This chapter makes the case for strong longtermism: the claim that, in many situations, impact on the long-run future is the most important feature of our actions. Our case begins with the observation that an astronomical number of people could exist in the aeons to come. Even on conservative estimates, the expected future population is enormous. We then add a moral claim: all the consequences of our actions matter. In particular, the moral importance of what happens does not depend on (...) when it happens. That pushes us toward strong longtermism. We then address a few potential concerns, the first of which is that it is impossible to have any sufficiently predictable influence on the course of the long-run future. We argue that this is not true. Some actions can reasonably be expected to improve humanity’s long-term prospects. These include reducing the risk of human extinction, preventing climate change, guiding the development of artificial intelligence, and investing funds for later use. We end by arguing that these actions are more than just extremely effective ways to do good. Since the benefits of longtermist efforts are large and the personal costs are comparatively small, we are morally required to take up these efforts. (shrink)

Background: Despite procedural innovations and increasing numbers of uterus transplant attempts worldwide, the perspectives of uterus transplant (UTx) trial participants are lacking. Methods: We conducted a mixed-methods study with women with absolute uterine factor infertility (AUFI). Participants included women who had previously contacted the Cleveland Clinic regarding the Uterine Transplant Trial and met the initial eligibility criteria for participation. In-depth interviews were conducted in conjunction with FertiQoL, a validated and widely used tool to measure the impact of infertility on the (...) quality of life of infertility patients. Results: All (n = 19) rated their overall health as good; some experienced grief and social isolation. AUFI is a life-framing experience that influences acceptance by family, partners, peers, and one’s self. UTx is a means to gain control of reproductive autonomy. UTx allows family-building and the ability to play an active role in prenatal health and well-being. Establishing and maintaining a supportive relationship is a key issue of AUFI and when considering UTx. Risks of UTx are perceived relative to risks to self/child/family posed by adoption/surrogacy. Participants had no overall preference regarding living or deceased donor. Conclusions: The ways in which women with AUFI conceptualize this condition in their lives and choices around UTx and participating in a study of the procedure are multifaceted and textured. These perspectives are critical to understanding its ethical, legal, and social implications. (shrink)

Hilary Putnam, who may have been the first philosopher to advance the notion that the computer is an apt model for the mind, takes a radically new view of his...

Could low-level exposure to polluting chemicals be analogous to exercise -- a beneficial source of stress that strengthens the body? Some scientists studying the phenomenon of hormesis claim that that this may be the case.s A Little Pollution Good For You? critically examines the current evidence for hormesis.

This paper examines the source and content of epistemic norms. In virtue of what is it that epistemic norms have their normative force? A semantic approach to this question, due to Alvin Goldman, is examined and found unacceptable. Instead, accounts seeking to ground epistemic norms in our desires are argued to be most promising. All of these accounts make epistemic norms a variety of hypothetical imperative. It is argued that such an account may be offered, grounding our epistemic norms in (...) desire, which nevertheless makes these imperatives universal. The account is contrasted with some recent work of Stephen Stich. (shrink)

Realists persuaded by indispensability arguments af- firm the existence of numbers, genes, and quarks. Van Fraassen's empiricism remains agnostic with respect to all three. The point of agreement is that the posits of mathematics and the posits of biology and physics stand orfall together. The mathematical Platonist can take heart from this consensus; even if the existence of num- bers is still problematic, it seems no more problematic than the existence of genes or quarks. If the two positions just described (...) were the only ones possible, there could be no objection to this melding of numbers with genes and quarks. However, the position I call contrastive empiricism (Sober 1990a) stands opposed to both realism and to Van Fraassen's em- piricism. As it turns out, contrastive empiricism entails that coalesc- ing mathematics with empirical science is highly problematic. I believe that there is an important kernel of truth in abductive ar- guments for genes and quarks. But no counterpart argument exists for the case of numbers. Of course, the existence of this third way would be uninteresting, if contrastive empiricism were wholly implausible. However, I will argue that contrastive empiricism captures what makes sense in standard versions of realism and empiricism, while avoiding the excesses of each. This third way is a middle way; it cannot be dismissed out of hand. (shrink)

Evolutionary theory is awash with probabilities. For example, natural selection is said to occur when there is variation in fitness, and fitness is standardly decomposed into two components, viability and fertility, each of which is understood probabilistically. With respect to viability, a fertilized egg is said to have a certain chance of surviving to reproductive age; with respect to fertility, an adult is said to have an expected number of offspring.1 There is more to evolutionary theory than the theory of (...) natural selection, and here too one finds probabilistic concepts aplenty. When there is no selection, the theory of neutral evolution says that a gene’s chance of eventually reaching fixation is 1/(2N), where N is the number of organisms in the generation of the diploid population to which the gene belongs. The evolutionary consequences of mutation are likewise conceptualized in terms of the probability per unit time a gene has of changing from one state to another. The examples just mentioned are all “forwarddirected” probabilities; they describe the probability of later events, conditional on earlier events. However, evolutionary theory also uses “backwards probabilities” that describe the probability of a cause conditional on its effects; for example, coalescence theory allows one to calculate the expected number of generations in the past that the genes in the present generation find their most recent common ancestor. (shrink)

A Philosopher Looks at Quantum Mechanics’ (Putnam [1965]) explained why the interpretation of quantum mechanics is a philosophical problem in detail, but with only the necessary minimum of technicalities, in the hope of making the difficulties intelligible to as wide an audience as possible. When I wrote it, I had not seen Bell ([1964]), nor (of course) had I seen Ghirardi et al. ([1986]). And I did not discuss the ‘Many Worlds’ interpretation. For all these reasons, I have decided to (...) make a similar attempt forty years later, taking account of additional interpretations and of our knowledge concerning non-locality. (The Quantum Logical interpretation proposed in Putnam [1968] is not considered in the present paper, however, because Putnam [1994b] concluded that it was unworkable.) Rather than advocate a particular interpretation, this paper classifies the possible kinds of interpretation, subject only to the constraints of a very broadly construed scientific realism. Section 7 does, however, argue that two sorts of interpretation—ones according to which a ‘collapse’ is brought about by the measurement (e.g. the traditional ‘Copenhagen’ interpretation), and the Many Worlds interpretation or interpretations—should be ruled out. The concluding section suggests some possible morals of a cosmological character. Background Scientific realism is the premise of my discussion What ‘quantum mechanics’ says—and some problems Other interpretations of quantum mechanics The problem of Einstein's bed Classification of the possible kinds of interpretation Which interpretations I think we can rule out The ‘moral’ of this discussion. (shrink)

One possible interpretation of the species concept is that specifies are natural kinds. Another species concept is that species are individuals whose parts are organisms. Philip Kitcher takes seriously both these ideas; he sees a role for the genealogical/historical conception and also for the one that is “purely qualitative”. I criticize his ideas here. I see the genealogical conception at work in biological discussion of species and it is presupposed by an active and inventive research program, but the natural kind (...) concept is not. I also criticize Kitcher’s criticisms against Hull’s position that species are individuals, including Kitcher’s idea that species are sets of organisms, his explanations of why “all swans are white” isn’t law-like, his discussion of the example of multiple origination. Finally, I argue that given the current evolutionary developments, pluralism is the "null hypothesis" that we should attempt to refute. (shrink)

In a recent article, Kim Sterelny and Philip Kitcher5 defend a version of genic selectionism and attempt to refute the criticisms I made of that doctrine. Their defense has two components. First, they find fault with the account I gave of the units-of-selection controversy-an account which uses the idea of probabilistic causality as a tool of explication. Second, they provide a positive account of their own of what that controversy concerns, one which they think allows genic selectionism to emerge as (...) a successful thesis. I believe that the position they sketch is mistaken, both in its general orientation and in its details. I believe that the Sterelny/ Kitcher position misunderstands what the biological question of the units of selection is about and that their criticisms of my own proposal are mistaken as well. (shrink)

The problem of simplicity involves three questions: How is the simplicity of a hypothesis to be measured? How is the use of simplicity as a guide to hypothesis choice to be justified? And how is simplicity related to other desirable features of hypotheses -- that is, how is simplicity to be traded-off? The present paper explores these three questions, from a variety of viewpoints, including Bayesianism, likelihoodism, and the framework of predictive accuracy formulated by Akaike (1973). It may turn out (...) that simplicity has no global justification -- that its justification varies from problem to problem. (shrink)

There has been relatively little effort to provide a systematic overview of different forms of exploratory experimentation (EE). The present paper examines the growing subdiscipline of nanotoxicology and suggests that it illustrates at least four ways that researchers can engage in EE: searching for regularities; developing new techniques, simulation models, and instrumentation; collecting and analyzing large swaths of data using new experimental strategies (e.g., computer-based simulation and "high-throughput" instrumentation); and structuring an entire disciplinary field around exploratory research agendas. In order (...) to distinguish these and other activities more effectively, the paper proposes a taxonomy that includes three dimensions along which types of EE vary: (1) the aim of the experimental activity, (2) the role of theory in the activity, and (3) the methods or strategies employed for varying experimental parameters. (shrink)

A system whose expected state changes with time cannot have both a forward-directed translationally invariant probabilistic law and a backward-directed translationally invariant law. When faced with this choice, science seems to favor the former. An asymmetry between cause and effect may help to explain why temporally oriented laws are usually forward-directed.

Ethicists widely accept the notion that scientists have moral responsibilities to benefit society at large. The dissemination of scientific information to the public and its political representatives is central to many of the ways in which scientists serve society. Unfortunately, the task of providing information can often give rise to moral quandaries when scientific experts participate in politically charged debates over issues that are fraught with uncertainty. This paper develops a theoretical framework for an “ethics of expertise” (EOE) based on (...) the notion that scientists have responsibilities to provide information in a way that promotes autonomous decision-making on the part of the public and its representatives. Moreover, insofar as the principle of informed consent has developed in biomedical ethics as a way for physicians to promote autonomous decision-making on the part of their patients, this paper suggests that the informed-consent concept may suggest a set of criteria and guidelines that can help scientists to fulfill their similar ethical responsibilities to the public. In order to illustrate how the resulting EOE could provide practical guidance for scientific experts, the paper examines a case study involving the dissemination of information about the low-dose biological effects of toxic chemicals and carcinogens. (shrink)

Maximum Parsimony (MP) and Maximum Likelihood (ML) are two methods for evaluating which phlogenetic tree is best supported by data on the characteristics of leaf objects (which may be species, populations, or individual organisms). MP has been criticized for assuming that evolution proceeds parsimoniously -- that if a lineage begins in state i and ends in state j, the way it got from i to j is by the smallest number of changes. MP has been criticized for needing to assume (...) some model or other of the evolutionary process even though biologists often do not know what that process really is. This paper critically evaluates both criticisms. (shrink)

This paper defends an approach to epistemology which treats the study of knowledge as on a par with the study of natural kinds. Knowledge is seen as a natural phenomenon subject to empirical investigation. In particular, it is argued that work in cognitive ethology is relevant to understanding the nature of knowledge, and that this approach sheds light on traditional philosophical questions about knowledge, including questions about the source of epistemic normativity.

In this article we attempt to complicate traditional--and, we argue, limited and exclusionary--definitions of interdisciplinarity as the bringing into dialogue of established disciplines without questioning the parameters and practices of those disciplines. We propose that interdisciplinarity instead might mean teaching and learning among, between, and in the midst of those of innate or learned capacities--not only college faculty but also students and staff. To illustrate this more radical iteration of interdisciplinarity, we draw on a range of definitions of the key (...) terms, “discipline” and “faculty,” and we offer a case study of a workshop we co-facilitated in which we brought differently positioned individuals together to engage in the educational process and the production of knowledge. We hope that this discussion contributes to expanding the notions and practices of interdisciplinarity. (shrink)

This paper examines Laurence BonJour''s defense of internalism inThe Structure of Empirical Knowledge with an eye toward better understanding the issues which separate internalists from externalists. It is argued that BonJour''s Doxastic Presumption cannot play the role which is required of it to make his internalism work. It is further argued that BonJour''s internalism, and, indeed, all other internalisms, are motivated by a Cartesian view of an agent''s access to her own mental states. This Caretsian view is argued to be (...) untenable, and, accordingly, so is internalism. (shrink)

A promising recent development in molecular biology involves viewing the genome as a miniecosystem, where genetic elements are compared to organisms and the surrounding cellular and genomic structures are regarded as the local environment. Here we critically evaluate the prospects of Ecological Neutral Theory, a popular model in ecology, as it applies at the genomic level. This assessment requires an overview of the controversy surrounding neutral models in community ecology. In particular, we discuss the limitations of using ENT both as (...) an explanation of community dynamics and as a null hypothesis. We then analyze a case study in which ENT has been applied to genomic data. Our central finding is that genetic elements do not conform to the requirements of ENT once its assumptions and limitations are made explicit. We further compare this genome-level application of ENT to two other, more familiar approaches in genomics that rely on neutral mechanisms: Kimura’s Molecular Neutral Theory and Lynch’s Mutational Hazard Model. Interestingly, this comparison reveals that there are two distinct concepts of neutrality associated with these models which we dub ‘fitness-neutrality’ and ‘competitive neutrality’. This distinction helps to clarify the various roles for neutral models in genomics, for example, in explaining the evolution of genome size. (shrink)

This paper proposes a game-theoretic solution of the surprise examination problem. It is argued that the game of “matching pennies” provides a useful model for the interaction of a teacher who wants her exam to be surprising and students who want to avoid being surprised. A distinction is drawn between prudential and evidential versions of the problem. In both, the teacher should not assign a probability of zero to giving the exam on the last day. This representation of the problem (...) provides a diagnosis of where the backwards induction argument, which “proves” that no surprise exam is possible, is mistaken. (shrink)

Laurence BonJour has defended the view that we have an a priori intellectual capacity to understand the nature of proper reason. This view is critically examined in detail and a naturalistic alternative is proposed and defended according to which our understanding of proper reasoning requires a posteriori support.

Originally published in 1940, this book by famous Plotinus scholar Arthur Hilary Armstrong assesses how the philosopher's hierarchy of reality fits into the wider universal order, and how the historical and philosophical tradition gave rise to Plotinus' own philosophies. Armstrong also supplies a bibliography broken down by topic for those who wish to pursue any aspect of the text in greater depth. This book will be of value to anyone with an interest in Plotinus, Neoplatonism and in the pagan (...) roots of Christian philosophy. (shrink)

Conway Morris argues against Stephen Jay Gould's argument that the history of life is radically contingent by describing the abundance of convergences, wherein different lineages starting in different states, arrive at the same adaptations. A standard example is the evolution of the camera eye. This review assesses the validity of Conway Morris' argument.

"We are omniscient but confused," says Leibniz. He also says that we live in the best of all possible worlds, yet do not causally interact. So what are we? Leibniz is known for many things, including the ideality of space and time, calculus, plans for a universal language, theodicy, and ecumenism. But he is not known for his ideas on the self and personal identity. This book shows that Leibniz offers an original, internally coherent theory of personal identity, a theory (...) that stands on its own even next to Locke's contemporaneous and more famous version. This book will appeal not only to students of Leibniz's thought but also to philosophers and psychologists interested in methodological problems in understanding or formulating theories of self and personal identity. (shrink)

This article explores areas of law loosely within English equity and trusts law that have not conventionally been subject to feminist debate, and within the context of a discussion about feminist method. The particular areas examined are whistleblowing and trustees’ powers of investment, each of which calls for consideration of decision-making processes which have an ethical content. These sites are chosen because they take debate outside the all too familiar locations of woman or ‘the body of woman’, including the family (...) home, where feminist analysis in relation to equity and trusts tends to stray. In exploring these chosen fields, Hobby’s (Feminist Perspectives on Equity and Trusts, Cavendish Publishing, 2001, pp. 219–255) critique of gender dimensions in relation to whistleblowing and Dunn’s (Feminist Perspectives on Equity and Trusts, Cavendish Publishing, 2001, pp. 179–196) account of women trustees’ investment decisions are evaluated and developed. The debate within feminist legal criticism of the possibility of integrating an ‘ethics of care’ and an ‘ethics of rights’ is acknowledged. Whilst acknowledging of the difficulty of adopting an approach that recognises ‘mixed logics’, it is concluded that women (and men) do integrate the ethics of care and the ethics of rights in their decision-making. It is argued that the effort should be made to trace the specific weave in particular circumstances, thereby paying suspicious attention to the values that underlie courts’ analyses of ethical choices. (shrink)

This three-volume series provides a critical examination of the history of theology in Scotland from the early middle ages to the close of the twentieth century. Volume II begins with the early Enlightenment and concludes in late Victorian Scotland.