Insulin is well known for its essential role in carbohydrate metabolism: insulin deficiency results in the development of diabetes mellitus. It has been known for many years that people with diabetes mellitus are predisposed to develop thrombotic diseases including myocardial infarction. It was thought that the thrombus formation was the consequence of impaired carbohydrate metabolism. In recent years, it has become apparent that insulin is capable of ameliorating several pathophysiological events, leading to the inhibition and dissolution of the formed thrombus (...) in the system. These insulin‐induced events include inhibition of platelet aggregation by prompting the synthesis of NO in platelet and prostacyclin in endothelial cells. Furthermore, insulin upregulates prostacyclin receptors and downregulates α2 adrenergic receptor in platelets, thereby amplifying the inhibition of platelet aggregation. Insulin also releases tissue plasminogen activator, a potent thrombolytic enzyme, from the platelet membrane which dissolves the formed thrombus leading to the resumption of normal blood circulation. In effect, insulin could be an essential tool in the control of thrombotic disorders. BioEssays 26:91–98, 2004. © 2003 Wiley Periodicals, Inc. (shrink)

Since Turing proposed the first test of intelligence, several modifications have been proposed with the aim of making Turing’s proposal more realistic and applicable in the search for artificial intelligence. In the modern context, it turns out that some of these definitions of intelligence and the corresponding tests merely measure computational power. Furthermore, in the framework of the original Turing test, for a system to prove itself to be intelligent, a certain amount of deceit is implicitly required which can have (...) serious security implications for future human societies. In this article, we propose a unified framework for developing intelligence tests which takes care of important ethical and practical issues. Our proposed framework has several important consequences. Firstly, it results in the suggestion that it is not possible to construct a single, context independent, intelligence test. Secondly, any measure of intelligence must have access to the process by which a problem is solved by the system under consideration and not merely the final solution. Finally, it requires an intelligent agent to be evolutionary in nature with the flexibility to explore new algorithms on its own. (shrink)