Is there a unique way to de-idealize models? If not, how might the possible ways of reducing the distortion between models and reality differ from each other? Based on an empirical case study conducted in financial markets, this paper discusses how a popular valuation model (the Discounted Cash Flow model) idealizes reality and how the market participants de-idealize it in concrete market situations. In contrast to Cartwright's view that economic models are generally over-constrained, this paper suggests that valuation models are (...) under-constrained. This serves as the reason why the relaxation of simplifying assumptions and concretization do not work as methods of de-idealization. The paper finds that financial market participants de-idealize models using commentary that takes the form of judgment. As a conclusion, a hypothesis is formulated that proposes that the more underdetermined the model is the bigger role narrative and other pragmatic elements play in the process of model application. (shrink)

In this article we analyze the methodological commitments of a radical embodied cognition (REC) approach to social interaction and social cognition, specifically with respect to the explanatory framework it adopts. According to many representatives of REC, such as enactivists and the proponents of dynamical and ecological psychology, sociality is to be explained by (1) focusing on the social unit rather than the individuals that comprise it and (2) establishing the regularities that hold on this level rather than modeling the sub-personal (...) mechanisms that could be said to underlie social phenomena. We point out that, despite explicit commitment, such a view implies an implicit rejection of the mechanistic explanation framework widely adopted in traditional cognitive science (TCS), which, in our view, hinders comparability between REC and these approaches. We further argue that such a position is unnecessary and that enactive mechanistic explanation of sociality is both possible and desirable. We examine three distinct objections from REC against mechanistic explanation, which we dub the decomposability, causality and extended cognition worries. In each case we show that these complaints can be alleviated by either appreciation of the full scope of the mechanistic account or adjustments on both mechanistic and REC sides of the debate. (shrink)

Social robots are gradually entering children’s lives in a period when children learn about social relationships and exercise prosocial behaviors with parents, peers, and teachers. Designed for long-term emotional engagement and to take the roles of friends, teachers, and babysitters, such robots have the potential to influence how children develop empathy. This article presents a review of the literature in the fields of human–robot interaction, psychology, neuropsychology, and roboethics, discussing the potential impact of communication with social robots on children’s social (...) and emotional development. The critical analysis of evidence behind these discussions shows that, although robots theoretically have high chances of influencing the development of empathy in children, depending on their design, intensity, and context of use, there is no certainty about the kind of effect they might have. Most of the analyzed studies, which showed the ability of robots to improve empathy levels in children, were not longitudinal, while the studies observing and arguing for the negative effect of robots on children’s empathy were either purely theoretical or dependent on the specific design of the robot and the situation. Therefore, there is a need for studies investigating the effects on children’s social and emotional development of long-term regular and consistent communication with robots of various designs and in different situations. (shrink)

We study the complexity of the isomorphism relation on classes of computable structures. We use the notion of FF-reducibility introduced in [9] to show completeness of the isomorphism relation on many familiar classes in the context of all ${\mathrm{\Sigma }}_{1}^{1}$ equivalence relations on hyperarithmetical subsets of ω.

The study of Borel equivalence relations under Borel reducibility has developed into an important area of descriptive set theory. The dichotomies of Silver [20] and Harrington, Kechris and Louveau [6] show that with respect to Borel reducibility, any Borel equivalence relation strictly above equality on ω is above equality on , the power set of ω, and any Borel equivalence relation strictly above equality on the reals is above equality modulo finite on . In this article we examine the effective (...) content of these and related results by studying effectively Borel equivalence relations under effectively Borel reducibility. The resulting structure is complex, even for equivalence relations with finitely many equivalence classes. However use of Kleene’s O as a parameter is sufficient to restore the picture from the noneffective setting. A key lemma is that of the existence of two effectively Borel sets of reals, neither of which contains the range of the other under any effectively Borel function; the proof of this result applies Barwise compactness to a deep theorem of Harrington establishing for any recursive ordinal α the existence of singletons whose α-jumps are Turing incomparable. (shrink)

We study the structure of Σ11 equivalence relations on hyperarithmetical subsets of ω under reducibilities given by hyperarithmetical or computable functions, called h-reducibility and FF-reducibility, respectively. We show that the structure is rich even when one fixes the number of properly equation imagei.e., Σ11 but not equation image equivalence classes. We also show the existence of incomparable Σ11 equivalence relations that are complete as subsets of ω × ω with respect to the corresponding reducibility on sets. We study complete Σ11 (...) equivalence relations and show that existence of infinitely many properly Σ11 equivalence classes that are complete as Σ11 sets is necessary but not sufficient for a relation to be complete in the context of Σ11 equivalence relations. (shrink)

For a class K of structures, closed under isomorphism, the index set is the set I of all indices for computable members of K in a universal computable numbering of all computable structures for a fixed computable language. We study the complexity of the index set of class of structures with decidable theories. We first prove the result for the class of all structures in an arbitrary finite nontrivial language. After the complexity is found, we prove similar results for some (...) well-known classes of structures, such as directed graphs, undirected graphs, partial orders and lattices. (shrink)

I assert that Bulgarian journalists recruited during communism to also serve the government as intelligence agents had the opportunity to make moral choices despite the country's dictatorship. Post-communist discussions in Bulgarian media focused on the extent of guilt of journalists who acted as spies. The three possibilities of forgetting the past, punishing those who spied, or forgiving them, are considered. The article concludes that the spy/journalists cannot be forgiven because they violated moral principles that had been vital in Eastern Europe (...) even during the communist regimes; a democratic society should rely on journalists with no history of deceiving audiences. (shrink)

The main characteristic of the modern environment is the negative change by its people – destruction and pollution. Man is part of the biosphere and the technogenic transformations of the biosphere inevitably affect him. Under the influence of technogenic civilization, all spheres of human activity undergo changes, and science above all. Ecology is especially keenly aware of the challenges of technogenic civilization. It focuses on anthropogenic factors, works with the human environment. At the same time, its problem field is expanding (...) due to interdisciplinary research and the allocation of knowledge of new environmental disciplines into an independent industry. The interdisciplinarity of modern ecology is most clearly visible on the example of such a direction as informational ecology. The presence of the digital environment in human life has grown so much that it requires the separation of the digital information environment into a separate subsystem. Information ecology studies the laws of the influence of information on the formation and functioning of man. In turn, interdisciplinarity, assuming the use of knowledge from various branches of science, brings us to the problems of the collective agent of cognition and distributed knowledge. In ecology, the problems of the collective agent of cognition are implemented through crowd-sourcing technology. Ecology is a science that requires massive collection of observation data (samples of water, air, soil pollution in various, sometimes hard-to-reach corners of the planet, observation of fluctuations in the number of species of animals and plants). The popularity of crowdsourcing projects in the field of ecology is explained by the fact that the challenges and threats of anthropogenic civilization have generated such a trend of our time as environmental orientation or environmentalism. Ecological crowdsourcing projects, inspired by the philosophy of environmentalism, can serve as an answer to the challenges of technogenic civilization. (shrink)

The purpose of the study is to determine the personal results of students with disabilities and to identify the necessary conditions for effective work with this category of children in distance learning. The analysis of the results revealed the need for the use of subject-oriented technology in the educational process, which contributes to the formation of the subjective position of students, allowing for the individualization of the educational process, maximally compensating for developmental deficits caused by diseases. As a result, the (...) necessity of organizing purposeful career guidance work with disabled children and educational work with parents was revealed. (shrink)

On the basis of both published and unpublished manuscripts written from 1914 to 1917, this article gives an overview of Lev Vygotsky’s early ideas. It turns out that Vygotsky was very much involved in issues of Jewish culture and politics. Rather surprisingly, the young Vygotsky rejected all contemporary ideas to save the Jewish people from discrimination and persecution by creating an autonomous state in Palestine or elsewhere. Instead, until well into 1917, Vygotsky proposed the rather traditional option of strengthening the (...) spiritual roots of the Jews by returning to the religious writings. Socialism was rejected, because it merely envisioned the compulsory redistribution of material goods and ‘man lives not by bread alone’. It was only after the October Revolution that Vygotsky switched from arguments in favour of the religious faith in the Kingship of God to the communist belief in a Radiant Future. (shrink)

Defining the degree of categoricity of a computable structure ${\mathcal{M}}$ to be the least degree d for which ${\mathcal{M}}$ is d-computably categorical, we investigate which Turing degrees can be realized as degrees of categoricity. We show that for all n, degrees d.c.e. in and above 0 (n) can be so realized, as can the degree 0 (ω).

In the current debate there are two epistemological approaches to the definition of ignorance: the Standard View and the New View. The former defines ignorance simply as not knowing, while the latter defines it as the absence of true belief. One of the main differences between these two positions lies in rejecting (Standard View) or in accepting (New View) the factivity of ignorance, i.e., if an agent is ignorant of φ, then φ is true. In the present article, we first (...) provide a criticism of the Standard View in favour of the New View. Secondly, we propose a formal setting to represent the notion of factive ignorance. (shrink)

For a computable structure $\mathcal {M}$, the categoricity spectrum is the set of all Turing degrees capable of computing isomorphisms among arbitrary computable copies of $\mathcal {M}$. If the spectrum has a least degree, this degree is called the degree of categoricity of $\mathcal {M}$. In this paper we investigate spectra of categoricity for computable rigid structures. In particular, we give examples of rigid structures without degrees of categoricity.

LetEbe a computably enumerable equivalence relation on the setωof natural numbers. We say that the quotient set$\omega /E$realizesa linearly ordered set${\cal L}$if there exists a c.e. relation ⊴ respectingEsuch that the induced structure is isomorphic to${\cal L}$. Thus, one can consider the class of all linearly ordered sets that are realized by$\omega /E$; formally,${\cal K}\left = \left\{ {{\cal L}\,|\,{\rm{the}}\,{\rm{order}}\, - \,{\rm{type}}\,{\cal L}\,{\rm{is}}\,{\rm{realized}}\,{\rm{by}}\,E} \right\}$. In this paper we study the relationship between computability-theoretic properties ofEand algebraic properties of linearly ordered sets realized (...) byE. One can also define the following pre-order$ \le _{lo} $on the class of all c.e. equivalence relations:$E_1 \le _{lo} E_2 $if every linear order realized byE1is also realized byE2. Following the tradition of computability theory, thelo-degrees are the classes of equivalence relations induced by the pre-order$ \le _{lo} $. We study the partially ordered set oflo-degrees. For instance, we construct various chains and anti-chains and show the existence of a maximal element among thelo-degrees. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Rhetoric 37.1 (2004) 1-20 [Access article in PDF] Endoxa, Epistemological Optimism, and Aristotle's Rhetorical Project Ekaterina V. Haskins Communication Department Boston College Aristotle's crucial role in institutionalizing the art of rhetoric in the fourth century BCE is beyond dispute, but the significance of Aristotle's rhetorical project remains a point of lively controversy among philosophers and rhetoricians alike. There are many ways of reading and evaluating Aristotle's (...) Rhetoric that depend on the philosophical, theoretical, and pedagogical purposes of the scholar.1 Most philosophical and rhetorical exegeses of the Rhetoric, however, while focusing on the text's connections to Aristotle's corpus and to the rhetorical tradition before and after Aristotle, seem to lack a critical perspective on Aristotle's relationship with his cultural context. Yet, like other parts of Aristotle's encyclopedic intellectual endeavor, much of Rhetoric 's cultural content was provided by endoxa, "reputable or received opinions."Since G. E. L. Owen's essay "Tithenai ta phainomena" (1961) many scholars have accepted the claim that endoxa, rather than empirical observations, are the source of Aristotle's own philosophical principles. The "linguistic" turn within Aristotelian studies has drawn attention to the role of "facts" of language and ordinary experience within Aristotle's philosophical method. As a result, a view of Aristotle as a hard-core empiricist has given way to a picture of a humanist who is attuned to the nuances of his cultural milieu. Still, this new portrait fails to take into account that Aristotle's manner of selecting and categorizing his linguistic resources allows him to transform what we would consider cultural beliefs into natural, and hence, atemporal premises. This pattern can be explained by Aristotle's "epistemological optimism," in itself a blend of several cultural assumptions about perception in general and vision in particular, the function of language, and the cyclical nature of human history. Part of this essay's objective, then, will be an explanation of these components of Aristotle's epistemological optimism. By appreciating Aristotle's difference [End Page 1] on these issues from our modern assumptions, we will be in a better position to understand why Aristotle relies on endoxa on all three levels of philosophical discourse (theoretical science, moral philosophy, and productive arts of poetics and rhetoric). Aristotle remains consistent in his treatment of endoxa throughout; rhetoric, however, presents a major challenge to Aristotle's epistemological optimism and his conception of language. I shall argue that Aristotle recognized this challenge and that he answered it by isolating proofs and rhetorical genres from their linguistic medium (lexis ), and postulating linguistic transparency (sapheneia ) as a stylistic norm. I. Aristotle's openness to appearances (phainomena ) and opinions (endoxa ) was accorded prominence especially thanks to the work of G. E. L. Owen and Martha Nussbaum. Owen was first to defend a linguistic translation of Aristotle's phainomena as "ordinary beliefs" and "appearances" against the then-prevalent rendition "observed facts." In so doing he asserted the crucial impact of the philosopher's cultural context on the formation of speculative discourse. Owen (1961) nonetheless demanded that phainomena be understood as empirical observations in Aristotle' treatises on biology and meteorology (84-86), so as to preserve the methodological and epistemological distinctions between inquiries into the natural world, on the one hand, and the world inhabited by human agents, on the other. Nussbaum (1986) went much further than Owen in asserting the role of phainomena and endoxa in Aristotle's inquiry. Unlike Owen, Nussbaum sees no fundamental difference between "experiences" of a philosopher and linguistic expressions of cultural beliefs and interpretations—his discursive data—from which Aristotle constructs his philosophical accounts. Nussbaum's chief (and highly influential) claim is that Aristotle's method is marked by a deep concern for the experiential world of his fellow men and their language. Aristotle's philosophical insights into the human condition, on this reading, echo and amplify classical Greek tragedy, despite the austere diction of Aristotle's extant treatises.Owing to this openness to the world of ordinary beliefs, Aristotle seems to depart from the Eleatic and Platonic distrust of human... (shrink)

The article is devoted to an anthropological study of psychotherapeutic discourse adaptation by religious specialists within the Catholic practice of spiritual exercises. Grounded in the therapeutic culture's notion that an individual's roots lie deeply within their family history and childhood experiences, this article examines how issues related to family relationships may surface during the development of psychotherapeutic techniques by religious groups. It also investigates the childhood images upon which these "syncretic" projects might be based. Considering the Catholic practice of spiritual (...) exercise allows us to explore the historical roots of the "personal relationship with God". This concept appears in various spiritual movements from the late Middle Ages and early Modern period, which emphasized emotional religiosity, meditation, and imaginative practices. In the present context, the interpretation of the relationship with God and other agents of divine nature in psychotherapeutic terms is based on a combination of traditional Jesuit spiritual direction practices with ideas from psychodynamic theories found in American spiritual direction manuals of the 1970s-1990s. From this angle, the image of God is interpreted as a projection of an authoritative adult image internalized in childhood, and problems in the "relationship with God" are seen as a consequence of unresolved issues with significant others. Using one of the most important therapeutic tropes of the "inner child" as the basis for meditation practice, spiritual directors invite participants to envision a scene where a child version of their personality receives unconditional love. However, unlike the therapeutic version of the practice of "inner child work,” in the Catholic paradigm, the individual should neither become the agent of their own healing nor reparent themselves. The logic of personal responsibility and "parenthood” as its metaphor is replaced by the logic of humility and surrendering oneself to the divine will, i.e., true childhood. The article highlights the need to closely examine imaginative techniques in religious cultures and psychotherapeutic contexts, and questions the commonality in their epistemological stance on the nature and function of imagination. (shrink)

The purpose of this study is to determine the features of creating integrated courses using a foreign language for university students. Achieving this goal requires solving the problems of developing a conceptual framework for the use of a foreign language in integrated courses in the educational process at the university. The article presents and analyzes: the definition, classification, typology, main characteristics and advantages of the work of a teacher with students in the university within the framework of an integrated course. (...) The conclusions of the study allowed us to present some of the most important features of the educational subjects working in the framework of an integrated course at the university. (shrink)

Name der Zeitschrift: Archiv für Geschichte der Philosophie Jahrgang: 98 Heft: 2 Seiten: 113-143.

Personal data use is increasingly permeating our everyday life. Informed consent for personal data use is a central instrument for ensuring the protection of personal data. However, current informed consent practices often fail to actually inform data subjects about the use of personal data. This article presents the results of a requirements analysis for informed consent from both a legal and usability perspective, considering the application context of educational assessment. The requirements analysis is based on European Union law and a (...) review of current practices. As the main outcome, the article presents a blueprint which will be the basis for the development of an informed consent template that supports data controllers in establishing an effective and efficient informed consent form. Because the blueprint, and subsequently, the template, distinguishes between legal and usability requirements, it also provides the basis for the mapping of legal requirements in other contexts. (shrink)

In the present-day information burst and information revolution epoch the mankind must realize the adaptation to the new conditions of its existence in the limited time. The most important problem is the problem of the human being successful adaptation to the modern information medium. The information medium is the factor demanding absolutely new adaptation of human being. Modern information medium specific character leads to correction of existing nature and social human being adaptation mechanisms and creation of new mechanisms. Information technologies (...) as a modern civilization core change not only quality and substance of present time human being life, but they threaten to transformate his way of existence in the modern world. (shrink)

Criticizing the works of "Western" specialists in semantics, Soviet academician M. M. Pokrovskij (1868-1942) comes to the conclusion that social factors are essential for semantic evolution, while psychological factors constitute an intermediate link between the "external" life of a society and the semantics of the corresponding language. This conception resembles the general explanations of semantic evolution proposed by N. Ja. Marr (1864-1934). Nevertheless, despite a number of common points in the semantic theories of these two researchers, Pokrovskij's attitude towards Marr (...) was negative: in particular, he disagreed with the thesis of the chronological primacy of Marr's discoveries in the domain of semantics. The article investigates why Pokrovskij had for a long time constituted an intermediate link between Russian and "Western" "traditions" in the field of semantics. (shrink)

This is a review of the book by E.G. Dragalina-Chyornaya “Informal notes on logical form". The review discusses the structure and the main ideas of the book. The review focuses on the author's arguments in favor of the dynamic regulatory model of logic and provides a critical analysis of them.

In this topical section, we highlight the next step of research on modeling aiming to contribute to the emerging literature that radically refrains from approaching modeling as a scientific endeavor. Modeling surpasses “doing science” because it is frequently incorporated into decision-making processes in politics and management, i.e., areas which are not solely epistemically oriented. We do not refer to the production of models in academia for abstract or imaginary applications in practical fields, but instead highlight the real entwinement of science (...) and policy and the real erosion of their boundaries. Models in decision making – due to their strong entwinement with policy and management – are utilized differently than models in science; they are employed for different purposes and with different constraints. We claim that “being a part of decision-making” implies that models are elements of a very particular situation, in which knowledge about the present and the future is limited but dependence of decisions on the future is distinct. Emphasis on the future indicates that decisions are made about actions that have severe and lasting consequences. In these specific situations, models enable not only the acquisition of knowledge (the primary goal of science) but also enable deciding upon actions that change the course of events. As a result, there are specific ways to construct effective models and justify their results. Although some studies have explored this topic, our understanding of how models contribute to decision making outside of science remains fragmentary. This topical section aims to fill this gap in research and formulate an agenda for additional and more systematic investigations in the field. (shrink)

Friedrich Nietzsche has emerged as one of the most important and influential modern philosophers. For several decades, the book series Monographien und Texte zur Nietzsche-Forschung (MTNF) has set the agenda in a rapidly growing and changing field of Nietzsche scholarship. The scope of the series is interdisciplinary and international in orientation reflects the entire spectrum of research on Nietzsche, from philosophy to literary studies and political theory. The series publishes monographs and edited volumes that undergo a strict peer-review process. The (...) book series is led by an international team of editors, whose work represents the full range of current Nietzsche scholarship. (shrink)

The research is devoted to a discussion of social and humanitarian problems associated with tectonic changes in human life against the backdrop of total digitalization. The author's attention is focused on the uniqueness of the modern situation: never before have innovative technologies had the ability to penetrate so rapidly and deeply into the foundation of modern society, have they become so widespread and accessible to almost all peoples and cultures. At the same time, the undeniable public good and the most (...) serious threats to society that digital reality technologies bring with them are in a very close relationship. This is especially true for artificial intelligence systems. Innovations transform the entire world order, bringing radical changes not only to the material sphere of life, but also to the spiritual and moral state of a person. The research notes that the introduction of information and communication technologies into the life of modern society occurs without reliable support on the results of preliminary experimental research, without taking into account a deep professional and responsible assessment of the social and psychological consequences of their impact on the individual and on society as a whole. As a result, at this stage, society is constantly faced with many negative aspects of the impact of high-tech means. The work examines some of them: a decrease in cognitive and analytical abilities, the devaluation of human labor, the criminalization of cyberspace, the spread of Deepfake technology. Particular attention is paid to the problem associated with the possibility of using information technology as a tool of psychological influence. Information and psychological warfare is implemented on the basis of social networks and artificial intelligence technologies, which provides the enemy with the opportunity to achieve superiority without the use of military force. Information and humanitarian actions in cyberspace, carried out by Western countries in order to destabilize our society, destroy its value foundations, reformat the consciousness, worldview and spiritual and moral qualities of citizens, are becoming increasingly large-scale and aggressive. The work notes that digitalization is gaining momentum, plunging society deeper into new circumstances and requiring decisive action aimed at overcoming the many threats specific to the modern high-tech era. (shrink)

Als »Zwischenreich«, »Drittes« oder »Mitte« bezeichnet, kommt der Imagination seit ihren Anfängen in der Antike die Rolle eines Mediums zu. Gleichzeitig bleibt ihr medialer Aspekt durchgehend ambivalent und prekär. Es ist Georg Wilhelm Friedrich Hegel, der die Imagination nicht mehr als subjektives Vermögen versteht, sondern als Kraft der »Entäußerung« und sie somit medial denkt. In einer bislang wenig beachteten Passage aus Hegels dritter Enzyklopädie von 1830 legt Ekaterina Vassilevski nicht nur die implizite Medialität der Imagination frei, sondern auch den (...) in Hegels Denken verborgenen Begriff des Medialen. (shrink)

The aim of the present paper is to introduce a system, where the epistemic state of an agent is represented truth-functionally. In order to obtain this system, we propose a four-valued logic, that we call the logic of rational agent, where the fact of knowing something is formalized at the level of valuations, without the explicit use of epistemic knowledge operator. On the basis of this semantics, a sound and complete system with two distinct truth-functional negations is provided. These negations (...) allow us to express the statements about knowing or not knowing something at the syntactic level. Moreover, such a system is applied to the analysis of knowability paradox. In particular, we show that the paradox is not derivable in terms of the logic of rational agent. (shrink)

RESUMO O uso de linguagem codificada e esópica nos trabalhos dos semioticistas que integraram a Escola Semiótica de Tártu-Mosou foi motivado pelo desejo de serem compreendidos pelo círculo e não compreendidos por possíveis intrusos indesejáveis dos órgãos de controle soviéticos. Um dos termos centrais utilizados pela Escola - os “sistemas modelizantes secundários” - foi sugerido por Vladímir Uspiénski com o objetivo de substituir a palavra "semiótica", associada à semiótica ocidental. Ao cotejar o artigo de Iúri Lotman Sobre o problema da (...) tipologia da cultura, de 1967, com a tradução para o português do Brasil de Lucy Seki, que integrou a coletânea Semiótica Russa, organizada por Boris Schnaiderman, objetivo verificar se as peculiaridades do texto original, que surgiram devido às condições histórico-políticos da sua criação, foram preservadas na tradução. ABSTRACT The use of codified and Aesopian language in the works of the semioticians who were members of the Tartu-Moscow Semiotic School was motivated by the desire to be understood by the School members and notunderstood by possible unwanted intruders from Soviet control organizations. One of the key terms they used was secondary modeling systems, which Vladimir Uspensky suggested to replace the word semiotics, associated with Western semiotics. By comparing Yuri Lotman’s essay Problems in the Typology of Culture to Lucy Seki’s translation of the essay into Brazilian Portuguese, which is part of the book Semiótica Russa [Russian Semiotics], edited by Boris Schnaiderman, I intend to verify if particularities of the original text, which resulted from the historical and political context in which the essay was produced, were maintained in the translation. (shrink)

Intracellular bacteria were recently shown to employ eukaryotic prenylation system for modifying activity and ensuring proper intracellular localization of their own proteins. Following the same logic, the proteins of viruses may also serve as prenylation substrates. Using extensively validated high-confidence prenylation predictions by PrePS with a cut-off for experimentally confirmed farnesylation of hepatitis delta virus antigen, we compiled in silico evidence for several new prenylation candidates, including IRL9 and few other proteins encoded by Herpesviridae, Nef, E1A, NS5A, PB2, HN, L83L, (...) MC155R, other Poxviridae proteins, and some bacteriophages of human associated bacteria. If confirmed experimentally, these findings may aid in dissection of molecular functions of uncharacterized viral proteins and provide a novel rationale for statin and FT/GGT1-based inhibition of viral infections. Prenylation of bacteriophage proteins may aid in moderation of microbial infections. Many human viruses, including HCV, HIV1, ASFV, and a number of Adeno-, Pox-, and herpesviruses, including CMV, encode the substrates for mammalian prenylation enzymes. Prenylation is advantageous for viral infection; its suppression by FT/GGT and FPPS inhibitors has antiviral effects. In bacteriophages, prenylation may aid in moderation of microbial infections. (shrink)

Man is a biosocial entity, so, in the study of his adaptive peculiarities two directions, that is, biologic and social, can be determined. Within the biological framework it is possible to combine evolutionary, genetic, medical-biological and ecological investigations. Recently, the problem of man’s adaptation to profound changes taking place in the environment, under the impact of man’s activity, becomes of growing importance. The second direction of the man adaptation research may be called social or socio-cultural. In the course of social (...) adaptation man acts as an adaptively-adapting entity, inasmuch as, unlike animals, he does not only adapt himself to the environment, but also transforms it in course of his activity, sometimes creating a new environment. The complex study of human being makes necessary a synthesis of natural-scientific and socialhumanitariansides of the man’s adaptation problem. The analysis of the above mentioned directions, of social and biological man’s adaptations research, enables us tocome to the conclusion that no one direction, taking separately, can resolve the problem of man’s adaptation, which has a complicated pattern with many aspects. The man’s adaptation problem emerged within the framework of biology, and during a long time it was of evolutionary-biological character. However, in the course of the development of science it has become an interdisciplinary issue. It may be conceived profoundly and with all aspects only by means of an interdisciplinary synthetic analysis. (shrink)