The objective of the new series, "Molecular Biology, Biochemistry and Biophysics", of which this brochure forms the first volume, is to produce more than another compilation of data. It is hoped that the new series will help the individual "specialist" keep abreast of important developments in the natural sciences at the molecular and subcellular level in fields complementary to his own. The predominant aim is not so much to increase the ever-growing body of information in an encyclopedic fashion but rather (...) to give, in addition to a well rounded factual presentation of subjects which have reached a degree of maturation, a leitmotiv developed by the individual authors from a more personal point of view. The reader should thus be able to use these mono graphs not only for acquisition of knowledge but as a source of further motiva tion in his own work. This latter and more consequential aim of the monograph series is one of the reasons for presenting here a most unusual talk which should enable the reader to sit back and view his own efforts in the context of science and creative attempts as a whole. The lecture is the virtually unknown inaugural address of the Dutch physical chemist JACOBUS HENRICUS VAN'T HOFF. As is shown in his short biography presented on pages 3 and 4 the principal thoughts of the molecular biologist of today are akin to his own and he clearly recognized the universality of molecular life processes. (shrink)

Summary In 1874, the Dutch chemist and Nobel prizewinner Jacobus Henricus van 't Hoff (1852?1911) laid the foundations for stereochemistry with a publication in which he openly suggested that molecules were real physical entities with a three-dimensional structure. He visualized this new spatial concept with illustrations, but also with the help of small cardboard molecular models, which he made himself. Some of these models have survived the ravages of time and are among the oldest molecular models in (...) the world still in existence. What is more, they are the first material models of a three-dimensional molecular structure ever made. This article describes the surviving Van 't Hoff models, kept in Museum Boerhaave in Leiden and in the Deutsches Museum in Munich. Special attention is paid to the use of these models and the specific purposes they served. A closer examination of the models and their context reveals that they had an essential part to play in the early development and spread of Van 't Hoff's stereochemistry theory: he put his molecular models not only to versatile use as didactic tools, scientific instruments, and precursors to experimental proof, but also as devices to persuade other scientists of the usefulness of his theory. (shrink)

After Jacobus Henricus van't Hoff had passed away on 1 March 1911, his pupil Charles Marinus van Deventer wrote a very personal ‘in memoriam’ in the Dutch literary periodical De Gids, pointing out that van't Hoff had merely been interested in scientific facts, not in the people discovering these facts. Van't Hoff considered the study of the history of chemistry, although by no means uncongenial, a matter of little importance. He once even said: ‘To me (...) historical research appears to be appropriate for a chemist in the decline of life, when he no longer creates professional ideas, and when the laboratory has become a burden to him’. Although van Deventer had studied physical chemistry at van't Hoff's Amsterdam laboratory and had been his assistant from 1885 until 1893, he disagreed with this verdict. Van Deventer was not only a capable physical chemist, he was also an active member of the Tachtigers, a circle of Dutch poets who around 1880 brought about a renewal in Dutch literature. He took a special interest in Greek philosophy. He did not graduate with van't Hoff, but with his colleague Jan Willem Gunning . His thesis was not based on physical-chemical, but on historical research: Schetsen uit de Geschiedenis van de Scheikunde . From 1922 to 1923 he lectured on the history of chemistry at Utrecht University. His fascinating lectures were published as Grepen uit de Historie der Chemie . This work reveals his particular interest in the development of chemical concepts. (shrink)

In this paper I explore the character and role of stereoformulas and models of the atom that appeared in the early history of stereochemistry, including those of Jacobus Henricus van't Hoff, Aemilius Wunderlich, Johannes Wislicenus, Victor Meyer, Arthur Hantzsch, Alfred Werner, and Hermann Sachse. I argue that stereochemists constructed and used stereoformulas in a pragmatic way that ignored the physical implications of the spatial distribution of valence, and that the models of the atom were created to reconcile (...) the physically curious concept of valence with known physical laws. Although such models were explanatory at a deeper level, they had little impact on the theory and practice of chemistry, and were not serious attempts to reduce chemical theory to physical laws. (shrink)

Chemical visualizations and models are special kinds of situated, inductive arguments. In this paper, I examine several historical case studies—an archive of images from museums, special collections, and popular magazines—as examples of emergent practices of physical modeling as theoretical play which became the basis for molecular biology and structural chemistry. Specifically, I trace a legacy of visualization tools that starts with Archibald Scott Cooper and Friedrich Kekulé in the late 1800s, crystallizes as material manipulatives in Kekulé’s student Jacobus (...) class='Hi'>Henricus Van’t Hoff and his folded paper “toys,” is legitimized in the California lab of Linus Pauling, and is glorified in the popular imaginary with James Watson and Francis Crick’s model of DNA. My tracing then follows several threads into contemporary modeling practices. I ultimately argue that modeling play, originally outside of the boundary of deductive, positivist science, is now an accepted mode of inductive reasoning in these related chemical fields. (shrink)

THE CONCEPTS OF ASYMMETRY and optical activity, although introduced fairly late into inorganic chemistry, have played venerable and central roles in organic chemistry. Modern organic chemistry is usually considered to commence with Friedrich Wohler's synthesis of urea in 1828, and Jean Baptiste Biot's discovery of optical activity in 1812 antedates the very genesis of this field. Moreover, Joseph Achille Le Bel and Jacobus Henricusvan't Hoff's concept of the tetrahedral carbon atom, which constitutes the foundation of stereochemistry, was proposed (...) a century ago (1874), primarily in order to explain the optical isomerism investigated by Louis Pasteur and others. It is to Alfred Werner, the founder of coordination chemistry, however, that we owe the introduction of the concept of optical activity into coordination chemistry, together with its experimental proof. ' The purpose of this paper is to examine and speculate upon the circumstances of Werner's discovery of optically active coordination compounds, to trace its antecedents in earlier work, and to assess its impact upon the future course of inorganic stereochemistry. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:PrefaceMary Jacobus (bio)Trauma theory, considered as a branch of psychoanalysis, focuses on the lasting effects on the psyche of events that—whether because of their devastating nature or because the psyche is unprepared or too immature to deal with them—cannot be integrated into the onward movement of patient’s lives. The trauma can never be undone; but perhaps the patient may be helped to live with, even mourn, its aftereffects. (...) Some approaches to trauma emphasize the event itself, along with the difficulty, and the need, to relive or re-present it. Some emphasize the structural nature of a trauma which may even be constitutive of subjectivity (castration anxiety, for instance, or primitive anxieties about separation and object loss). Still other approaches point to the meaning of the trauma to the individual, arguing that only by exploring the preexisting constellation of object relations can the significance of the trauma to that particular individual be understood. Trauma may plunge the survivor into never completed mourning, or replace an ordinary guilt with an unresolvable one. Whatever the different inflection of trauma theory, it derives its contours from psychoanalysis, past and present, and, in particular, from the impact on Freud and his successors of some of the most devastating and momentous historical events of modern times, including modern warfare, the Holocaust, and industrialization. But trauma theory also takes account of events that happen (both chronically and diachronically, so to speak) in the intimacy of the family and in the ambiguously interpersonal and social dimensions of sexuality, where events intersect with issues involving gender, power, and powerlessness as well as with preexisting psychic structures.The essays in this collection arise not only from the continuing engagement with trauma theory on the part of psychoanalysts in their clinical and therapeutic work with patients, but from the surge of interest in trauma theory viewed as a way to invest the study of literature with urgent concerns, at once topical and timeless, and to understand literariness itself. A number of essays included in this special issue focus on the notion of the archive, whether viewed as a form of record which remains in abeyance (Jonathan Elmer’s starting point for considering Jefferson’s encounter with the Native American past) or as the place of a misunderstanding, even destructiveness (the point of departure for Herman Rapaport’s reading of Derrida’s Archive Fever). Appropriately, this issue also includes a photo-essay by Laurie Sieverts Snyder, which represents not only a family archive but a collection of memories that inscribe a larger historical displacement and relocation. The intertwined evolution of trauma theory and war neurosis, and the consequent unsexing of trauma, can give rise to a post-Freudian inquiry into the writing of anxiety (such as we see in Lyndsey Stonebridge’s reading of the war novels of Henry Green, where war “is” sex). At the same time, we can glimpse how the belatedness of trauma not only gets recoded as suspension or “falling” but gives rise to a philosophic discourse of trauma (see Eleanor Kaufman’s reading of Perec’s W together with Cathy Caruth’s Unclaimed Experience). Given its centrality to contemporary literary-critical readings of trauma, it is not surprising that a number of essays should address Cathy Caruth’s work directly (many of the essays included here also do so indirectly). Her writing remains central to current literary and theoretical discussions of trauma, whether viewed as a phenomenology of trauma (as it is, for instance, by Eleanor Kaufman) or as a vantage point from which to define the modern predicament of mutually entangled histories, communities, and writings (this is how Petar Ramadanovic links Freud’s diasporic movement to the history of slavery and Toni Morrison’s Beloved). [End Page 3]The final section of this special issue returns trauma to the consulting room. Essays on pain (Mary Jacobus on the place of psychoanalysis “between” therapy and hermeneutics as represented by the writings of Wifred Bion) and melancholia (Angelika Rauch’s Kristevan essay on post-traumatic hermeneutics and problems in contemporary trauma therapy) pay particular attention to the question of interpretation in psychoanalysis. They also shift the discussion in the direction of contemporary post... (shrink)

John Bell showed that a big class of local hidden-variable models stands in conflict with quantum mechanics and experiment. Recently, there were suggestions that empirically adequate hidden-variable models might exist which presuppose a weaker notion of local causality. We will show that a Bell-type inequality can be derived also from these weaker assumptions.

The first Ukrainian translation of J. Thomasius’ work “Nucleus disputationis de plagio literario maxime theoreticus, thesibus paucis & brevibus comprehensus”.

Originally published in 1529, the Declamation on the Preeminence and Nobility of the Female Sex argues that women are more than equal to men in all things that really matter, including the public spheres from which they had long been excluded. Rather than directly refuting prevailing wisdom, Agrippa uses women's superiority as a rhetorical device and overturns the misogynistic interpretations of the female body in Greek medicine, in the Bible, in Roman and canon law, in theology and moral philosophy, and (...) in politics. He raised the question of why women were excluded and provided answers based not on sex but on social conditioning, education, and the prejudices of their more powerful oppressors. His declamation, disseminated through the printing press, illustrated the power of that new medium, soon to be used to generate a larger reformation of religion. (shrink)

In this book Otfried Hoffe provides a comprehensive introduction to the life and work of Aristotle, covering well-known Aristotelian topics such as ethics, ...

In this article, we evaluate various responses to a noteworthy objection, namely, the infinite God objection to the kalām cosmological argument. As regards this objection, the proponents of the kalām argument face a dilemma—either an actual infinite cannot exist or God cannot be infinite. More precisely, this objection claims that God’s omniscience entails the existence of an actual infinite with God knowing an actually infinite number of future events or abstract objects, such as mathematical truths. We argue, however, that the (...) infinite God objection is based on two questionable assumptions, namely, that it is possible for an omniscient being to know an actually infinite number of things and that there exist an actually infinite number of abstract objects for God to know. (shrink)

Artikelen over het grensgebied tussen psychologie, recht en moraal vanuit een rechtspsychologisch en behavioristisch uitgangspunt, waarbij de auteur zich onder meer baseert op het gedachtegoed van de Amerikaanse psycholoog Skinner.

Psychologische, rechtstheoretische en sociobiologische benadering van altruïstisch gedrag als grondslag van de menselijke samenleving.

In this article we examine how Qumran Hebrew can contribute to our knowledge of historical Hebrew linguistics. The premise of this paper is that Qumran Hebrew reflects a distinct stage in the development of Hebrew which sets it apart from Biblical Hebrew. It is further assumed that these unique features are able to assist us to understand the nature of the development of Biblical Hebrew in a more precise way. Evidence from the syntax of participial negation at Qumran as opposed (...) to Biblical Hebrew provides evidence for this claim. (shrink)

The Heythrop Journal, Volume 63, Issue 2, Page 196-209, March 2022.

Kant is widely acknowledged for his critique of theoretical reason, his universalistic ethics, and his aesthetics. Scholars, however, often ignore his achievements in the philosophy of law and government. At least four innovations that are still relevant today can be attributed to Kant. He is the first thinker, and to date the only great thinker, to have elevated the concept of peace to the status of a foundational concept of philosophy. Kant links this concept to the political innovation of his (...) time, a republic devoted to human rights. He extends the concept by adding to it the right of nations and cosmopolitan law. Finally, Kant democratizes Plato's notion of philosopher kings with a concept of 'kingly people'. This book examines all aspects of this important, but neglected, body of Kant's writings. (shrink)

In der von Otfried Höffe herausgegebenen Reihe Klassiker Auslegen werden die bedeutendsten Werke der Philosophiegeschichte in Form kooperativer Kommentare von international renommierten Philosophen entschlüsselt und kommentiert. Dabei folgen sämtliche Bände der Reihe dem inneren Aufbau der betreffenden Klassikerwerke. In 12 bis 15 Beiträgen erschließen sie die großen Themen der Philosophie ohne den zeitraubenden Gang durch die Sekundärliteratur und bilden so eine Pflichtlektüre für Studierende, Hochschullehrer und Forscher.

This book offers a discussion of the kalām cosmological argument, and presents a defence of a version of that argument after critically evaluating three of the most important versions of the argument. It argues that, since the versions of the kalām cosmological argument defended by Philoponus (c. 490–c. 570), al-Ghazālī (1058– 1111), and the contemporary philosopher, William Lane Craig, all deny the possibility of the existence of an actual infinite, these arguments are incompatible with Platonism and the view that God (...) foreknows an endless future. This conclusion, however, is not a problem for the proponents of the kalām cosmological argument, for the book shows how the argument can be defended without denying the possibility of the actual infinite. -/- In order to offer a comprehensive analysis of Philoponus and al-Ghazālī’s cosmological arguments, the book draws on recent English translations of some of their works. Next, the book advances a detailed argument against the popular argument based on the impossibility of an actual infinite. Finally, the book offers a unique defence of the kalām cosmological argument by defending philosophical arguments for a beginning of time that do not deny the actual infinite, evaluating which hypothesis best explains the discoveries of modern cosmology, and offering an argument in support of the premise that, if the universe came into existence, then God brought it into existence. (shrink)

Within a literary ontology, YHWH in the Hebrew Bible is technically also a fictional entity or object. In Hebrew Bible scholarship, a variety of philosophical issues surrounding fiction have received sustained and in-depth attention. However, the mainstream research on these matters tends to focus on the philosophical foundations of or backgrounds to a particular literary theory, rather than on metaphysical puzzles as encountered in the philosophy of fiction proper. To fill this gap, the present article seeks to provide a meta-theoretical (...) overview of the main contemporary philosophical perspectives on the metaphysics of fictional objects. Three views are discussed, namely possibilism, Meinongianism and creationism. Each view's theory is introduced and critically appropriated with reference to what is implied to be an answer to the question of what exactly the biblical character YHWH can meaningfully be said to be in the context of the metaphysics of fictional objects. In this way, the present study also goes beyond the traditional concern with the nature of God in Old Testament theology. (shrink)

In a recent article, Andrew Ter Ern Loke raises several objections to Jacobus Erasmus and Anné Hendrik Verhoef’s exposition and response to the so-called ‘Infinite God Objection’ to the kalām cosmological argument. According to this objection, the argument against the possibility of an actual infinite brings into question the view that God’s knowledge is infinite. Erasmus and Verhoef’s solution to this objection, which Loke criticises, depends on an unusual account of omniscience. In this article, I respond to Loke and (...) show that his objections are unsuccessful. (shrink)

Thomas Hobbes’ Lebensaufgabe besteht in einer wissenschaftlichen Staatsphilosophie. Dabei stellt er sich den drei Herausforderungen seiner Epoche: methodisch dem Beweisideal der Mathematik, politisch der blutigen Wirklichkeit der Kriege und Bürgerkriege und moralisch dem Schwinden gemeinsamer Überzeugungen. Weil er sich allen drei Herausforderungen stellt, zugleich sie miteinander verbindet, schafft er das die Tradition stürzende Argumentationsmuster der politischen Moderne, die Vertragstheorie. Mit ihr bringt er eine der größten Staatsphilosophien der abendländischen Geistesgeschichte hervor. In De cive / Vom Bürger (1642), das noch vor (...) dem Leviathan (1651) entstand, finden sich bereits zahlreiche von Hobbes’ zentralen Gedanken zur politischen Philosophie. Diese Schrift wird hier durchgängig von international renommierten Autoren kommentiert. Mit Beiträgen von Jeremy Adler, Ronald Asch, Dirk Brantl, Franz Hespe, Moritz Hildt, Otfried Höffe, Heiner Klemme, Elif Özmen, Dietrich Schotte, Peter Schröder, Patricia Springborg, Tom Sorell und Lothar Waas. (shrink)

An introduction to Thomas Hobbes as a systematic and not merely political philosopher. Best known for his contributions to political philosophy, Thomas Hobbes set out to develop a coherent philosophical system extending from logic and natural philosophy to civil and religious philosophy. In this introduction to Hobbes’s thought, Otfried Höffe begins by providing an overview of the entire scope of his work, making clear its systematic character through analysis of his natural philosophy, his individual and social anthropology, and his political (...) thought. He then offers an innovative examination of religious and ecclesiastical questions, touching not only on the political implications of religion so important to Hobbes, but also on his attempt to reconstruct Christianity in terms of a materialistic philosophy. He also explores Hobbes’s continuous critique of Aristotle and Aristotelian Scholastics, in which Höffe argues that Hobbes and Aristotle have much more in common philosophically than is normally supposed—and certainly more than Hobbes himself acknowledged. Finally, Höffe sketches the influence Hobbes had and continues to have on the development of legal and political philosophy. “A thoroughly successful introduction to the philosophy of Thomas Hobbes ” — Reinhard Brandt, in Süddeutsche Zeitung, in praise of the German edition. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Pain in the Patient’s KneeMary Jacobus* (bio)We know very little about pain either.—Sigmund Freud, Inhibitions, Symptoms, and AnxietyPain cannot be absent from the personality.—Wilfred Bion, The Elements of Psycho-AnalysisBetween Therapy and HermeneuticsWhat is the place of a psychoanalysis that exists “between” therapy (considered both as a theory and a practice, but also as a theory of practice) and hermeneutics, or the theory of interpretation and understanding? How (...) do we understand psychoanalytic “understanding” itself, as a mental process that involves both the analyst and the analysand in the analytic encounter? I want to approach these related questions by way of the writing of the British psychoanalyst Wilfred Bion (1897–1979). Bion is best known outside the psychoanalytic profession as a pioneer of the so-called leaderless group and a theorist of group process [see Bion, Experiences in Groups]. But his collected theoretical and clinical oeuvre represents—especially in its “epistemological” period during the early 1960s, from Learning from Experience (1962) to Transformations (1965)—the most systematic, original, and philosophical revision of psychoanalytic theory since Melanie Klein’s controversial development of Freudian ideas during the middle decades of this century.1 Consequently, Bion’s influence pervades, and in some cases underpins, the rethinking of psychoanalytic theory and practice that characterizes British object relations in the wake of Klein. In particular, it gives contemporary post-Kleinian analysis its distinctive focus on (not) learning, (non)meaning, and (un)knowing, with an accompanying emphasis on the destruction of the links that make thought possible, as well as on the importance of being able to learn from experience and being able to bear not knowing. In other words, it brings to the fore difficulties associated specifically with questions involving interpretation and understanding in an analytic context.Bion’s writing is noted for its paradoxical combination of directness and difficulty, and for its emphasis on primitive emotional states and experiences, on the one hand, and epistemology and consciousness, on the other. Rigorous in its clinical focus, it also makes [End Page 99] frequent reference to philosophy, mathematics, and other branches of contemporary science. André Green, in the context of the new impetus that Bion gave to orthodox Kleinianism by linking it back to Freud, suggests that his particular contribution lay in realizing that the unconscious phantasies and archaic anxieties emphasized by Klein coincided with thought processes. Finding in Bion “an author who could measure up to Lacan,” Green saw the two as engaged in the common project of “reformulating psychoanalytic theory within a contemporary epistemological framework.” But for Green, “Lacan made the error of excessive abstraction, whereas Bion, with his constant reference to affect and the process of transformation, is the more authentically intellectual” [10–11].2 Although Bion’s writing is read wherever the theory and practice of British object relations psychoanalysis is seriously taught and studied, for the most part it remains surprisingly unknown within the academy. This is especially the case in America—even when it comes to literary critics and theorists with an interest in the “authentically intellectual,” who are often, by contrast, steeped in Lacan and well versed in recent Continental psychoanalytic writing. If only for this reason, but also because Bion’s work is particularly relevant to issues involving the relation between therapy and hermeneutics, I want to focus on the culminating book of Bion’s “epistemological” period during the early 1960s, Transformations—so called because of Bion’s analogy between the psychoanalyst’s representation of the experience of the analytic encounter and the artist’s transformation of the experience of what he sees.Bion’s writing, although terse and at times humorous, makes considerable demands on the reader, particularly on the capacity of the mind to entertain a new thought or consider it from a radically new perspective. He places pressure on thinking (including his own), as well as attempting to communicate the seeming incomprehensibility or hallucinatory dimensions of psychotic thought processes (which are often continuous with normal thought processes). In what follows, I will address both the kind of communication made by Bion himself—which is subject to its own interpretive difficulties and obscurities—and the relation between therapy... (shrink)

A politics of women's writing, then, if it is not to fall back on a biologically based theory of sexual difference, must address itself, as Luce Irigary has done in "Pouvoir du discours, subordination du feminin," to the position of mastery held not only by scientific discourse , not only by philosophy, "the discourse of discourses," but by the logic of discourse itself. Rather than attempting to identify a specific practice, in other words, such a feminist politics would attempt to (...) relocate sexual difference at the level of the text by undoing the repression of the "feminine" in all systems of representation for which the other must be reduced to the economy of the Same .Mary Jacobus is an associate professor of English and of women's studies at Cornell University. She is the author of a book on Wordsworth as well as the editor of a collection of feminist criticism, Women Writing and Writing about Women. Currently she is at work on a study of Thomas Hardy and a collection of essays on Romantic poetry and prose. (shrink)

Volume 80, Issue 3, July 2019, Page 303-304.

Anknüpfend an den Beitrag von U. Steinvorth in Heft 1/1980 wird die Auffassung vertreten, daß die moderne allgemeine Wissenschaftstheorie bisher keine überzeugende Antwort auf die Frage nach dem Status der Politischen Wissenschaft und ihrer theoretischen Erzeugnisse gegeben hat. In diesem Beitrag wird in Auseinandersetzung mit Steinvorth u. a. hervorgehoben: Analog zu der These, daß in der Politik Vernünftigkeit nicht auf Rationalität reduziert werden darf, ist es weder möglich noch wünschenswert, für alle spezifischen politischen Wertungen einen Erklärungstyp zu begründen oder als (...) verbindlich vorzuschreiben. Die Wissenschaftstheorie muß sich in bezug auf die Frage nach dem Status "politischer" Theorien mit einem Theorietypus beschäftigen, der ein neues Abgrenzungskriterium voraussetzt, nämlich einen spezifischen Satz von Prinzipien und Regeln zur Konstruktion politikwissenschaftlicher Theorien. (shrink)

In a recent paper, John J. Park argues (1) that an abstract object can bring a universe into existence, and (2) that, according to the Big Bang Theory, the initial singularity is an abstract object that brought the universe into existence. According to Park, if (1) and (2) are true, then the kalam cosmological argument fails to show that the cause of the universe must be divine. I argue, however, that both (1) and (2) are false. In my argument I (...) analyse the abstract/concrete distinction and conclude that, by its nature, an abstract object is causally inefficacious in the sense that it cannot bring something into existence. (shrink)

Molinism is founded on two ‘pillars’, namely, the view that human beings possess libertarian free will and the view that God has middle knowledge. Both these pillars stand in contrast to naturalistic determinism and divine determinism. In this article, however, the authors offer philosophical and theological grounds in favor of libertarian free will and middle knowledge.

In this article, James 5:13-20 is investigated. This section deals with the confession of sins in the community of faith and the subsequent healing that will result. James will be compared to Philodemus, a philosopher who comes from Galilee, just like James. It is not argued that James was influenced by Philodemus but that a comparison between the two might open up fresh perspectives for the interpretation of James 5:13-20. This will especially become clear when the themes of moral exhortation, (...) community health, communal confession and the role of the psychagogue are discussed. (shrink)