Constructive Neutral Evolution is an evolutionary mechanism that can explain much molecular inter-dependence and organismal complexity without assuming positive selection favoring such dependency or complexity, either directly or as a byproduct of adaptation. It differs from but complements other non-selective explanations for complexity, such as genetic drift and the Zero Force Evolutionary Law, by being ratchet-like in character. With CNE, purifying selection maintains dependencies or complexities that were neutrally evolved. Preliminary treatments use it to explain specific genetic and molecular structures (...) or processes, such as retained gene duplications, the spliceosome, and RNA editing. Here we aim to expand the scope of such explanation beyond the molecular level, integrating CNE with Multi-Level Selection theory, and arguing that several popular higher-level selection scenarios are in fact instances of CNE. Suitably contextualized, CNE occurs at any level in the biological hierarchy at which natural selection as normally construed occurs. As examples, we focus on modularity in protein–protein interaction networks or “interactomes,” the origin of eukaryotic cells and the evolution of co-dependence in microbial communities—a variant of the “Black Queen Hypothesis” which we call the “Gray Queen Hypothesis”. (shrink)

The counterfactual and regularity theories are universal accounts of causation. I argue that these should be generalized to produce local accounts of causation. A hallmark of universal accounts of causation is the assumption that apparent variation in causation between locations must be explained by differences in background causal conditions, by features of the causal-nexus or causing-complex. The local account of causation presented here rejects this assumption, allowing for genuine variation in causation to be explained by differences in location. I argue (...) that local accounts of causation are plausible, and have pragmatic, empirical and theoretical advantages over universal accounts. I then report on the use of presheaves as models of local causation. The use of presheaves as models of local variation has precedents in algebraic geometry, category theory and physics; they are here used as models of local causal variation. The paper presents this idea as stemming from an approach using presheaves as models of local truth. Finally, I argue that a proper balance between universal and local causation can be assuaged by moving from presheaves to fully-fledged sheaf models. (shrink)

Recent debates about the biological and evolutionary conditions for sentience have generated a renewed interest in fine-grained functionalism. According to one such account advanced by Peter Godfrey-Smith, sentience depends on the fine-grained activities characteristic of living organisms. Specifically, the scale, context and stochasticity of these fine-grained activities. One implication of this view is that contemporary artificial intelligence is a poor candidate for sentience. Insofar as current AI lacks the ability to engage in such living activities it will lack sentience, no (...) matter what its coarse-grained functions. In this paper, we review the case for fine-grained functionalism and show that there are contemporary machines that fulfil the fine-grained functional criteria identified by Godfrey-Smith, and thus are candidates for sentience. Molecular machines such as Brownian computers are analogous to metabolic activity in their scale, context and stochasticity, and can serve as the basis of AI. Molecular computation is a promising candidate for artificial sentience according to contemporary philosophical accounts of sentience. (shrink)

Several approaches to clinical ethics consultation (CEC) exist in medical practice and are widely discussed in the clinical ethics literature; different models of CECs are classified according to their methods, goals, and consultant’s attitude. Although the “facilitation” model has been endorsed by the American Society for Bioethics and Humanities (ASBH) and is described in an influential manual, alternative approaches, such as advocacy, moral expertise, mediation, and engagement are practiced and defended in the clinical ethics field. Our Clinical Ethics Center in (...) Paris was founded in 2002 in the wake of the Patients’ Rights Act, and to date it is the largest center that provides consultation services in France. In this article we shall describe and defend our own approach to clinical ethics consultation, which we call the “Commitment Model,” in comparison with other existing models. Indeed commitment implies, among other meanings, continuity through time, a series of coherent actions, and the realization of important social goals. By drawing on a recent consultation case, we shall describe the main steps of our consultation procedure: interviews with major stakeholders, including patients and proxies; case conferences; and follow up. We shall show why we have chosen the term “commitment” to represent our approach at three different but interrelated levels: commitment towards patients, within the case conference group, and towards society as a whole. (shrink)

Νέα ανάγνωση των επιγραφών που αφορούν τις ιερές αγροικίες του Απόλλωνα στη Δήλο και τη Ρήνεια. Α. Το είδος των επιγραφών επιβάλλει περιορισμούς στην ερμηνεία τους : δεν μπορούν να μας πληροφορήσουν ούτε για τη θέση των αγροικιών αλλά ούτε και για τη μορφή τους. Το γεγονός ότι υπάρχουν δεν πρέπει να μας κάνει να υποτιμήσουμε την σπουδαιότητα των ιδιωτικών αγροκτημάτων για τα οποία δεν διαθέτουμε κανένα παρόμοιο αρχείο. Β. Το έδαφος της Δήλου δεν ήταν λιγότερο πλούσιο από αυτό της (...) Ρήνειας και δεν είχε αποκλειστικό προορισμό την κτηνοτροφία : η αποκατάσταση της ID 452, 16-32 σε σχέση με την ID 467 βεβαιώνει την ύπαρξη ενός αμπελώνα στα Επισθένεια. Η έλλειψη μυλώνα στις αγροικίες της Δήλου δεν αποδεικνύει με κανένα τρόπο την απουσία καλλιέργειας δημητριακών αλλά πρέπει να συσχετισθεί με τον αριθμό των ατόμων που ζούσαν στις αγροικίες. Ενα μικρό ομοιογενές σύνολο κιστοφόρων τετραδράχμων της εποχής των Ατταλιδών είχε αποδοθεί, σε ένα πρόσφατα δημοσιευμένο corpus, στις Σάρδεις και τα Σύνναδα. Προσπαθούμε να αποδείξουμε ότι θα έπρεπε να ακολουθήσουμε ένα διαφορετικό συλλογισμό και τα νομίσματα αυτά να αποδοθούν σε τέσσερεις διαφορετικές πόλεις. Οι πόλεις αυτές θα μπορούσαν να είναι η Διονυσούπολις, η Βλαύνδος, η Λυσιάς ή τα Συννάδα και μία τέταρτη της οποίας η ταυτότητα παραμένει αβέβαιη. Βρισκόμαστε στη Φρυγία και προβληματιζόμαστε για τους λόγους ύπαρξης αυτών των σύντομων νομισματοκοπών. (shrink)

Our aim in this paper is to take quite seriously Heinz Post’s claim that the non-individuality and the indiscernibility of quantum objects should be introduced right at the start, and not made a posteriori by introducing symmetry conditions. Using a different mathematical framework, namely, quasi-set theory, we avoid working within a label-tensor-product-vector-space-formalism, to use Redhead and Teller’s words, and get a more intuitive way of dealing with the formalism of quantum mechanics, although the underlying logic should be modified. We build (...) a vector space with inner product, the Q-space, using the non-classical part of quasi-set theory, to deal with indistinguishable elements. Vectors in Q-space refer only to occupation numbers and permutation operators act as the identity operator on them, reflecting in the formalism the fact of unobservability of permutations. Thus, this paper can be regarded as a tentative to follow and enlarge Heinsenberg’s suggestion that new phenomena require the formation of a new “closed” (that is, axiomatic) theory, coping also with the physical theory’s underlying logic and mathematics. (shrink)

Cette monumentale etude d'Olivier Brunet reste assurement la reference majeure concernant la philosophie esthetique de David Hume (1711-1776). Les questions et les problemes relatifs au "beau", au "jugement de gout" ne se presentent pas, dans l'oeuvre du penseur ecossais, de maniere detachee, isolee du reste de sa philosophie. C'est l'un des merites d'Olivier Brunet d'avoir montre que les reflexions de Hume sur l'esthetique sont inseparables de ses concepts essentiels. Ainsi, lorsque l'on recherche les racines conceptuelles de la definition (...) du "jugement de gout" chez Hume, on retrouve les memes jalons qui structurent son ethique. En morale comme en esthetique, les "passions" jouent un role central et sont liees - chacune a leur facon - a l'"utile"; celui-ci participe a la cause du "plaisir esthetique" qui est lui-meme etroitement lie a la fameuse "sympathie", sentiment desinteresse reglant le comportement moral tel que definit par Hume. La boucle est-elle bouclee? Loin de la, car l'esthetique humienne serait encore impossible a saisir, sans y considerer l'usage que le fondateur de l'empirisme moderne fait de ses concepts-phares : la croyance, le scepticisme, l'experience, l'habitude. Olivier Brunet, enfin, ne borne pas son etude a la philosophie esthetique de Hume. De tres belles pages sont consacrees a la relation personnelle que ce dernier entretenait avec l'art, ainsi qu'aux vertus sociales, psychologiques et morales que l'auteur du Traite de la nature humaine deduisait de la contemplation du Beau. (shrink)

The concept of individuality in quantum mechanics shows radical differences from the concept of individuality in classical physics, as E. Schrödinger pointed out in the early steps of the theory. Regarding this fact, some authors suggested that quantum mechanics does not possess its own language, and therefore, quantum indistinguishability is not incorporated in the theory from the beginning. Nevertheless, it is possible to represent the idea of quantum indistinguishability with a first-order language using quasiset theory (Q). In this work, we (...) show that Q cannot capture one of the most important features of quantum non-individuality, which is the fact that there are quantum systems for which particle number is not well defined. An axiomatic variant of Q, in which quasicardinal is not a primitive concept (for a kind of quasisets called finite quasisets), is also given. This result encourages the searching of theories in which the quasicardinal, being a secondary concept, stands undefined for some quasisets, besides showing explicitly that in a set theory about collections of truly indistinguishable entities, the quasicardinal needs not necessarily be a primitive concept. (shrink)

In this paper we enrich the orthomodular structure by adding a modal operator, following a physical motivation. A logical system is developed, obtaining algebraic completeness and completeness with respect to a Kripkestyle semantic founded on Baer*-semigroups as in [22].

What should we do when two conflicting ontologies are both fruitful, though their fruitfulness varies by context or location? To achieve reconciliation, it is not enough to advocate pluralism. There are many varieties of pluralism and not all pluralisms will serve equally well; some may be inconsistent, others unhelpful. This essay considers another option: local ontology. For a pair of ontologies, a local ontology consists of two claims: (1) each location enjoys a unique ontology, and (2) neither ontology is most (...) fundamental nor most global. To argue for this view and provide an example, I develop a local ontology for two scientific ontologies: processualism and new mechanism. To further support this ontology, I argue against two varieties of pluralism: first, a pluralism based on directly unifying the assumptions of both ontologies and, second, one of allowing both ontologies to coexist within a discipline. I argue that the first option is inconsistent and the second is unhelpful. I conclude that this local ontology provides us with a consistent and fruitful account that includes elements from both mechanism and processualism. (shrink)

La question des productions agricoles à Délos a fait l'objet d'un intérêt renouvelé ces dernières années : les vestiges d'aménagements agricoles, les fermes et les inscriptions ont été réétudiés. Une des questions en suspens concernait la destination des pressoirs situés dans la ville : produisaient-ils du vin ou de l'huile? En 1997, la fouille d'une installation de pressurage située dans le Quartier du théâtre a permis de démontrer qu'il s'agissait d'une huilerie. Aménagée au début du Ier s. av. J.-G, elle (...) comportait deux pressoirs à levier, trois récipients de décantation et six pithoi de stockage. Elle était installée dans une maison dont les origines remontaient au Ve s. av. J.-C. et qui, depuis lors, avait connu plusieurs remaniements. Outre des données nouvelles sur l'histoire du quartier, cette fouille apporte des éclaircissements sur la végétation des îles proches, sur les variétés d'olives cultivées et sur l'économie de la fin de la période hellénistique. Ces realia rééquilibrent la documentation tirée des inscriptions en faisant une certaine place à l'oléiculture au moins aux IIe et Ier s. av. J.-C. (shrink)

Punctuated by joy, disappointments, and conflicts, research evaluation constitutes an intense, emotional moment in scientific life. Yet reviewers and research institutions often expect evaluations to be conducted objectively and dispassionately. Inspired by the scholarship describing the role of emotions in scientific practices, we argue instead, that reviewers actively define, display and manage their emotions in response to the structural organization of research evaluation. Our article examines reviewing practices used in the European Research Council’s (ERC) Starting and Consolidator grants and in (...) the Marie Skłodowska-Curie Action’s (MSCA) Individual Fellowships. These two European funding mechanisms offer different perspectives on the organization of grant evaluation. We conducted interviews with review panel members and analyzed various institutional documents. By drawing on the sociological concepts of feeling rules and emotional work, we demonstrate that reviewers define rules concerning how emotions should be experienced and expressed to ensure the proper functioning of evaluation, and that reviewers experience the need to actively regulate their emotions to comply with these rules. We present four feeling rules concerning the experience and expression of: (1) excitement for novelty during individual evaluation; (2) respect for others’ opinions and the absence of anger in review panels; (3) attentiveness and interest, which are seen as missing in online evaluations. Reviewers also expect ERC candidates to (4) avoid pride and manifest modesty during interviews. These rules demonstrate that proposal peer review is governed by emotional norms, and show the influence of organizational settings and moral requirements on research evaluation. (shrink)

The origin of the notochord is one of the key remaining mysteries of our evolutionary ancestry. Here, we present a multi‐level comparison of the chordate notochord to the axochord, a paired axial muscle spanning the ventral midline of annelid worms and other invertebrates. At the cellular level, comparative molecular profiling in the marine annelids P. dumerilii and C. teleta reveals expression of similar, specific gene sets in presumptive axochordal and notochordal cells. These cells also occupy corresponding positions in a conserved (...) anatomical topology and undergo similar morphogenetic movements. At the organ level, a detailed comparison of bilaterian musculatures reveals that most phyla form axochord‐like muscles, suggesting that such a muscle was already present in urbilaterian ancestors. Integrating comparative evidence at the cell and organ level, we propose that the notochord evolved by modification of a ventromedian muscle followed by the assembly of an axial complex supporting swimming in vertebrate ancestors. (shrink)

The current conception of the plurality of worlds is founded on a set theoretic understanding of possibilia. This paper provides an alternative category theoretic conception and argues that it is at least as serviceable for our understanding of possibilia. In addition to or instead of the notion of possibilia conceived as possible objects or possible individuals, this alternative to set theoretic modal realism requires the notion of possible morphisms, conceived as possible changes, processes or transformations. To support this alternative conception (...) of the plurality of worlds, I provide two examples where a category theoretic account can do work traditionally done by the set theoretic account: one on modal logic and another on paradoxes of size. I argue that the categorial account works at least as well as the set theoretic account, and moreover suggest that it has something to add in each case: it makes apparent avenues of inquiry that were obscured, if not invisible, on the set theoretic account. I conclude with a plea for epistemological humility about our acceptance of either a category-like or set-like realist ontology of modality. (shrink)

Traditional epistemic and doxastic logics cannot deal with inconsistent beliefs nor do they represent the evidence an agent possesses. So-called ‘evidence logics’ have been introduced to deal with both of those issues. The semantics of these logics are based on neighbourhood or hypergraph frames. The neighbourhoods of a world represent the basic evidence available to an agent. On one view, beliefs supported by evidence are propositions derived from all maximally consistent collections evidence. An alternative concept of beliefs takes them to (...) be propositions derivable from consistent partitions of one’s inconsistent evidence; this is known as Schotch-Jennings Forcing. This paper develops a modal logic based on the hypergraph semantics to represent Schotch-Jennings Forcing. The modal language includes an operator U(φ1,…,φn;ψ)\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$U(\varphi _1, \ldots, \varphi _n;\psi )$$\end{document} which is similar to one introduced in Instantial Neighbourhood Logic. It is of variable arity and the input formulas enjoy distinct roles. The U operator expresses that all evidence at a particular world that supports ψ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\psi $$\end{document} can be supported by at least one of the φi\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\varphi _i$$\end{document}s. U can then be used to express that all the evidence available can be unified by the finite set of formulas φ1,…,φn\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\varphi _1,\ldots, \varphi _n$$\end{document} if ψ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\psi $$\end{document} is taken to be ⊤\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\top $$\end{document}. Future developments will then use that semantics as the basis for a doxastic logic akin to evidence logics. (shrink)

Constructive Neutral Evolution theory provides selectively neutral explanations of the origin and maintenance of biological complexity. This essay provides an analysis of CNE as an explanatory strategy defined by a tripartite set of conditions, and shows how this applies to cases of the evolution of complexity at higher-levels of the biological hierarchy. CNE was initially deployed to help explain a variety of complex molecular structures and processes, including spliceosomal splicing, trypansomal pan-editing, scrambled genes in ciliates, duplicate gene retention and fungal (...) ATP synthetase structure. CNE has also been generalized to apply to phenomena at the cellular level, including protein-protein interaction network modularity, obligate microbial symbioses, eukaryogenesis and microbial unculturability. This essay further extends CNE to cases of complexity at levels of organization higher than the molecular and cellular. These are multicellular phenotypic complexity, multicellular ecological complexity and, some cases of cultural complexity. (shrink)

L’analyse du jugement juridique par ce que l’on appelle le réalisme juridique entend souligner la dimension subjective qu’implique l’acte de juger et la part importante de pouvoir discrétionnaire dont bénéficient les juges. Néanmoins, loin de verser dans une analyse psychologisante et naïve, le réalisme d’hier et celui d’aujourd’hui sollicitent les outils et exploitent les résultats que les autres sciences sociales leur offrent pour mettre en évidence la complexité du jugement juridique qui ne saurait être réduit à une opération purement logique (...) et déductive ni avoir l’ampleur d’une argumentation philosophique. (shrink)

SummaryHeterozygous 4.1 hereditary elliptocytosis results from the absence of one haploid set of protein 4.1, a major component of the red cell skeleton. Two successive epidemiological investigations revealed fifteen probands in the French Northern Alps. The frequency of this disease seems to be very high in four small villages isolated in the Aravis mountains. The genealogical study shows that eleven probands share common ancestors who lived eight or ten generations ago in these villages. Thus there was probably a founder effect (...) from one pair of ancestors, strengthened by endogamy. In contrast, four probands originate from another area and are not genealogically related. Recent results in molecular genetics support the present data. (shrink)

En dépit de la littérature relativement abondante à son sujet, quelle que soit la langue dans laquelle on pratique la théorie du droit , le réalisme scandinave reste assez mal connu. On n’en retient bien souvent que quelques bribes : lutte contre la métaphysique, empirisme, démystification, idéologie des juges, faits, fictions, prédictions… On ne manque pas non plus de rappeler quelques critiques, plus ou moins sévè..

This article offers a critical analysis of John Broome's conception of practical reasoning. I first introduce his main claims and then point out some of the difficulties raised by the notion of “double expression” and by some aspects of the cognitivism which he explicitly endorses. I then emphasize two consequences of these criticisms: one concerning the link he sees between belief and intention, and the other concerning the idea that our practical reasonings are inextricably linked to our theoretical reasonings. Finally, (...) I argue that the problem Broome seems to be facing has its source in the difficulty of distinguishing clearly between reasoning (a relation between mental states) and the description of its content (a relation between propositions). (shrink)

Les travaux de Jean Piaget sur le développement cognitif ont largement mis en relief ce que comporte de génétique toute acquisition de connaissance sensible ou intellectuelle. Bien plus: le pere de la psychologie dite justement genetique voit dans la genése, entendue au sens de processus selon lequel le sujet connaissant construit l'objet, ce qui definit essentiellement toute connaissance. On sait que cette these piagetienne s'oppose á l'enseignement d'Aristote, qui conçoit la connaissance comme adaptation sui generis d'une faculte a un objet (...) donne independamment du sujet et voit l'essence du connaitre dans une simple copie des choses, dans un acte ou l'intelligence devient l'objet. Ne serait-ce qu'en raison de cette opposition, on n'aura pas tort de qualifier d'anti-genetique la psychologie de la connaissance d'Aristote. D'autant plus que la psychologie aristotelicienne n'est pas une psychologie scientifique au sens moderne du terme, de sorte qu'on y chercherait en vain des concepts a caractere operationnel tel le concept piagetien de genese. Pourtant, comme cet article tachera de le mettre en evidence, Aristote est loin d'avoir neglige l'aspect genese que comporte la connaissance sensible et intellectuelle. Conjointement a ses prises de position sur la nature de la connaissance, on trouve chez Aristote une description des activites sensibles et intellectuelles qui laisse au sujet bien plus d'initiative et s'avere bien plus « genetique » qu'on ne le suppose habituellement. (shrink)