© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

Could there have been nothing? is the first book-length study of metaphysical nihilism - the claim that there could have been no concrete objects. It critically analyses the debate around nihilism and related questions about the metaphysics of possible worlds, concrete objects and ontological dependence.

Working Feminism looks at key concepts and debates within feminist theory and puts them to work concretely in relation to the real problems faced by Filipina ...

This commentary focuses on the bidirectional links between unconscious influences and decision making. In particular, it examines the extent to which awareness is (not) necessary to the impact of decisions on psychological processes such as preferences. This analysis might help researchers to gain an extended perspective of Newell & Shanks' (N&S's) concerns regarding the role of unconscious influences in theories of decision making.

This selection of essays represents a continuous and coherent developing work which integrates philosophical (abstract) and political (concrete) concerns. The essays draw on an extensive knowledge of and familiarity with 20th-century European philosophy.

AU cœur de la vie politique des hommes gît un trésor, aujourd'hui perdu. Les révolutionnaires du XVIIIe siècle pouvaient encore le nommer. En Amérique on l'appelait " bonheur public ", dans la France des Lumières son nom était " liberté publique ". EN certaines circonstances, rares et précaires, ce trésor sans âge ressurgit dans l'action politique conduite à plusieurs, lorsqu'elle se crée un espace public où la liberté peut paraître. Alors un lien se noue, qui déploie entre les hommes un (...) monde commun. Tel est le bien public. En évoquant ce trésor perdu, la philosophie d'Hannah Arendt nous invite à retrouver, à l'écart de tout pragmatisme comme de tout moralisme, le sens instituant de l'action politique qui a le monde comme condition et comme fin. C'est dans la mesure où les actions sont politiques que le monde peut être partagé ; et dans la mesure où elles visent un monde commun que ces actions sont proprement politiques. Toute politique s'apprécie au regard du monde qu'elle est susceptible d'instaurer. N'est-ce pas pourtant à l'aliénation du monde que la politique moderne nous condamne au contraire? Le trésor serait-il pour nous définitivement perdu? Ce livre suggère que, loin de proposer une philosophie politique parmi d'autres, la réflexion arendtienne inaugure une intelligence de l'action politique qui redonne sens au " vivre-ensemble ". En son cœur se tient l'analyse originale et décisive de ce qu'on peut nommer l'acosmisme du monde moderne, cette perte du monde éprouvée aussi bien dans le système totalitaire que dans la prétention technoscientifique de nos sociétés à maîtriser les conditions de l'existence. (shrink)

Toujours, les révolutions s'inversent en terreur, la libération fait naître la domination, le pouvoir abuse, ment, échoue... Pourquoi continue-t-on pourtant à croire que le gouvernement des hommes a pour but de transformer la société alors qu'il se réduit souvent à une gestion de la situation? C'est cette question qui résonne singulièrement en ces temps de changement de gouvernance que lance ici Etienne Tassin, se reposant sur une formule de Merleau-Ponty : "On veut oublier un problème que l'Europe soupçonne depuis (...) les Grecs : n'y a-t-il pas un maléfice de la vie à plusieurs?" Les Grecs seront donc nos guides pour éclairer notre démocratie contemporaine, Oreste pour appréhender la question de la justice, Oedipe celle du maléfice, Antigone la dissidence, Socrate l'utopie, Caton les révolutions, Gygès les oubliés du régime libéral, Achille le courage, Diogène la question des migrants... Ils nous aideront à affronter cette idée tragique : il n'y a pas de bonne solution, la politique n'est pas une affaire de réussite ou d'échec mais de risque, celui de vivre à plusieurs. Elle est la condition humaine. (shrink)

This book is an account of the important influence on the development of mathematical logic of Charles S. Peirce and his student O.H. Mitchell, through the work of Ernst Schroder, Leopold Lowenheim, and Thoralf Skolem. As far as we know, this book is the first work delineating this line of influence on modern mathematical logic.

Al iniciar con la discusión suscitada por la redacción de los artículos 10 y 11 de la Declaración de los derechos humanos y del ciudadano de 1789, Etienne Tassin establece la diferencia entre la tolerancia como principio de cortesía democrática y la laicidad como principio de ciudadanía republicana. El autor sugiere que la laicidad es la política de la tolerancia cuando la tolerancia es la ética de la política, y que la forma republicana del poder político es la condición (...) de posibilidad de una sociedad democrática. Se puede, entonces, entender que la intransigencia política de la laicidad es como la condición trascendental de la tolerancia civil en el seno de las sociedades democráticas, o incluso que la intransigencia cívica es la única manera de garantizar la tolerancia civil. (shrink)

Does a concurrent cognitive task affect the dynamics of bimanual rhythmic coordination? In‐phase coordination was performed under manipulations of phase detuning and movement frequency and either singly or in combination with an arithmetic task. Predicted direction‐specific shifts in stable relative phase from 0° due to detuning and movement frequency were amplified by the cognitive task. Nonlinear cross‐recurrence analysis suggested that this cognitive influence on the locations of the stable points or attractors of coordination entailed a magnification of attractor noise without (...) a reduction in attractor strength. An approximation to these findings was achieved through parameter changes in a motion equation in relative phase. Results are discussed in terms of dual‐task performance as limited resources, dynamics rather than chronometrics, and reparameterization rather than degradation. (shrink)

Pour une théorisation explicite des temporalités patrimoniales en SHS Les études patrimoniales constituent un champ de recherches interdisciplinaires particulièrement fécond pour la théorisation des temporalités en sciences humaines et sociales. En effet, le patrimoine est un construit social caractérisé par un rapport spécifique aux temporalités, résultat de la patrimonialisation, l’« ensemble des processus de collecte et de valorisation par lesquels un groupe social sort un objet – au sens le plus large du terme – du cours ordinaire du temps pour (...) l’ériger en emblème de son identité dans le temps » (A. Micoud, 2005). Il naît de l’« édification d’un objet ou d’un bâtiment (ou d’une pratique, ou d’un savoir…) en signe de quelque chose d’autre que lui-même : une partie de notre passé, de notre identité, de nos valeurs communes » (M. Rautenberg, 2024, p. 19). Le patrimoine, « instrument moderne pour organiser la cohérence entre le présent et le passé », désigne « un ensemble de repères... (shrink)

The article explores the different modalities of the notion of bond in Rousseau’s philosophy (social, civil, political) according to the main axes of his thinking. We begin with the criticism of the sociability of Enlightenment developed in the Discourse on the Origins and Basis of Inequality among Men in order to compare it with the political remedy that emerges in the Social Contract, as well as the analysis that is conducted in the Émile around “the abstract man” cultivating his capacity (...) for attachment. Thus the genealogy of the links can emerge from the relationships of need. Alongside the condemnation of mutual dependence, mapping the notions of link, bond, relationship, node and spring offers full meaning to the positive definition of Man as a “relative being”. (shrink)

The study of metaphysical possibility involves two central questions: What are possible worlds? Is there an empty possible world? In looking at the first question we consider the different accounts of possible worlds—Lewisian realism, ersatzism, etc. In looking at the second question we consider the discussions of metaphysical nihilism, the modal ontological arguments, etc. In this paper I am drawing these two questions together in order to show how the position we hold on one of these issues affects the position (...) we should hold on the other. (shrink)

The author divides this work into three parts entitled: analytical therapy; yoga; and a comparison.

This article reports on a series of 5 analyses of spontaneous production of verbal inflection (tense and person–number agreement) by 2‐year‐olds acquiring French as a native language. A formal analysis of the qualitative and quantitative results is developed using the unique resources of Optimality Theory (OT; Prince & Smolensky, 2004). It is argued that acquisition of morphosyntax proceeds via overlapping grammars (rather than through abrupt changes), which OT formalizes in terms of partial rather than total constraint rankings. Initially, economy of (...) structure constraints take priority over faithfulness constraints that demand faithful expression of a speaker's intent, resulting in child production of tense that is comparable in level to that of child‐directed speech. Using the independent Predominant Length of Utterance measure of syntactic development proposed in Vainikka, Legendre, and Todorova (1999), production of agreement is shown first to lag behind tense then to compete with tense at an intermediate stage of development. As the child's development progresses, faithfulness constraints become more dominant, and the overall production of tense and agreement becomes adult‐like. (shrink)

Transformative unlearning: safety, discernment and communities of learningThis paper aims to stimulate awareness about the intellectual and emotional work of ‘unlearning’ in knowledge workers in the emerging learning age. The importance of providing a safe space for dialogue to promote transformative learning, through building ‘communities of learning’, is highlighted. Unlearning is conceptualized within a transformative education paradigm, one whose primary orientation is discernment, a personal growth process involving the activities of receptivity, recognition and grieving. The author utilizes the metaphor of (...) an unfolding spiral path to explore her experience of needing to ‘unlearn’ a trusted nursing practice prior to ‘learning’ new best caring practices related to infant sleep positions. Macro and micro approaches to facilitating unlearning in organizations, in learners and in nurses are suggested. (shrink)

Drawing on an ethnography among Quebecois and French female new Muslims, I consider how converts epitomize and embody the “encounter” between Muslim and western societies. By choosing Islam, converts position themselves on the margins, giving them a unique perspective on the “West.” My participants’ reflexive narratives hinge on continuity/disruption dialectics that dissolve the commonly held dichotomy between Sameness and Otherness. In analyzing these narratives, I view subjectivity as a rhetorical construction and elaborate upon converts’ daily intimate encounters and dialogues with (...) Otherness in social spaces. In light of Simmel’s figure of the Stranger based on distance and proximity, I show that converts’ experiences echo the “pacific coexistence” that Muslim and European populations have experienced historically. I argue that narratives are crucial to understanding how Islam—as a political and symbolic language of Otherness—can help frame and profile emergent western subjects and identities. (shrink)

Here we reconsider teachers’ changing subjectivities as autonomous agents whose practices acknowledge risk as an essential element in intellectual inquiry. We seek alternative descriptions to the limiting language of teachers’ current practices within the primacy of the market. We are convinced by Levinas’s claim that ethics is the first philosophy with its concomitant responsibility for the Other. This provides a valuable point of departure and our understanding of its relevance is expanded by Biesta and Todd. This perspective allows interruption of (...) the global reform ensemble with its reductionist understandings of teachers’ subjectivities within concerns for a ‘visible pedagogy’ and performativity. We illustrate how this global policy imperative is reworked in policies in the Republic of Ireland and share reflexive insights from our tutoring of teachers studying for a Master’s degree in Education. We show that teachers’ autonomy, which we understand as the capacity of teachers to facilitate risk and make ethically informed local judgements, is severely restricted by imposed standards, codes and laws to which there is tightly policed adherence. Instead we describe teachers’ practices occurring within an Invisible Pedagogy, which is not concerned with totalising and limited performativity but instead, explores risks associated with existential possibilities beyond commodification. (shrink)

This paper aims to contribute to intercorporeal ethics studies by enlarging their political understanding. Intercorporeal ethics revolve around the idea that, within organizations, our embodied interaction with each other is a conduit to enact genuine ethical relations of autonomy, mutual recognition, respect, care and responsibility. However, how intercorporeality can also be a means for organizations to shape and control their members’ ethical relationships in pursuit of corporate interests remains to be examined. We explore this political perspective on intercorporeality by combining (...) insights from Merleau-Ponty and Nussbaum. We analyze how the deployment of a lean management program in a financial institution produces unethical relations of objectification between employees by influencing their embodied interactions. Our study thus enlarges the political understanding of intercorporeality by showing the processes through which the embodied experience of one another is conditioned not only by our corporeal sensibility but also by managerial prescriptions. This provides a more nuanced understanding of intercorporeality as a basis to counter control and domination in organizations. (shrink)

Neste artigo, discutiremos os limites do modelo de estabilização empregado nas operações da Organização das Nações Unidas para construção da paz de longo prazo. Nosso argumento é que a estratégia política da estabilização, por ser baseada no uso robusto da força para combater grupos armados e apoiar governos no restabelecimento da autoridade estatal, acaba perdendo de vista os esforços de resolução dos conflitos, o que, no limite, contribui para o prolongamento da violência. Metodologicamente, o artigo se baseia no estudo do (...) caso do combate ao grupo armado M23 pela MONUSCO na RDC, por meio da análise de dados e documentos que nos permitam avaliar dois aspectos principais: (i) os níveis de violência armada; e (ii) a condução de um processo político de resolução do conflito. (shrink)

In the theoretical description of prospect theory, distinct sets of parameters can control the curvature of the value function and the shape of the probability weighting function. There is one for the gain domain and one for the loss domain. However, in most estimations, behaviour over losses is assumed to perfectly reflect behaviour over gains, through a unique set of parameters. We examine the consequences of relaxing this simplifying assumption in the context of Tanaka et al.’s (Am Econ Rev 100(1):557–571, (...) 2010) risk-elicitation procedure based on multiple price lists. We show that subjects’ behaviour for gains is mostly reflected for losses at the aggregate and individual levels, and is consistent with the distinctive prospect theory fourfold pattern. Reflection is only partial as the mean curvature of the value function is slightly less convex for losses than it is concave for gains. These results are robust to a high-stake context. However, we demonstrate that assuming reflection can have huge consequences on loss-aversion measures. Incidentally, we also highlight the existence of a strong, negative and persistent pure loss-frame effect on elicited loss aversion. We recommend that future practitioners and modellers are particularly cautious about the loss-aversion values they obtain or use because these are especially sensitive to parametric assumptions and framing. (shrink)

As part of a research conducted in the field of professional didactics for the design of video-based training for saddlers, we mobilize an iterative and collaborative analysis protocol with professionals. We compare the effects produced during a debate between experts mediated by the researcher, based sometimes on a confrontation with video traces of the activity, sometimes on the temporary diagrams of a conceptual structure of the situation. Using the argumentative trilogue analysis framework, we show how these methodologies are able to (...) foster the expression of a process of conceptualization depending on whether professionals are confronted with lived images or concep-tualizations produced by the researcher. (shrink)

A printed record of the symposium held in 1971 that was sponsored by the University of California's medical campus in San Francisco and the City and County of San Francisco to examine man's destiny and moral development.

Cet article se propose de réinterroger les relations entre le régime d’historicité « présentiste » et le régime de patrimonialité contemporain à partir de l’étude du conflit patrimonial en cours autour de l’ancien couvent Reille, situé dans le 14 e arrondissement de Paris, en attente d’un réemploi et/ou d’un projet immobilier. Cette friche est étudiée comme révélatrice de la fragilité et des apories temporelles de « l’omnipatrimonialisation », qui se caractérise par une dissociation inédite de la reconnaissance et de la (...) protection patrimoniales, par une diversification des processus de patrimonialisation et même par une nécessaire patrimonialisation par réemploi. La brèche du temps ouverte par la défonctionnalisation du couvent se trouve prolongée et élargie par un processus de patrimonialisation multiforme, mené notamment par les riverains mobilisés, et instaure, à l’occasion de la révision du plan local d’urbanisme de la Ville de Paris, un temps d’attente fructueux, propice à l’éla... (shrink)

This article examines the relationship between spirituality and politics. The author states her frustration at spirituality which is deployed against ethics in the service of politics, this she believes is inherent in many discourses and practices of spirituality. The article asks us to look again at many of the liberation theologies not because they are believed to be wrong, simply disappointing, that is to say they seem to end in concrete identities rather than pushing the very boundaries of meaning and (...) identity themselves. The article calls for spirituality that does not split us off from this world and thus from our creativity and the potential subversive possibilities that lie within it. (shrink)

Among Marxists and Communists, Louis Althusser has long had a reputation for theoreticism and scientism, the factors most often cited to explain the eclipse of his work since the 1960’s. According to the standard account, the distinguishing characteristic and major flaw of his work is that it brings everything back to knowledge. In this essay, I interrogate this understanding of Althusser by reconsidering two cornerstones of Althusserian theory that seem most to exemplify his extreme privileging of epistemology: the symptom and (...) the interpellation theory of ideology. I argue not that taking them to work on the epistemological level is wrong but rather incomplete; there exists a not quite acknowledged beyond of knowledge and interpellation in Althusser, which takes the form of a traumaticnarrative of history, enjoyment, and desire. The production of knowledge in Althusser unfolds as a pathos-laden story, which on one level gestures toward the turbulent world history in which he developed his theory: primarily WW II and the post-war Stalinist revelations, along with the conflicts it provoked in the Communist Party, and the French Communist Party in particular. Although not the subject of extended analysis, these events haunt Althusser’s texts in the form of allusions and the surprisingly violent figurative language with which Althusser discusses theoretical labor. I contend that they call to be analyzed as a kind of return of the repressed, best approached through Slavoj Žižek’s psychoanalytically inflected theory of ideology. (shrink)