Definition of the problem Compassionate use is the use of unapproved drugs in groups of patients suffering from a disease that, in the absence of an alternative treatment option, is life-threatening or leads to severe disability. Physicians are not in charge because access to the drug is only granted by pharmaceutical companies, which comes along with many ethical issues. Launched in 2020, the program of Onasemnogenum abeparvovecum against spinal muscular atrophy in children reached a new dimension. The intent of this (...) drug is to stop the progression of the disease with just a single dose, but the company limited the doses in the program to only 100. The global allocation was by lottery, which was considered a novelty in compassionate use history and therefore widely criticized. This paper investigates alternative allocation principles. Arguments Each possible principle is accompanied by many aspects that need to be considered with regard to urgency and global distribution. This makes some principles like first-come-first-served seem negligible. Remaining principles are ordered hierarchically to derive an algorithm that can represent an alternative to a lottery. A combination of willingness to participate in research, urgency, and likelihood of success (relative to the availability of supportive treatment options) may be considered in similar cases in future global compassionate use programs with children. Conclusion Since universal algorithms are difficult to define, allocation criteria should always be discussed by an independent panel of experts. Both the constitution of such a panel and its mandatory consultation are necessary in order to decrease the burden for all those involved and to prevent arbitrariness. (shrink)

This article is the editors’ introduction to the transcript of a lecture that Harold Garfinkel delivered to a seminar in 1993. Garfinkel extensively discusses the relevance of Aron Gurwitsch’s phenomenological treatment of Gestalt theory for ethnomethodology. Garfinkel uses the term “misreading” to signal a respecification of Gurwitsch’s phenomenological investigations, and particularly his conceptions of contextures, functional significations, and phenomenal fields, so that they become compatible with detailed observations and descriptions of social actions and interactions performed in situ. Garfinkel begins with (...) Gurwitsch’s demonstrations with line drawings and other abstract examples, and suggests how they can be used to suggest original procedures for investigating the vicissitudes of embodied practical actions in the lifeworld. This introduction to the lecture aims to provide some background on the scope of Gurwitsch’s phenomenological critique and elaboration of Gestalt theory and Garfinkel’s “misreading” of it in terms of his own conceptions of indexicality and accountability, and ethnomethodological investigations of the production of social order. (shrink)

Ethical concerns regarding agricultural practices can be found to co-evolve with technological developments. This paper aims to create an understanding of ethics that is helpful in debating technological innovation by studying such a co-evolution process in detail: the development and adoption of the milking robot. Over the last decade an increasing number of milking robots, or automatic milking systems (AMS), has been adopted, especially in the Netherlands and a few other Western European countries. The appraisal of this new technology in (...) ethical terms has appeared to be a complicated matter. Compared to using a conventional milking parlor, the use of an AMS entails in several respects a different practice of dairy farming, the ethical implications and evaluation of which are not self-evident but are themselves part of a dynamic process. It has become clear that with its use, the entire practice of dairy farming has been reorganized around this new device. With a robot, cows must voluntarily present themselves to be milked, whereby an ethical norm of (individual) freedom for cows can be seen to emerge together with this new technology. But adopting a robot also implies changes in what is considered to be a good farmer and an appropriate relation between farmer and cow. Through interviews, attending “farmers’ network” meetings in the Netherlands, and studying professional literature and dedicated dairy farming web forums, this paper traces the way that ethical concerns are a dynamic part of this process of rearranging a variety of elements of the practice of dairy farming. (shrink)

Love, hate, slavery, torture, addiction and death - as this book shows, only psychoanalysis can speak well of such matters. Psychoanalysis was the most important intellectual development of the 20th century, which left no practice from psychiatry to philosophy to politics untouched. Yet it was also in many ways an untouchable project, caught between science and poetry, medicine and hermeneutics. This unsettled, unsettling status has recently induced the philosopher Alain Badiou to characterise psychoanalysis as an 'antiphilosophy', that is, as a (...) practice that issues the strongest possible challenges to thought. Justin Clemens takes up the challenge of this denomination here, by re-examining a series of crucial psychoanalytic themes: addiction, fanaticism, love, slavery and torture. Drawing from the work of Freud, Lacan, Badiou, Agamben and others, Psychoanalysis is an Antiphilosophy offers a radical reconstruction of the operations and import of key psychoanalytic concepts and a renewed sense of the indispensable powers of psychoanalysis for today. (shrink)

It seems misleading to regard Georg Simmel as one of the founders of modern cultural studies. Instead, it is argued that Simmel's cultural sociology remained oriented to 19th century's culture. In this sense the article reconstructs his theory of individual and collective cultivation as standing in contrast to currently dominating cultural concepts based on egalitarianism.

“Almost in the same historical moment when Galileo directed all modern physics to the reading of that book which Nature was supposed to have written herself in geometric or, subsequently, algebraic signs, the modern novel and modern theatre stepped in as evidence that modern readers and spectators enjoy the effects of those fictions most of all when they are altogether free of science.” Friedrich Kittler, “Man as a drunken town musician”.

This paper studies the influence of agency conflicts on the irreversibility effect. Using a dynamic variant of the static Baron and Myerson :911–930, 1982) adverse selection model, we characterize under which circumstances the irreversibility effect arises in the presence and absence of an agency conflict. In particular, we find that in the presence of an agency conflict the irreversibility effect arises in more circumstances than in the standard first-best analysis that abstracts from agency problems.

By looking back to the early days of network building within the Internet, Clemens Apprich looks at how those pioneer projects have shaped new forms of media and social practices, and critically engages with current discourses about the weal and woe of the Internet.

The new series of 'Studies on Ethics and Science' complements the Yearbook for Ethics and Science edited since 1995 by the Institute for Science and Ethics in Bonn and published by de Gruyter. The monographs and collected volumes in the series cover the same subjects as the Yearbook, namely outstanding and innovative contributions to the investigation of ethical questions connected with modern science and its development. Particular interest is directed towards ethical questions in medicine and the biological sciences.

A plethora of ethical issues in livestock agriculture has emerged to public attention in recent decades, of which environmental and animal welfare concerns are but two, albeit prominent, themes. For livestock agriculture to be considered sustainable, somehow these interconnected themes need to be addressed. Ethical debate on these issues has been extensive, but mostly started from and focused on single issues. The views of farmers in these debates have been largely absent, or merely figured as interests, instead of being considered (...) morally worthwhile themselves. In this paper the relevance for ethical debates of the ways farmers discuss and engage with moral concerns is explored. The variety of norms that figure in contemporary farming practices is sketched in its multifarious complexity, illustrated by ethnographic fieldwork, and systematized in terms of “orders of worth.” Reviewing the practical arguments and commitments of farmers within this framework reveals that farming practices are subject to mixed motives, in which an amalgam of types of concerns play a role. Recognition of the peculiarly entangled nature of the ethics of farming practices could counter the tendency in policy making, technological innovation, and ethical thought to compartmentalize our moral landscape. Understanding farming practice as the integration of a mosaic of concerns in the light of a variety of moral experiences would foster public appreciation of positions of farmers in debates on improving the sustainability and societal acceptability of livestock agriculture. (shrink)

In this article, the authors articulate the question “From where do we speak?” They explain the status of this question and then discuss the question “From where do the authors of the document Justice in the World speak?” They identify four reference points: a pneumatologic commitment, a perception of injustice, a belief in the Gospel basis of action on behalf of justice, and a recognition of self-involvement. This part of the text has been written by Clemens Sedmak. In the (...) second part, they ask the question: “From where do we speak now?” After a few remarks on the climate crisis and the sexual abuse crisis, they focus on “the wounded sociality” of the present day. They explore the relationship between justice and this wounded sociality, taking the categories of social friendship and fraternity as points of reference (from Pope Francis’s encyclicals Laudato si’ and Fratelli tutti), and enter a conversation with three authors: Michael Sandel, Teresa Godwin Phelps, and Paul Ricoeur. This section has been authored by Mathias Nebel. (shrink)

§ 1. Introduction. In this communication we present some recent results on the classification of Polish metric spaces up to isometry and on the isometry groups of Polish metric spaces. A Polish metric space is a complete separable metric space.Our first goal is to determine the exact complexity of the classification problem of general Polish metric spaces up to isometry. This work was motivated by a paper of Vershik [1998], where he remarks : “The classification of Polish spaces up to (...) isometry is an enormous task. More precisely, this classification is not ‘smooth’ in the modern terminology.” Our Theorem 2.1 below quantifies precisely the enormity of this task.After doing this, we turn to special classes of Polish metric spaces and investigate the classification problems associated with them. Note that these classification problems are in principle no more complicated than the general one above. However, the determination of their exact complexity is not necessarily easier.The investigation of the classification problems naturally leads to some interesting results on the groups of isometries of Polish metric spaces. We shall also present these results below.The rest of this section is devoted to an introduction of some basic ideas of a theory of complexity for classification problems, which will help to put our results in perspective. Detailed expositions of this general theory can be found, e.g., in Hjorth [2000], Kechris [1999], [2001]. (shrink)

Since the 1970s, historical sociology in the United States has been constituted by a configuration of substantive questions, a theoretical vocabulary anchored in concepts of economic interest and rationalization, and a methodological commitment to comparison. More recently, this configuration has been destabilized along each dimension: the increasing autonomy of comparative-historical methods from specific historical puzzles, the shift from the analysis of covariation to theories of historical process, and new substantive questions through which new kinds of arguments have been elaborated. Although (...) the dominant responses have centered on methodological elaboration and epistemological debate, greater attention to historical process also informs new strategies for defining cases and framing puzzles, thereby highlighting different categories of empirical questions: social caging, group formation, and multiple orders. The most striking shift is from the imagery of systems-and-crises, which highlighted revolution and state-building, to multidimensional understandings of emergence and destabilization. (shrink)

Das Werk "Metaphysicae systema methodicum" des Steinfurter Gymnasialprofessors Clemens Timpler (1563/64-1618) war, als es 1604 erstmals erschien, das erste Lehrbuch der Metaphysik aus protestantischer Feder und schon damit vor allem in Form und Stil, aber auch dem Inhalt nach wegweisend für die gesamte deutsche Schulphilosophie. Fest verwurzelt in der Tradition des Aristoteles und seiner thomistischen Auslegung und in stetem Bezug auf Suarez' seinerzeit gerade erschienene "Disputationes metaphysicae", entwickelt Timpler eine Lehre von erstaunlicher Eigenständigkeit, die akademisch umfassend rezipiert und intensiv (...) diskutiert wurde. Es ist davon auszugehen, dass sie auch Wolff nicht unbekannt gewesen sein wird, insbesondere wenn man etwa Timplers Bestimmungen der Philosophie und der Metaphysik, der Modalitäten und der Willensfreiheit betrachtet. The Metaphysicae systema methodicum by the Steinfurt professor Clemens Timpler (1563/4-1618) was, when it first appeared in 1604, the first textbook of metaphysics by a Protestant author, and was thus already a groundbreaking work of German academic philosophy, primarily in form and style but also in content. Firmly rooted in the tradition of Aristotle and the thomistic interpretation of his works, and making constant reference to Suarez’s recently-published Disputationes metaphysicae, Timpler developed a theory of astonishing originality, which was widely absorbed and intensively discussed in academic circles. It follows that the work would not have been unknown to Wolff, especially in view of Timpler’s designations of philosophy and metaphysics, modalities and freedom of will. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be (...) preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

© The Author. Published by Oxford University Press on behalf of the Oxford Centre for Islamic Studies. All rights reserved. For Permissions, please email: [email protected] the best tradition of Max Weber’s theses on the Protestant ethic and its role in the evolution of modern capitalism Edward Schneier’s book is a daring and inspiring attempt to assess another form of religion’s impact on society. The focus here is on Islam, or, more precisely on the broad range of Islamic political thought and (...) ideals and their impact on democracy in not less than the Islamic world as a whole. Concerned by the heated debates on Islam, violence, and authoritarianism triggered by the terrorist attacks in the United States in 2001, the troubled history of the Middle East since the invasion in Iraq in 2003, and the Arab Spring in 2011, Schneier starts with the question what the resources of ‘Islamic... (shrink)

We introduce the computable FS-jump, an analog of the classical Friedman–Stanley jump in the context of equivalence relations on the natural numbers. We prove that the computable FS-jump is proper with respect to computable reducibility. We then study the effect of the computable FS-jump on computably enumerable equivalence relations (ceers).

Synthetic biology is a research field that has grown rapidly and attracted considerable attention. Most prominently, it has been labelled the ‘engineering of biology’. While other attempts to label the field have been also pursued, the program of engineering can be considered the core of the field’s disciplinary program, of its identity. This article addresses the success of the ‘engineering program’ in synthetic biology and argues that its success can partly be explained by distinct practices of persuasion that aim at (...) persuading scientific, but also non-scientific audiences. The article explores two different modes of persuasion:, building tools as heuristic models and posing visionary claims. Objects such as the toggle switch or the synthetic oscillator in synthetic biology can more adequately be described as heuristic models of engineering instead of simply as prototypes of ‘tools’. Posing visionary claims can be also understood as a persuasion practice, since the claims are used to construct the societal relevance of the field. Drawing upon Michel Callon’s ‘sociology of translation’, I argue that both practices of persuasion aim at ‘enrolling’ entities into the disciplinary identity. The article is based on the textual analysis of rhetorical practices in three synthetic biology review articles which are considered seminal for the history of the field. (shrink)

We introduce a new family of jump operators on Borel equivalence relations; specifically, for each countable group [Formula: see text] we introduce the [Formula: see text]-jump. We study the elementary properties of the [Formula: see text]-jumps and compare them with other previously studied jump operators. One of our main results is to establish that for many groups [Formula: see text], the [Formula: see text]-jump is proper in the sense that for any Borel equivalence relation [Formula: see text] the [Formula: see (...) text]-jump of [Formula: see text] is strictly higher than [Formula: see text] in the Borel reducibility hierarchy. On the other hand, there are examples of groups [Formula: see text] for which the [Formula: see text]-jump is not proper. To establish properness, we produce an analysis of Borel equivalence relations induced by continuous actions of the automorphism group of what we denote the full [Formula: see text]-tree, and relate these to iterates of the [Formula: see text]-jump. We also produce several new examples of equivalence relations that arise from applying the [Formula: see text]-jump to classically studied equivalence relations and derive generic ergodicity results related to these. We apply our results to show that the complexity of the isomorphism problem for countable scattered linear orders properly increases with the rank. (shrink)

Foucaults Werk hat nicht nur die Kultur- und Sozialwissenschaften entscheidend beeinflusst. Das Handbuch gibt einen systematischen Überblick über Foucaults Leben und Werk. Es stellt die Kontexte dar, aus denen heraus seine Werke entstanden sind und erklärt Grundbegriffe des Foucault‘schen Denkens wie Archiv, Biopolitik, Diskurs, Dispositiv, Genealogie, Körper und Macht. Mit einem umfangreichen Kapitel zur Rezeption in den verschiedenen Disziplinen. Für die 2. Auflage wurde das Handbuch durchgesehen und aktualisiert sowie um neue Artikel zu Foucaults journalistischen und medizingeschichtlichen Arbeiten sowie zu (...) seinen Vorlesungen über das Wahrsprechen und zur Ödipus-Thematik erweitert. Außerdem setzt sich ein Beitrag ausführlich mit dem 2018 posthum erschienenen vierten Band der Geschichte der Sexualität auseinander. (shrink)

More than any other thinker, Giorgio Agamben shows us that philosophy is also a matter of style and politics a matter of poetics. This book explores the unexpected and illuminating paths that his work traces across the territories of law and literature, linguistics, dance or cinema, in search of a new idea and practice of the community. It offers an irreplaceable introduction to one of the most fascinating thinkers of our time.'Jacques RanciereGathering some of the most important established and emerging (...) scholars to examine his body of work, this collection of essays seeks to explore Agamben's thought from these broader philosophical and literary concerns, underpinning its place within larger debates in continental philosophy. Including a contribution by Agamben himself, it is essential reading for anyone interested in his work.In the past five years, Giorgio Agamben has emerged as one of the most important continental philosophers. This burgeoning popularity of his work has largely been confined to a study of the homo sacer series. Yet these later 'political' works have their foundation in Agamben's earlier works on the philosophy of language, aesthetics and literature. From a philosophy of language and linguistics that leads to a broader theory of representation, Agamben develops a critical theory that attempts to explore the hiatuses and paradoxes that govern discursive practice across a broad range of disciplines. (shrink)