RNA localization is a powerful strategy used by cells to localize proteins to subcellular domains and to control protein synthesis regionally. In germ cells, RNA targeting has profound implications for development, setting up polarities in genetic information that drive cell fate during embryogenesis. The frog oocyte offers a useful system for studying the mechanism of RNA localization. Here, we discuss critically the process of RNA localization during frog oogenesis. Three major pathways have been identified that are temporally and spatially separated (...) in oogenesis. Each pathway uses a different mechanism to effect RNA localization. In some cases, localization elements within the 3' untranslated region have been identified and have provided unique insights into the localization process. This important field is still in its infancy, however, and much remains to be learned. BioEssays 21:546–557, 1999. © 1999 John Wiley & Sons, Inc. (shrink)

On September 3, 2015, the Political Epistemology/ideas, Knowledge, and Politics section of the American Political Science Association sponsored a roundtable on epistemic democracy as part of the APSA’s annual meetings. Chairing the roundtable was Daniel Viehoff, Department of Philosophy, University of Sheffield. The other participants were Jack Knight, Department of Political Science and the Law School, Duke University; Hélène Landemore, Department of Political Science, Yale University; and Nadia Urbinati, Department of Political Science, Columbia University. We thank the participants (...) for permission to republish their remarks, which they edited for clarity after the fact. (shrink)

The philosophy of George Santayana is best considered as a complement to that of Spinoza, to whom Santayana once referred as his “hero.” Like Spinoza, Santayana refused to accept any God steeped in revelation or mythology, yet he appreciated Spinoza’s wisdom in reclaiming the name of God non-anthropomorphically. For Santayana, God symbolizes a single “omnificent” natural power that transcends human understanding. Santayana went beyond his hero by striving to love not merely the real but also the ideal. We should view (...) people and things in their greatest possible beauty, and love them with depth and passion. (shrink)

In this article we address torture in military and police organizations as a public health and human rights challenge that needs to be addressed through multiple levels of intervention. While most mental health approaches focus on treating the harmful effects of such violence on individuals and communities, the goal of the project described here was to develop a primary prevention strategy at the institutional level to prevent torture from occurring in the first place. Such an approach requires understanding and altering (...) the conditions that cause and sustain “atrocity producing situations”. Given the persistence of torture across the world and its profound health consequences, this is an increasingly important issue in global health and human rights. (shrink)

In the classic Miners case, an agent subjectively ought to do what they know is objectively wrong. This case shows that the subjective and objective ‘oughts’ are somewhat independent. But there remains a powerful intuition that the guidance of objective ‘oughts’ is more authoritative—so long as we know what they tell us. We argue that this intuition must be given up in light of a monotonicity principle, which undercuts the rationale for saying that objective ‘oughts’ are an authoritative guide for (...) agents and advisors. (shrink)

Exploring online criticisms of the ‘take the knee’ protest during ‘Euro 2020’, this article examines how alt- and far-right conspiracies were both constructed and communicated via the social media platform, Twitter. By providing a novel exploration of alt-right conspiracies during an international football tournament, a qualitative thematic analysis of 1,388 original tweets relating to Euro 2020 was undertaken. The findings reveal how, in criticisms levelled at both ‘wokeism’ and the Black Lives Matter movement, antiwhite criticisms of the ‘take the knee’ (...) protest were embroiled in alt-right conspiracies that exposed an assumed Cultural Marxist, ‘woke agenda’ in the tournament’s organization and mainstream media coverage. In conclusion, it is argued that conspiratorial discourses, associated with the alt-right, provided a framework through which the protest could be understood. This emphasises how the significance of conspiracy functions to promote the wider dissemination of alt-right ideology across popular cultural contexts, such as sport. (shrink)

Increasing emphasis on genetic research means that growing numbers of human research projects in Australia will involve complex issues related to genetic privacy, familial information and genetic epidemiology. The Office of Population Health Genomics (Department of Health, Western Australia) hosted an interactive workshop to explore the ethical issues involved in the disclosure of genetic information, where researchers and members of human research ethics committees (HRECs) were asked to consider several case studies from an ethical perspective. Workshop participants used a variety (...) of approaches to examine the complex ethical issues encountered, but did not consistently refer to the values and principles outlined in the National Statement on Ethical Conduct in Human Research (NHMRC 2007) or apply rational ethical approaches. Overall, the data suggested that both researchers and HREC members may benefit from further education and support regarding the application of ethical frameworks to the issues encountered in genetic research. (shrink)

The Human Agenda is the first Special Edition of The Cambridge Journal of Law, Politics, and Art (CJLPA), an interdisciplinary journal founded at the University of Cambridge. Focused on the unique intersections of law, politics and art in the context of human rights, contributors to the Special Edition include David Baragwanath, Luis Moreno Ocampo, Nadia Murad, Nancy Hollander, Andrew Clapham, Vladimir Osechkin, Mansour al-Omari, and many others. A full table of contents is available through the publication's own page.

We applaud Shen et al. (2024) for offering a framework to address how to return research results from digital phenotyping within the discipline of psychiatry. However, given the value-laden nature...

The development of culture-independent strategies to study microbial diversity and function has led to a revolution in microbial ecology, enabling us to address fundamental questions about the distribution of microbes and their influence on Earth’s biogeochemical cycles. This article discusses some of the progress that scientists have made with the use of so-called “omic” techniques (metagenomics, metatranscriptomics, and metaproteomics) and the limitations and major challenges these approaches are currently facing. These ‘omic methods have been used to describe the taxonomic structure (...) of microbial communities in different environments and to discover new genes and enzymes of industrial and medical interest. However, microbial community structure varies in different spatial and temporal scales and none of the ‘omic techniques are individually able to elucidate the complex aspects of microbial communities and ecosystems. In this article we highlight the importance of a spatiotemporal sampling design, together with a multilevel ‘omic approach and a community analysis strategy (association networks and modeling) to examine and predict interacting microbial communities and their impact on the environment. (shrink)

In ordinary circumstances, human actions have a myriad of unintended and often unforeseen consequences for the lives of other people. Problems of pollution are serious examples, but spillovers and side effects are the rule, not the exception. Who knows what consequences this essay may have? This essay is concerned with the problems of justice created by spillovers. After characterizing such spillovers more precisely and relating the concept to the economist's notion of an externality, I shall then consider the moral conclusions (...) concerning spillovers that issue from a natural rights perspective and from the perspective of welfare economics supplemented with theories of distributive justice. I shall argue that these perspectives go badly awry in taking spillovers to be the exception rather than the rule in human interactions. I. Externalities Economists have discussed spillovers under the heading of “externalities.” To say this is not very helpful, since there is so much disagreement concerning both the definition and significance of externalities. (shrink)

In spite of advances in medicine and public health, malaria and other mosquito‐borne diseases are on the rise worldwide. Although vaccines, genetically modified mosquitoes and safer insecticides are under development, herein we examine a promising new approach to malaria control through better repellents. Current repellents, usually based on DEET, inhibit host finding by impeding insect olfaction, but have significant drawbacks. We discuss how comparative genomics, using data from the Anopheles genome project, allows the rapid identification of members of three protein (...) classes critical to insect olfaction: odorant‐binding proteins, G‐protein‐coupled receptors, and odorant‐degrading enzymes. A rational design approach similar to that used by the pharmaceutical industry for drug development can then be applied to the development of products that interfere with mosquito olfaction. Such products have the potential to provide more complete, safer and longer lasting protection than conventional repellents, preventing disease transmission by interrupting the parasite life cycle. BioEssays 25:1011–1020, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

Patients fit with cochlear implants commonly indicate at the time of device fitting and for some time after, that the speech signal sounds abnormal. A high pitch or timbre is one component of the abnormal percept. In this project, our aim was to determine whether a number of years of CI use reduced perceived upshifts in frequency spectrum and/or voice fundamental frequency. The participants were five individuals who were deaf in one ear and who had normal hearing in the other (...) ear. The deafened ears had been implanted with a 18.5 mm electrode array which resulted in signal input frequencies being directed to locations in the spiral ganglion that were between one and two octaves higher than the input frequencies. The patients judged the similarity of a clean signal presented to their implanted ear and candidate, implant-like, signals presented to their normal-hearing ear. Matches to implant sound quality were obtained, on average, at 8 months after device activation and at 35 months after activation. At Time 1, the matches to CI sound quality were characterized, most generally, by upshifts in the frequency spectrum and in voice pitch. At Time 2, for four of the five patients, frequency spectrum values remained elevated. For all five patients F0 values remained elevated. Overall, the data offer little support for the proposition that, for patients fit with shorter electrode arrays, cortical plasticity nudges the cortical representation of the CI voice toward more normal, or less upshifted, frequency values between 8 and 35 months after device activation. Cortical plasticity may be limited when there are large differences between frequencies in the input signal and the locations in the SG stimulated by those frequencies. (shrink)

In response to John Bishop's (2007) account of passionally caused believing, Dan-Johan Eklund (2014) argues that conscious non-evidential believing is (conceptually) impossible, that is, it's (conceptually) impossible consciously to believe that p whilst acknowledging that the relevant evidence doesn't support p's being true, for it conflicts with belief being a truth-oriented attitude, or so he argues. In this article, we present Eklund's case against Bishop's account of passionally caused believing, and we argue that it's unpersuasive, at least to those who (...) accept permissivism about evidence, that is, that it's possible for there to be more than one rational response to a given body of evidence. We do this through a novel application of a case of nurtured belief, that is, of a person holding a belief simply because she was caused to do so by her upbringing, and we use it to show exactly where Eklund's argument goes wrong. We conclude by drawing a general lesson drawn from this debate: if permissivism about evidence is true, then belief being truth-oriented is consistent with non-evidential believing being possible. (shrink)

We present a new understanding of Christ’s real presence in the Eucharist on the model of Stump’s account of God’s omnipresence and Green and Quan’s account of experiencing God in Scripture. On this understanding, Christ is derivatively, rather than fundamentally, located in the consecrated bread and wine, such that Christ is present to the believer through the consecrated bread and wine, thereby making available to the believer a second-person experience of Christ, where the consecrated bread and wine are the way (...) in which she shares attention with him. The consecrated bread and wine are then, in a sense, icons of Christ. (shrink)

We provide a retrospective of 25 years of the International Conference on AI and Law, which was first held in 1987. Fifty papers have been selected from the thirteen conferences and each of them is described in a short subsection individually written by one of the 24 authors. These subsections attempt to place the paper discussed in the context of the development of AI and Law, while often offering some personal reactions and reflections. As a whole, the subsections build into (...) a history of the last quarter century of the field, and provide some insights into where it has come from, where it is now, and where it might go. (shrink)

This paper proposes to examine Daniel Cohen’s recent attempt to apply virtues to argumentation theory, with special attention given to his explication of how open-mindedness can be regarded as an argumentational or critical virtue. It is argued that his analysis involves a contentious claim about open-mindedness as an epistemic virtue, which generates a tension for agents who are simultaneously both an arguer and a knower (or who strive to be both). I contend that this tension can be eased or (...) resolved by clarifying the nature of open-mindedness and by construing open-mindedness in terms of its function. Specifically, a willingness to take a novel viewpoint seriously is sufficient for making open-mindedness both an epistemic and a critical virtue. (shrink)

It is regrettably common for theorists to attempt to characterize the Humean dictum that one can’t get an ‘ought’ from an ‘is’ just in broadly logical terms. We here address an important new class of such approaches which appeal to model-theoretic machinery. Our complaint about these recent attempts is that they interfere with substantive debates about the nature of the ethical. This problem, developed in detail for Daniel Singer’s and Gillian Russell and Greg Restall’s accounts of Hume’s dictum, is (...) of a general type arising for the use of model-theoretic structures in cashing out substantive philosophical claims: the question of whether an abstract model-theoretic structure successfully interprets something often involves taking a stand on non-trivial issues surrounding the thing. In the particular case of Hume’s dictum, given reasonable conceptual or metaphysical claims about the ethical, Singer’s and Russell and Restall’s accounts treat obviously ethical claims as descriptive and vice versa. Consequently, their model-theoretic characterizations of Hume’s dictum are not metaethically neutral. This encourages skepticism about whether model-theoretic machinery suffices to provide an illuminating distinction between the ethical and the descriptive. (shrink)

Contributors: Steven Barbone, Laurent Bove, Edwin Curley, Valérie Debuiche, Michael Della Rocca, Simon B. Duffy, Daniel Garber, Pascale Gillot, Céline Hervet, Jonathan Israel, Chantal Jaquet, Mogens Lærke, Jacqueline Lagrée, Martin Lin, Yitzhak Y. Melamed, Pierre-François Moreau, Steven Nadler, Knox Peden, Alison Peterman, Charles Ramond, Michael A. Rosenthal, Pascal Sévérac, Hasana Sharp, Jack Stetter, Ariel Suhamy, Lorenzo Vinciguerra.

Jack, who is seventy‐five years old, is in the hospital with a terminal condition that has undermined his cognitive faculties. He has left no advance directive and has never had a conversation in which he made his treatment wishes remotely clear. Yet now, a treatment decision must be made, and in modern American medicine, the treatment decision for Jack is supposed to be made by a surrogate decision‐maker, who is supposed to use a decision‐making standard known as “substituted (...) judgment.” According to the substituted judgment standard, Jack’s surrogate decision‐maker, his wife, is supposed to decide on his treatment by determining what Jack would do if he did have decisional capacity. That is, she is supposed to answer the question, what would the patient choose? I will argue that this is the wrong question to ask because when the question has a determinate answer, that answer is sometimes not sufficiently connected to the value that is supposed to make the question morally salient, and because sometimes, perhaps often, there is no determinate answer to the question of what the patient would choose. Jointly, these two problems suggest the need for a different question. (shrink)

© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

In this chapter I seek to rehabilitate and elaborate the so-called “mischief rule” of English law. I begin by interrogating two views of legal and constitutional interpretation which make symmetrical mistakes about legal interpretation: Larry Alexander and Emily Sherwin’s view in Demystifying Legal Reasoning and Jack Balkin’s in Living Originalism. Against these views I argue that the appropriate interpretation of laws is guided by the “mischief” the legislators were trying to remedy when they created the law and by what (...) the legislators and the subjects of the law understand when laws are created or changed. (shrink)

Abstractabstract:Being a parent is hard, particularly parenting adolescents, who need to be given choices and allowed the space to learn how to make choices for themselves, even when those choices result in negative consequences. This essay explores how Steven Sondheim and James Lapine's 1987 musical Into the Woods provides relatable stories of the challenges of being a parent, the challenges of parenting adolescents, and just how messy parents and families can be despite everyone trying their best. The stories of Little (...) Red Riding Hood, Rapunzel, Jack, and Cinderella show us various stages, trajectories, and occasional tragedies of adolescents' emerging autonomy, while the Baker's and the Witch's struggles becoming and being parents encapsulate how disorderly and untidy parenting often is. Pediatricians and clinical bioethicists, who are often in a position to scrutinize the choices of parents and teens, should remember that parents and adolescents are almost always motivated by good intentions and doing the best that they can. Perhaps the best we can do is accompany them on their journey "into the woods.". (shrink)

As critics, a vital part of our task is to examine the ways in which language mystifies and reveals, serves and disserves human desires and aspirations. In that spirit we feel that engaging the leading Palestinian intellectual in the United States in a critical dialogue is a vital task. Although this reply takes issue with several points in Edward Said’s paper, “An Ideology of Difference” , our critique is intended as part of the struggle for increased mutual empathy. We in (...) no way wish to deny Said’s claims regarding the legitimacy of Palestinian aspirations, nor the validity of Said and other Palestinian intellectuals’ efforts to counter the destructive military, political, and ideological forces that stand in the way of the Palestinians’ achievement and self-determination. Said’s critiques of the idea that Israel is somehow above criticism, and of the elimination of the Palestinians from “Western” discourse, are both valid.2We wish to make our own perspective clear at the start. We are both Jewish nationalists. We believe that it’s a good thing to be Jewish. We believe that those of Jewish heritage who fail to explore and re-create that heritage lose something of themselves. We think that Judaism still has a role to play in the healing of the world. By making this statement, we are not claiming that our views are identical,3 nor that they are the same from day to day, nor, a fortiori, that they are identical or even similar to those of many or most other people who would define themselves in that way. This, we note, touches on one of the aspects of Said’s paper of which we are most critical: The statements that he makes at several points, which seem to reify Zionists and Zionism into one model of theory and social practice, as well as his occlusion of the fact that other options for Jewish self-renewal were obviated by genocide or Soviet repression. 2. We are hardly alone among Jewish intellectuals in concurring with this point. Compare the recent comments by the American Jewish leader Rabbi Arthur Hertzberg:In memory of the Holocaust we have been reminded by you that silence is a sin. You have spoken out against indifference and injustice. Why are you making a special exception of Israel? Do you think that our silence will help Israel? The texts that we study and restudy teach the contrary. Daniel Boyarin is associate professor of midrash at Bar-Ilan University. His articles on midrash and theory have appeared in Poetics Today and Representations, and a monograph on the subject is forthcoming this year. Jonathan Boyarin is a fellow of the Max Weinreich Center at the VIVO Institute for Jewish Research. He edited and translated, with Jack Kugelmass, From a Ruined Garden: The Memorial Books of Polish Jewry, and is currently completing an ethnography of Polish Jews in Paris. He is active in the International Jewish Peace Union. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Rhetoric 36.2 (2003) 172-176 [Access article in PDF] The Rhetorical Imagination of Kenneth Burke. Studies in Rhetoric/Communication. Ross Wolin. Series ed. Thomas W. Benson. Columbia, SC: University of South Carolina Press, 2001. Pp. xviii + 256. $34.95, cloth. Ross Wolin's The Rhetorical Imagination of Kenneth Burke offers its readers an interesting mix of intellectual history and conceptual explication, along with an element of biography, which Wolin performs (...) in an effort to trace the movements of Burke's thought as it developed over time within particular socio-political circumstances. The book is divided into three parts, each corresponding to Wolin's three-part division of Burke's intellectual [End Page 172] career. Part I, "Towards a Better Life through Art, Criticism and Politics," begins with a chapter on Burke's formation as a critic in the bohemian, avant-garde culture of post-World War I Greenwich Village. Wolin offers an account of how the dynamics of this social milieu prompted Burke to incorporate politics into his already established aesthetic interests, and of this fusion's manifestation in left-leaning periodicals of the time. While some might be tempted to see this first chapter as having limited value in comparison to Jack Selzer's richly detailed Kenneth Burke in Greenwich Village : Conversing with the Moderns, 1915-1931, it should be noted that Wolin does a fine job of helping his readers—in chapter one and those which follow—to understand explicitly how specific contexts shaped Burke's ideas and his rhetoric (something that Selzer's book does not do). Wolin is particularly adept at showing how, for Burke, there is an inextricable link between aesthetics, rhetoric, politics, and social life in general. This aesthetic-rhetorical connection to politics and life, argues Wolin, is key to understanding all of Burke's work. According to Wolin, equally important is how this connection informed the essays that comprised Burke's Counter-Statement, which Wolin sees as the seed from which all of Burke's theoretical and critical writings grew. For Wolin, to understand Burke one must understand Counter-Statement, and understand it within the historical circumstances that prompted and shaped its concepts and their rhetorical presentation.Chapter two is thus devoted to a discussion of the significance of Counter-Statement within Burke's oeuvre. It is in Counter-Statement, Wolin contends, that one can discern not only the fundaments of Burke's later work but also the "Critics Credo" that organized Burke's rhetorical efforts from Permanence and Change to The Rhetoric of Religion. Wolin's attempt to demonstrate the operation of this credo in all of Burke's books as an organizing principle pushes the limits of credulity at times, but readers should not let this obscure the insight Wolin offers us into Burke's responses to and interventions in early twentieth-century intellectual culture. Chapters three, four, and five comprise Part II of Wolin's book, "The Tactics of Conflict and Cooperation," which discusses in succession the three books that followed Counter-Statement chronologically: Permanence and Change, Attitudes Towards History, and The Philosophy of Literary Form. In these chapters, Wolin makes numerous interesting and novel points about Burke's thought. In the chapter on Permanence and Change, for example, Wolin highlights the conception of ethics implicit in that work, one that has its roots in poetics (particularly tragedy) and which refuses "to supplant traditional [End Page 173] ethics with another system [that is] equally fixed" (77). Although he does not state this, implicit in Wolin's reading is the suggestion that within Burke's work lies an alternative to the neo-Aristotelian virtue ethics and Habermasian universal pragmatics so many rhetorical scholars seem to embrace when theorizing a rhetorical ethics. (A "dramatistic" ethics of discourse and public life is, I think, an untapped potential of Burke's work.) Part III, "The Tactics of Motivation," offers similarly insightful and contextualized readings of A Grammar of Motives, A Rhetoric of Motives, The Rhetoric of Religion, and Language as Symbolic Action. Particularly interesting is Wolin's discussion in chapter seven of the importance of style... (shrink)

Sudah sejak awal abad pertama Kristianisme memisahkan diri dari tradisi Yudaisme dan menjadi agama baru sama sekali, meskipun Yesus yang menjadi pokok iman mereka adalah seorang Yahudi. Agama Kristen diajarkan oleh Yesus dengan melepaskan diri dari tradisi Yahudi yang ortodoks, demikianlah anggapan umum hingga sekarang. Maka baik bagi orang Kristen maupun orang Yahudi, seluruh ajaran Kristiani tidak bisa dikembalikan pada akar tradisi Yahudi. Keduanya saling membedakan diri satu sama lain. Yesus mengajarkan “cinta kasih” dan para murid-Nya mempertentangkan ajaran ini dengan (...) ajaran Taurat yang sangat menekankan hukum. Sementara itu jemaat Yahudi menuduh orang Kristen (Yahudi) murtad dari tradisi mereka. Kesan mengenai pertentangan yang sangat keras antara Kristianisme dan Yudaisme di masa lalu ini antara lain juga yang menjadi sebab dari dan memicu—atau setidaknya diduga demikian—munculnya gerakan antisemitisme di Eropa hingga abad keduapuluh. Akan tetapi apakah Kristianisme dan Yudaisme patut dipertentangkan satu sama lain? Dalam buku kecil ini, Daniel Boyarin—seorang rabi Yahudi yang ortodoks serta Profesor Retorika dan Budaya Talmud, Universitas California, Berkeley—mengajukan pandangan bahwa Yesus adalah seorang yang setia pada tradisi Yahudi. Ini berarti ajaran-ajaran yang disampaikan-Nya, setidaknya yang asli, tidaklah menyimpang dari Taurat dan Kitab para Nabi. Jikalau dalam Kristianisme terdapat ajaran yang menyimpang dari sumber Yahudi, maka kiranya karena hal itu ditambahkan atau ditafsirkan secara lain oleh para murid Yesus di kemudian hari, tetapi bukan dari Yesus sendiri. Dari lain pihak, menurut Boyarin, apa yang diajarkan oleh Yesus dapat dilacak kembali dari sumber aslinya dalam Kitab Suci Yahudi. Ajaran Yesus sungguh merupakan bagian dari Yudaisme sendiri. Boyarin mencoba merunut ajaran Yesus yang asli dari sumber-sumber Yudaisme dan mempertemukan tradisi Kristen yang paling awal ini dengan tradisi asli Yahudi............ Dalam bab 4 Boyarin membicarakan penderitaan Kristus. Pokok ini sering dikaitkan dengan Yesaya 53 tentang hamba yang setia. Tetapi sekali lagi di sini, kontroversi yang terjadi adalah bahwa sebagian penafsir menempatkan bangsa Yahudi sebagai hamba itu, dan bukan individu, sebagaimana tafsir Kristiani yang menempatkan Yesus dalam posisi tersebut. Alasannya, menurut kebanyakan tafsir Yahudi, “Mesias” tidak menderita. Penderitaan dianggap sebagai aib. Mengutip Joseph Klausner (“The Jewish and Christian Messiah,” dalam The Messianic Idea in Israel, from Its Beginning to the Completion of the Mishnah, trans. W.F. Stinespring, New York: Macmillan, 1955) topik penderitaan Messias dalam Kristianisme diangkat setelah Yesus mengalaminya, jadi semacam apologi (hlm. 130). Kalau demikian, mengapa Allah membiarkan “hamba pilihan”-Nya menderita? Klausner menjawab, demi atau untuk penebusan manusia, sebagaimana diramalkan Yesaya 53. Di sini Klausner mengubah pan-dangan Yahudi, penderitaan itu bukan ramalan tentang pengejaran bangsa Yahudi, melainkan tentang penderitaan Yesus (hlm. 131-132). Menurut Boyarin, tampaknya Midrash dan tradisi ortodoks rabi Yahudi memberi ruang juga pada penderitaan Mesias, karena kedekatan teks Markus 8:38 (“… barangsiapa malu karena Aku dan perkataan-Ku…”), yang menggunakan gaya Middrash untuk mengembangkan gagasan itu untuk Yesus menyangkut penderitaan-Nya, sementara penderitaan dan kematian Mesias juga merupakan bagian dari ajaran umum ortodoksi rabinik (hlm. 134). Tidak semua tafsir Boyarin dapat diangkat dalam resensi pendek ini, tetapi secara umum jalan pikirannya mudah dipahami, juga oleh mereka yang tidak ahli dalam Kitab Suci. Secara ringkas, dalam buku ini Profesor Boyarin mendalami akar Yudaisme dalam Kristianisme awal dan menemukan bahwa ajaran Yesus sama sekali tidak menyimpang dari tradisi Yahudi dan bahwa konsep inkarnasi dan Trinitas pun sudah ada benihnya dalam sumber Yahudi. Maka sebenarnya, tidak ada pemutusan (break) antara ajaran Yesus yang awal dengan Yudaisme sebab kedatangan Messias yang diajarkan Yesus merupakan bagian utuh dari kepercayaan Yahudi, sebagaimana terdapat dalam sumber mereka. (A. Sudiarja, Fakultas Teologi, Universitas Sanata Dharma, Yogyakarta). (shrink)

Daniel Defoe’s fictional autobiographies often contain a puritanical conversion narrative, but Colonel Jack’s narrator is unique in his problematized relationship to Christian conversion. Alert to the negative implications of mercenary conversion, Defoe presents in Colonel Jack a hero who not only revels in his complex ploys to evade the law, but explicitly rejects conversion to Christianity at several points in the narrative. By reading Colonel Jack alongside narratives of European enslavement and incarceration, I suggest that in (...) this text Defoe deliberately reproduces the form of the popular Barbary captivity narrative. This subgenre of narrative portrays conversion as a force to be resisted, informs Jack’s reluctance to embrace Christianity, and ultimately suggests that living in a Christian nation may actually be a hindrance to conversion, making Catholic South America a milieu more conducive to the protagonist’s religious transformation than Protestant Virginia. (shrink)

Much of the intuitive appeal of evidentialism results from conflating two importantly different conceptions of evidence. This is most clear in the case of perceptual justification, where experience is able to provide evidence in one sense of the term, although not in the sense that the evidentialist requires. I argue this, in part, by relying on a reading of the Sellarsian dilemma that differs from the version standardly encountered in contemporary epistemology, one that is aimed initially at the epistemology of (...) introspection but which generalizes to theories of perceptual justification as well. (shrink)

To what extent are cognitive capacities, especially perceptual capacities, informationally encapsulated and to what extent are they cognitively penetrable? And why does this matter? Two reasons we care about encapsulation/penetrability are: (a) encapsulation is sometimes held to be definitional of modularity, and (b) penetrability has epistemological implications independent of modularity. I argue that modularity does not require encapsulation; that modularity may have epistemological implications independently of encapsulation; and that the epistemological implications of the cognitive penetrability of perception are messier than (...) is sometimes thought. (shrink)

This paper provides a reply to articles by Nicola Angius and Guiseppe Primiero responding to our paper “Software Intensive Science”.

This interview with Bernard Stiegler’s long-time translator and collaborator, Daniel Ross, examines the connections between different periods of Stiegler’s work, thought, writing and activism. Moving from the three volumes of Technics and Time to the final large-scale collaborative project of The Internation, the discussion concentrates on Stiegler’s conceptualization of ‘protentionality’, hope and care for a world confronted by climate crises, entropy and computational economic reconfigurations of work, economy and imaginations for futural possibilities. The interview foreshadows the special issue on (...) The Internation project planned by Bishop and Stiegler for TCS that will appear in the near future. (shrink)

This short paper argues that two attempts in this journal to argue for the moral permissibility of homosexual activity do not succeed.

We describe an emerging field, that of nonclassical computability and nonclassical computing machinery. According to the nonclassicist, the set of well-defined computations is not exhausted by the computations that can be carried out by a Turing machine. We provide an overview of the field and a philosophical defence of its foundations.

A myth has arisen concerning Turing's paper of 1936, namely that Turing set forth a fundamental principle concerning the limits of what can be computed by machine - a myth that has passed into cognitive science and the philosophy of mind, to wide and pernicious effect. This supposed principle, sometimes incorrectly termed the 'Church-Turing thesis', is the claim that the class of functions that can be computed by machines is identical to the class of functions that can be computed by (...) Turing machines. In point of fact Turing himself nowhere endorses, nor even states, this claim (nor does Church). I describe a number of notional machines, both analogue and digital, that can compute more than a universal Turing machine. These machines are exemplars of the class of _nonclassical_ computing machines. Nothing known at present rules out the possibility that machines in this class will one day be built, nor that the brain itself is such a machine. These theoretical considerations undercut a number of foundational arguments that are commonly rehearsed in cognitive science, and gesture towards a new class of cognitive models. (shrink)

Embraces the principle of homeostasis and the necessarily egocentric and essentially innate nature of the mechanisms for control of one's equilibrium. Employing H. Werner's concept of a unity that organisms create with their environments, interactive behaviors are described that demonstrate how all such behavior, even the interaction with oneself, is guided by that principle to create and preserve a unity. The interactive behaviors of humans that are described are seen to be animistic-like in that they appear to arbitrarily assign motives (...) to others who do not have those motives. The animistic behaviors are seen to be the means whereby humans become attached to others when they form relationships. These then develop in an individual into a complex fixed permanent unity. 2012 APA, all rights reserved). (shrink)

Accelerated Turing machines are Turing machines that perform tasks commonly regarded as impossible, such as computing the halting function. The existence of these notional machines has obvious implications concerning the theoretical limits of computability.