_Philosophy of Molecular Medicine: Foundational Issues in Theory and Practice_ aims at a systematic investigation of a number of foundational issues in the field of molecular medicine. The volume is organized around four broad modules focusing, respectively, on the following key aspects: What are the nature, scope, and limits of molecular medicine? How does it provide explanations? How does it represent and model phenomena of interest? How does it infer new knowledge from data and experiments? The essays collected here, authored (...) by prominent scientists and philosophers of science, focus on a handful of mainstream topics in the philosophical literature, such as _causation_, _explanation_, _modeling_, and _scientific inference_. These previously unpublished contributions shed new light on these traditional topics by integrating them with problems, methods, and results from three prominent areas of contemporary biomedical science: _basic research_, _translational_ and _clinical research_, and _clinical practice_. (shrink)

Esse artigo visa demonstrar como o psicanalista francês Jacques Lacan delineou e reformulou o conceito freudiano de pulsão de morte no interior dos três registros da experiência humana. Dito isso, iremos inicialmente compreender de forma geral como o conceito de pulsão de morte aparece na obra lacaniana, de maneira a demonstrarmos como ela é reformulada pelo autor francês. Depois, iremos delinear como esse conceito aparece no interior dos registros do Imaginário, Simbólico e Real; desse modo, estaremos envoltos com o Estágio (...) do Espelho desenvolvido por Lacan no decorrer dos anos 1930 e 1940, a teoria do significante fundada por nosso autor mais atentamente nos anos 1950 e por último o registro do Real, o qual foi introduzido com mais atenção a partir dos anos 1960 em diante. (shrink)

The Decameron was written in the wake of the Black Death, a shattering epidemic which had shaken Florence's confident entrepreneurial society to its core. In a country villa outside the city, ten young noble men and women who have escaped the plague decide to tell each other stories. Boccaccio's skill as a dramatist is masterfully displayed in this virtuoso performance of one hundred tales, vivid portraits of people from all stations in life, with plots which revel in a bewildering variety (...) of human reactions. Themes are playfully restated from one story to another within an elegant and refined framework. One of Chaucer's most fruitful sources for the Canterbury Tales, Boccaccio's work artfully combines the essential ingredients of narrative: fate and desire, crises and quick-thinking. This new translation by Guido Waldman captures the exuberance and variety and tone of Boccaccio's masterpiece. ABOUT THE SERIES: For over 100 years Oxford World's Classics has made available the widest range of literature from around the globe. Each affordable volume reflects Oxford's commitment to scholarship, providing the most accurate text plus a wealth of other valuable features, including expert introductions by leading authorities, helpful notes to clarify the text, up-to-date bibliographies for further study, and much more. (shrink)

Der weltweit erste Mitochondrien-Transfer, auch als Erzeugung eines „Drei-Eltern-Kindes“ bezeichnet, hat 2016 eine intensive Debatte ausgelöst. Hinsichtlich des Verfahrens, das bisher nur in Großbritannien zugelassen ist, werden auch verschiedene ethische Aspekte angesprochen. Dazu gehören die Risikoabwägung, die reproduktive Selbstbestimmung und die psychosoziale Entwicklung eines Kindes, das von drei Individuen abstammt. Dabei fällt auf, dass zentrale konzeptuelle Fragen hinsichtlich des Mitochondrien-Transfers nicht geklärt sind. Ist der Mitochondrien-Transfer eine genetische Intervention in die Keimbahn? Handelt es sich bei dem Verfahren um eine medizinisch (...) indizierte Therapie oder um eine elektive Behandlung assistierter Reproduktion? Welche Konzepte von Identität und Elternschaft liegen der Auffassung eines „Drei-Eltern-Kindes“ zugrunde? Im Kontext dieser konzeptuellen Fragen muss eine ethische Analyse des Mitochondrien-Transfers durchgeführt werden. In den meisten Fällen zeigt sich allerdings, dass die ethische Analyse zu stark auf Einzelaspekte fokussiert ist, wodurch diese konzeptuellen Fragen aus dem Blick geraten. Daher verbinden wir in unserem Beitrag die ethische Analyse mit konzeptuellen Überlegungen. Dabei ist es von zentraler Bedeutung, auch die biomedizinischen Grundlagen des Verfahrens eingehend zu erörtern, um die konzeptuellen Aspekte angemessen einordnen zu können. In einem ersten Schritt erläutern wir die unterschiedlichen Verfahren des Mitochondrien-Transfers. In einem zweiten Schritt schlagen wir eine konzeptuelle Klärung der drei genannten Fragen vor. Diese konzeptuelle Klärung dient als Grundlage, um die ethischen Aspekte der reproduktiven Selbstbestimmung, Risikoabwägung sowie Elternschaft und Identitätskonzeption zu analysieren. In einem dritten Schritt fassen wir die Ergebnisse zusammen. (shrink)

The field of psychiatry has long struggled with developing models of practice; most underemphasize the interpersonal aspects of clinical practice. This essay is unique in putting intersubjectivity front and centre. It is an attempt to provide a clinical method to re-establish the fragile dialogue of the soul with oneself and with others.

This paper examines the effectiveness of the use of executive compensation linked to Corporate Social Responsibility (CSR) goals across US firms. Empirical analysis of a cross-industry sample of 746 listed companies for the period 2002–2013 showed that the use of CSR-linked compensation contracts for Named Executive Officers (NEOs) promotes CSR performance. More specifically, we found that linking NEOs’ compensation to CSR goals produces positive effects in the 3rd year after adoption. As firms accumulate experience and learn how to use the (...) system over the following eight periods, CSR performance increases monotonically. Furthermore, experience accumulated over time affects the different specifications of CSR performance asymmetrically, by reducing both environmental and social CSR concerns and increasing only environmental CSR strengths. Interestingly, we also found that the simultaneous use of other CSR-focused governance systems moderates the effect of a firm’s accumulated experience in using CSR-linked executive compensation on CSR performance: the existence of a CSR committee at the board level and the public release of a CSR report are likely to have a positive moderating effect, while the purchase of a CSR audit has no moderating effect. (shrink)

The complexity of intracellular molecular pathways can be simplified by the use of Network Biology that breaks down the intricacy of biological processes into components and interactions among them. In the paper we show that any complex interactome, that is, a biological network representing protein-protein, protein-DNA and DNA-RNA interactions, can be decomposed into a conjunction of logical theorems expressed in terms of Zsyntax, a formal language which allows representing biological pathways. This result, illustrated with the case study of melanoma network, (...) opens the possibility for a computable model of the cell expressed in a logical language and shows how a formal way of intending philosophy can be useful to cope with the complexity of the biological world. (shrink)

In 1685, during the heyday of Scottish Cartesianism, regent Robert Lidderdale from Edinburgh University declared Cartesianism the best philosophy in support of the Reformed faith. It is commonplace that Descartes was ostracised by the Reformed, and his role in pre-Enlightenment Scottish philosophy is not yet fully acknowledged. This paper offers an introduction to Scottish Cartesianism, and argues that the philosophers of the Scottish universities warmed up to Cartesianism because they saw it as a newer, better version of their own traditional (...) Reformed scholasticism, chiefly in metaphysics and natural philosophy. (shrink)

The author investigates the origin and development of the concept of liberty and its special meaning in the Republican tradition of political thought. The origin of the Western concept of liberty lies in ancient Greece, in the opposition between liberty and slavery conceived after the liberation of Athens from tyranny and the victory over the Persian empire. The author then investigates the Republican notion of liberty that originates in ancient Rome and reaches its peak with Cicero. This conception of liberty (...) emphasizes self-government and partecipation in common deliberation and runs through Western political thought up to Rousseau, Tocqueville and the authors of the Federalist Papers. (shrink)

Objetiva-se mostrar que a filosofia crítica comporta uma refutação integral da analogia técnica operada por Descartes. Para tanto, após apresentar a pertinência do tema da analogia em relação aos movimentos gerais da _Crítica_, utilizamo-la para interpretar o debate moderno acerca da razão dos animais. Posteriormente, acompanhamos a consolidação da noção kantiana da analogia a partir dos cursos de _Lógica _e centramo-nos, em seguida, na _Crítica da Faculdade de Julgar Teleológica_, a qual abriga uma reelaboração do conceito de arte, bem como (...) a refutação da tese cartesiana dos animais-máquina. A partir dela, pretendendo mostrar tanto as razões pelas quais Kant a rejeita, como o modo pelo qual ele a leva à contradição, sinalizamos que Descartes inconscientemente supõe o contrário do que gostaria de provar. Permeando essa discussão, esforçamo-nos por bem situar as teses do texto em relação ao próprio sistema da _Crítica_, segundo o tema da analogia. (shrink)

Tensegrity, multivocity and the ethics of images When transposed to the field of philosophy, the notion of tensegrity can become the matrix to justify an approach to reality, based on the contextual action of several factors. This specificity is shown with reference to the photographs of patients allegedly hysterical, photographed at the end of the nineteenth century in the Hospital Salpêtrière in Paris. The ethics of images is anchored in this possibility. In fact, it is not indifferent with respect to (...) both the modalities in which a knowledge can be correctly configured, and with respect to the role of the subject-spectator in such an operation. (shrink)

Etica-politica come scienza unitaria: problemi di fondazione -- L'originaria costituzione intersoggettiva dell'uomo: amicizia e giustizia -- La comunità politica e la teoria delle costituzioni.

Thomas Reid presented a two-dimensional geometry of the visual field in his Inquiry into the Human Mind (1764). The axioms of this geometry are different from those of Euclidean plane geometry. The ‘geometry of visibles’ is the same as the geometry of the surface of the sphere, described without reference to points and lines outside the surface itself. In a recent article, James Van Cleve has argued that Reid can secure a non-Euclidean geometry of visibles only at the cost of (...) abandoning his direct realist theory of perception, and reintroducing sense-data. The question will be reexamined by considering two aspects of Reid’s theory of vision: the claim that we do not directly perceive distance by sight and Reid’s characterization of visible figure as a partial notion of an external object. (shrink)

This article was inspired by the recent publication of a volume that brings together the Italian translation of Das Heilige and other important writings of Rudolf Otto. It explores in particular the reception of this theologian and philosopher of religion's thought in Italy during the first half of the twentieth century by such important figures as Ernesto Buonaiuti, Benedetto Croce, Giovanni Miegge and Piero Martinetti.

The centrally-planned Soviet command economy was one of the twentieth century’s most radical and complex economic, political and social experiments. Its establishment did not coincide with the onset of Soviet power across the former Russian Empire in 1917-1918, but instead resulted from fifteen years of shifts, readjustments and breaks, and through experiments with both quasi-socialist market economics and centralised administrative command practices. The present article surveys the conflictual relationship between Soviet planning and Marxism in this period. It demonstrates how the (...) Stalinist command economy contradicted much of the theory and practice that the Bolsheviks themselves had thought ought to characterise the new economic system. (shrink)