Detailed introduction and annotations with English translation of the Tibetan text of the Nītiśāstra of Masūrākṣa; dealing on Buddhist ethic for statecraft.

Adaptive immunity is unique to the vertebrates, and the molecules involved (including immunoglobulins, T cell receptors and the major histocompatibility complex molecules) seem to have diversified very rapidly early in vertebrate history. Reconstruction of gene phylogenies has yielded insights into the evolutionary origin of a number of molecular systems, including the complement system and the major histocompatibility complex (MHC). These analyses have indicated that the C5 component of complement arose by gene duplication prior to the divergence of C3 and C4, (...) which suggests that the alternative complement pathway was the first to evolve. In the case of the MHC, phylogenetic analysis supports the hypothesis that MHC class II molecules evolved before class I molecules. The fact that the MHC‐linked proteasome components that specifically produce peptides for presentation by class I MHC appear to have originated before the separation of jawed and jawless vertebrates suggests that the MHC itself may have been present at this time. Immmune system gene families have evolved by gene duplication, interlocus recombination and (in some cases) positive Darwinian selection favoring diversity at the amino acid level. (shrink)

In the past decade, policy-makers in science have been concerned with harmonizing research integrity standards across Europe. These standards are encapsulated in the European Code of Conduct for Research Integrity. Yet, almost every European country today has its own national-level code of conduct for research integrity. In this study we document in detail how national-level codes diverge on almost all aspects concerning research integrity – except for what constitutes egregious misconduct. Besides allowing for potentially unfair responses to joint misconduct by (...) international collaborations, we argue that the divergences raise questions about the envisaged self-regulatory function of the codes of conduct. (shrink)

In these essays, Hugh J. McCann develops a unified perspective on human action. Written over a period of twenty-five years, the essays provide a comprehensive survey of the major topics in contemporary action theory. In four sections, the book addresses the ontology of action ; the foundations of action ; intention, will, and freedom; and practical rationality. McCann works out a compromise between competing perspectives on the individuation of action ; explores the foundations of action and defends a volitional (...) theory; argues for a libertarian view of both the formation and the execution of intention; and considers the question of consistency in rational intentions, as well as the relationship between practical and theoretical reasoning. -/- Among the original features of McCann's work are his defense of both fine- and coarse-grained actions and his arguments for a noncausal theory of the relation between intention and action. He also suggests that intentions need not be consistent, either with each other or with beliefs about success. And he contends that intention formation is an intrinsically ratiocinative procedure, distinct from reasoning about what action would be best. (shrink)

The elimination of gatekeepers for scientific publication has been represented as a means to promote the core moral values of open science, including democratic decision-making and inclusiveness. I argue that this framing ignores the reality that gatekeeping is a way of structuring prestige hierarchies, and that without gatekeeping, some other structuring would be needed: the flattening of prestige hierarchies is not possible given scientists’ need to navigate information overload. I consider two potential restructurings of prestige hierarchies, one based on citation (...) count and the other on search algorithm rank. These are shown to simply reintroduce status biases and hierarchies in ways that either do not further the open science ideals of democracy and inclusiveness, or else involve some de facto gatekeeping. Gatekeeper elimination should not be thought of as an intrinsic part of the open science movement. In fact, insofar as gatekeeping is guided by professional ideals of impartiality and diligence, it can be thought of as an ally of open science values. (shrink)

The dominant view today on evolutionary progress is that it has been thoroughly debunked. Even value-neutral progress concepts are seen to lack important theoretical underpinnings: natural selection provides no rationale for progress, and natural selection need not even be invoked to explain large-scale evolutionary trends. In this paper I challenge this view by analysing how natural selection acts in heterogeneous environments. This not only undermines key debunking arguments, but also provides a selectionist rationale for a pattern of “evolutionary unfolding”, where (...) life radiates across an increased range of exploitation of environmental heterogeneity. (shrink)

Each of the five volumes in the Stone Art Theory Institutes series—and the seminars on which they are based—brings together a range of scholars who are not always directly familiar with one another’s work. The outcome of each of these convergences is an extensive and “unpredictable conversation” on knotty and provocative issues about art. This fourth volume in the series, _Beyond the Aesthetic and the Anti-Aesthetic_, focuses on questions revolving around the concepts of the aesthetic, the anti-aesthetic, and the political. (...) The book is about the fact that now, almost thirty years after Hal Foster defined the anti-aesthetic, there is still no viable alternative to the dichotomy between aesthetics and anti- or non-aesthetic art. The impasse is made more difficult by the proliferation of identity politics, and it is made less negotiable by the hegemony of anti-aesthetics in academic discourse on art. The central question of this book is whether artists and academicians are free of this choice in practice, in pedagogy, and in theory. The contributors are Stéphanie Benzaquen, J. M. Bern­stein, Karen Busk-Jepsen, Luis Camnitzer, Diarmuid Costello, Joana Cunha Leal, Angela Dimitrakaki, Alexander Dumbadze, T. Brandon Evans, Geng Youzhuang, Boris Groys, Beáta Hock, Gordon Hughes, Michael Kelly, Grant Kester, Meredith Kooi, Cary Levine, Sunil Manghani, William Mazzarella, Justin McKeown, Andrew McNamara, Eve Meltzer, Nadja Millner-Larsen, Maria Filomena Molder, Carrie Noland, Gary Peters, Aaron Richmond, Lauren Ross, Toni Ross, Eva Schürmann, Gregory Sholette, Noah Simblist, Jon Simons, Robert Storr, Martin Sundberg, Timotheus Vermeulen, and Rebecca Zorach. (shrink)

The success of precision medicine depends on obtaining large amounts of information about at-risk populations. However, getting consent is often difficult. Why? In this commentary I point to the differentials in social status involved. These differentials are inevitable once personal information is surrendered, but are particularly intense when the studied populations are socioeconomically or socioculturally disadvantaged and/or ethnically stigmatized groups. I suggest how the deep distrust of the latter groups can be partially justified as a lack of confidence that their (...) core values or interests will sufficiently be taken into account. Hence, the ethical challenge here lies not in avoiding status differentials, but in dealing with them appropriately. Scientists should not assume trust from others but adopt a norm of “demonstrating trustworthiness”. (shrink)

Background Professional communities such as the medical community are acutely concerned with negligence: the category of misconduct where a professional does not live up to the standards expected of a professional of similar qualifications. Since science is currently strengthening its structures of self-regulation in parallel to the professions, this raises the question to what extent the scientific community is concerned with negligence, and if not, whether it should be. By means of comparative analysis of medical and scientific codes of conduct, (...) we aim to highlight the role of negligence provisions in codes of conduct for scientists, and to discuss the normative consequences for future codes of conduct. -/- Methods We collected scientific and medical codes of conduct in a selection of OECD countries, and submitted each code of conduct to comparative textual analysis. -/- Results Negligence is invariably listed as an infraction of the norms of integrity in medical codes of conduct, but only rarely so in the scientific codes. When the latter list negligence, they typically do not provide any detail on the meaning of ‘negligence’. -/- Discussion Unlike codes of conduct for professionals, current codes of conduct for scientists are largely silent on the issue of negligence, or explicitly exclude negligence as a type of misconduct. In the few cases where negligence is stipulated to constitute misconduct, no responsibilities are identified that would help prevent negligence. While we caution against unreasonable negligence provisions as well as disproportionate sanctioning systems, we do argue that negligence provisions are crucial for justified trust in the scientific community, and hence that there is a very strong rationale for including negligence provisions in codes of conduct. (shrink)

Environmental heterogeneity is invoked as a key explanatory factor in the adaptive evolution of a surprisingly wide range of phenomena. This article aims to analyze this explanatory scheme of categorizing traits or properties as adaptations to environmental heterogeneity. First it is suggested that this scheme can be understood as a reaction to how heterogeneity adaptations were discounted or ignored in the modern synthesis. Then a positive account is proposed, distinguishing between two broad categories of adaptation to environmental heterogeneity: properties selected (...) for by well-defined patterns of environmental heterogeneity, and properties that help organisms exploit novel patterns of environmental heterogeneity. (shrink)

This paper challenges current dominant thinking in Universities about the processes of ethical appraisal of research studies in the Social Sciences. It considers this to be founded on unjustifiable and inappropriate principles, the origins of which are presented before discussing alternative, more inclusive and ethically defensible approaches. The latter are based on dialogic processes to sustain respectful and empowering ethical reviews which appreciate the situated nature of research. The empirical evidence for this comes from papers about ethnographic studies with children (...) and adults in various educational spaces in Western Europe, originally a symposium on the practice of ethics in educational ethnography at ECER, 2017, now forming a book published by Routledge, 2019. The dialogic processes help researchers to carry out culturally-appropriate research with the demonstrable ethical integrity that participants and stakeholders reasonably expect. The authors argue that currently risk-averse Universities need to change their research cultures to support all research methodologies and fieldwork practices that have ethical integrity and create valuable research that is socially beneficial, to enhance their lustre. (shrink)

First published in 1998. Routledge is an imprint of Taylor & Francis, an informa company.

Most philosophers have given up George Berkeley’s proof for the existence of God as a lost cause, for in it, Berkeley seems to conclude more than he actually shows. I defend the proof by showing that its conclusion is not the thesis that an infinite and perfect God exists, but rather the much weaker thesis that a very powerful God exists and that this God’s agency is pervasive in nature. This interpretation, I argue, is consistent with the texts. It is (...) also an important component of Berkeley’s philosophical project, which consists of launching many small arguments against his philosophical and theological opponents. (shrink)

In the spring of 1985, 272 upper?class and graduate students from four large journalism schools completed a questionnaire indicating their beliefs on issues relevant to media ethics. Respondents indicated a strong tendency to follow their audiences rather than their personal beliefs, when the two conflict, in making editorial judgments. They also placed high emphasis on audience research rather than on audience needs not fully appreciated by audience members. Contrary to what recent research literature suggests, those inclined to stress audience research (...) most tended to subscribe to a least common denominator mode, rather than an audience segmentation approach, when taking their audiences into account as prospective professional communicators. Results are considered in light of four postulates derived from recent literature on ethics. (shrink)

The Sallustian Suasoriae are far from being works whose origin and authenticity can be claimed as matters of earth-shaking importance. As forms of composition their interest is mild; linguistically they are less valuable than bizarre; and as historical records theysuffer from the defect of most Suasoriae—that the author cannot advise about the past and is compelled to deal chiefly with the potentialities of the future. But in spite of this it is not without reason that in Germany much attention has (...) been paid to these few pages of Latin during the last twenty years. If they are what they seem to be, their evidence, such as it is, must at least be taken seriously. And this evidence is not without promise; for not only do these pieces contain several scraps of otherwise missing information largely about the prosopography of the last century B.C., but in general they purport to express the views of Sallust—a man who was no fool, even if his ability was not so great as has some-times been alleged—on the political and economic difficulties of Rome during the closing phase of the career of Julius Caesar. Material of this kind cannot lightly be neglected; but at the same time the significance, both of the author's suggestions and of his casual references to events inthe past, will depend to a great extent on the author having been Sallust himself, and not a member of some rhetor's establishment writing perhaps a hundred years or more after the events with which he pretends to be contemporary. So though there may be no welcome for yet another addition to the literature of a subject whose bibliography is already long, it may still be worth while to make some observations which will perhaps help to show that, wherever the true conclusion about the authenticity of these pamphlets may lie, at least it does not lie in the direction which has been taken in recent years by several scholars—in particular by Pöhlmann and Eduard Meyer. (shrink)

Ever since its inception, the theory of evolution has been reified into an “-ism”: Darwinism. While biologists today tend to shy away from the term in their research, the term is still actively used in the broader academic and societal contexts. What exactly is Darwinism, and how precisely are its various uses and abuses related to the scientific theory of evolution? Some call for limiting the meaning of the term “Darwinism” to its scientific context; others call for its abolition; yet (...) others claim the term refers to a myth-like story. In this paper we propose a conceptually grounded overview of the term. We show how the scientific dimension of Darwinism feeds into, and is influenced by, guises of Darwinism as a methodology and as an ethically and politically charged “worldview”. The full meaning of Darwinism, as well as how this meaning has changed over time, can only be understood through the complex interaction between these three dimensions. (shrink)

This 'paper' was intended as the first chapter of a book. It sketches Aristippus'theory of ethics, and discusses various objections to it (Plato, Aristotle, etc.).