Adapter molecules in a variety of signal transduction systems link receptors to a limited number of commonly used downstream signaling pathways. During T‐cell development and mature T‐cell effector function, a multichain receptor (the pre‐T‐cell antigen receptor or the T‐cell antigen receptor) activates several protein tyrosine kinases. Receptor and kinase activation is linked to distal signaling pathways (PLC‐γ1 activation, Ca2+ influx, PKC activation and Ras/Erk activation) via the adapter protein LAT (Linker for Activation of T cells). Structure/function studies of LAT including (...) expression of selected LAT point mutations in vivo reveals that these multiple pathways are integrated at the level of the LAT adapter. These studies suggest that similar levels of control may be found in other systems where adapter molecules are known to have important functions. BioEssays 26:61–67, 2004. Published 2003 Wiley Periodicals, Inc. (shrink)

Examines the cultural implications of society's declining appreciation and recognition of common sense while exploring the process by which the concept is learned.

Cahoone carefully develops the idea of subjectivity and narcissism using psychological theory, the dialectical theory of the Frankfurt school, and historians.

Disc 1. Philosophy and the modern age ; Scholasticism and the scientific revolution -- Disc 2. The rationalism and dualism of Descartes ; Locke's empiricism, Berkeley's idealism -- Disc 3. Neo-Aristotelians : Spinoza and Leibniz ; The Enlightenment and Rousseau -- Disc 4. The radical skepticism of Hume ; Kant's Copernican revolution -- Disc 5. Kant and the religion of reason ; The French Revolution and German idealism -- Disc 6. Hegel, the last great system ; Hegel and the English (...) century -- Disc 7. The economic revolution and its critic, Marx ; Kierkegaard's Critique of reason -- Disc 8. Nietzsche's Critique of morality and truth ; Freud, Weber, and the mind of modernity -- Disc 9. Rise of 20th-century philosophy, pragmatism ; analysis -- Disc 10. Rise of 20th-century philosophy, phenomenology ; Physics, positivism and early Wittgenstein -- Disc 11. Emergence and Whitehead ; Dewey's American naturalism -- Disc 12. Heidegger's Being and time ; Existentialism and the Frankfurt School -- Disc 13. Heidegger's turn against humanism ; Culture, hermeneutics, and structuralism -- Disc 14. Wittgenstein's turn to ordinary language ; Quine and the end of positivism -- Disc 15. New philosophies of science ; Derrida's deconstruction of philosophy -- Disc 16. The challenge of postmodernism ; Rorty and the end of philosophy -- Disc 17. Rediscovering the premodern ; Pragmatic realism, reforming the modern -- Disc 18. The reemergence of emergence ; Philosophy's death greatly exaggerated. (shrink)

In _Civil Society_, Lawrence Cahoone stages a critical engagement between the social-political viewpoints of liberalism, communitarianism, and conservatism in order to effect a balanced relation that will bypass or overcome the inadequacies of each position.

Environmental ethicists typically find value in living things or their local environments: (1) anthropocentists insofar as they have value for human beings; (2) biocentrists in all organisms; and (3) ecocentrists in all ecosystems. But does the rest of nature have value? If so, is it merely as instrument or stage setting for life? A fanciful thought experiment focuses the point: is stellar nucleosynthesis a good thing? There are reasons to believe that it is intrinsically good, that even before life evolved, (...) stellar nucleosynthesis was a good. If so, then the three views above are incomplete as accounts of natural value. It further implies that some non-biological criterion can serve as a rational standard of value: namely, complexity. The attempt to answer the question of the value of stellar nucleosynthesis leads to a clarification of the meaning of intrinsic value, which also has implications for more local questions of environmental values. (shrink)

Lawrence Johnson advocates a major change in our attitude toward the nonhuman world. He argues that nonhuman animals, and ecosystems themselves, are morally significant beings with interests and rights. The author considers recent work in environmental ethics in the introduction and then presents his case with the utmost precision and clarity. Written in an attractive, nontechnical style, the book will be of particular interest to philosophers, environmentalists and ecologists.

This revised and expanded second edition of Cahoone's classic anthology provides an unparalleled collection of the essential readings in modernism and postmodernism. Places contemporary debate in the context of the criticism of modernity since the seventeenth century. Chronologically and thematically arranged. Indispensable and multidisciplinary resource in philosophy, literature, cultural studies, social theory, and religious studies.

In some part, the ideas presented here are anticipated in a paper by Frank Tillman, through I present a broader theory intended to have utility in connection with the theory of truth.

Shaftesbury's Characteristics of Men, Manners, Opinions, Times was first published in 1711. It ranges widely over ethics, aesthetics, religion, the arts, and ancient and modern history, and aims at nothing less than a new ideal of the gentleman. Together with Locke's Essay Concerning Human Understanding and Addison and Steele's Spectator, it is a text of fundamental importance for understanding the thought and culture of Enlightenment Europe. This volume, first published in 2000, presents an edition of the text together with an (...) introduction, explanatory notes and a guide to further reading. (shrink)

Future generations do not exist, and are not determinate in their make-up. The moral significance of future generations cannot be accounted for on the basis of a purely individualistic ethic. Yet future generations are morally significant. The Person-Affecting Principle, that (roughly) only acts which are likely to affect particular individuals are morally significant, must be augmented in such a way as to take into account the moral significance of Homo sapiens, a holistic entity which certainly does exist. Recent contributions to (...) Environmental Values by Alan Carter and Ernest Partridge are criticised (but not entirely rejected). (shrink)

The classical social theorist Emile Durkheim proposed the counterintuitive thesis that crime is beneficial for society because it provokes punishment, which enhances social solidarity. His logic, however, is blemished by a reified view of society that leads to group-selectionist thinking and a teleological account of the causes of crime. Reconceptualization of the relationship between crime and punishment in terms of evolutionary game theory, however, suggests that crime (cheating) may confer benefits on cooperating individuals by promoting stability in their patterns of (...) cooperation. (shrink)

I develop the thesis that species and ecosystems are living entities with morally significant interests in their own right and defend it against leading objections. Contrary to certain claims, it is possible to individuate such entities sufficiently well. Indeed, there is a sense in which such entities define their own nature. I also consider and reject the argument that species and ecosystems cannot have interests or even traits in their own right because evolution does not proceed on that level. Although (...) evolution proceeds on the level of the genotype, those selected are able to cooperate in entities of various higher orders—including species and ecosystems. Having their own nature and interests, species and ecosystems can meaningfully be said to have moral standing. (shrink)

“Whatever else of metaphysical or philosophical significance may be involved in a biblical pericope, it remains true that the writer or speaker was directing his words to something which he considered to be a vital element in the human situation, to understanding man's humanness as it finds expression in his life with others in a social context.”.