Dr. Galasso’s (2024) insightful article expands the ongoing debate on the utility and equity of precision medicine in public and population health. The initiatives mentioned, Genomics England and t...

If one formulates Helmholtz's ideas about perception in terms of modern-day theories one arrives at a model of perceptual inference and learning that can explain a remarkable range of neurobiological facts. Using constructs from statistical physics it can be shown that the problems of inferring what cause our sensory inputs and learning causal regularities in the sensorium can be resolved using exactly the same principles. Furthermore, inference and learning can proceed in a biologically plausible fashion. The ensuing scheme rests on (...) Empirical Bayes and hierarchical models of how sensory information is generated. The use of hierarchical models enables the brain to construct prior expectations in a dynamic and context-sensitive fashion. This scheme provides a principled way to understand many aspects of the brain's organisation and responses. In this paper, we suggest that these perceptual processes are just one emergent property of systems that conform to a free-energy principle. The free-energy considered here represents a bound on the surprise inherent in any exchange with the environment, under expectations encoded by its state or configuration. A system can minimise free-energy by changing its configuration to change the way it samples the environment, or to change its expectations. These changes correspond to action and perception, respectively, and lead to an adaptive exchange with the environment that is characteristic of biological systems. This treatment implies that the system's state and structure encode an implicit and probabilistic model of the environment. We will look at models entailed by the brain and how minimisation of free-energy can explain its dynamics and structure. (shrink)

Kant's Reason develops a novel interpretation of Kant’s conception of reason and its philosophical significance, focusing on two claims. First, it argues that Kant presents a powerful model for understanding the unity of theoretical and practical reason as two manifestations of a unified capacity for theoretical and practical understanding (or “comprehension”). This model allows us to do justice to the deep commonalities between theoretical and practical rationality, without reducing either to the other. In particular, through it, we see why the (...) activities of both theoretical and practical reason are governed by a version of the Principle of Sufficient Reason, while also seeing why reason is essentially autonomous. At the same time, Kant's Reason also reads Kant as presenting us with a compelling picture of the role that reason (as a capacity or power) should play in a systematic approach to foundational philosophical questions. In doing so, it argues for an account of the fundamental norms that apply to rational beings that treats as fundamental neither substantive reasons or values nor merely structural rationality, but instead a robust conception of reason as a power or capacity — namely, the capacity for theoretical and practical understanding. The result is a form of “rational constitutivism” – one which contrasts both with the forms of “reasons fundamentalism” that are currently fashionable and the forms of “agency-first constitutivism” that have dominated much of Kantian metaethics. In this sense, the aim of the book is to vindicate Kant’s insistence that his philosophy represents nothing more or less than reason’s implicit self-understanding coming to explicit and systematic self-consciousness. (shrink)

In this essay, I develop and defend a virtue‐theoretic conception of rationality as a capacity whose function is understanding, as opposed to mere truth or correctness. I focus on two main potential advantages of this view. First, its ability to explain the rationality of forms of explanatory reasoning, and second, its ability to offer a more unified account of theoretical and practical rationality.

“There could be no fairer destiny for any. . . theory than that it should point the way to a more comprehensive theory in which it lives on, as a limiting case.” ALBERT EINSTEIN..

It features Easton and Guddat's own highly regarded translations (based on the best German editions as well as on the original manuscripts and first editions) ...

A common complaint about Kantian ethics is that it cannot do justice to the social or intersubjective dimensions of human life – that, unlike Fichte, Hegel, or Marx, Kant remains caught within a fundamentally individualistic perspective on practical or moral questions. In this way, the objection goes, Kantian ethics leaves agents alienated from others around them and their larger community. While not entirely unnatural, I argue here that such concerns rest on a mischaracterization of where the most serious problems in (...) this region for Kant lie. Far from being too individualistic, the real worry about Kantian moral theory is that it may not be individualistic enough. In a contemporary context, where Kantian ethics is associated with the “self-constitution” of agents or the “separateness of persons”, the idea that it is insufficiently concerned with individual persons may come as a surprise. But it would not surprise Kant’s immediate successors like Fichte and Hegel. For this is where they often located the deepest problems facing Kant’s moral philosophy. As we will see, in making such points, they were in some ways closer to Kant’s own views than they recognized. Nonetheless, if this is right, Kantian ethics may in fact more anti-individualistic than many of the ethical systems that followed in his wake. And the most radical elements in Kant’s ethics might point, less to Fichte and Hegel, and more to figures like Schopenhauer who sought to develop a synthesis of Kant and ideas from South Asian philosophy. Perhaps, we might say, Kant has been sitting under the Bodhi tree all along? (shrink)

This is the commentary on John Baker, "H. P. Grice's Construction of Value", read at the 34th Annual Congress of the Canadian Philosophical Association, May 1990, Victoria, British Columbia.

There is a growing trend in policy making of holding people responsible for their lifestyle-based diseases. This has sparked a heated debate on whether people are responsible for these illnesses, which has now come to an impasse. In this paper, I present a psychological model that explains why different views on people’s responsibility for their health exist and how we can reach a resolution of the disagreement. My conclusion is that policymakers should not perceive people as responsible while health care (...) personnel should take the opposing view. (shrink)

In the 1950s and 1960s, the search for the mechanism of oxidative phosphorylation by biochemists paralleled the description of mitochondrial form by George Palade and Fritiof Sjöstrand using electron microscopy. This paper explores the extent to which biochemists studying oxidative phosphorylation took mitochondrial form into account in the formulation of hypotheses, design of experiments, and interpretation of results. By examining experimental approaches employed by the biochemists studying oxidative phosphorylation, and their interactions with Palade, I suggest that use of mitochondrial form (...) as a guide to experimentation and interpretation varied considerably among investigators. Most notably, Peter Mitchell, whose chemiosmotic hypothesis was ultimately the basis of the correct mechanism of oxidative phosphorylation, incorporated crucial aspects of mitochondrial form into his model that others failed to recognize. I discuss these historical observations in terms of the background and training of the biochemists, as well as a proposed heuristic of form, whose use may increase the possibility that biologically meaningful molecular mechanisms will be discovered. (shrink)

This paper discusses various problems of explanations by mechanisms. Two positions are distinguished: the narrow position claims that only explanations by mechanisms are acceptable. It is argued that this position leads to an infinite regress because the discovery of a mechanism must entail the search for other mechanisms etc. Another paradoxical consequence of this postulate is that every successful explanation by mechanisms is unsatisfactory because it generates new ``black box'' explanations. The second – liberal – position that is advanced in (...) this paper regards, besides explanations by mechanisms, also the discovery of bivariate correlations as a first step of an explanation by mechanisms as meaningful. It is further argued that there is no contradiction between causal analysis and the explanation by mechanisms. Instead, explanations by mechanisms always presuppose the analysis of causal structures (but not vice versa). The final point is that an explanation by mechanisms is not inconsistent with the Hempel-Oppenheim scheme of explanation. (shrink)

In recent years the normativity of thought and meaning has been the subject of an extensive debate. What is at issue is whether intentionality has normative features, and if so, whether that constitutes a problem for naturalistic attempts to account for intentional phenomena. The origin of the debate is Saul Kripke’s interpretation of Ludwig Wittgenstein’s later philosophy, published in Wittgenstein on Rules and Private Language. Kripke claimed, on behalf of Wittgenstein, that dispositional accounts of linguistic meaning - accounts, i.e., which (...) attempt to reduce semantic phenomena to facts about how speakers are disposed to employ words - fail to ground the factuality of semantic statements. From this, and other arguments, the far reaching conclusion was drawn by Kripke’s Wittgenstein that there are no semantic facts, that every application of a word is “a leap in the dark”. This position has become known as meaning scepticism. In the present essay, it will be argued that meaning scepticism is incoherent, but that the normativity argument is interesting in its own right. The development of the debate will be traced, primarily through detailed consideration of the writings of Paul Boghossian, who has shifted the focus from the normativity of linguistic meaning to that of belief. It will be contended that even though Boghossian’s attempt to locate a normativity of belief fails, there is a related form of normativity that has to do with the intrinsic badness of false beliefs. Also, suggestions made by Kripke regarding the normativity of intentions will be investigated, and related to contemporary arguments in the philosophy of rationality. The tentative conclusion is that there are some interesting kinds of normativity associated with the intentional, but of a somewhat different variety than those usually discussed. (shrink)

Keine ausführliche Beschreibung für "Die geistige Situation der Zeit" verfügbar.

This essay develops a theological naturalism using Gordon Kaufman's nonpersonal idea of God as serendipitous creativity in contrast to the personal metaphorical theology of Sallie McFague. It then develops a Christian theological naturalism by using Kaufman's idea of historical trajectories, specifically Jesus trajectory1 and Jesus trajectory2. The first is the trajectory in the early Christian church assuming a personal God in the framework of Greek philosophy that results in the Trinity. The second is the naturalistic-humanistic trajectory of creativity (God) that (...) evolves from nonpersonal interactions in the universe and life to creativity in persons and is manifested in Jesus as love. This is elaborated further with Dean Keith Simonton's Darwinian understanding of genius and Marcus Borg's analysis of Jesus as Jewish mystic, teacher of alternative wisdom, and nonviolent resister to the domination system of the Roman Empire. What makes Jesus a religious genius is his exemplifying unconditional, universal love—a new mode of creativity (God) that has evolved from nonhuman to a human form. (shrink)

In an evolutionary world, humans need “salvation” understood as restoring and maintaining well‐being or functioning well. Humans are embedded in, embodiments of, and emergent creative‐creatures of the universe. We have evolved also as ambivalent creatures—doing good, harm, and being bystanders while harm is being done. Multiple factors—for example, genetic, neurological, child developmental, and societal—contribute to malfunctioning and harmful behavior, and multiple religious and secular approaches help restore well‐being. I develop a view of Jesus as a “religious genius” who, grounded in (...) a direct experience of God, taught undiscriminating love and engaged in nonviolent political activism against the unjust domination system of the Roman Empire. Christians and others can follow Jesus by engaging in meditative practices that facilitate well‐being out of which compassion for others and a passion for justice flows. Universal love rooted in Jesus is compatible with an evolutionary perspective that all humans are part of a natural family. (shrink)

At fertilization in mammals the sperm activates the egg by triggering a series of oscillations in the intracellular free Ca2+ concentration. The precise sequence of events that occur between sperm‐egg contact and the increases in intracellular Ca2+ remains unknown. Here, we discuss recent evidence supporting the hypothesis that a cytosolic sperm protein enters the egg after gamete membrane fusion and triggers Ca2+ oscillations from within the egg cytoplasm. Biochemical studies suggest that there exists a novel sperm protein, named oscillin, that (...) specifically comigrates with Ca2+ oscillation‐inducing activity. Oscillin has been immunolocalised to the region of the sperm that first fuses with the egg. The concept of a specific protein that triggers Ca2+ oscillations may have wider physiological significance since sperm oscillin can induce Ca2+ oscillations in somatic cells, such as neurons and hepatocytes. Unravelling the novel signalling system involved in mammalian fertilization may help reveal some fundamental molecular mechanisms responsible for triggering cytoplasmic Ca2+ oscillations. (shrink)

I enjoyed reading this compelling account of Conviction Narrative Theory (CNT). As a theoretical neurobiologist, I recognised – and applauded – the tenets of CNT. My commentary asks whether its claims could be installed into a Bayesian mechanics of decision-making, in a way that would enable theoreticians to model, reproduce and predict decision-making.

Mangan’s hypothesis, that consciousness is an information-bearing medium, presents an alternative to Dennett’s brand of functionalism, and Dennett’s counterattacks have yet to address Mangan’s main assertion. The medium hypothesis does not entail Cartesian theater assumptions concerning the localization, causal status, and “filling in” of consciousness in the brain. In principle, it is compatible with distributed information transfer between different media, epiphenomenalism, and gaps in visual experience. However, Mangan’s strongest empirical argument, based on consciousness’ limited “bandwidth,” does not necessarily show that (...) transduction between media of different information-bearing capacities occurs between the brain and consciousness. The features of consciousness that he attributes to a lower bandwidth medium can be explained in terms of functional constraints on a single medium. Furthermore, empirical results showing gaps and anomalies in visual experience speak against consciousness being a medium. (shrink)