Precision medicine and molecular systems medicine (MSM) are highly utilized and successful approaches to improve understanding, diagnosis, and treatment of many diseases from bench-to-bedside. Especially in the COVID-19 pandemic, molecular techniques and biotechnological innovation have proven to be of utmost importance for rapid developments in disease diagnostics and treatment, including DNA and RNA sequencing technology, treatment with drugs and natural products and vaccine development. The COVID-19 crisis, however, has also demonstrated the need for systemic thinking and transdisciplinarity and the limits (...) of MSM: the neglect of the bio-psycho-social systemic nature of humans and their context as the object of individual therapeutic and population-oriented interventions. COVID-19 illustrates how a medical problem requires a transdisciplinary approach in epidemiology, pathology, internal medicine, public health, environmental medicine, and socio-economic modeling. Regarding the need for conceptual integration of these different kinds of knowledge we suggest the application of general system theory (GST). This approach endorses an organism-centered view on health and disease, which according to Ludwig von Bertalanffy who was the founder of GST, we call Organismal Systems Medicine (OSM). We argue that systems science offers wider applications in the field of pathology and can contribute to an integrative systems medicine by (i) integration of evidence across functional and structural differentially scaled subsystems, (ii) conceptualization of complex multilevel systems, and (iii) suggesting mechanisms and non-linear relationships underlying the observed phenomena. We underline these points with a proposal on multi-level systems pathology including neurophysiology, endocrinology, immune system, genetics, and general metabolism. An integration of these areas is necessary to understand excess mortality rates and polypharmacological treatments. In the pandemic era this multi-level systems pathology is most important to assess potential vaccines, their effectiveness, short-, and long-time adverse effects. We further argue that these conceptual frameworks are not only valid in the COVID-19 era but also important to be integrated in a medicinal curriculum. (shrink)

How does one arrive at a life in politics and policy? What happens to one's ideals when confronted with the reality that the only way to get things done in Washington is compromise? Who are the men and women who help shape our national agenda, and what drives their work? Dispatches From the Eastern Front provides fascinating, intensely personal, yet universal answers to these central questions. Recounting four decades inside Washington politics, Gerald Felix Warburg brings remarkable candor to a (...) most unusual memoir. An idealistic California baby boomer transported to the intimidating world of Capitol Hill policymaking at a young age, Warburg finds himself working to reform nuclear energy, strategic arms control, and foreign policy. As his access and power grow, greater challenges loom: how to maintain principles while cutting deals, and how to balance public purpose with private interests. An eclectic career reveals the slow and often painful development of emotional intelligence for work at the highest reaches of the public arena. (shrink)

Classical realism and Morgenthau in particular have recently experienced a revived interest in International Relations (IR). The evolving debate has helped to contextualise and reconstruct Morgenthau's thought which until now had been misrepresented in structural realist and early poststructuralist interpretations. However, despite all of its achievements, we have yet to draw more attention to Morgenthau's contribution to contemporary IR theory. To contribute to the closing of this research gap this article considers a set of questions which Morgenthau himself asked at (...) the beginning of his career as its conceptual framework. It is argued that Morgenthau was particularly concerned with the dehumanisation of socio-political life in modern democracies evoked through processes of ideologisation, technologisation, and scientification, which he countered by focusing on a re-introduction of the human factor to politics. This demonstrates that Morgenthau's work is a rich source for IR theory because his intellectual agenda was driven by concerns similar to what we find in poststructuralism. (shrink)

Este artigo visa analisar de que modo as questões pertinentes à situação do Paraguai do Pós-Guerra da Tríplice Aliança serviram de instrumento de luta político-partidária entre nacionalistas e autonomistas durante a campanha presidencial argentina de 1873 e 1874. Para isso, foram consultados alguns jornais de Buenos Aires, uma vez que eram os principais canalizadores dos debates públicos e difusores de representações. Da análise das fontes pode-se apontar que a facção autonomista fez daquele conflito, da ocupação do Paraguai e das questões (...) pendentes daquele evento uma das suas principais armas de combate em sua luta eleitoral contra o nacionalismo. (shrink)

People partaking in a conversation can add to the common ground of said conversation by performing different speech acts. That is, they can influence which propositions are presumed to be shared among them. In this paper, I am going to apply the common ground framework to the phenomenon of epistemic injustice. In doing so, I am going to focus on two kindsof speech acts: making assertions and asking certain kinds of questions. And I am going to look at three varieties (...) of epistemic injustice: testimonial injustice, inquiring injus-tice and interpretative injustice.I am going to argue that what all these varieties of epistemic injustice have in common is that they unfairly inhibit the speaker’s ability to add to the common ground in the way intended by her. This in turn negatively affects which con-versational roles a speaker can play in a given conversation. Based on these results, I am going to end by looking at some of the harms that epistemic injustice inflicts upon its victims. (shrink)

McGarvey (Econometrica, 21(4), 608–610, 1953) has shown that any irreflexive and anti-symmetric relation can be obtained as a relation induced by majority rule. We address the analogous issue for dominance relations of finite cooperative games with non-transferable utility (coalitional NTU games). We find any irreflexive relation over a finite set can be obtained as the dominance relation of some finite coalitional NTU game. We also show that any such dominance relation is induced by a non-cooperative game through β-effectivity. Dominance relations (...) obtainable through α-effectivity, however, have to comply with a more restrictive condition, which we refer to as the edge-mapping property. (shrink)

What is salvific community for Ignatius of Loyola? It is communion with Christ, a dynamic for which Ignatius used the expression ‹societies Jesu›. This wording has a revealing intertextuality. ‹Societas› is the Vulgate’s rendering of Pauline and Johannine koinōnia: «sharing in (Christ)». The NT overtones of the Ignatian experience of communion can be explored regarding a theology of relationship (person), of action (history) and of the Church (representation). Being a person is understood as being friend and servant, history as the (...) salvific kairos of Christ’s activity, and the Church as the communion representing him—each time a typically Christian conception deciding always for that option that cannot be generalised through abstraction. (shrink)

The article analyses the problems and possibilities in saying that Judaism, Christianity and Islam ‹have the same God›.

São duas as obras de Foucault privilegiadas neste estudo: As palavras e as coisas, de 1966, e Nascimento da biopolítica, de 1979. Uma das razões pelas quais é possível criar linhas diagonais de interpretação entre estes dois momentos da obra de Foucault é que em ambos os textos ele se debruça sobre a economia política de Smith, com um rigor tamanho que nos pareceu possível extrair daí o esboço de uma breve história do pensamento econômico. O objetivo deste artigo é (...) esboçar esta história, definir as condições de emergência da economia política na epistèmê moderna, entender simultaneamente em que medida a economia assumirá a função de base de cálculo que irá impor à razão governamental moderna uma modalidade nova de limitação dos seus desígnios. (shrink)

Latin American integration, and particularly Caribbean integration is an urgent matter in both practice and theory, one that concerns not only economists, but jurist and historians. It requires a debate around themes of culture, identity and diversity. In this essay, the idea that culture identity ..

:Es preciso fijar nuestra atención en los principales supuestos que implica la declaración de Derechos Humanos, especialmente respecto de aquellos que actualmente se encuentran bajo una discusión controvertida dentro del campo de la filosofía. En este trabajo, el autor, de acuerdo con las ideas de las diferentes declaraciones de Derechos Humanos, sostiene que estos no son sólo un instrumento jurídico positivo, sino también, y principalmente, un elevada conquista humana basada en el descubrimiento y reconocimiento de la dignidad y del valor (...) inherentes en toda persona humana. Los derechos humanos son el resultado de una larga tradición de gente que lucho en favor del ser humano, en todas las sociedades y en todo momento de la historia de la humanidad. Los Derechos Humanos son universales, y todo gobierno ha de protegerlos y defender su total observancia. La persona humana es el sujeto central de los Derechos Humanos, por lo que se considera que es pura confusión hablar de los derechos de animales. El derecho de la gente a autodeterminarse, como una parte de los Derechos Humanos, se aplica solamente en las situaciones particulares de poblaciones en situaciones coloniales u otras formas de dominación extranjera. Los Derechos Humanos también implican un alto nivel de virtudes, y el reconocimiento de los seres humanos como miembros de una comunidad que hace posible que exista la persona humana. Aunque se suelen centrar en las dimensiones políticas y sociales de la vida humana, también pueden ser perseguidos en pro de la felicidad, de la paz, la democracia, la justicia, la igualdad, el pluralismo, en definitiva, como mejor nivel de vida y de solidaridad. Ahora bien, existe un problema práctico que reclama nuestra unión: crear las condiciones sociales, políticas, económicas y culturales que hagan posibles los objetivos de la declaración de Derechos Humanos. (shrink)

En este artículo se trata la formalización del poder político de las nuevas dinastías (msñik al-fawd'~fjl que gobemaron en al-Andalus tras la desaparición del califato omeya. Para ello se ha tenido en cuenta el análisis de las inscripciones que aparecen en las monedas emitidas por estas dinastías, específicamente la de los 'Amiríes instalados en Denia, que acuñaron primeramente en Etola y treinta años después en la misma Denia yen Mallorca. Tanto las variables inscripciones reconociendo la autoridad de un imóm, como (...) los nombres inscritos de miembros de las familías gobemantes o del séquito palatino revelan de manera conspicua esta nueva legalidad, finalmente cuestionada. (shrink)

This work intends to point out the role that the idea of God has in Cartesian morals. Both the conception of a God responsible of an universal rational order and the solution to evil question are the grounds for the idea of happiness related to the virtue understood as rational control of passions. Devotion, passion derived from love, is considered by Descartes as the most useful passion that man can experience, as it contributes to the strengthening of the thinking subject, (...) to the so-called ‘generosity’, the true objective of Cartesian ethics. (shrink)

El presente artículo pretende acercarse a la propuesta de una concepción republicana de la ética empresarial realizada por la Escuela de Erlangen que se ha convertido en una referencia ineludible a nivel europeo. Esta propuesta, fundamentada en el constructivismo de la Escuela de Erlangen y la ética del discurso de la Escuela de Frankfurt, empezó a fraguarse a finales de los años ochenta en Alemania y define a la empresa como una institución con responsabilidades y deberes públicos. Con este artículo (...) se pretende mostrar una concepción de la ética empresarial sólida y coherente, tanto desde el punto de vista teórico como práctico, dada su capacidad de integrar las exigencias éticas con los aspectos organizativos, su proximidad a la praxis y su sistematicidad. The main purpose of this paper is to present the proposals of the Erlangen School for a republican conception of business ethics, which has become a key reference in the European context. Republican business ethics, based on the constructivism of the Erlangen School and the discourse ethics of the Frankfurt School, began to take shape at the end of the eighties in Germany and defines the company as "an institution with public responsibilities and duties". Throughout this article I will attempt to present a solid and coherent conception of business ethics, from both the theoretical and the practical points of view. Republican business ethics is capable of integrating ethical claims with organizational aspects, it comes close to praxis and it is systematic. (shrink)

Le réflexe est un mouvement naturel et spontané qui semble dépourvu de teneur morale car il ne relèverait pas de la responsabilité du sujet. Il est ce qui échappe à la maitrise du corps et à la civilité des mœurs. Le mauvais réflexe se produit lorsque le corps réagit trop vite, emporté par la colère ou la situation dans un temps plus rapide que celui de la conscience réfléchie : le temps du corps vivant est en avance, par anticipation motrice, (...) sur celui de la conscience du corps vécu. Relire avec les yeux de Georges Canguilhem le coup de tête de Zidane, mauvais réflexe face aux insultes de son adversaire en finale de la Coupe du monde de football de 2006, montrera de quelle façon la nervosité, de Descartes à l’électrophysiologie moderne, sert d’argument à une causalité neurophysiologique du mauvais réflexe. (shrink)

Roger Boscovich, belonging to XVIII century, halfway from Newton to Faraday, is traditionally considered as a newtonian philosopher. Nevertheless, following Berkson’s suggestion, he could be a Field Theory forerunner. In this work, we will try to go on with the idea of this suggestion in order to show this possible Boscovich’s contribution.

How does Christian philosophy address phenomena in the world? Felix Ó Murchadha believes that seeing, hearing, or otherwise sensing the world through faith requires transcendence or thinking through glory and night. By challenging much of Western metaphysics, Ó Murchadha shows how phenomenology opens new ideas about being, and how philosophers of "the theological turn" have addressed questions of creation, incarnation, resurrection, time, love, and faith. He explores the possibility of a phenomenology of Christian life and argues against any simple (...) separation of philosophy and theology or reason and faith. (shrink)

La psicología y los psicólogos han dedicado bastante esfuerzo para conseguir una comprensión mejor y más profundea de las emociones y los sentimientos. Roberto Colom con sus respuestas nos ofrece una visión de primera mano de todas esas aportaciones así como el punto de vista de un psicólogo sobre el valos y la importancia de las emociones, los sntimientos y la vida afectiva en general para la personalidad humana.

Sebastian Grève interviews Felix Mühlhölzer on his work on the philosophy of mathematics.

This collection of original essays on political and legal theory concentrates on themes dealt with in the work of Felix Oppenheim, including fundamental political and legal concepts and their implications for the scope of morality in politics and international relations. Among the issues addressed are the relationship between empirical and normative definitions of "freedom", "power", and "interests", whether governments are free to act against the national interest, and whether they can ever be morally obliged to do so.

Both the sound and the sea are characterized by a constant fluidity and transformation, which has been considered as a creative foundation for expanded sonic practices that identify, capture and experiment with natural elements. The text aims to explore how the idea of sonification as a process of translating qualities and data into sound constitutes the departure point towards contemporary sound practices that encourage deeper listening and immersive experiences. Taking the sea-responsive sound installations of French artist Félix Blume, Rumors from (...) the Sea and Suspiros as a foundation, the article presents a reflective conversation between Félix Blume and Bill Psarras on aspects of such artworks that highlight ideas of sea and limens, listening experience, sound ecology and sonic instruments through performative, inventive and participatory lenses. (shrink)

Schizoanalytic Cartographies represents Félix Guattari's most important later work and the most systematic and detailed account of his theoretical position and his therapeutic ideas. Guattari sets out to provide a complete account of the conditions of 'enunciation' - autonomous speech and self-expression - for subjects in the contemporary world. Over the course of eight closely argued chapters, he presents a breathtakingly new reformulation of the structures of individual and collective subjectivity. Based on research into information theory and new technologies, Guattari (...) articulates a vision of a humanity finally reconciled with its relationship to machines. Schizoanalytic Cartographies is a visionary yet highly concrete work, providing a powerful vantage point on the upheavals of our present epoch, powerfully imagining a future 'post-media' era of technological development. This long overdue translation of this substantial work offers English-speaking readers the opportunity finally to fully assess Guattari's contribution to European thought. (shrink)