Challenging the image of physics as dry and dusty, The Beautiful Invisible shows that this highly abstract science is in fact teeming with beautiful concepts, ...

Over these last few years once again the relationship between biology and information has been debated with great liveliness. The crucial points concern the meaning of the term ‘information’ and whether the so-called “information talk” is really necessary inside biology.I will proceed by first commenting on some points of the debate (§ 2), then showing that a biophysical account of the process from the nucleotide sequences to the correlated amino acid sequences is possible (§ 3). In this way, I will (...) suggest that a satisfying account of that process can be offered without entering the quicksand of information. (shrink)

The concept of living has changed in time along the history of biology and its specificity has been associated or to a particular matter, active such as the chemical one, or was considered as a product of the spatial organization of a passive matter. Today, these two paths can be merged in the chemical perspective that takes account of the general reflections on the complexity and on the systemic, in the “systemic complexity” approach.

A long-standing question in cognitive science is how high-level knowledge is integrated with sensory input. For example, listeners can leverage lexical knowledge to interpret an ambiguous speech sound, but do such effects reflect direct top-down influences on perception or merely postperceptual biases? A critical test case in the domain of spoken word recognition is lexically mediated compensation for coarticulation (LCfC). Previous LCfC studies have shown that a lexically restored context phoneme (e.g., /s/ in Christma#) can alter the perceived place of (...) articulation of a subsequent target phoneme (e.g., the initial phoneme of a stimulus from a tapes-capes continuum), consistent with the influence of an unambiguous context phoneme in the same position. Because this phoneme-to-phoneme compensation for coarticulation is considered sublexical, scientists agree that evidence for LCfC would constitute strong support for top–down interaction. However, results from previous LCfC studies have been inconsistent, and positive effects have often been small. Here, we conducted extensive piloting of stimuli prior to testing for LCfC. Specifically, we ensured that context items elicited robust phoneme restoration (e.g., that the final phoneme of Christma# was reliably identified as /s/) and that unambiguous context-final segments (e.g., a clear /s/ at the end of Christmas) drove reliable compensation for coarticulation for a subsequent target phoneme. We observed robust LCfC in a well-powered, preregistered experiment with these pretested items (N = 40) as well as in a direct replication study (N = 40). These results provide strong evidence in favor of computational models of spoken word recognition that include top–down feedback. (shrink)

An overview of current scholarship in ontology places one before two parallel lines that never meet: on the one hand there are essays in so-called “analytic ontology”, on the other hand, there are studies developed within so-called Aristotelian-Thomistic ontology. However, even though it is frequently ignored, there is an interesting philosophical current of thought within so-called “analytical Thomism”, which joins contemporary debates of “analytic ontology” from the perspective of an Aristotelian-Thomistic ontology. The main contributors to this current are P. Geach (...) and B. Miller, who have proposed a new theory about existence, called “two sense theory”. It is a view intermediate between the well known Fregean and Meinongian views, arguing for the possibility of two senses of “exists”: as first- and as second-order predicate. The object of this paper is to present this current of thought, and to evaluate it from the point of view of the history of ontology and of “continental” Thomism. (shrink)

_Philosophy of Molecular Medicine: Foundational Issues in Theory and Practice_ aims at a systematic investigation of a number of foundational issues in the field of molecular medicine. The volume is organized around four broad modules focusing, respectively, on the following key aspects: What are the nature, scope, and limits of molecular medicine? How does it provide explanations? How does it represent and model phenomena of interest? How does it infer new knowledge from data and experiments? The essays collected here, authored (...) by prominent scientists and philosophers of science, focus on a handful of mainstream topics in the philosophical literature, such as _causation_, _explanation_, _modeling_, and _scientific inference_. These previously unpublished contributions shed new light on these traditional topics by integrating them with problems, methods, and results from three prominent areas of contemporary biomedical science: _basic research_, _translational_ and _clinical research_, and _clinical practice_. (shrink)

In this paper a post-Kantian theory of scientific concepts is proposed. In particular, by differentiating the representational level, the intentional level and the real level, it is argued that a scientific concept has to be understood both as a representation and as a rule.

“ >. Das hiess doch: Wenn du dir gewisse Tatsachen anders denkst,sie anders beschreibst, als sie sind, dann kannst du die Anwendung gewisser Begriffe dir nicht mehr vorstellen, weil die Regeln ihrer Anwendung kein Analogon unter den neuen Umständen haben.”.

The Decameron was written in the wake of the Black Death, a shattering epidemic which had shaken Florence's confident entrepreneurial society to its core. In a country villa outside the city, ten young noble men and women who have escaped the plague decide to tell each other stories. Boccaccio's skill as a dramatist is masterfully displayed in this virtuoso performance of one hundred tales, vivid portraits of people from all stations in life, with plots which revel in a bewildering variety (...) of human reactions. Themes are playfully restated from one story to another within an elegant and refined framework. One of Chaucer's most fruitful sources for the Canterbury Tales, Boccaccio's work artfully combines the essential ingredients of narrative: fate and desire, crises and quick-thinking. This new translation by Guido Waldman captures the exuberance and variety and tone of Boccaccio's masterpiece. ABOUT THE SERIES: For over 100 years Oxford World's Classics has made available the widest range of literature from around the globe. Each affordable volume reflects Oxford's commitment to scholarship, providing the most accurate text plus a wealth of other valuable features, including expert introductions by leading authorities, helpful notes to clarify the text, up-to-date bibliographies for further study, and much more. (shrink)

In 1882, Tommaso de Amicis, dermatologist and venereologist at the University of Naples, Italy, published a description of twelve cases of Kaposi's sarcoma. This article is the second report about the above-mentioned disease after the first description of five cases by Moritz Kaposi ten years earlier. The publication by De Amicis was organized as a collection of case reports followed by a section containing general considerations about the etiopathogenesis, pathology, diagnosis and therapy of Kaposi's sarcoma. Ten cases are typical of (...) the so-called 'classic' form of the disease, that has a peculiar indolent chronic course, while two out of the twelve cases strongly resemble the clinical form of Kaposi's sarcoma currently recognized as that associated with the acquired immunodeficiency syndrome (AIDS). The nature of Kaposi's sarcoma is still being debated, but current evidence suggests that it is a viral-associated, if not viral-induced, tumor and its relationship with AIDS is that of an opportunistic disease. Thus, the presence of the clinical form of AIDS-related Kaposi's sarcoma can be used as a marker of the presence of sporadic cases of AIDS much earlier than its pandemic diffusion. (shrink)

This volume collects for the first time in a single volume all of Kant's writings on religion and rational theology. These works were written during a period of conflict between Kant and the Prussian authorities over his religious teachings. His final statement of religion was made after the death of King Frederick William II in 1797. The historical context and progression of this conflict are charted in the general introduction to the volume and in the translators' introductions to particular texts. (...) All the translations are new with the exception of The Conflict of the Faculties, where the translation has been revised and re-edited to conform to the guidelines of the Cambridge Edition. As is standard with all the volumes in this edition, there are copious linguistic and explanatory notes, and a glossary of key terms. (shrink)

This work addresses biological explanations and aims to provide a philosophical account which brings together logical-procedural and historical-processual aspects when considering molecular pathways. It is argued that, having molecular features as explananda, a particular non-classical logical language – Zsyntax – can be used to formally represent, in terms of logical theorems, types of molecular processes, and to grasp how we get from one molecular interaction to another, hence explaining why a given outcome occurs. Expressing types of molecular biology processes in (...) terms of the Zsyntax language allows us to represent causal interactions by taking into account their context-sensitivity, and amounts to partly reviving the spirit of the so-called received view of explanation – which aimed to capture scientific explanatory accounts in terms of their logical structure and their appealing to nomological relations. Such a partial revival is pursued by invoking here non-classical deductions and empirical generalisations, which are called to provide the epistemic norms to explain the behavior of molecular pathways. (shrink)

We propose a formal representation of objects , those being mathematical or empirical objects. The powerful framework inside which we represent them in a unique and coherent way is grounded, on the formal side, in a logical approach with a direct mathematical semantics in the well-established field of constructive topology, and, on the philosophical side, in a neo-Kantian perspective emphasizing the knowing subject’s role, which is constructive for the mathematical objects and constitutive for the empirical ones.

Peirce did not achieve a final systematization of his work. Beyond the difficulties in explaining so many philosophical tools that he introduced—suffice it to mention semiotic, abductive logic, a heuristic based on continuity, scholastic realism—, there is a theoretical reason for this incompletion. All those new philosophical tools indicated a conception of synthesis very different from the one he received from Kant. Peirce did not realize the profound direction of his enquiry so that he did not directly question neither Kant’s (...) legacy on this issue nor the idea of necessity that presides over it. Starting from Peirce’s conception of continuity and change, this paper will give a new definition of synthetic and analytic judgments and reasoning, completing the picture with a third “vague” judgment and reasoning. In this new definition a synthetic judgment is a judgment that recognizes identity through changes. An analytical judgment is a judgment that loses identity through changes. A vague judgment is a judgment that it is blind to identity through changes. How do we perform synthetic reasoning? Following Peirce’s semiotic study of elements of Gamma Graphs as the sheet of assertion and the line of identity, the paper will first individuate the semiotic characteristics necessary for the recognition of identity. These characteristics lead us to discover “complete gesture” as the tool that we use in our every-day reasoning in order to acquire new knowledge synthetically. “Complete gestures” are actions through which we carry and recognize significant meanings. This new paradigm should provide an improved account of common-sense knowledge as well as of particular creative and hypothetic stages of conception in both scientific and humanistic thought. (shrink)

The essay explores the philosophical concept of fear as it appears in the chapter of Hegel’s Phenomenology of Spirit entitled Absolute Freedom & Terror , dedicated to the analysis of the French Revolution. The aim of the essay is to show Hegel’s critique against the abstract logic of modern political rationalism implied by the Revolution itself. This critique finds its base in a new productive concept of fear, which, in the form of Terror [ Schrecken ], represents the dialectic driving (...) force for the affirmation of the freedom of Spirit. (shrink)

The core of Hegelian idealism is the concept of dialectic, the soul of logic and the fundamental law of reality in all its forms. This dialectic is as vastly different from Platonic dialectic as the categories or pure concepts of the Transcendental Logic in the Critique of Pure Reason are from Plato’s ideas and Aristotle’s universals, and its character cannot be more plainly indicated than by this very contrast of the category with the Platonic idea and the Aristotelian universals.

Fink’s early thought is characterized by a sort of fragmentation and concealment, since it must be reconstructed by bringing together the few texts that he wrote during his collaboration with Husserl – and mainly for him – with the great number of private notes and drafts that accompanied, quasi subterraneous, his assistant activity. Based on these materials, the present papers intend to bring to light the coherent theoretical framework which underlies Fink’s conception of philosophy as meontic phenomenology and especially as (...) catastrophic thinking (katastrophales Denken). Based on a clarification of the concepts of “world” and “absolute”, Fink’s thought will be investigated in the light of the double movement of )kbasis and kat'basis that he established between the two realms of what is constituted and what is constituting. It will lead, through a radicalization of the reduction as dehumanizing and absolution, to a new phenomenological understanding of philosophy as “katastroph)”, which is based on a definitive breaking of the hermeneutic circle. (shrink)

Scientific understanding in the field of cognitive sciences is a multifaceted concept that necessitates reflecting on the integration of various explanations. In this paper, I argue that different kinds of explanations regarding cognitive sciences can be integrated into an account of explanatory scientific understanding, as proposed by Khalifa. Moreover, I propose that scientific understanding should be distinct from mere knowledge and should be conceptualized as a nexus of explanation. This paper explores the theoretical foundations of scientific understanding, discusses different types (...) of explanations in cognitive sciences, criticises a reduction problem in Khalifa’s account and elucidates how these explanations can be effectively integrated to foster a holistic understanding of cognitive phenomena. Through an interdisciplinary approach, the aim of this paper is to enrich our comprehension of cognitive sciences and promote a more unified perspective on scientific understanding. (shrink)