self-referential paradoxes contain infinitely many sentences of infinite out-degree (called “social sentences”). We then strengthen this result in two respects. First, among these social sentences, infinitely many appear in one ray. Second, among these social sentences, infinitely many have infinitely many out-neighbors, none of which will eventually get to a sink. These observations provide helpful information towards the following conjecture proposed by Beringer and Schindler [Bull. of Symb. Logic 23(4): 442–492, 2017]: every dangerous acyclic digraph contains the Yablo digraph as a finitary minor. (shrink)

Chinese culture is a lively and active organism. If we are to get to the real image of Chinese culture, we should take as a starting point the first passage of the Chung-yung [Doctrine of the Mean], which expounds its basic principles: "That which Heaven has decreed is called Nature, to follow that Nature is called tao [way] and to cultivate the tao is called instruction." This passage uses three phrases and one breath; these three phrases have a unified nature (...) which cannot be separated and which constitute one long sentence. Because of this, the words as a whole lead people to think of a richly vital and great tree which has the will of Heaven as its roots, human nature as its shoots, the tao as its trunk, and cultural instruction as its branches, leaves, and blossoms. As for the fruit, in terms of the individual, it is the achievement of a completely beautiful character, and in terms of the masses of the people, it is the ordering of the country and the pacification of the realm, the progression from the era of peace under the ancient kings to the age of the Grand Unity [ta-t'ung]. (shrink)

Algorithmically driven online dating platforms today promise the ability to sort through relevant data and identify one’s ideal amorous matches effectively. Yet the appeal of technological and scientific solutions to the messy problem of finding partners is hardly new. This introduction to the Focus section “It’s a Match!” argues that the history of amorous matching has long been part and parcel of the history of science, in particular the social sciences. Taking matching as an “applied science of social harmony,” the (...) authors argue that concern over more reliable techniques for determining the suitability of partners has formed an essential part of both the maintenance of social order and the shaping of subjectivities, enabling discourses of informed choice and the rational management of the passions, while also reinforcing and subverting structures of age, gender, race, and sexuality. (shrink)

Using data on shareholder-initiated class action lawsuits in the US, I investigate the corporate scandals of US-listed foreign firms. The shareholders of scandal firms suffer considerable loss in both the short term and the long term. I document that firms domiciled in countries with weak institutions are more likely to be embroiled in corporate scandals, but such a relation can be moderated by the presence of Big 4 auditors. Investors automatically adjust for undiscovered misconduct when valuing the stocks of non-scandal (...) firms. Investors rely on the audit quality to form their expectations about the severity of undiscovered misconduct, and thus impose less negative spillovers on firms with Big 4 auditors, especially when the firms are from countries with weak institutions. Taken together, my results suggest that listing on US exchanges does not fully compensate for weak local institutions; voluntarily bonding to a more stringent audit process has an incremental effect on protecting shareholder interests and enhances the confidence of investors in firms’ financial integrity. (shrink)

The purpose of this study is to extend prior research on this topic by investigating whether the impact of ownership concentration moderates the link between corporate social performance and financial performance. This study uses a set of unique, hand-collected pollution control data to measure CSP, based on a sample of Taiwanese listed companies during the period from 1996 to 2006. The results of the empirical analysis provide firm support for the idea that the divergence between control rights and the cash (...) flow rights of controlling owners negatively moderates the link between social and short- and long-run FP. (shrink)

Many philosophers insist that the most plausible solution to the exclusion problem is to adopt the so-called ‘autonomy approach’, which denies either upward or downward causation between mental and physical properties. But the question of whether the autonomy approach is compatible with respectable theories of causation has seldom been discussed in the literature. This paper considers two influential theories of causation, the counterfactual account and the regularity account. I argue that neither the counterfactual theory nor the regularity theory can support (...) the autonomy approach – while the counterfactual approach fails to block downward causation, the regularity approach is unable to refute upward causation. (shrink)

This paper at first presents Saṃghabhadra's core argument against reflexive self-cognition and extracts a reflective model of cognition from Saṃghabhadra's work. Second, from the perspective of this model, we aim to elaborate on D. M. Armstrong's idea of introspective consciousness and so-called higher-order perception theory of consciousness. We assume that our model of consciousness is reflective, perceptual, causal and fallible, contingently private, and theory-laden. Third, to explore the potential of this reflective model, we try to bring out its implications and (...) defend it against criticisms. Finally, following the Buddhist doctrines of non-self and dependent origination, on... (shrink)

In 2016, Taiwan’s President Tsai Ing-wen officially apologised to the island’s indigenous peoples. This national apology not only plays a persuasive role in informing the general public about the historical wrongdoings inflicted on the Taiwanese aborigines, but also constitutes a therapeutic and restorative role in the process of reconciliation with the indigenous victims. This article provides a critical discourse analysis of President Tsai’s apology. In particular, it examines the power and ideology embedded in both the speech and the related ceremony, (...) and is supplemented with extracts from interviews with a cross-section of key stakeholders, such as a former Constitutional/supreme Court Justice, indigenous/tribal leaders and members/staff/advisers from the Presidential Office Indigenous Historical Justice and Transitional Justice Committee. The analysis reveals that, despite President Tsai’s apology and reconciliation policies, instead of facilitating reconciliation, the apology appears to exacerbate the long-standing latent tension between indigenous and non-indigenous groups. While the apology opens a window for reconciliation, a higher level of commitment is required to promote structural and systemic changes, such as land restitution, before the apology can be deemed adequate. (shrink)

Cook regards Sorenson’s so-called ‘the no-no paradox’ as only a kind of ‘meta-paradox’ or ‘quasi-paradox’ because the symmetry principle that Sorenson imposes on the paradox is meta-theoretic. He rebuilds this paradox at the object-language level by replacing the symmetry principle with some ‘background principles governing the truth predicate’. He thus argues that the no-no paradox is a ‘new type of paradox’ in that its paradoxicality depends on these principles. This paper shows that any theory is inconsistent with the T-schema instances (...) for the no-no sentences, plus the T-schema instance for a Curry sentence associated with the symmetry of the no-no sentences. It turns out that the no-no paradox still depends on the problematic instances of the T-schema in a way that the liar paradox does. What distinguishes the no-no paradox is the T-schema instance for the above Curry sentence, which encodes Sorensen’s symmetry principle at the object-language level. (shrink)

This study investigates the psychological process of how authentic leadership affects employee voice behaviors. The theoretical model of this study proposes that employee positive mood and leader–member exchange (LMX) quality mediate the relationship between authentic leadership and voice behavior, while the procedural justice climate moderates the mediation effects of positive mood and LMX quality. Multi-level data from 70 workgroups of a real estate agent company in Taiwan support all hypotheses. This study reveals the cross-level effects of authentic leadership, and provides (...) practical suggestions to help employees express their opinions in organizations. (shrink)

This article is a lecture note I wrote for my philosophy of mathematics course. Its main task is to explain the main ideas of Gupta's acceptable model proposed in his paper [J. Philos. Logic 11(1), 1–60, 1982]. I aim to provide detailed information on a result established by Gupta. On the one hand, I hope this explanation can be helpful for those who are learning Gupta's acceptable model, and on the other hand, I also hope to provide a guide for (...) beginners to interpret literature. (shrink)

In various theories of truth, people have set forth many definitions to clarify in what sense a set of sentences is paradoxical. But what, exactly, is _a_ paradox per se? It has not yet been realized that there is a gap between ‘being paradoxical’ and ‘being a paradox’. This paper proposes that a paradox is a minimally paradoxical set meeting some closure property. Along this line of thought, we give five tentative definitions based upon the folk notion of paradoxicality implied (...) in Tarski’s undefinability theorem of truth and the dependence relation proposed by Leitgeb (J Philos Log 34(2):155–192, 2005). A definition of ‘being a paradox’ is acceptable if its extension must be sufficiently comprehensive to include all known paradoxes on the one hand, and its standard must also be high enough to exclude those that are evidently not paradoxes on the other hand. It turns out that only the last attempt is acceptable: a set of sentences is a paradox if it is paradoxical and self-dependent, and at the same time, it and any of its paradoxical and self-dependent subsets bisimulate each other. In this way, we articulate in what sense a set of sentences is a paradox, and so establish a connection between the notion of a paradox and the notion of paradoxicality. (shrink)