mRNA synthesis in all organisms is performed by RNA polymerases, which work as nanomachines on DNA templates. The rate at which their product is made is an important parameter in gene expression. Transcription rate encompasses two related, yet different, concepts: the nascent transcription rate, which measures the in situ mRNA production by RNA polymerase, and the rate of synthesis of mature mRNA, which measures the contribution of transcription to the mRNA concentration. Both parameters are useful for molecular biologists, but they (...) are not interchangeable and they are expressed in different units. It is important to distinguish when and where each one should be used. We propose that for functional genomics the use of nascent transcription rates should be restricted to the evaluation of the transcriptional process itself, whereas mature mRNA synthesis rates should be employed to address the transcriptional input to mRNA concentration balance leading to variation of gene expression. (shrink)

We revisit the concept of fairness in the Student Placement framework. We declare an allocation as α\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\upalpha $$\end{document}-equitable if no agent can propose an alternative allocation that nobody else might argue to be inequitable. It turns out that α\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\upalpha $$\end{document}-equity is compatible with efficiency. Our analysis fills a gap in the literature by giving normative support to the allocations improving, in terms of (...) efficiency, the Student Optimal Stable allocation. (shrink)

This paper uses the conceptual apparatus of Wittgenstein’s later philosophy to tackle a foundational issue in the philosophical literature on group identity, namely, the problem of difference. This problem suggests that any appeal to a collective identity is oppressive because it imposes a shared identity on the members of a group and suppresses the internal differences of the group. I develop a Wittgensteinian view of identity that dissolves this problem by showing the conceptual confusions on which it rests. My Wittgensteinian (...) view of identity tries to establish two main theses: first, that identity is bound up with difference and presupposes heterogeneity; and second, that the solidarity of identity groups, far from being obstructed by differences, actually requires diversity. Drawing from gender and sexuality studies, I use the mechanism of disidentification to show how there can be shared identities and identity-based solidarity without the erasure of differences. Key Words: community • difference • ethnicity • familial view • gender • identity • race • sexuality • solidarity • Wittgenstein. (shrink)

In this essay I examine the contributions of the pragmatist tradition to the philosophy of ethnicity. From the pragmatist philosophies of Dewey and Locke I derive a reconstructive model for the clarification and improvement of the life experiences of ethnic groups. Addressing various problems and objections, I argue that this Deweyan and Lockean reconstructive model rejects any sharp separation between race and ethnicity and avoids the pitfalls of the biologist race paradigm and the culturalist ethnicity paradigm. I explore some of (...) the social and political implications of this reconstructive model through a discussion of José Martí's inspiring account of Hispanic identity. (shrink)

Through a new interpretation of Wittgenstein's rule-following discussions, this article defends a negotiating model of normativity according to which normative authority is always subject to contestation. To refute both individualism and collectivism, I supplement Wittgenstein's Private Language Argument with a Social Language Argument, showing that normativity cannot be monopolized either individually or socially (i.e. it cannot be privatized or collectivized). The negotiating view of normativity here developed lays the foundations of a politics of radical contestation which converges with Chantal Mouffe's (...) framework of 'radical democracy', while departing from her agonism in preserving the structuring and constraining role that tacit agreement in action plays in rule-following practices. My account of the 'burdens of eccentricity' elucidates how the normative force of dissidence can be properly recognized and used effectively for social transformations. I argue that there is a 'presumption of normalcy' in favour of the established consensus of action, but that this presumption is defeasible: in normative disagreements, a violation of expected normalcy shifts the burden onto the shoulders of rebellious agents who must show that their dissenting behaviour can be a legitimate extension, revision, or transformation of the practice in question. (shrink)

This paper defends a contextualist approach to epistemic injustice according to which instances of such injustice should be looked at as temporally extended phenomena (having developmental and historical trajectories) and socially extended phenomena (being rooted in patterns of social relations). Within this contextualist framework, credibility excesses appear as a form of undeserved epistemic privilege that is crucially relevant for matters of testimonial justice. While drawing on Miranda Fricker's proportional view of epistemic justice, I take issue with its lack of attention (...) to the role that credibility excesses play in testimonial injustices. I depart from Fricker's view of the relation between credibility excesses and credibility deficits, and I offer an alternative account of the contributions that undeserved epistemic privileges make to epistemic injustices. Then, through the detailed analysis of To kill a mockingbird, I elucidate the crucial role played by the social imaginary in creating and sustaining epistemic injustices, developing an analysis of the kind of social blindness produced by an oppressive social imaginary that establishes unjust patterns of credibility excesses and deficits. (shrink)

While in agreement with Miranda Fricker’s context-sensitive approach to hermeneutical injustice, this paper argues that this contextualist approach has to be pluralized and rendered relational in more complex ways. In the first place, I argue that the normative assessment of social silences and the epistemic harms they generate cannot be properly carried out without a pluralistic analysis of the different interpretative communities and expressive practices that coexist in the social context in question. Social silences and hermeneutical gaps are misrepresented if (...) they are uniformly predicated of an entire social context, instead of being predicated of particular ways of inhabiting that context by particular people in relation to particular others. I contend that a more nuanced—polyphonic—contextualization offers a more adequate picture of what it means to break social silences and to repair the hermeneutical injustices associated with them. In the second place, I argue that the particular obligations with respect to hermeneutical justice that differently situated subjects and groups have are interactive and need to be determined relationally. That is, whether individuals and groups live up to their hermeneutical responsibilities has to be assessed by taking into account the forms of mutual positionality, relationality, and responsivity (or lack thereof) that these subjects and groups display with respect to one another. The central argument is developed through an examination of what in race theory and in contemporary epistemologies of ignorance has been termed “white ignorance”; that is, the kind of hermeneutical inability of privileged white subjects to recognize and make sense of their racial identities, experiences, and social positionality. (shrink)

In this essay I argue that epistemic injustices can be understood and explained as social pathologies of recognition, and that this way of conceptualizing epistemic injustices can help us develop proper diagnostic and corrective treatments for them. I distinguish between two different kinds of recognition deficiency—quantitative recognition deficits and misrecognitions—and I ague that while the rectification of the former simply requires more recognition, the rectification of the latter calls for a shift in the mode of recognition, that is, a deep (...) transformation of the recognition dynamics so that other forms of recognition can emerge. Arguing against incremental recognitional approaches that aim only at increasing social visibility/audibility, I examine communicative dysfunctions around the phenomenon of racist violence in order to show how problems of misrecognition persist and become recalcitrant even when quantitative recognition deficits disappear. (shrink)

This book explores the epistemic side of racial and sexual oppression. It elucidates how social insensitivities and imposed silences prevent members of different groups from listening to each other.

Develops a contextualist view of identity, agency, and discursive practices.

This paper analyses the place of sortition in the political philosophy of Jacques Rancière. The idea of sortition is linked to a philosophical reflection on arithmetic equality and geometric equality. Thus, starting from an important work of Cornelius Castoriadis in this sense, we will analyze below the relationship of Rancière’s political philosophy with equality. Finally we will analyze the sortition and the place it occupies in his work. Bernard Manin’s work on ancient democracies and systems of representative government will help (...) us contextualize Rancière’s proposals on the use of random selection in politics. (shrink)

En este artículo analizo aportaciones de Michel Foucault y Antoni Domènech, relacionadas ambas con una filosofía política del cuerpo. Para ello estudio sus acercamientos respectivos a la ética clásica, ya sea como una estética de la existencia o como una razón erótica que se opone a una razón inerte. Posteriormente, y tras confirmar sus concomitancias, propongo completarlos con una lectura de El banquete de Platón. Finalmente ejemplifico cómo podría funcionar este programa analizando la conformidad y la resistencia contra la imposición (...) de una ortodoxia corporal. (shrink)

En este artículo me preguntaré por las razones que hicieron a Foucault, Castoriadis y Rancière ocuparse por la democracia antigua, básicamente a principios de los años 80 del siglo XX. Para dilucidar tales razones los vincularé con una tradición del helenismo francés–la Escuela de París–, con una trayectoria biográfica específica a cada uno de ellos y con los desafíos que representa la crisis del marxismo. Terminaré explicando por qué podemos aprender de nuestros tres autores gracias a un estudio del contexto (...) en el que produjeron sus ideas. (shrink)

[Medina In the margin of a congress on the presence of Ortega’s legacy].

A lo largo de su obra, Louis Althusser elabora distintas concepciones de la filosofía. En la Conferencia de Granada de 1976, Althusser consuma el proceso de autocrítica que le había llevado a retractarse de sus posiciones iniciales y a introducir la noción de explotación como concepto clave para comprender la práctica filosófica. El objeto de este trabajo es doble. En primer lugar, se trata de esclarecer el vínculo que Althusser establece entre filosofía y explotación, haciendo explícito el modo en que (...) la filosofía explota a las prácticas sociales y a las ciencias. En segundo lugar, nos proponemos ofrecer una lectura de la nueva práctica de la filosofía esbozada por Althusser como una práctica socialista y democrática de la filosofía. (shrink)

_ Source: _Volume 29, Issue 1, pp 39 - 65 Since Euclid, optics has been considered a geometrical science, which Aristotle defines as a “mixed” mathematical science. Hobbes follows this tradition and clearly places optics among physical sciences. However, modern scholars point to a confusion between geometry and physics and do not seem to agree about the way Hobbes mixes both sciences. In this paper, I return to this alleged confusion and intend to emphasize the peculiarity of Hobbes’s geometrical optics. (...) This paper suggests that Hobbes’s conception of geometrical optics, as a mixed mathematical science, greatly differs from Descartes’s one, mainly because they do not share the same “mechanical conception of nature.” I will argue that Hobbes and Descartes also have in common the quest for a different kind of geometry for their optics, different from that of the Ancients. I will show that this departure is not recent since Hobbes’s approach is already evident in 1636, when he judges the demonstrations of his contemporary friends, Claude Mydorge and Walter Warner. Finally the paper broadly suggests what is noteworthy in Hobbes’s optics, that is, the importance of the idea of force in his mechanics, although he was not able to conceptualize it in other terms than “quickness.”. (shrink)

RESUMEN El presente trabajo describe los cambios estratégicos del Centro de Inmunología y Productos Biológicos de la Universidad de Ciencias Médicas de Camagüey que contribuyen a la formación profesional, la investigación y los servicios científico técnicos. Recoge los resultados obtenidos desde el 2015 hasta el 2017. Los referentes teóricos permiten un acercamiento epistémico que facilita la relación con el conocimiento y la creación de concepciones para abordar los problemas de salud. El centro tiene cuatro proyectos asociados a programas y 11 (...) institucionales. Se posee 2,7 publicaciones por autor y 18 participaciones en eventos, de ellos, ocho internacionales. Se perfecciona un sistema de gestión de la calidad, nueve servicios científico-técnicos, diversos servicios a la docencia y proyectos de investigaciones. Se aprovecha el potencial que genera el proceso de auto-organización del trabajo colectivo, para un mejor funcionamiento, sinergia y sustentabilidad de la gestión de una unidad de desarrollo e innovación. ABSTRACT The present work describes the strategic changes of the Center of Immunology and Biological Products of the University of Medical Sciences of Camagüey that contributes to the professional training, the investigation and the technical-scientist services. It gathers the results obtained from 2015 to 2017. The theoretical bases allow an epistemic approach that facilitates the relation with the knowledge and the creation of conceptions to tackle the health problems. The center has four projects associated with programs and 11 institutional ones. There are possessed 2.7 publications per author and 18 participations in events, of them, eight international ones. Scientist - technical staff perfects a system of management of the quality, nine services, diverse services to the teaching and projects of investigations. One makes use of the potential that generates the auto-organization process of collective work, for a better functioning, synergy and sustainability of the management of a unit of development and innovation. (shrink)

Drawing on contemporary epistemologies of ignorance, I analyze the American ideology of color blindness as a recalcitrant form of active ignorance that operates at a meta-level. I contend that the meta-ignorance involved in color blindness operates through distorting second-order attitudes about one's cognitive and affective attitudes, resulting in cognitive and affective numbness with respect to racial matters: ignorance of one's racial ignorance and insensitivity to one's racial insensitivity. I contend that the black/white binary that has dominated the American racial imagination (...) has contributed tremendously to establish and maintain meta-blindness about racial differences. I suggest that overcoming the black/white binary demands that we expand current conceptions of racial lucidity and that we go beyond the notions of double consciousness that critical race theorists have defended since Du Bois and Fanon. According to a more expansive social pluralism, lucidity with respect to racial differences requires a kaleidoscopic consciousness that does not reinscribe the black/white binary in one's racial imagination. (shrink)

Using Iris Marion Young’s framework, this essay looks at racial violence as one of the many “faces” of racial oppression. In the light of this analysis I argue that the fight against racial violence requires much more than identifying the perpetrators of such violence and bringing them to justice; it requires, I argue, thick critical engagements with multiple publics and institutions and with society at large, engagements that are not only cognitive and argumentative but also affective, imaginal, and action-oriented. My (...) argument about the broad range of thick critical engagements needed in anti-racist-violence activism focuses especially on what I term epistemic activism, which refers to the critical activities of denouncing, contesting, and resisting the cognitive-affective attitudes and sensibilities that facilitate complicity with racial oppression and with racial violence. My analysis pays particular attention to the role that affectivity plays in complicity with racial violence and how affective attitudes can be used in epistemic activism to disrupt complicity and to mobilize people in the fight against racial violence. My analysis and argumentation are developed through a case study of epistemic activism: the activism against racial violence in the United States and the changes in public life and institutional recognition that activist organizations such as the National Association for the Advancement of Colored People and the Equal Justice Initiative have aimed to promote. (shrink)

Cet article analyse la lecture effectuée par Foucault de la démocratie athénienne des années 1980 et la compare à la lecture de Cornelius Castoriadis. L’article propose donc deux interprétations différentes de la figure de Périclès par deux philosophes. Nous montrons que notre compréhension de l’idéologie de Foucault est plus profonde que notre compréhension de la réalité historique et des projets politiques de Périclès.

Setting the stage with a selection of readings from important nineteenth century philosophers, this reader on truth puts in conversation some of the main philosophical figures from the twentieth century in the analytic, continental, and pragmatist traditions. Focuses on the value or normativity of truth through exposing the dialogues between different schools of thought Features philosophical figures from the twentieth century in the analytic, continental, and pragmatist traditions Topics addressed include the normative relation between truth and subjectivity, consensus, art, testimony, (...) power, and critique Includes essays by Kierkegaard, Nietzsche, James, Heidegger, Merleau-Ponty, Wittgenstein, Levinas, Arendt, Foucault, Rorty, Davidson, Habermas, Derrida, and many others. (shrink)

This article studies how people leave eating disorders. The article is based on a study of how the labor market influences eating disorders. We present conflicts in which workers are involved. Finally, we propose policies to combat lines, in the labor market against the disease.

Drawing on American and Latin American philosophers such as John Dewey, Alain Locke, and José Martí, this chapter articulates a thoroughgoing pluralistic view of ethnic identity in general and of Hispanic identity in particular. The chapter argues that the best way of elucidating ethnic experiences and identities without relying on essentialist assumptions is offered by a radical pluralism that we can find in the pragmatist tradition. This radical pluralism understands ethnic identity as intrinsically heterogeneous, that is, as necessarily containing (...) inner diversity. (shrink)

This paper offers an analysis of how the American criminal justice system sets unfair constraints on the epistemic agency of detained subjects and promotes unfair negative consequences on the exerc...

This article elucidates and expands on María Lugones's account of complex communication across liminal sites as the basis for deep coalitions among oppressed groups. The analysis underscores the crucial role that emotions and resistant imaginations play in complex communication and world-traveling across liminal sites. In particular, it focuses on the role of emotional echoing and epistemic activism in complex forms of communication among oppressed subjects. It elucidates Gloria Anzaldúa's storytelling and Doris Salcedo's visual art as exemplary forms of epistemic activism (...) that issue coalitional gestures and critical provocations that can wake people up from their epistemic slumbers and instigate forms of complex communication that can create new possibilities for coalitional politics. (shrink)

Expanding Miranda Fricker's (2007) concept of epistemic injustice, recent accounts of agential epistemic injustice (Lackey, 2020; Medina, 2021; Pohlhaus, 2020) have focused on cases in which the epistemic agency of individuals or groups is unfairly blocked, constrained, or subverted. In this article I argue that agential epistemic injustice is perpetrated against marginalized groups not only when their group epistemic agency is excluded, but also when it is included but receives defective uptake that neutralizes their capacity to resist epistemic oppression. (...) I identify two harms that such injustice inflicts on marginalized groups: epistemic disempowerment and critical defanging of resistant epistemic group agency. My analysis shows how the harms of agential epistemic injustice can occur through unfair epistemic exclusions in group dynamics, but also through forms of inclusion in group dynamics that distort or coopt the epistemic agency of the group. Following Emmalon Davis (2018) and her analysis of epistemic appropriation, I argue that the harms of agential epistemic injustice can occur when the resistant epistemic resources of a marginalized group are appropriated in a way that disempowers them and critically defangs their resistant epistemic agency. I use Taylor Rogers’ (2021) analysis of the epistemic appropriation of “#MeToo” and “intersectionality” to show how epistemic disempowerment and critical defanging work in unjust epistemic group dynamics. The article offers a diagnosis of the failures of epistemic responsibility involved in agential epistemic injustice, and some suggestions for resisting those failures and working toward more responsible and just epistemic group dynamics. (shrink)

Homo academicus propone una reflexión epistemológica de interés para investigaciones similares y para la práctica sociológica en general. En segundo lugar, propone un mapa del mundo universitario francés, de las diferentes formas de capital que lo configuran y de los diversos tipos de carrera académica. Más allá del origen nacional de su análisis, Bourdieu insiste en el valor del modelo. En tercer lugar, Bourdieu ofrece una explicación de un acontecimiento histórico que trasciende la universidad, pero en el que ésta jugó (...) un papel de primer orden. Mayo del 68 muestra cómo un acontecimiento histórico desestabiliza parcialmente el orden social existente. Este artículo interroga Homo academicus desde un punto de vista epistemológico, estructural e histórico. (shrink)

This article argues that critical epistemology should aim at centering the voices and perspectives of those who have been excluded and silenced, proposing a way of doing that by combining Black feminist standpoint theory and Latina feminist theory as they converge in María del Rosario Acosta López’s philosophy of radical listening. The article also argues for the crucial significance of aesthetic interventions for creating epistemic friction that can transform our sensibilities so that we can start to listen to silences. The (...) author offers an analysis of the subversive potential in Doris Salcedo’s public art as an illustration of how aesthetic resistance can be used in practices of epistemic activism that resist insensitivity and promote new ways of listening to silenced voices and liminal sites. (shrink)

Atenas: viaje de ida y vuelta. Introducción al monográfico _Recepciones de la democracia antigua_”.

En este trabajo se estudia la teoría del cambio revolucionario en dos autores inspirados por corrientes diferentes del marxismo. En el caso de Étienne Balibar se analiza su teoría de la violencia y la civilidad, mientras que en el de Erik Olin Wright se estudia su análisis de la depresión de transición. El artículo muestra cómo nuestros dos pensadores presentan una teoría convergente de abandono del modelo leninista de cambio social.

En este artículo defendemos el valor de la perspectiva de Ortega sobre el problema del anacronismo en historia. Para ello, exponemos dicho problema en la Escuela de París. Seguidamente, explicamos las aportaciones de Ortega sobre ese problema en los años 40. Finalmente, hacemos un balance de las aportaciones de Ortega y su actualidad.

While in the movies or reading a novel, how can we feel terrified by monsters, ghosts, and fictional serial killers? And how can we feel sad or outraged by depictions of cruelty? After all, we know that the imagined threats that we fear do not exist and, therefore, pose no real threat to us; and we know that the instances of cruelty that bring tears to our eyes have not happened. And yet, the fear, the sadness, or the outrage experienced (...) in our imaginations feels very real. This is the so-called paradox of "fictional emotions." This and related paradoxes have become recalcitrant problems for a purely representational approach to the imagination that tries to accommodate the imagination in a belief-desire psychology, explaining our imaginings as mental states that are similar to beliefs or desires in some ways but not others—as "quasi-beliefs" or "quasi-desires." This representational approach can be seen, for example, in Kendall Walton's influential account of the imagination as "make-believe," or in Shaun Nichols and Stephen Stich's boxological account of the imagination as a "pretend box," which is in close interaction with the suspiciously similar "belief box". (shrink)

This paper analyzes the innovative way of doing critical philosophy that María del Rosario Acosta López proposes in her aesthetics of resistance and grammars of the unheard. The paper examines the contributions of two sets of conversations with Acosta López’s critical philosophy. In the first place, staging a dialogue between Acosta López and Black feminist philosophy, the article offers a defence of reconceptualizing philosophy in the 21st Century through a dialogue with the voices and perspectives of the excluded and silenced—a (...) reconceptualization that reimagines the critical role of philosophy. In the second place, the paper calls attention to the crucial significance of Acosta López’s aesthetics of resistance for contemporary debates in contemporary political epistemology, putting in conversation her grammars of the unheard with my epistemology of resist- ance and María Lugones’s concept of complex communication. This second conversation also underscores a new way of understanding the critical and transformative function of philosophy by centering the voices and perspectives of the excluded and silenced. (shrink)