Ciliated protozoa have separate germline and somatic nuclei, yet unlike larger organisms, both nuclei reside in the same cytoplasm. The micronuclei contain the germline and the macronucleus is the somatic nucleus. Thousands of DNA elements are normally removed from the micronuclear genome as it forms a new macronucleus during each sexual cycle. A recent study directly links the excision of these internal eliminated sequences (IESs) to mating type determination by showing that a pleiotropic mutation affecting mating type also prevents the (...) excision of an IES from a surface protein gene(1). Remarkably, once the IES is present in the old macronucleus it prevents excision of that specific IES during formation of the next macronucleus. (shrink)

Explores the theories of democratic individualism articulated in the works of the American transcendentalist writer Ralph Waldo Emerson, pragmatic philosophers William James and John Dewey, and African-American novelist and essayist Ralph Ellison.

While supporting the cosmopolitan pursuit of a world that respects all rights and interests, James D. Ingram believes political theorists have, in their approach to this project, compromised its egalitarian and emancipatory principles. Focusing on recent debates without losing sight of cosmopolitanism's ancient and Enlightenment roots, Ingram confronts the philosophical difficulties of defending universal ideals and the implications for ethics and political theory. In morality as in politics, theorists have generally focused first on discovering universal values and second on (...) their implementation. Ingram argues that only by prioritizing the development and articulation of universal values through political action in the fight for freedom and equality can theorists do justice to these efforts and cosmopolitanism's universal vocation. Only by proceeding from the local to the global, from the bottom up rather than from the top down, on the basis of political practice rather than moral ideals, can we salvage moral and political universalism. In this book, Ingram provides the clearest, most systematic account yet of this schematic reversal and its radical possibilities. (shrink)

Aristotle is a rarity in the history of philosophy and science - he is a towering figure in the history of both disciplines. Moreover, he devoted a great deal of philosophical attention to the nature of scientific knowledge. How then do his philosophical reflections on scientific knowledge impact his actual scientific inquiries? In this book James Lennox sets out to answer this question. He argues that Aristotle has a richly normative view of scientific inquiry, and that those norms are (...) of two kinds: a general, question-guided framework applicable to all scientific inquiries, and domain-specific norms reflecting differences in the target of inquiry and in the means of observation available to researchers. To see these norms of inquiry in action, the second half of this book examines Aristotle's investigations of animals, the soul, material compounds, the motions of heavenly bodies, and respiration. (shrink)

This is an Introduction to the special issue of Metaphilosophy entitled Philosophy as a Way of Life, giving a brief account of the genesis of the project, an overview of the topic, and a summary of the topics covered in the issue.

Explores the Pragmatists' contributions to American social thought, drawing upon the writings of William James, John Dewey, George Herbert Mead, James Hayden Tufts, and their various critics. This work also explores the Pragmatic analysis of society's potential for ongoing intelligent inquiry and cooperative evaluation to address social ills.

A dispute in the form of rival interpretations of Carneades arose in the New Academy about whether the wise person is permitted to form opinions. One party rejected opinion; the other defended it. Because the terms enjoy a certain currency, the positions are here labelled ‘radical’ and ‘moderate’ respectively. This essay tackles the question whether and how they differed. It argues that the disagreement was less about human epistemic capacities than about the standards and aspirations against which they should be (...) measured and that Cicero, our principal source, was a consistent adherent of the ‘radical’ party. (shrink)

Humility has not always been regarded as a virtue. Aristotle, if he recognized it at all, seems to have regarded it as a vice, a deficiency in regard to magnanimity. In the popular culture of the twenty-first century, while courage is held in high moral esteem, the regard given to humility is more questionable. Humility, however, is not universally dismissed as a virtue. Many see it as having moral value. In fact, a number of contemporary philosophers are relatively clear that (...) humility is a morally valuable trait and so is a moral virtue, although they disagree about its character. For traditional Christianity and Judaism, of course, and for other religious traditions, humility is a religious virtue. However, if humility is a religious virtue, is it different from humility as a moral virtue? Below, we shall start in section II with the question, What is the best way to understand the general notion of humility? In section III it shall be followed by the question, What are the core contrasting states that humility opposes? Third , in section IV we shall ask, Does humility as a religious virtue have a distinctive and abiding character? (shrink)

David Hume (1711-76) is one of the greatest figures in the history of British philosophy. Of all of Hume's writings, the philosophically most profound is undoubtedly his first, A Treatise on Human Nature. Hume on Morality introduces and assesses: Hume's life and the background of the Treatise ; the ideas and text in the Treatise ; and Hume's continuing importance to philosophy. James Baillie provides us with a map to Books 2 and 3 of the Treatise, focusing on Hume's (...) theory of the passions and morality. This book sets out its principal ideas and arguments of the Treatise in a clear and readable way and is ideal for anyone coming to Hume's work for the first time. (shrink)

The present dilemma in philosophy -- What pragmatism means -- Some metaphysical problems pragmatically considered -- The one and the many -- Pragmatism and common sense -- Pragmatism's conception of truth -- Pragmatism and humanism -- Pragmatism and religion.

Here is a sketch of a genealogy of political theory for the last century. This is a genealogy in Nietzsche’s sense: therefore, neither unhistorical taxonomy, nor a history of political theory as it is written by historians, but a typology in time. Four types of modern political theory are distinguished. These are called, with some justification, positive, normative, third way and sceptical political theory. Seen from the vantage of the twenty-first century, they form an instructive sequence, emerging as a series (...) of reactions to the canonical political theory that was established in the universities in the late nineteenth century. None of the four should be excluded from our conception of what political theory has been, though most of them, when seen genealogically, reveal their defects more clearly than they do when treated purely theoretically. Since this is a sceptical finding, the genealogy is a polemic against the first three types of modern political theory in favour of the last. (shrink)

Reply in Book Symposium on James Ladyman, Don Ross: 'Everything must go: metaphysics naturalized', Oxford: Oxford University Press, 2007.

In his recent book, Causation: A Realistic Approach , Michael Tooley discusses the following thesis, which he calls the ‘thesis of the Humean Supervenience of Causal Relations’: The truth values of all singular causal statements are logically determined by the truth values of statements of causal laws, together with the truth values of non-causal statements about particulars . represents one version of the ‘Humean’ idea that there is no more factual content to the claim that two particular events are causally (...) connected than that they occur, instantiate some law or regularity, and perhaps bear some appropriate non-causal to each other. This is an idea that is tacitly or explicitly assumed in most familiar accounts of singular causal statements. For example is assumed by many probabilistic theories of singular causal statements, by theories which attempt to analyse singular causal statements in terms of necessary and sufficient conditions, and, as I shall argue below, by David Lewis' counterfactual theory. (shrink)

The eighteenth century is still the bottleneck of the history of political theory: the century that separates pre-economic theorists such as Machiavelli, Bodin and Hobbes from post-economic theorists such as Hegel, Mill and Marx. Political thinking became immeasurably much more complicated in the eighteenth century: and yet historians, after at least half a century of extremely judicious scholarship, still have difficulty explaining its significance for contemporary theory. Sagar's Adam Smith Reconsidered is an important contribution to the attempt to clarify just (...) how modern political theorists should look backward – without hastening back to the abstractions of the seventeenth century or remaining confined to particular involutions of the nineteenth century. Its specific originality is in drawing attention to two important ideas of Adam Smith, seldom seen clearly or at all, ‘the quirk of rationality’ and ‘the conspiracy of merchants’. Political theorists as well as historians of political thought will benefit from familiarising themselves with these ideas. (shrink)

A bewildering array of accounts of the ontology of musical works is available. Philosophers have held that works of music are sets of performances, abstract, eternal sound-event types, initiated types, compositional action types, compositional action tokens, ideas in a composer’s mind and continuants that perdure. This paper maintains that questions in the ontology of music are, in Rudolf Carnap’s sense of the term, pseudo-problems. That is, there is no alethic basis for choosing between rival musical ontologies. While we have no (...) alethic basis for choosing any ontology of music, pragmatic reasons can be given for favoring certain ontologies of musical works over others. (shrink)

When does a person qualify for protected and continuing life? At a time when technology can sustain marginal life, it is ever more important to understand what constitutes a person.

A PERSONAL PHILOSOPHY FOR WAR TIME BY THE AUTHOR OF STREAMLINE YOUR MIND A Personal Philosophy for War Time JAMES L. MURSELL Professor of Education Teachers ...

Originally published in in 1893, this book contains the text of the Socratic dialogue Protagoras, which discusses a variety of Sophistic and Socratic tenets, including the teachability of virtue. The dialogue also provides an interesting view on the connection between pederasty and education in ancient Athens. Notable Plato scholars James and Adele Adams present an introduction addressing the purpose and themes of the dialogue; a biography of Protagoras and extant fragments of his works are also included. This book will (...) be of value to anyone with an interest in the Platonic, Socratic or Sophistic philosophies. (shrink)

"We reap as we sow. Those things which come to us, though not by our own choosing, are by our causing." JAMES ALLEN A Complete and Unabridged edition of James Allen's book "Foundation Stones to Happiness and Success." Part of The Works of James Allen Series. Other works by James Allen include:- Above Life's Turmoil All These Things Added As a Man Thinketh Byways of Blessedness Entering the Kingdom (Part of- "All These Things Added") From Passion (...) to Peace From Poverty to Power James Allen's Book of Meditations for Every Day in the Year Light on Life's Difficulties Man: King of Mind, Body and Circumstance Men and Systems Morning and Evening Thoughts Out from the Heart (Sequel to "As a Man Thinketh") Poems of Peace The Divine Companion The Eight Pillars of Prosperity The Heavenly Life (Part of-"All These Things Added") The Life Triumphant The Mastery of Destiny The Path to Prosperity (Part of-"From Poverty to Power") The Shining Gateway The Way of Peace (Part of-"From Poverty to Power") Through the Gate of Good. (shrink)

In this paper I argue for a computational theory of thinking that does not eliminate the mind. In doing so, I will defend computationalism against the arguments of John Searle and James Fetzer, and briefly respond to other common criticisms.

This paper attempts to examine some of Rorty’s recent writings on religious beliefs. Two claims stand at the core of these texts: (1) that religious beliefs are “private projects” and (2) that those who maintain such beliefs are not intellectually responsible for them because of their essentially private character. Other commentators on Rorty have challenged one or the other of these claims by utilizing resources outside the pragmatic tradition. But since Rorty typically allies himself with this tradition, I try to (...) examine both claims by employing the writings of two classical pragmatists, i.e., William James and John Dewey. I argue that neither James nor Dewey would accept the claims that stand at the core of Rorty’s view with respect to religious beliefs. In effect, Rorty’s thinking on religious beliefs marks a significant departure from his pragmatic forebears, even though he employs them (especially Dewey) to bolster his own position. (shrink)

This book discusses a theory called "success emulation," formulated several years ago by James Lewis, Jr. The essence of this theory is that a person or an organization can attain a high degree of success or excellence by studying the products, programs, principles, and practices of successful organizations and then adopting those that are appropriate in the new situation, with or without modifications. Lewis presents 12 important lessons which will show school districts how to achieve excellence by adopting those (...) principles and practices that have worked for the best-run companies in America. ISBN 0-915253-03-8: $18.95. (shrink)

In _The Life of the Mind,_ Georgetown University’s James V. Schall takes up the task of reminding us that, as human beings, we naturally take a special delight and pleasure in simply knowing. Because we have not only bodies but also minds, we are built to know what is. In this volume, Schall, author of _On the Unseriousness of Human Affairs __,_ among many other volumes of philosophical and political reflection, discusses the various ways of approaching the delight of (...) thinking and the way that this delight begins in seeing and hearing and even in making and walking. We must be attentive to and cultivate the needs of the mind, argues Schall, for it is through our intellect that all that is not ourselves is finally returned to us, allowing us to live in the light of truth. (shrink)

The claim to rationality is disputed by two rival enlightenments, which collided in the dispute between Plato, Socrates and the Sophists, and which Marx united critically. He criticizes the capitalist system immanently as restrictive of production, and its market as not a case of freedom or equality. However, Marx is most concerned with ontological injustice, coerced alienation of the human into being a commodity. He retains Promethean Enlightenment values however: technology, creativity, democracy, which should be economic, participatory and international. Marx (...) criticized Hegel’s rationalization, idealization, ‘transfiguration and glorification’ of private property and the market. But he retains key elements of the idealist notion of human nature: that human is a ‘universal, therefore free being.’ The proletariat, with no other class to exploit, is therefore the philosophical ‘universal class.’ Freedom is class emancipation, justice is common ownership. There is an unwarranted skepticism about the rationality of such values and ideals. Rawls for instance misrepresents them by putting them in the same category as wants or preferences. Ideals, values, and enlightenments can and should be rationally argued over, in dialogue. (shrink)

For Husserl excess is a part of any phenomenon. For Heidegger the horizon of the phenomenon is also excessive. Levinas and Marion ask us to think about what exceeds the horizon. I focus on Marion’s fifth kind of saturated (transcendent) phenomenon, revelation. How are we to understand it? Marion says he argues only for the possibility of revelation, but only Jesus could be the revelation for which he argues. The excess of the divine cannot remain merely a metaphysical beyond. It (...) must reveal itself in the world as a possible phenomenon, as Flesh, for there is no excess without flesh, and no flesh without being. Excess is either enfleshed or thingly excess. For the Christian this being-together of flesh and word in God means the same being-together in us: Christian life is fully incarnate life, life as enspirited flesh rather than as dead body. Thus the being-together of flesh and word is “in the accusative”. Christian life is, prior to action, a life of submission. That, however, explicitly puts Christian belief and practice at odds with any unrecuperated, merely metaphysical metaphysics which undercuts not only the Christian dogma of Christ’s incarnation and incarnate resurrection, but also the Christian message that the divine life is found only in the life that bends its knee and seeks to bring about justice: dikaiosunae. (shrink)

The ideas of mindfulness and no-self are intimately connected in Buddhist philosophy. This is because, in Buddhist Philosophy, the practice of mindfulness leads to the realization that there is no self. In contemporary mindfulness in psychology, the no-self theory has not played such a basic role. An outline of Buddhist philosophy is given showing how the ‘root delusion’ of having a self lies at the base of human suffering and how mindfulness, when appropriately deployed, enables one to free oneself from (...) this delusion and thus achieve psychological well-being. This is not to say that mindfulness based interventions do not help to alleviate suffering. Nor is it to say that people working in these areas should not use mindfulness in their own way. It is only to say that by ignoring the no-self experience, teachers and practioners are falling short of achieving what mindfulness was originally employed to achieve. (shrink)

Cognitive biases play an important role in creating and perpetuating problems that lead to foodborne illness outbreaks. By using insights from behavioral ethics, we argue that sometimes people engage in unethical behavior that increases the likelihood of foodborne illness outbreaks without necessarily intending to or being consciously aware of it. We demonstrate these insights in an analysis of the 2011 Listeriosis outbreak in the U.S. from the consumption of contaminated cantaloupes. We then provide policy implications that can improve our understanding (...) of other kinds of disease outbreaks and epidemics. (shrink)