Understanding how neurons represent, process, and manipulate information is one of the main goals of neuroscience. These issues are fundamentally abstract, and information theory plays a key role in formalizing and addressing them. However, application of information theory to experimental data is fraught with many challenges. Meeting these challenges has led to a variety of innovative analytical techniques, with complementary domains of applicability, assumptions, and goals.

Complex diseases involve both a genetic component and a response to environmental factors or lifestyle changes. Recently, genome-wide association studies (GWAS) have succeeded in identifying hundreds of polymorphisms that are statistically associated with complex diseases. However, the association is usually weak and none of the associated allelic forms is either necessary or sufficient for the disease occurrence. We argue that this promotes a network view, centred on functional redundancy. We adapted reliability theory to the concerned sub-network, modelled as a parallel (...) array of functional modules. In our model, as long as one module remains active, the function correlated with the respective disease is ensured and disease does not occur. Genetic factors reduce the initial number of available modules while environment, contingent surroundings, personal history, epigenetics, and some intrinsic stochasticity influence their persistence time. This model reproduces age-specific incidence curves and explains the influence of environmental changes. It offers a new paradigm, according to which disease occurs due to a lack of functional elements, depending on many idiosyncratic factors. Genetic risk assessed from GWAS is only a statistical notion with no direct interpretation at the individual level. However, genomic profiling could be useful at population level in devising models to guide decisions in health care policy. (shrink)

El Naturalismo Trascendental del Ultimo Wittgenstein The present article considers an internal tension in Wittgenstein's late philosophy. In what I call his 'naturalism', Wittgenstein circumscribes philosophical reflection to natural objects, to «making natural history». In his 'transcendentalism' he focuses on the «possibility of phenomena» and distinguishes philosophical method from the method of the natural sciences. I show that his 'transcendentalism' is present in his discussion of rules and prívate language, arguing for an interpretation in terms of a kantian type of (...) transcendental synthesis. But far from contradicting his 'naturalism', both tendencies are inseparable and essential to the main purpose of his Philosophical Investigations. (shrink)

Is it possible to measure the dispersion of ex ante chances among people, be it gambling, health, or social opportunities? We explore this question and provide some tools, including a statistical test, to evidence the actual dispersion of ex ante chances in various areas, with a focus on chronic diseases. Using the principle of maximum entropy, we derive the distribution of the risk of becoming ill in the global population as well as in the population of affected people. We find (...) that affected people are either at very low risk, like the overwhelming majority of the population, but still were unlucky to become ill, or are at extremely high risk and were bound to become ill. (shrink)

El tercer volumen incluye un total de 70 textos que dan cuenta de la historia conflictiva de la formación profesional del arquitecto posrevolucionario y el surgimiento de la arquitectura moderna en México. Una referencia esencial para la evolución de la arquitectura en el siglo 20 en México. La antología completa cuenta de la producción académica y analítica importante, así como la calidad de las ideas que transformaron la producción de la arquitectura mexicana a finales del siglo 19 y durante el (...) siglo 20. (shrink)

Il peut paraître singulier, pour une revue trimestrielle, de vouloir analyser l’actualité politique, alors que celle-ci change au jour le jour. Mais, dans ce débit à jets continus, il est des événements, parfois des détails, qui sont plus importants que d’autres ; il est des actes ou des faits que les historiens retiendront comme ayant marqué un moment, voire même leur...