"Nietzsche versus Wagner", sometimes translated "Nietzsche against Wagner", is a critical examination of the composer Richard Wagner, whom Nietzsche praised in his early years and later declared his enemy. Nietzsche was close to the entire Wagner family, even Wagner's wives, but later had a falling out and spent a significant amount of energy attacking him. In this work, Nietzsche distances himself from Wagner's music and ideology, criticizing the composer's embrace of German nationalism and his turn to Christianity. Nietzsche contrasts Wagner's (...) decadent, pessimistic art with his own vision of a life-affirming, Dionysian aesthetic. The book reflects Nietzsche's broader concerns about the role of art and culture in society and his ongoing exploration of the tensions between Apollonian and Dionysian forces. Nietzsche also addresses the psychological and philosophical implications of Wagner's music, arguing that it represents a retreat from the complexities of reality into the comforting illusions of myth and religion. He sees Wagner's work as symptomatic of a broader cultural malaise characterized by a loss of vitality and authenticity. Through his critique of Wagner, Nietzsche seeks to reaffirm the values of individualism, creativity, and the joyful affirmation of life that he believes are essential to the rejuvenation of culture and the realization of human potential. This is one of three major works attacking Wager's music and legacy Nietzsche issued. This work was assembled and published at the end of 1888 under the title Nietzsche contra Wagner, shortly before his final mental collapse in January 1889. The text was published in December 1888 by C. G. Naumann in Leipzig. This new 2024 translation of the original 1888 German manuscript includes a new afterword by the translator, a timeline of Nietzsche's life and works, an index with descriptions of his key concepts, and summaries of his complete works. This translation is designed to allow the armchair philosopher to engage deeply with Nietzsche's works without having to be a full-time Academic. The language is modern and clean, with simplified sentence structures and diction to make Nietzsche's complex language and arguments as accessible as possible. This Reader's Edition also contains extra material that amplifies the manuscript with autobiographical, historical and linguistic context. This provides the reader a holistic view of this very enigmatic philosopher as both an introduction and an exploration of Nietzsche's works; from his general understanding of his philosophic project to an exploration of the depths of his metaphysics and unique contributions. This edition contains: • An Afterword by the Translator on the history, impact and intellectual legacy of Nietzsche • Translation notes on the original German, Latin and Greek manuscript • An index of Philosophical concepts used by Nietzsche with a focus on Existentialism and Phenomenology • A chronological list of Nietzsche's entire body of works • A detailed timeline of Nietzsche's life and works. (shrink)

Drosophila melanogaster is one of the most popular and powerful model organisms that helpour understanding of mammalian (human) life processes at the molecular level. Calpains are Ca2+‐activated cytoplasmic proteases thought to play multiple roles in intracellular signal processing by limited proteolysis of target substrate proteins, thereby changing their function. The calpain superfamily consists of 14 genes in mammals, but only 4 genes in Drosophila. One may assume that the calpain system, i.e. recognizing calpain‐dependent life processes and identifying the substrates cleaved (...) while exerting their functions, would prove easier to solve in Drosophila than in mammals. Recently, major progress has been made in characterizing Drosophila Calpain A, Calpain B and Calpain C. The fourth member, Calpain D (or SOL), was analyzed earlier. At this juncture, it seems justifiable to summarize our knowledge about the Drosophila enzymes, in comparison to the ubiquitous mammalian ones, as regards structure–function relations, mode of activation by Ca2+ and other factors, inhibition, potential targeting, expression pattern in vivo, etc. Equipped with all this information, we may now embark on the genetic modification of family members, interpreting mutant phenotypes in terms of the cell biology of calpains. BioEssays 26:1088–1096, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

The articles in this volume deal with the main inferential methods that can be applied to different kinds of experimental evidence.

Excerpt from Charles Renouvier's Philosophie der Praktischen Vernunft Kritisch Beleuchtet Als die notwendigen und ausreichenden Grundlagen der Sittlichkeit gibt R. Im 1. Kapitel seiner "reinen rationalen Moral die zwei Tatsachen an: I. Der Mensch ist mit Vernunft begabt, 2. Der Mensch hält sich für frei. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct (...) the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works. (shrink)

On the Genealogy of Morals is a book about the history of ethics and about interpretation. Nietzsche rewrites the former as a history of cruelty, exposing the central values of the Judaeo-Christian and liberal traditions - compassion, equality, justice - as the product of a brutal process of conditioning designed to domesticate the animal vitality of earlier cultures. The result is a book which raises profoundly disquieting issues about the violence of both ethics and interpretation. Nietzsche questions moral certainties by (...) showing that religion and science have no claim to absolute truth, before turning on his own arguments in order to call their very presuppositions into question. (shrink)