We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

In the years following the COVID‐19 pandemic, issues such as high job demands, burnout, and turnover continue to influence the nursing workforce, with heavier impacts to marginalized groups. Understanding the work and life contexts of nurses of color can help guide strategies for workplace equity and meaningful support. This qualitative study explored the experiences of nurses of color in the United States during the pandemic, focusing on feelings about the profession and job decisions. The overarching theme was “answering the call,” (...) with subthemes of “COVID shone a light,” “being consumed by COVID,” and “is it worth it?” Participants shared how their racial identities shaped their perceptions and job decisions in positive and negative ways, noting how racism impacted many facets of their work and added to the stressors felt in the workplace and the community. Findings provide insight into the underrepresented perspectives of nurses of color and suggest strategies to eliminate racism in nursing. (shrink)

Dementia patients in the moderate-late stage of the disease can, and often do, express different preferences than they did at the onset of their condition. The received view in the philosophical literature argues that advance directives which prioritize the patient’s preferences at onset ought to be given decisive moral weight in medical decision-making. Clinical practice, on the other hand, favors giving moral weight to the preferences expressed by dementia patients after onset. The purpose of this article is to show that (...) the received view in the philosophical literature is inadequate and is out of touch with real clinical practice. I argue that having dementia is a cognitive transformative experience and that preference changes which result from this are legitimate and ought to be given moral weight in medical decision-making. This argument ought to encourage us to reduce our confidence in the moral weight of advance directives for dementia patients. (shrink)

In _The Later Middle Ages,_ the third volume of his monumental _History of Political Ideas,_ Eric Voegelin continues his exploration of one of the most crucial periods in the history of political thought. Illuminating the great figures of the high Middle Ages, Voegelin traces the historical momentum of our modern world in the core evocative symbols that constituted medieval civilization. These symbols revolved around the enduring aspiration for the _sacrum imperium,_ the one order capable of embracing the transcendent and immanent, (...) the ecclesiastical and political, the divine and human. The story of the later Middle Ages is that of the "civilizational schism"—the movement in which not only the reality but the aspiration for the _sacrum imperium_ gradually disappeared and the unification of faith and reason dissolved. His recognition of this civilizational schism provides Voegelin with a unique perspective on medieval society. William of Ockham, Dante, Giles of Rome, and Marsilius of Padua all emerge in Voegelin's study as predecessors to modern thought; each turns to personal authority and intellectual analysis in an attempt to comprehend the loss of the _sacrum imperium_ as an authoritative ideal. Voegelin is further drawn into investigations that, despite insufficient attention by scholars, still bear relevance to the study of the later Middle Ages. The mysticism apparent in _Piers Plowman_ and the apocalyptic revolt of Cola di Rienzo are merely two reactions to the disintegration of wholeness. Yet the story of the later Middle Ages does not merely revolve around disintegration. Voegelin recognizes the emergence of the constitutional political tradition as the most positive development of this period. He is at his best when explaining the difference between the presence of a representative institution and the growth of communal consciousness. Voegelin's study of the English political pattern is matched only by his unique perspective on the German imperial zone, culminating in a fitting conclusion on Nicholas of Cusa—the one political thinker with the ability to evoke the unity of mankind beyond fragmentation. _The Later Middle Ages_ is at once a brilliant examination of the symbols that characterized medieval society and a remarkable predecessor to Voegelin's study of the modern world, beginning with the Renaissance and the Reformation. (shrink)

Is there anything peculiarly "photographic" about photography—something which sets it apart from all other ways of making pictures? If there is, how important is it to our understanding of photographs? Are photographs so unlike other sorts of pictures as to require unique methods of interpretation and standards of evaluation? These questions may sound artificial, made up especially for the purpose of theorizing. But they have in fact been asked and answered not only by critics and photographers but by laymen. Furthermore, (...) for most of this century the majority of critics and laymen alike have tended to answer these questions in the same way: that photographs and paintings differ in an important way and require different methods in interpretation precisely because photographs and paintings come into being in different ways. These answers are interesting because, even within the rather restricted classes of critics, photographers, and theorists, they are held in common by a wide variety of people who otherwise disagree strongly with each other—by people who think that photographs are inferior to paintings and people who believe they are superior; by people who think that photographs ought to be "objective" and those who believe they should be "subjective"; by those who believe that it is impossible for photographers to "create" anything and by those who believe that they should at least try. Joel Snyder teaches criticism and history of photography at the University of Chicago and is presently compiling a book of his own photographs. His contributions to Critical Inquiry include "Picturing Vision" and "Reflexions on Las Meninas: Paradox Lost", written with Ted Cohen in the Winter 1980 issue. Neil Walsh Allen produces educational audio-visual materials and has designed eight permanent exhibits on the history and applications of photography for the Smithsonian Institution. (shrink)

The most compelling extant accounts of explanation casts all explanations as causal. Yet there are sciences, theoretical population biology in particular, that explain their phenomena by appeal to statistical, non-causal properties of ensembles. I develop a generalised account of explanation. An explanation serves two functions: metaphysical and cognitive. The metaphysical function is discharged by identifying a counterfactually robust invariance relation between explanans event and explanandum. The cognitive function is discharged by providing an appropriate description of this relation. I offer examples (...) of explanations from portfolio theory and population genetics that meet this characterisation. In each case the invariance relation holds between a statistical property of an ensemble and a change in structure of the ensemble. In neither case, however, does the statistical property cause the outcome it explains. There are genuine statistical, non-causal scientific explanations. (shrink)

I argue that recent advances in developmental biology demonstrate the inadequacy of suborganismal mechanism. The category of the organism, construed as a ’natural purpose’ should play an ineliminable role in explaining ontogenetic development and adaptive evolution. According to Kant the natural purposiveness of organisms cannot be demonstrated to be an objective principle in nature, nor can purposiveness figure in genuine explain. I attempt to argue, by appeal to recent work on self-organization, that the purposiveness of organisms is a natural phenomenon (...) and, by appeal to the apparatus of invariance explanation, that biological purposiveness provides genuine, ineliminable biological explanations. (edited). (shrink)

Examines the moral obligations of psychology. An inquiry into the main priorities of academic and professional psychology suggests that contributions to human welfare, its preeminent moral obligation, comes in third after guild issues and professional self-interest, and the pursuit of knowledge. In an effort to reassign moral philosophy a place of prominence and to broaden the ethical discourse of psychology, the authors use the term "moral imperative" . The promotion of the MI entails the exploration of 3 fundamental questions. These (...) concern the extent that the present social order promotes human welfare for everyone, the extent that psychology supports or challenges the present social order, and the contributions that psychology can make to the advent of the "good" society. The MI advances 4 human agency values: self-determination, distributive justice, collaborative and democratic participation, and relationality. 2012 APA, all rights reserved). (shrink)

. Philosophers and scientists often cite ontic factors when explaining the methods and success of scientific inquiry. That is, the adoption of a method or approach is explained in reference to the kind of system in which the scientist is interested: these are explanations of why scientists do what they do, that appeal to properties of their target systems. We present a framework for understanding such “Opticks to his Principia. Newton’s optical work is largely experiment-driven, while the Principia is primarily (...) mathematical, so usually, each work is taken to exemplify a different kind of science. However, Newton himself often presented them in terms of a largely consistent method. We use our framework to articulate an original and plausible position: that the differences between the Opticks and the Principia are due to the kinds of systems targeted. That is, we provide an ontic-driven explanation of methodological differences. We suspect that ontic factors should have a more prominent role in historical explanations of scientific method and development. (shrink)

Sylvia Walsh explores Kierkegaard's understanding of Christianity and the existential mode of thinking theologically appropriate to it in the context of the ...

This article pursues the hypothesis that there is a structural affinity between the case study as a genre of writing and the question of gendered subjectivity. With John Forrester’s chapter ‘Inventing Gender Identity: The Case of Agnes’ as my starting point, I ask how the case of ‘Agnes’ continues to inform our understanding of different disciplinary approaches (sociological and psychoanalytic) to theorizing gender. I establish a conversation between distinct, psychoanalytically informed feminisms (Simone de Beauvoir, Juliet Mitchell, Judith Butler, and Denise (...) Riley) to move from the mid-20th century to contemporary cultural debate. (shrink)

Book Information A Theory of Justice: Revised Edition. By John Rawls. Oxford University Press. Oxford. 1999. Pp. xxii + 538. Hardback, £25.00. Paperback, £12.99.

The paper begins with an overview of the historical roots of philosophical hermeneutics grounded in the work of Husserl and Heidegger. It goes on to explore the philosophical hermeneutics of Hans Georg Gadamer as a philosophy useful to nursing research. The four concepts of prejudice, the fusion of horizons, the hermeneutic circle and play are discussed, as are the implications these concepts have for nursing research. These concepts have been utilized in the author's own research and examples from this research (...) are given to illuminate how these concepts can be shaped to the purposes of nursing research. While the concepts discussed stem from the work of Gadamer, the ways they have been utilized by the author do not represent a Gadamerian method. Gadamer's project is purely philosophical. (shrink)

Newton’s famous pronouncement, Hypotheses non fingo, first appeared in 1713, but his anti-hypothetical stance was present as early as 1672. For example, in his first paper on optics, Newton claims that his doctrine of light and colours is a theory, not a hypothesis, for three reasons (1) It is certainly true, because it supported by (or deduced from) experiment; (2) It concerns the physical properties of light, rather than the nature of light; and (3) It has testable consequences. Despite his (...) clear anti-hypothetical statements, a corpuscular hypothesis lies beneath Newton’s theory of colours. What are we to make of this? Is Newton guilty of feigning a hypothesis? Some writers, such as Sabre and Dear, argue that Newton’s Hypotheses non fingo is merely ‘lip-service’ to the dominant methodological tradition. Others, such as Janiak, argue that Newton’s anti-hypotheticalism is a polemic device, designed specifically to oppose his Cartesian and Leibnizian critics. I argue that, despite his corpuscular hypothesis, we should take Newton’s pronouncement as a genuine account of his methodology. I take a fresh look at Newton’s first optical papers in light of the role of hypotheses in the Baconian-experimental tradition in which Newton’s early research was conducted. I argue that Newton is working with a rough but genuine distinction between hypothesis and theory. This distinction is consistent with both the Baconian-experimental method and with his later anti-hypothetical pronouncements. I conclude that Newton did not ‘feign’ the corpuscular hypothesis. (shrink)

Recently among analytic political philosophers there has been a considerable revival of interest in the normative evaluation of the market and of economic processes more generally. While not rejecting markets in toto , philosophers such as Elizabeth Anderson and Amartya Sen have raised questions about the proper range of the market, explored the role of normative considerations in economic decision-making and raised doubts about the view that normative constraints are never legitimately placed on economic activity. In this article I experience (...) the relevance to such explorations of the economic casuistry of the medieval schoolmen. Key Words: Just Price • medieval philosophy • usury • distributive justice • Aquinas. (shrink)

Moral distress has been the subject of extensive research and debate in the nursing ethics literature since the mid-1980s, but the concept has received comparatively little attention from those working outside of applied ethics. In this article, I defend a care ethical account of moral distress, according to which the phenomenon is the product of an agent’s inability to live up to one of her caring commitments. This account has a number of attractions. First, it places a greater emphasis on (...) the importance of the relationship between the caregiver and her cared-for than that found in previous accounts. Second, it does not make problematic assumptions about the correctness of a caregiver’s moral judgments, as has been claimed in relation to previous accounts of moral distress. Finally, my account allows for a clear conceptual distinction to be drawn between moral distress and other forms of negative moral emotion such as guilt and regret. Earlier accounts draw this distinction by appealing to the causal aetiology of moral distress, but as I show here, such appeals are ultimately unsuccessful unless they are made from an explicitly care ethical starting point. One of the implications of my account is that moral distress has the potential to occur in the context of any caregiving relationship. This claim is explored in the final section of the paper, in relation to student-teacher and parent-child caregiving. (shrink)

Neoliberalism and financialization are not synonymous developments. Financialized nations are directed by particularly financialized epistemologies, cultures, and practices, not only neoliberal ones. In examining the financialization of the UK economy since the mid-1970s, this study discovers a socio-economic shift beyond the broad transition from Keynesianism towards free-market fundamentalism. Economic developments were guided by the very particular economic paradigms, discursive practices, and financial devices of the City of London, as financial elites became influential in the Thatcher governments. Five epistemological elements specific (...) to finance are discussed: the creation of money in financial markets, the transactional focus of finance, the centrality of financial markets to economic management, the orthodoxy of shareholder value, and the intensely micro-economic approach to financial calculation. Identifying these distinctions creates new possibilities for understanding financialization, elites, and the neoliberal condition that brought about both the financial crash of 2007–8 and the political and economic crises that have followed. (shrink)

This essay takes as its focus Japanese philosopher Nishida Kitar? (1870?1945) and his seminal first text, An Inquiry into the Good (or in Japanese zen no kenky?). Until now scholarship has taken for granted the predominantly Buddhist orientation of this text, centered around an analysis of the central concept of ?pure experience? (junsui keiken) as something Nishdia extrapolates from his early experience of Zen meditation. However, in this paper I will present an alternative and more accurate account of the origins (...) of this important work, a text often seen as marking the beginning of Modern Japanese philosophy. I will show that while Buddhism is an important part of Nishida's early intellectual development, there is ample biographical and textual evidence to suggest that zen no kenky? is at its core a text which attempts to solve key ethical problems via a modern interpretation of concepts drawn from the Confucian tradition. This analysis thus places the concept of ?Conduct? (koi), rather than ?pure experience?, at the center of the text, suggesting that ethics, rather than metaphysics, is the core theme of the book. (shrink)

In this paper, I develop an argument for the thesis that ‘maximality is extrinsic’, on which a whole physical object is not a whole of its kind in virtue of its intrinsic properties. Theodore Sider has a number of arguments that depend on his own simple argument that maximality is extrinsic. However, Peter van Inwagen has an argument in defence of his Duplication Principle that, I will argue, can be extended to show that Sider's simple argument fails. However, van Inwagen's (...) argument fails against a more complex, sophisticated argument that maximality is extrinsic. I use van Inwagen's own commitments to various forms of causation and metaphysical possibility to argue that maximality is indeed extrinsic, although not for the mundane reasons that Sider suggests. I then argue that moral properties are extrinsic properties. Two physically identical things can have different moral properties in a physical world. This argument is a counterexample to a classical ethical supervenience idea (often attributed to G.E. Moore) that if there is identity of physical properties in a physical world, then there is identity in moral properties as well. I argue moral value is ‘border sensitive’ and extrinsic for Kantians, utilitarians, and Aristotelians. (shrink)

This paper focuses on ethics in community-based participatory research (CBPR) from inception to post-publication. Central to CBPR is a collaborative, partnership approach that recognises the strengths of partners and engages their distinctive voice and knowledge in the research process. While the ethical complexities that arise in the course of research practice in CBPR can transcend individual projects, they are also grounded in the particularity of the project, community, and research partners. This paper reflects on the experiences of two participatory social (...) policy research projects on housing in Ireland, conducted over the past three years. These projects involved collaborating with older people living in rural areas nationwide and with residents of small communities on offshore islands. The paper explores the ethics of engagement (regarding methods of involvement and access), and the ethics of representation (incorporating the depiction and sharing of research findings) and argues that researchers must pay attention to the specificity of each project and be alive to generating an organic research ethics in how research is set up, conducted, represented, and disseminated. In so doing, we can better foster agency and authenticity in the relationships developed throughout research processes and reflect on and meet shared values and responsibilities. (shrink)

Philosophy of history is not a subject which has hitherto attracted much attention in this country. Preoccupation with the methods and achievements of the natural sciences, and distaste for the sort of rationale of history as a whole which Hegel and others offered under the title in the early nineteenth century, have served to make most British philosophers accord its problems only the most casual recognition. It is therefore all the more interesting to find an English writer of unusual powers (...) both of argument and expression, who was himself an historian of distinction in his special field, devoting a large part of his philosophical thinking to the problems of historical knowledge and their wider implications. Unfortunately, R. G. Collingwood was not able to begin the major work on philosophy of history, to writing which, as we are told in the introduction to the present book, he had looked forward for twenty-five years, until his powers were seriously affected by bad health, and he did not live to complete it. But though the full results of his thinking on the subject are lost, we are now able, thanks to the skilful work of his friend Professor T. M. Knox, to study what is in effect an extensive interim report on it. Professor Knox has produced The Idea of History largely on the basis of lectures which Collingwood prepared in 1936, supplemented by two essays already published which date from the same period and a certain amount of material from the unfinished Principles of History written in 1939. (shrink)

Ordinal analysis is a research program wherein recursive ordinals are assigned to axiomatic theories. According to conventional wisdom, ordinal analysis measures the strength of theories. Yet what is the attendant notion of strength? In this paper we present abstract characterizations of ordinal analysis that address this question. -/- First, we characterize ordinal analysis as a partition of $\Sigma^1_1$-definable and $\Pi^1_1$-sound theories, namely, the partition whereby two theories are equivalent if they have the same proof-theoretic ordinal. We show that no equivalence (...) relation $\equiv$ is finer than the ordinal analysis partition if both: (1) $T\equiv U$ whenever $T$ and $U$ prove the same $\Pi^1_1$ sentences; (2) $T\equiv T+U$ for every set $U$ of true $\Sigma^1_1$ sentences. In fact, no such equivalence relation makes a single distinction that the ordinal analysis partition does not make. -/- Second, we characterize ordinal analysis as an ordering on arithmetically-definable and $\Pi^1_1$-sound theories, namely, the ordering wherein $T\leq U$ if the proof-theoretic ordinal of $T$ is less than or equal to the proof-theoretic ordinal of $U$. The standard ways of measuring the strength of theories are consistency strength and inclusion of $\Pi^0_1$ theorems. We introduce analogues of these notions---$\Pi^1_1$-reflection strength and inclusion of $\Pi^1_1$ theorems---in the presence of an oracle for $\Sigma^1_1$ truths, and prove that they coincide with the ordering induced by ordinal analysis. (shrink)

In recent years, Early Modern Philosophy has seen frequent and urgent calls for more diverse, equitable, and inclusive teaching and research. These are calls fo.

One hundred years ago, in his lecture Science as a Vocation, Max Weber prefigured a transition from science as a calling to science as bureaucratically organized work. He argued that a calling for science is critical for sustaining scientific work. Using Weber’s arguments for science as a vocation as a lens, in this paper, we discuss whether a calling for science may become difficult to maintain in increasingly bureaucratized scientific work—and also whether such a calling is necessary for the advance (...) of science. We present empirical evidence for this bureaucratization of scientific work and further develop Weber’s discussion of science by contrasting it with the views of other theorists of science and innovation. Finally, we discuss the implications of these theories, develop a set of policy recommendations, and outline a research agenda designed to develop science policies and a sociology of science that match this shift from vocation to bureaucracy in scientific work. (shrink)

Singles are an understudied yet growing segment of the adult population. The current study aims to expand the lens of relationship science by examining the well-being of unpartnered, single adults using latent profile analysis. We recruited singles closely matched to the United States census for an exploratory cross-sectional survey using five variables that strongly predict well-being. All five variables significantly predicted life satisfaction for the full sample. Latent profile analyses detected 10 groups of singles. Half of the profiles were happy (...) and half of the profiles were unhappy. Each profile had its own unique patterns relating to personal relationships, self-esteem, and personality traits. The happiest profile had the best relationships, self-esteem, and personality, while the unhappiest profile had the worst relationships, self-esteem, and personality. The profiles in between these two extremes had more nuanced patterns. For example, one relatively happy profile in the middle had high friendship satisfaction but low family satisfaction, while an adjacent profile showed the opposite pattern. Overall, singles who had positive relationships—both with themselves and others—were happiest. (shrink)

While French biologists were turning a cold shoulder to On the Origin of Species in the 1860s, Charles Darwin was earnestly pursuing a professional connection with one French physiologist in particular: Charles Brown-Séquard. Darwin had been closely following Brown-Séquard’s startling experiments on guinea pigs, which demonstrated that experimentally induced epilepsy could pass from parent to offspring. In Darwin’s mind, Brown-Séquard had produced the most convincing evidence to date that acquired traits could be inherited. Darwin saw opportunities in Brown-Séquard and his (...) work. If Brown-Séquard realized the evolutionary implications of his experiments, and then endorsed the Origin in Paris, Darwin could be well on his way to securing a French audience for his theories. Darwin quickly mobilized his powers of correspondence to make this French connection, but Brown-Séquard received Darwin’s advances with caution. A connection with Darwin could be useful in London and America, where he was increasingly spending time, but to publicly support Darwin would be professionally damaging back home in Paris. This paper examines the dance of letters between Darwin and Brown-Séquard, the politics of citation, and the delicacy of sustaining a transnational biological career between France and Britain in the 1860s. This paper casts a new perspective on an old debate in the history of biology. I show that from within the “heavy cloud” of anti-evolutionary thought in France, there existed a live wire between Brown-Séquard and Darwin. I argue that British evolutionary theory in the age of Darwin was built, in part, with French participation. (shrink)

Aristotle’s best human life is attained through theoretical contemplation, and Confucius’ is attained through practical cultivation of the social self. However, I argue that in the best human life for both Confucius and Aristotle, a form of theoretical contemplation must occur and can only occur with an ethical commitment to community life. Confucius, like Aristotle, sees that the best contemplation comes after later-life, greater-learning and is central to ethical and community life. Aristotle, like Confucius, sees the best contemplation as presupposing (...) full ethical commitment to community life. So, I argue for the theses that: on Aristotle’s view, the best human contemplation requires one be fully morally good; on Confucius’ view, to be fully morally good requires the best human contemplation; being fully morally good for both requires commitment to the good of others and the community. (shrink)

The aim of this article is to address the recently renewed debate pertaining to esotericism, secret messages encoded within writings from antiquity, especially in the writings of Plato. The question of esotericism has assumed a prominent role within debates concerning the history of political thought. Ever since Leo Strauss offered his suspicion that there were secrets ‘buried in the writings of the rhetoricians of antiquity’, the idea that philosophers deliberately concealed their true beliefs in a way that few could detect (...) has been fiercely debated. More recently, the research of J.B. Kennedy has made international headlines for discovering a musical pattern embedded within Platonic writings, a pattern that Kennedy insists is evidence of Plato’s Pythagorean allegiance. The theses proffered by Strauss and Kennedy are empty doctrines of esotericism, or empty esotericisms. These doctrines insinuate the presence of secret or coded writing within Platonic dialogues but reveal no actual secret. These theses of esotericism falsely represent Plato as hyper-cryptic.Without actually providing substantive content, these notions of esotericism compel the reader to merely negate the exoteric writings of Plato, which actually render his already heterodox writings as commonplace and orthodox. (shrink)

La entrevista recorre conceptos como “las geopolíticas del conocimiento” aplicada a América Latina y postula que la región es un producto geopolítico fabricado e impuesto por la “modernidad”, donde “América Latina” se fue fabricando como algo desplazado de la modernidad; o a la filosofía, que se narra de Grecia a Europa, quedando todo el resto del planeta fuera de la historia de la filosofía. Invita el entrevistado a dejar de pensar que lo que vale como conocimiento está en ciertas lenguas (...) y viene de ciertos lugares. Recorre desde este enfoque temas como la infección recíproca entre cosmología indígena y cosmología marxista; la distinción entre "interculturalidad" y "multiculturalidad.", y la re-articulación del poder en la "cuarta guerra mundial.". (shrink)

Lea & Webley (L&W) provide two alternative biological accounts of human monetary motivations, the Tool Theory and the Drug Theory. They argue that both are required for an adequate explanation. I explore the applicability of these models to philosophical discussions of how we might justify such motivations. I argue their approach is not entirely satisfactory for normative questions, since it precludes the possibility of rational non-instrumental attitudes towards money. (Published Online April 5 2006).