Numerous mediators are involved in both the control and the transmission of nociceptive messages, and several lines of research have been developed in the management of pain. Complete enkephalin- degrading enzyme inhibitors, which produce naloxone-reversible analgesia in all tests where morphine has been found to be active, remains the most promising way. CCK compounds, especially the CCKB antagonists also may be interesting drugs. Indeed, they are able to strongly potentiate the antinociceptive effects of the opioids. [dickenson, wiesenfeld-hallin et al.].

Resumen El artículo revisa los discursos de viaje dentro de dos relatos escritos por mujeres durante el período imperialista del fin de siècle, quienes viajaron por espacios marginales a la modernidad. La primera autora es Florence Dixie, noble inglesa que escribe su relato de viaje a la Patagonia durante 1879, mientras que Iris, mujer igualmente aristócrata y chilena, escribe su periplo realizado por el lago Ranco en 1910. Independiente de la nacionalidad de origen de estas mujeres y sus (...) diferencias personales, en tanto el rol jugado por ellas en el grupo de expedición, ambas escritoras viajeras son depositarias de una mirada imperial, que se vuelca en la manera que se internan narrativamente por los espacios explorados.The article reviews the journey discourses in two narratives written by two women during the imperialist period of the fin de siècle, who traveled through marginal spaces to modernity. The first author is Florence Dixie, an English noblewoman who writes her travelogue to Patagonia during 1879, while Iris, an equally aristocratic, and Chilean woman, writes her journey made through Ranco lake in 1910. Independent of nationality of origin of these women and their personal differences, as long as the role played by them in the expedition group, both traveling writers are repositories of an imperial gaze, that shows in the way they go into theirs narrative through the spaces explored. (shrink)

The Decameron was written in the wake of the Black Death, a shattering epidemic which had shaken Florence's confident entrepreneurial society to its core. In a country villa outside the city, ten young noble men and women who have escaped the plague decide to tell each other stories. Boccaccio's skill as a dramatist is masterfully displayed in this virtuoso performance of one hundred tales, vivid portraits of people from all stations in life, with plots which revel in a (...) bewildering variety of human reactions. Themes are playfully restated from one story to another within an elegant and refined framework. One of Chaucer's most fruitful sources for the Canterbury Tales, Boccaccio's work artfully combines the essential ingredients of narrative: fate and desire, crises and quick-thinking. This new translation by Guido Waldman captures the exuberance and variety and tone of Boccaccio's masterpiece. ABOUT THE SERIES: For over 100 years Oxford World's Classics has made available the widest range of literature from around the globe. Each affordable volume reflects Oxford's commitment to scholarship, providing the most accurate text plus a wealth of other valuable features, including expert introductions by leading authorities, helpful notes to clarify the text, up-to-date bibliographies for further study, and much more. (shrink)

This epic piece of storytelling brings the world of fifteenth-century Italy to life as it traces Machiavelli's rise from young boy to controversial political thinker. The often-vilified Renaissance politico and author of The Prince comes to life as a diabolically clever, yet mild mannered and conscientious civil servant. Author Joseph Markulin presents Machiavelli's life as a true adventure story, replete with violence, treachery, heroism, betrayal, sex, bad popes, noble outlaws, deformed kings, menacing Turks, even more menacing Lutherans, unscrupulous astrologers, (...) untrustworthy dentists--and, of course, forbidden love. While sharing the stage with Florence's Medici family, the nefarious and perhaps incestuous Borgias, the artists Leonardo da Vinci and Michelangelo, and the doomed prophet Savonarola, Machiavelli is imprisoned, tortured, and ultimately abandoned. Nevertheless, he remains the sworn enemy of tyranny and a tireless champion of freedom and the republican form of government. Out of the cesspool that was Florentine Renaissance politics, only one name is still uttered today--that of Niccolo Machiavelli. This mesmerizing, vividly told story will show you why his fame endures. (shrink)

As we navigate post-pandemic educational recovery and future-oriented design, the Handbook of Research in Online Learning: Insights and Advances emerges as a scholarly authority to illuminate existing questions and catalyze conversations on imperative transformations in education. Tailored for researchers, designers, educators, administrators, and stakeholders, this handbook delves into the nuanced landscape of online learning. Curated by leading experts, each chapter provides a deep exploration of critical online teaching and learning dimensions. Whether you're navigating the complexities of instructional design, exploring the (...) impact of digital learning on diverse student populations, or delving into the transformative potential of AI, each chapter illuminates critical aspects of online education. It merges current significant works with unpublished manuscripts, embodying the interdisciplinary essence of online learning research. Grounded in diverse theoretical frameworks and research methods, it offers theoretical insights and actionable guidance for cutting-edge educational methodologies. This handbook is not just a compendium; it's an indispensable guide for shaping the future of education. Contributors are: Michael Ahlf, Stephen Allen, Tonya Amankwatia, Fatih Ari, Ismahan Arslan-Ari, Michael K. Barbour, Gail Alleyne Bayne, Karen Bellnier, M. Aaron Bond, Victoria Brown, George Bradford, William Cain, Sumie Chan, Lauren Cifuentes, Laura DaVinci, Gina Deckard, Shernette Dunn, Anne Fensie, Holly Fiock, Sara Flowers, Carla Karen Fortune, Theodore Frick, Michael M. Grant, Alexis Guethler, Dan He, Atsusi "2c" Hirumi, Charles B. Hodges, Stephanie Hostetter, Michael Houdyshell, Fethi A. Inan, Frank Jamison, Amir Kalan, Meryl Krieger, Jessica Lantz, Mary Lefaiver, Juhong Christie Liu, Noble Lo, Barbara Lockee, Fatemeh Marzban, Trey Martindale, Sara McNeil, Laura McNeill, Stephanie Moore, Martha Lorena Obermeier, Larisa Olesova, Jennifer Jihae Park, Sanghoon Park, Yujin Park, AnthTony Pina, Drew Polly, Yingxiao Qian, Thomas Reeves, Christiane Reilly, Jennifer Richardson, Aubrey Rogowski, Leanne Rutherford, Kay Seo, Sanga Song, Edwin Teye Sosi, Stefan Stenbom, Sharon Stidham, David Tai, Hengtao Tang, Torrey Trust, Shannon Tucker, Denis Unal, Lucas Vasconcelos, Charles Xiaoxue Wang, Florence Williams, Ying Xie and Fan Xu. (shrink)

Is the 20th Century as obviously preferable to all other times as Rawls would have us assume? Is 20th Century Stockholm preferable to 12th Century Florence in each and every way? In 12th Century Florence men lived without liberty or equality. Yet Florentines were reasonably happy, accepted their place in life, and communicated directly with others. R. Dworkin, ‘The Social Contract’, The Sunday Times, 9 July 1972, p. 31. It was a society with sharply marked class distinctions. In (...) such a society the lowly can gain more self-respect through identity, excellence, and capacity within their station than in an egalitarian society. The lowly can perceive the importance of their labour, be secure that their place is assured by powerful protectors, see models of virtue to admire, and derive a sense of contributing to a meangingful social drama. They may also learn something of the difference between the noble and the ignoble. Are these not qualities Aristotle would appreciate? Medieval man was certainly not free but 'sneither was he alone and isolated ... Man was rooted in a structuralized whole, and thus life had a meaning which left no place, and no need, for doubt.Eric Fromm, Escape From Freedom (New York: Rinehart, 1941), p. 41. In a brief reference to feudalism Rawls himself seems to realise this state of affairs (74). In contrast, Stockholm is a competitive society where loneliness, anxiety, and identity crises have been endlessly documented by social scientists, all occurring despite the high material standard of living. Yet Stockholm would seem to be the model for Rawls and obviously not Florence. One wonders if this social scientific knowledge of Stockholm will be part of the knowledge available to persons in the original position.One critic lauds Rawls's grasp of the social sciences, but perhaps he is not serious, see Hugo Bedau, ‘Rawls’, Nation, 11 September 1972.Justice is not quantitative but qualitative, so Aristotle might say in a brief discussion. In a just society a person's possessions and consumptions are not on the minds of the other people with whom they meet and treat. When Odysseus came home he was delighted to climb into a peasant's cart to ride the last mile home. Contrast this king with King Arthur riding with another peasant on another road, choking with the anxiety that he may not be acting kingly by being in the cart. In Ithaca both king and commoner were sure of each other and, more importantly of themselves. (shrink)

Introduction Les femmes n'ont eu véritablement accès au pastorat dans les Églises protestantes françaises qu'en l966. Certes, une femme avait été consacrée en 1948, mais à condition de rester célibataire et sans enfants. Celles qui dans les années suivantes exercèrent exceptionnellement la fonction pastorale ne furent pas consacrées. L'accès des femmes au ministère féminin vient couronner de succès les efforts de plusieurs générations de partisans de l'égalité des sexes au sein du pro..

Have I made a mistake in my Anarchism, or has the editor of Liberty himself tripped? At any rate, I must challenge the Anarchism of one sentence in his otherwise masterful paper upon 'State Socialism and Anarchism.' If I am wrong, I stand open to conviction. It is this. 'They [Anarchists] look forward to a time...when the children born of these relations shall belong exclusively to the mothers until old enough to belong to themselves.'.

What is Life? This is the question asked by Denis Noble in this very personal and at times deeply lyrical book. Noble is a renowned physiologist and systems biologist, and he argues that the genome is not life itself: to understand what life is, we must view it at a variety of different levels, all interacting with each other in a complex web. It is that emergent web, full of feedback between levels, from the gene to the wider (...) environment, that is life. (shrink)

"An impressively reasoned and startlingly unorthodox treatise on religion." - Belles Lettres Florence Nightingale (1820-1920) is famous as the heroine of the Crimean War and later as a campaigner for health care founded on a clean environment and good nursing. Though best known for her pioneering demonstration that disease rather than wounds killed most soldiers, she was also heavily allied to social reform movements and to feminist protest against the enforced idleness of middle-class women. This original edition provides bold (...) new insights into Nightingale's beliefs and a new picture of the relationship between feminism and religion. Suggestions for Thought to the Searchers after Truth Among the Artisans of England (1860), which contains the novel Cassandra , is a central text in 19th-century history of feminist thought and is published here for the first time. Nightingale argues that work was the means by which every individual sought self-fulfillment and served God. She wrote influentially about the group most Victorians declared to be above work: unmarried, middle-class women. (shrink)

The extensive range and depth of the twenty commentaries on my target article confirms that something has gone deeply wrong in biology. A wide range of biologists has more than met my invitation for “others to pitch in and develop or counter my arguments.” The commentaries greatly develop those arguments. Also remarkably, none raise issues I would seriously disagree with. I will focus first on the more critical comments, summarise the other comments, and then point the way forward on what (...) I view as a necessary and long-overdue transition in the foundations of biology. (shrink)

Background Seeking assent from children for participation in medical research is an ethical imperative of numerous institutions globally. However, none of these organizations provide specific guidance on the criteria or process to be used when obtaining assent. The primary objective of this scoping review was to determine the descriptions of assent discussed in the literature and the reported criteria used for seeking assent for research participation in pre-adolescent children. Methods Medline and Embase databases were searched until November 2020 using the (...) term “assent” in the title or abstract. Inclusion criteria were (1) studies enrolling children which specifically described operationalization of the assent process and (2) studies of the assent process which provided a description of assent. Data collected included participant information, patient criteria for seeking assent, guidelines referenced, description of assent reported, how assent was obtained and assent information presented, and reported assent rate. For qualitative articles focusing on the assent process, important themes were identified. Results A total of 116 articles were included of which 79 (68.9%) operationalized assent and 57 studies (%) described the assent process. The most commonly reported criterion used to determine the ability of a child to assent was age (35.4%, 28/79). The reported minimal age for obtaining pediatric assent varied considerably across and within jurisdictions (5–13 years; median 7.5 years, IQR 7.0, 9.75). Cognitive ability was reported as a criterion for obtaining assent in 5.1% (4/79) of studies. Assent rates were only reported in 17.7% (14/79) of citations and ranged from 32.0 to 100%. Analysis of the 57 studies describing the assent process identified several themes, including age thresholds, assessment of capacity, variable knowledge of pediatric assent and parental roles. Conclusion We found significant variation in criteria used for assessment of patient capacity, delivery of information used to obtain assent and documentation of the assent process. While we acknowledge that individual children, settings and jurisdictions may require different approaches to obtaining assent, there should be agreement on important principles to be followed with resulting common guidance on assessing capacity, delivering information and documentation of the assent process for publication. (shrink)

Que vient révéler une grossesse en adolescence? Derrière cette question mettant en scène plusieurs personnages (certains dans les coulisses) se cachent plusieurs générations, des couples, la famille au sens intergénérationnel et aussi parfois au sens transgénérationnel. Comment penser ces fécondations qui entraînent des grossesses – à interrompre? à poursuivre? Quelles places pour les sujets, les couples et les familles? Trente ans d’expérience en centre de planification et d’éducation familiale nourrissent le questionnement dont l’auteur fait part dans cet article.

Although informed consent models for prescribing hormone replacement therapy are becoming increasingly prevalent, many physicians continue to require an assessment and referral letter from a mental health professional prior to prescription. Drawing on personal and communal experience, the author argues that assessment and referral requirements are dehumanising and unethical, foregrounding the ways in which these requirements evidence a mistrust of trans people, suppress the diversity of their experiences and sustain an unjustified double standard in contrast to other forms of clinical (...) care. Physicians should abandon this unethical requirement in favour of an informed consent approach to transgender care. (shrink)

What is Life? To answer this question, Denis Noble argues that we must look beyond the gene's eye view. For modern 'systems biology' considers life on a variety of levels, as an intricate web of feedback between gene, cell, organ, body, and environment. He shows how it is both a biologically rigorous and richly rewarding way of understanding life.

Florence Chiew interviews Maurizio Meloni on his new book, Impressionable Biologies: From the Archaeology of Plasticity to the Sociology of Epigenetics. The conversation reflects on a number of key themes and arguments in Meloni’s work, such as the use of the term ‘impressionability’ to explore longstanding ideas of the permeable body in constant flux in response to cosmological changes. This notion of the body-porous is one whose history Meloni traces back to ancient traditions and systems of medicine, such as (...) humoralism. In this important book, Meloni makes a compelling argument for questioning the current emphasis on the novelty of biological plasticity as an exclusively contemporary phenomenon, and urges us to take a longer genealogical perspective to appreciate how histories of corporeal plasticity have always been part of deeply gendered, racialized and classed discourses in which social hierarchies have been made through physiological distinctions. (shrink)

Research on racism in the workplace has long focused on organizational remedies for this moral problem. Given the acknowledged inadequacies of organizational solutions such as anti-racism training, attention is now turning to how immigrants manage their individual experiences of racism in a western context. Employing an agentic lens, this article describes a qualitative study of 43 African nurses in the UK in which their capacity for withstanding workplace racism is examined. It investigates how participants draw upon a range of religious (...) coping strategies to make sense of and respond to racism. The data indicate that African nurses rely on specific coping strategies at different points in time and across various contexts, adapting their coping approaches to accommodate their personal growth and individual experiences. This underscores the versatility, context-dependency, and temporal aspects of religious coping among immigrants. The study’s findings are particularly interesting given the limited role that religion plays in western organizations. (shrink)

Assessment, new techno-scientific muse, which pilots the structural system reform and the style of management in schools today with hope of a greater efficiency, withdraws humanity to pedagogical practices and develop a anxiety’s climate, not conducive to learning. This impasse of desire, by a « case-file child » logic, threatens the very symbolic structures and the construction of thought. This perverse cycle uncovers the obscure side to good intentions, echoing the historical past of the Occident.

In recent years, the long-standing questions of why, how, and which farm families continue farming in the face of ongoing changes have increasingly been studied through the resilience lens. While this body of work is providing updated and novel insights, two limitations, a focus on macro-level challenges faced by the farm operation and a mismatch between the scale of challenges and resilience measures, likely limit our understanding of the factors at play. We use the example of medical economic vulnerability, a (...) micro-level challenge traditionally confined to the household sphere of the agri-family system, as a way to call attention to these limitations. Focusing on United States farm households, we assess: To what extent are they experiencing medical economic vulnerability when using objective and subjective outcome measures? Which demographic and farm characteristics are associated with experiencing medical economic vulnerability? What is the association between institutional arrangements and medical economic vulnerability? Our analysis of over 900 surveys coupled with a conceptual framework merging complementary insights from three bodies of literature revealed seemingly large differences in the prevalence of medical economic vulnerability across the objective and subjective measures with the subjective measure indicating a general sentiment of medical economic vulnerability in a majority of respondents. Conversely, limited variations were noted in who experiences medical vulnerability on the basis of demographic and farm characteristics, with stronger associations being connected to the households’ health insurance arrangements. We conclude with three implications of our findings for the farm resilience literature. (shrink)

This is an open access title available under the terms of a CC BY NC ND 4.0 International license. It is free to read at Oxford Scholarship Online and offered as a free PDF download from OUP and selected open access locations. In Contentious Minds, Florence Passy and Gian-Andrea Monsch explain how cognitive and relational processes allow activists participate in and sustain their commitment to activism. Based on a wide array of survey and interview data with activists engaged in (...) protest, volunteering and unions, they highlight how a commitment community develop shared values, identities, and meanings through interaction. (shrink)

Despite 40-year-old evidence of childcare challenges limiting women’s participation in agriculture in the United States, it was not until a major societal crisis, COVID-19, that farm organizations and policy makers began to recognize that these challenges negatively impact the farm enterprise. Among farm persistence and farm transition scholars, farm households’ social and economic needs, including childcare, have also been underappreciated despite the constant exchange of time, money, and energy between the farm household and the enterprise. We use survey responses from (...) 729 U.S. farm families to understand how children and their childcare needs shape the farm enterprise and the extent to which childcare arrangements, farm individuals and households, and farm enterprise characteristics interact with these decisions. A high proportion of respondents made changes to adapt to the needs of children with the greatest impact on farm productivity, followed by impact on the structure of labor on- and off- the farm, and impact on the farm enterprise structure. These impacts likely have short- and long-term consequences on the trajectory of the farm enterprise and well-being of the household. Different decisions required a different calculus and the trade-offs that respondents considered were shaped by access to a support system, access to financial resources, and specific needs of the children. Last, the limited variations across the four decisions for a number of farm individual and household characteristics hint both at the universality of being a farm parent needing to constantly adapt amid high rates of childcare challenges and inadequate social safety nets. We conclude our article by discussing the implications of our findings along with future research avenues. (shrink)

As global warming continues to attract growing levels of attention, various stakeholders have put climate change on corporate agendas and expect firms to disclose relevant greenhouse gas information. In this paper, we investigate the consistency of the GHG information voluntarily disclosed by French listed firms through two different communication channels: corporate reports and the Carbon Disclosure Project. More precisely, we contrast the amounts of GHG emissions reported and the methodological explanations provided in each channel. Consistent with a stakeholder theory perspective, (...) we find that GHG amounts are significantly lower in the CR than in the CDP. We also find that firms increase the CR figures’ traceability when there is a discrepancy between disclosures in the two channels. We suggest that the aim of this greater traceability is to enhance information credibility across the different channels used. (shrink)

Florence Larocque et Anne-Marie Reynaud.

Joan Maragall es representante del modernismo catalán, afín al simbolismo y al parnasianismo de Francia. En el poesía y vida van estrechamente ligados. Acentúa la dimensión ética y cultural de exigencia de fidelidad a la experiencia personal de sinceridad. Llega a la cuestión última sin dejar de profundizar la absoluta relación del sujeto con el mundo. Combina la profundidad unamuniana y la mundanidad orteguiana.

Drawing on the principle of subsidiarity, this article develops a framework for allocating medical decision-making authority in the absence of capacity to consent and argues that decisional authority in paediatric transgender healthcare should generally lie in the patient. Regardless of patients’ capacity, there is usually nobody better positioned to make medical decisions that go to the heart of a patient’s identity than the patients themselves. Under the principle of subsidiarity, decisional authority should only be held by a higher level decision-maker, (...) such as parents or judges, if lower level decision-makers are incapable of satisfactorily addressing the issue even with support and the higher level decision-maker is better positioned to satisfactorily address the issue than all lower level decision-makers. Because gender uniquely pertains to personal identity and self-realisation, parents and judges are rarely better positioned to make complex medical decisions. Instead of taking away trans youth’s authority over their healthcare decisions, we should focus on supporting their ability to take the best possible decision for themselves. (shrink)

A recent paper by Teresa Baron and Geoffrey Dierckxsens argues that puberty blockers and hormone therapy should be disallowed before adulthood on prudential and consent-related grounds. This response contends that their argument fails because it is predicated on unsupported premises and misinterpretations of the available evidence. There is no evidence that a large proportion of pubertal and postpubertal youths later discontinue medical transition. Meaningful assent is a viable and commonly accepted alternative to meaningful consent in paediatric bioethics. And finally, the (...) primary purpose of transition-related interventions is to actualise youths’ gendered self-image, not treat an underlying mental illness. (shrink)

In this paper, we demonstrate (1) how harnessing stochasticity can be the basis of creative agency; (2) that such harnessing can resolve the apparent conflict between reductionist (micro-level) accounts of behaviour and behaviour as the outcome of rational and value-driven (macro-level) decisions; (3) how neurophysiological processes can instantiate such behaviour; (4) The processes involved depend on three features of living organisms: (a) they are necessarily open systems; (b) micro-level systems therefore nest within higher-level systems; (c) causal interactions must occur across (...) all the boundaries between the levels of organization. The higher levels constrain the dynamics of lower levels. The experimental evidence and theoretical arguments are shown to be consistent with previous research on the neuronal mechanisms of conscious choice, and with the interconnected multi-level processes by which organisms harness stochasticity, whether conscious or unconscious. (shrink)

Volume 19, Issue 6, June 2019, Page W3-W4.

How to account for participants’ psychological and emotional exhaustion with research has been under‐explored in the research ethics literature. Research fatigue, as it is known, has significant impacts on patients’ well‐being and their ongoing and future participation in studies. From the perspective of researchers and researched communities, research fatigue also creates selection bias and opportunity costs, negatively impacting the collective scientific enterprise. Institutional Review Boards should systematically consider research fatigue during the research approval process and strive to mitigate it.

By attending to how people speak about their gender, we can find diverse answers to the question of what it is like to have a gender identity. To some, it is little more than having a body whereas others may report it as more attitudinal or dispositional—seemingly contradictory views. In this paper, I seek to reconcile these disparate answers by developing a theory of how individual gender identity comes about. In the simplest possible terms, I propose that gender identity is (...) how we make sense of our gender subjectivity, the totality of our gendered experiences of ourselves. Gender identity is constituted by gender subjectivity, but this constitutive relationship is underdetermined. While gender subjectivity may narrow the range of inhabitable gender identities, it is always compatible with more than one. To arrive at a gender identity, we arrange gender subjectivity like building materials. My theory helps us understand how different people offer seemingly incompatible accounts of their gender identity without questioning their authenticity or validity. They simply arrange similar building materials differently. (shrink)