Various publications claim that medical AI systems perform as well, or better, than clinical experts. However, there have been very few controlled trials and the quality of existing studies has been called into question. There is growing concern that existing studies overestimate the clinical benefits of AI systems. This has led to calls for more, and higher-quality, randomized controlled trials of medical AI systems. While this a welcome development, AI RCTs raise novel methodological challenges that have seen little discussion. We (...) discuss some of the challenges arising in the context of AI RCTs and make some suggestions for how to meet them. (shrink)

Issues of reliability are claiming center-stage in the epistemology of machine learning. This paper unifies different branches in the literature and points to promising research directions, whilst also providing an accessible introduction to key concepts in statistics and machine learning – as far as they are concerned with reliability.

As a discipline, psychiatry is in the process of finding the right set of concepts to organize research and guide treatment. Dissatisfaction with the status quo as expressed in standard manuals has animated a number of computational paradigms, each proposing to rectify the received concept of mental disorder. We explore how different computational paradigms: normative modeling, network theory and learning-theoretic approaches like reinforcement learning and active inference, reconceptualize mental disorders. Although each paradigm borrows heavily from machine learning, they differ significantly (...) in their methodology, their preferred level of description, the role they assign to the environment and, especially, the degree to which they aim to assimilate psychiatric disorders to a standard medical disease model. By imagining how these paradigms might evolve, we bring into focus three rather different visions for the future of psychiatric research. Although machine learning plays a crucial role in the articulation of these paradigms, it is clear that we are far from automating the process of conceptual revision. The leading role continues to be played by the theoretical, metaphysical and methodological commitments of the competing paradigms. (shrink)

Peer review is a widely accepted instrument for raising the quality of science. Peer review limits the enormous unstructured influx of information and the sheer amount of dubious data, which in its absence would plunge science into chaos. In particular, peer review offers the benefit of eliminating papers that suffer from poor craftsmanship or methodological shortcomings, especially in the experimental sciences. However, we believe that peer review is not always appropriate for the evaluation of controversial hypothetical science. We argue that (...) the process of peer review can be prone to bias towards ideas that affirm the prior convictions of reviewers and against innovation and radical new ideas. Innovative hypotheses are thus highly vulnerable to being “filtered out” or made to accord with conventional wisdom by the peer review process. Consequently, having introduced peer review, the Elsevier journal Medical Hypotheses may be unable to continue its tradition as a radical journal allowing discussion of improbable or unconventional ideas. Hence we conclude by asking the publisher to consider re-introducing the system of editorial review to Medical Hypotheses. (shrink)

In this paper, we will discuss Peter van Inwagen’s contribution to the epistemological debate about revealed peer disagreement. Roughly, this debate focuses on situations in which at least two participants disagree on a certain proposition based on the same evidence. This leads to the problem of how one should react rationally when peer disagreement is revealed. Van Inwagen, as we will show, discusses four possible reactions, all of which he rejects as unsatisfying. Our proposal will be to point to hidden (...) assumptions in van Inwagen’s reasoning and ask whether he is willing to reject at least one of these to get rid of the problem. In short, our thesis amounts to the following: Of the two epistemological claims, which we call “Weak” and “Full-blown Fallibilism”, van Inwagen cannot simultaneously accept the first and reject the latter, while this is what he seems to suggest. Revealing this potential dilemma for van Inwagen’s position will lead to a more detailed discussion of how “rationality”, “truth”, “evidence” and “justification” interrelate and how a closer look at their relation might help solving the puzzle of revealed peer disagreement. (shrink)

Zusammenfassung Konstantin VII. Porphyrogennetos hatte neben seinem bekannten Sohn Romanos (dem späteren Kaiser Romanos II.) noch einen weiteren Sohn namens Leon. Dieser Leon erblickte um 939 das Licht der Welt. Es ist möglich und sogar wahrscheinlich, läßt sich aber nicht mit absoluter Sicherheit sagen, ob er der ältere und damit erstgeborene der beiden Brüder war. Der Altersunterschied der beiden Brüder war jedenfalls nicht allzu groß. Aus einem Brief ihres Vaters geht hervor, daß beide Brüder in ihrer frühen Kindheit anscheinend (...) relativ schwer erkrankt waren. Es ist möglich, aber doch eher unwahrscheinlich, daß gerade diese, in dem Brief erwähnte Erkrankung zum Tode Leons führte. Leon war möglicherweise noch gegen Ende der Herrschaft des Kaisers Romanos I. Lakapenos, im Jahre 944 am Leben. Er starb aber vermutlich in diesem Jahr oder zu Beginn des nächsten Jahres. Am 6. April 945, zum Zeitpunkt der Mitkaiserkrönung seines Bruders Romanos, weilte er jedenfalls nicht mehr unter den Lebenden. Es ist möglich, aber nicht zu beweisen, daß er in dem im Zeremonienbuch erwähnten kleinen Larnakion im Heroon Konstantins des Großen in der Apostelkirche zu Konstantinopel, der Begräbnisstätte seiner Familie, beigesetzt war. (shrink)

Non-epistemic values play important roles in classificatory practice, such that philosophical accounts of kinds and classification should be able to accommodate them. Available accounts fail to do so, however. Our aim is to fill this lacuna by showing how non-epistemic values feature in scientific classification, and how they can be incorporated into a philosophical theory of classification and kinds. To achieve this, we present a novel account of kinds and classification, discuss examples from biological classification where non-epistemic values play decisive (...) roles, and show how this account accommodates the role of non-epistemic values. (shrink)

While attention is widely recognised as central to perception, the term is often used to mean very different things. Prominent theories of attention — notably the premotor theory — relate it to planned or executed eye movements. This contrasts with the notion of attention as a gain control process that weights the information carried by different sensory channels. We draw upon recent advances in theoretical neurobiology to argue for a distinction between attentional gain mechanisms and salience attribution. The former depends (...) upon estimating the precision of sensory data, while the latter is a consequence of the need to actively engage with the sensorium. Having established this distinction, we consider the intimate relationship between attention and salience. (shrink)

"De ente et essentia" from Thomas Aquinas. Thomas Aquinas (1225-1274), sanctus, doctor Ecclesiae catholicae, theologus italianus et philosophus mediaevalis.

We provide a formally rigorous framework for integrating singular causation, as understood by Nuel Belnap's theory of causae causantes, and objective single case probabilities. The central notion is that of a causal probability space whose sample space consists of causal alternatives. Such a probability space is generally not isomorphic to a product space. We give a causally motivated statement of the Markov condition and an analysis of the concept of screening-off. 1. Causal dependencies and probabilities1.1Background: causation in branching space-times1.2What are (...) probabilities defined for?2. Basic transitions2.1Basics of basic transitions2.2Sets of basic transitions3. Causal probability theory3.1Some simple cases3.2General causal probabilities3.3Application: probability of suprema of a chain. (shrink)

Does the viability of the discovery program depend on showing either (1) that methods of generating new problem solutions, per se, have special probative weight (the per se thesis); or, (2) that the original conception of an idea is logically continuous with its justification (anti-divorce thesis)? Many writers have identified these as the key issues of the discovery debate. McLaughlin, Pera, and others recently have defended the discovery program by attacking the divorce thesis, while Laudan has attacked the discovery program (...) by rejecting the per se thesis. This disagreement over the central issue has led to communication breakdown. I contend that both friends and foes of discovery mistake the central issues. Recognizing a form of divorce helps rather than hurts the discovery program. However, the per se thesis is not essential to the program (nor is the related debate over novel prediction); hence, the status of the per se thesis is a side issue. With these clarifications in hand, we can proceed to the next stage of the discovery debate--the development (or revival) of a generative conception of justification which goes beyond consequentialism to forge a strong linkage of generation (or rather, generatability) with justification. (shrink)

Hanks has defended a novel account of what propositions are. His key argument against Soames' rival view is that predication is not neutral. According to Hanks, predication is essentially committal. I show that Hanks' argument for this conclusion raises problems for his own account of questions and orders.

While some philosophers believe disabilities constitute a “bad-difference,” others think they constitute a “mere-difference” (Barnes 2016). On this latter view, while disabilities may create certain hardships, having a disability is not bad in itself. I argue that chronic pain problematizes this disability-neutral view. In doing so, I first survey the literature on chronic pain (§1). Then, I argue that Barnes’s mere-difference view cannot adequately accommodate the lived experiences of many people who suffer from chronic pain (§2). Next, I consider two (...) ways Barnes might respond and I explain why these responses are not workable (§3). Finally, I conclude with a brief discussion of disability variantism, the view that just as some disabilities can be neutral or even positive for some individuals, other disabilities like chronic pain can understandably make some people’s lives miserable not because society has failed them but simply because some conditions can openly conflict with well-being (§4). (shrink)

Communication involves a great deal of uncertainty. Prima facie, it is therefore surprising that biological communication systems—from cellular to human—exhibit a high degree of ambiguity and often leave its resolution to contextual cues. This puzzle deepens once we consider that contextual information may diverge between individuals. In the following we lay out a model of ambiguous communication in iterated interactions between subjectively rational agents lacking a common contextual prior. We argue ambiguity’s justification to lie in endowing interlocutors with means to (...) flexibly adapt language use to each other and the context of their interaction to serve their communicative preferences. Linguistic alignment is shown to play an important role in this process; it foments convergence of contextual expectations and thereby leads to agreeing use and interpretation of ambiguous messages. We conclude that ambiguity is ecologically rational when interlocutors’ contextual expectations are generally in line or they interact multiple times in an informative context, enabling for the alignment of their expectations. In light of these results meaning multiplicity can be understood as an opportunistic outcome enabled and shaped by linguistic adaptation and contextual information. 1Meaning Multiplicity in Communication 2Ambiguous Signalling through Pragmatic Inference 2.1Preliminaries 2.2Signalling behaviour 2.3Communicative success 2.4Iterated interactions 3Predictions for Single and Iterated Interactions 3.1Simulations 3.2Exploration and past experience 3.3Preemptive adaptation 4Discussion 5Conclusion Appendix. (shrink)

In recent years historians have revisited the creation of the United Nations (UN) system by highlighting the enduring influence of Empire and recognizing the substantial role of cultural and scientific actors in wartime international diplomacy. The British biochemist Joseph Needham, who participated in the creation of the United Nations Educational, Scientific and Cultural Organization (UNESCO), was one of them. Yet, if historians have recognized his role as the leading architect of the sciences at UNESCO, they still fall short of engaging (...) with the Chinese and imperial geography of his involvement with UNESCO. During the Second World War, Needham was stationed in war-torn China. As director of the Sino-British Scientific Cooperation Office, Needham not only organized Sino-British scientific cooperation against the Japanese invasion, but his mission inspired his engagement for a reform of international science and fueled an international campaign that led him to become the director of UNESCO’s Natural Science division after the war. By reconstructing his campaign in context, this article seeks to demonstrate how the imperial and transnational scientific networks of the wartime era fostered the creation of a scientific mandate for UNESCO. It situates Needham’s activism and ideas in the context of the Sino-Japanese war, imperial wartime technocracy, and China’s scientific nationalism. In so doing, it reveals a string of forgotten partners from China and the British Empire. Their conception of a reorganized international science and shared belief in modern science and its ideal of universality shaped Needham’s vision for science at UNESCO, while their activism contributed decisively to the success of his campaign. This inquiry hence participates in recent efforts to challenge the existing Eurocentrism corseting the historiography of the UN and expands the historiography of scientific internationalism beyond Europe and North America. Importantly, it also contributes to uncovering the technocratic ties established between Empire and the UN system from its onset. (shrink)

Thomas Alured Faunce, College of Law, Fellows Road, Acton, Canberra ACT 0200, Australian National University, Fax: 61 2 61253971, Email: Thomas.Faunce{at}anu.edu.au ' + u + '@' + d + ' '//-->This paper sets out to analyse three different academic proposals for addressing the needs of the poor in relation to new, rather than ‘essential’ medicines. It focuses particularly on research and development prize funds, a health impact fund system and a multilateral treaty on health technology cost-effectiveness evaluation and (...) competitive tender. It compares the extent to which each responds to the ‘market fundamentalist’ philosophy and begins to analyse their respective strengths and weaknesses. CiteULike Connotea Del.icio.us What's this? (shrink)

Hass wird in der Arbeit als eine anhaltende affektive Gesinnung verstanden, die auf eine erlebte Kränkung oder Ungerechtigkeit zurückgeht und auf Rache an ihrem Urheber, in extre­men Fällen auf die Vernichtung des Feindes gerichtet ist. Die Dynamik und Radikalität insbesondere des malignen Hasses resultiert, so die These des Autors, aus einer Affektretention, die durch die selbst empfundene Schwäche oder Ohnmacht des Hassenden bedingt ist. Durch diesen Rückstau wird der Hass demnach in der Latenzphase immer weiter genährt, bis er schließlich in (...) akute destruktive Handlungen umschlagen kann. Als charakteristische Struktur des Hasses wird dabei eine Dialektik von Selbststeigerung und Selbstdestruktivität mit fortschreitender Entleerung des Selbst herausgearbeitet. Diese indivi­duelle Dynamik findet sich in oft potenzierter Form im Hass von Gruppen wieder. Der Autor untersucht die Phänomenologie des Hasses und die daraus resultierende Form von Destruktivität anhand literarischer Beispiele, psychischer Störungen und gesellschaftlicher Phänomene. (shrink)

Paragraph 50 of Wittgenstein'sPhilosophical Investigationsfamously says that there is one thing of which one can neither state that it is 1 m long nor that it isn't: the standard metre in Paris. Consensus appears to be that (1) exegetically speaking, Wittgenstein affirms this claim, and (2) systematically, whether or not one agrees with it, the practice of using a material artefact as a measurement standard has important philosophical consequences. In this paper, in contrast, we show that (1') Wittgenstein does not (...) affirm the standard metre claim and (2') historical facts about material length standards do not warrant deeper philosophical conclusions. References to material measurement standards in the literature gravely distort the actual metrological practices of developing and using such standards. (shrink)

'Methinks I am like a man, who having narrowly escap'd shipwreck', David Hume writes in A Treatise of Human Nature, 'has yet the temerity to put out to sea in the same leaky weather-beaten vessel, and even carries his ambition so far as to think of compassing the globe'. With these words, Hume begins a memorable depiction of the crisis of philosophy and his turn to moral and political philosophy as the path forward. In this groundbreaking work, Thomas W. (...) Merrill shows how Hume's turn is the core of his thought, linking Hume's metaphysical and philosophical crisis to the moral-political inquiries of his mature thought. Merrill shows how Hume's comparison of himself to Socrates in the introduction to the Treatise illuminates the dramatic structure and argument of the book as a whole, and he traces Hume's underappreciated argument about the political role of philosophy in the Essays. (shrink)

In this paper I will develop the argument that a cognitivist and virtue ethical approach to moral reasons is the only approach that can sustain a non-alienated relation to one’s character and ethical commitments. [Thomas, 2005] As a corollary of this claim, I will argue that moral reasons must be understood as reasonably partial. A view of this kind can, nevertheless, recognise the existence of general and positive obligations to humanity. Doing so does not undermine the view by leading (...) to a highly demanding view of morality. Indeed, it offers a defence against the view that an analogy between obligations of immediate rescue to particular individuals and general and positive obligations to humanity leads to the conclusion that morality is highly demanding. The plan of this paper is as follows. The first section sets out the main elements of a cognitivist and virtue ethical approach to moral reasons. The second applies it to the test case of an argument that claims that one way in which one seeks to lead a non-alienated ethical life, a life of integrity, is incompatible with the requirements of consequentialism given certain very general facts about the moral state of the world. [Ashford, 2000] My.. (shrink)

Standard definitions of lying imply that intending to deceive others is a necessary condition of one's telling a lie. In an earlier paper, which appeared in this journal, Wokutch, Murrmann and I argued that intending to deceive others is not a necessary condition of one's telling a lie and proposed an alternative definition. In a reply which also appeared in this journal, Gary Jones argues that our arguments fail to establish the claim that it is possible to lie without intending (...) to deceive others, and that the objections which we raise for standard definitions apply equally to our own. The present paper argues that one can lie without intending to deceive others. I concede Jones' second criticism and propose a new alternative definition. (shrink)

Overview of the definition of art and its relationship to definitions of the individual art forms, with an eye to clarifying the issues separating dominant institutionalist and skeptical positions from non-skeptical, non-institutional ones. Section 2 indicates some of the key philosophical issues which intersect in discussions of the definition of art, and singles out some important areas of broad agreement and disagreement. Section 3 critically reviews some influential standard versions of institutionalism, and some more recent variations on them. Section 4 (...) discusses some recent reductionist approaches to definitional questions, which advocate a shift of philosophical focus from the macro- to the micro-level —from art to the individual art forms. Section 5 outlines an alternative, non-institutionalist and non-reductionist approach to definitional questions. (shrink)

Condorcet's jury theorem shows that when the members of a group have noisy but independent information about what is best for the group as a whole, majority decisions tend to outperform dictatorial ones. When voting is supplemented by communication, however, the resulting interdependencies between decision makers can strengthen or undermine this effect: they can facilitate information pooling, but also amplify errors. We consider an intriguing non-human case of independent information pooling combined with communication: the case of nest-site choice by honeybee (...) (Apis mellifera) swarms. It is empirically well documented that when there are different nest sites that vary in quality, the bees usually choose the best one. We develop a new agent-based model of the bees' decision process and show that its remarkable reliability stems from a particular interplay of independence and interdependence between the bees. (shrink)

Science is atypical because it is cultivated with communal participation from throughout the world. This global formation has evolved recently. It originates in the institutionalization of a cosmopolitan tradition in Europe. The cosmopolitan orientation and the perceived usefulness of the European tradition promoted its adoption and institutionalization in the non-Western civilizations. A global institutional frame, including a global science policy regime, sustains communal participation in world science. Participation is described in terms of individual, national, and global communalformations.

Because wicked problems are beyond the scope of normal, industrial-age engineering science, sustainability problems will require reform of current engineering science and technology practices. We assert that, while pluralism concerning use of the term sustainability is likely to persist, universities should continue to cultivate research and education programs specifically devoted to sustainable engineering science, an enterprise that is formally demarcated from business-as-usual and systems optimization approaches. Advancing sustainable engineering science requires a shift in orientation away from reductionism and intellectual specialization (...) towards integrative approaches to science, education, and technology that: draw upon an ethical awareness that extends beyond the usual bounds of professional ethics or responsible conduct of research to include macroethics, adopt anticipatory and adaptive approaches to unintended consequences resulting from technological innovation that result in more resilient systems, and cultivate interactional expertise to facilitate cross-disciplinary exchange. Unfortunately, existing education and research training programs are ill-equipped to prepare scientists and engineers to operate effectively in a wicked problems milieu. Therefore, it is essential to create new programs of graduate education that will train scientists and engineers to become sustainable engineering science experts equipped to recognize and grapple with the macro-ethical, adaptive, and cross-disciplinary challenges embedded in their technical research and development programs. Content Type Journal Article Category Articles Pages 1-18 DOI 10.1007/s10806-011-9342-2 Authors Thomas Seager, School of Sustainability and The Built Environment, Arizona State University, Phoenix Metropolitan Area, AZ, USA Evan Selinger, Department of Philosophy, Rochester Institute of Technology, Henrietta, NY, USA Arnim Wiek, School of Sustainability, Arizona State University, Phoenix Metropolitan Area, AZ, USA Journal Journal of Agricultural and Environmental Ethics Online ISSN 1573-322X Print ISSN 1187-7863. (shrink)

Although several theories of online syntactic processing assume the parallel activation of multiple syntactic representations, evidence supporting simultaneous activation has been inconclusive. Here, the continuous and non‐ballistic properties of computer mouse movements are exploited, by recording their streaming x, y coordinates to procure evidence regarding parallel versus serial processing. Participants heard structurally ambiguous sentences while viewing scenes with properties either supporting or not supporting the difficult modifier interpretation. The curvatures of the elicited trajectories revealed both an effect of visual context (...) and graded competition between simultaneously active syntactic representations. The results are discussed in the context of 3 major groups of theories within the domain of sentence processing. (shrink)

This paper investigates the concept of Heimat in the work of philosopher, writer, and journalist Fritz Mauthner (1849–1923). It points out a conflict between Mauthner’s language philosophy and his political views. In his philosophical work, he argues that language is an insufficient tool for the acquisition of knowledge. When he writes about his heritage and uses notions such as Heimat, Volk, or Vaterland, Mauthner makes claims about the formation of social communities based on a shared language and neglects a critical (...) analysis. It appears as if he ignores the philosophical critique of language when it comes to political concepts. Thus, his political position is usually described without regard to his language philosophy, and Mauthner is conceived as a devoted German nationalist and a typical example of Jewish self-hatred. That reading can be contrasted with parts of his work – especially the late book Muttersprache und Vaterland (1920) – in which he criticizes political concepts from a language-philosophical point of view. I argue that Mauthner, read as a philosopher, cannot be typecast as a naïve nationalist as he is too contradictory. I show that his writings offer both a historical example of German nationalism and a deconstruction of nationalism. (shrink)

The fifth “deduction” in Plato’s Parmenides concerns the consequences that follow for a one from the hypothesis that it is not. I argue that the subject of this hypothesis is, effectively, any Form, considered just insofar as it is one Form. The hypothesis, I further argue, does not concern any essential aspect of a Form, but rather posits its contingent non-instantation. The motion this deduction attributes to its one is a special type of motion: motion into and out of instantiation.

I am the LawIt is hard to imagine two more disparate characters than Judge Joseph Dredd and Hercules J—the one an over-muscular, faceless and heavily armed street judge astride a Lawmaster motorcycle who overidentifies with his role ; the other devoid of any physical presence or image, and structurally decoupled from the execution of law by a fierce determination to maintain the separation of powers and accountability which Dredd so effortlessly ignores. Hercules J is the embodiment of an intellectualised, yet (...) creative, operationalisation of law. To the academic spirit, Hercules is infinitely preferable as a model of judicial activism: his world conjures a contemplative modality, ever alert to the requirements of rights and largely aligned with the temper of the post-Enlightenment. By contrast, Dredd is the personification of the worst aspects of law-and-order as the debased and politicised manifestation of the Rule of Law. His is an intensely visceral presence, the metonymic blindness of Themis replaced by the Dredd’s fractured eyeline: blindness as a signifier of impartiality yields to blindness as a symptom of institutional rage. This article interrogates the characters, actions and values of Hercules J and Dredd J, viewed primarily through the lens of Jacques Derrida’s Force of Law, focusing on the relationship between law and violence as it is exposed in Hercules’s and Dredd’s worlds, and then turning to judicial confrontation with the aporetic: the aporias, identified by Derrida and others, that law must confront. The interrogation continues, finally contemplating the current state of law in the common law world—the world of liberal democracies, suggesting that the high point of democracy may well have passed, and that we are on a Dredd-ward trajectory. (shrink)

One prevalent type of slippery slope argument has the following form: (1) by doing some initial act now, we will bring it about that we subsequently do some more extreme version of this act, and (2) we should not bring it about that we do this further act, therefore (3) we should not do the initial act. Such arguments are frequently regarded as mistaken, often on the grounds that they rely on speculative or insufficiently strong empirical premises. In this article (...) I point out another location at which these arguments may go wrong: I argue that, in their standard form, the truth of their empirical premises constitutes evidence for the falsity of their normative premises. If we will, as predicted, do the further act in the future, this gives us at least a prima facie reason to believe that the performance of this further act would be good, and thus something we should try to bring about. I end by briefly assessing the dialectic implications of my argument. I delineate a subset of slippery slope arguments against which my objection may be decisive, consider how the proponents of such arguments may evade my objection by adding further premises, and examine the likely plausibility of these additional premises. (shrink)

This essay adopts a semiotic perspective focused on practices of communication, movement, and translation to examine the global impact of A. J. Greimas and his oeuvre. The linguist and semiotician’s lecture trips abroad, the number and provenance of international students in his Paris seminar, and the chronology and linguistic geography of translations of his work help describe, gauge, and explain the dissemination and development of his ideas throughout the world. His project has engendered distinctive appropriations and at times productive institutional (...) structures in a number of cultural and linguistic contexts, notably Romance, Anglo-American, Germanic, Russian, Lithuanian, and Chinese. The broader historical relations between France and other lands, and the extent of each society’s use of the French language have conditioned, fostered, or impeded responses to his proposals. The conclusion’s discussion of the relative importance of personal contacts, socio-historical context, and the sociolinguistic and pedagogical status of French for his international reception aims to contribute to general methodological debates in the history of science and ideas and in transnational history. (shrink)