In this paper we work in an arbitrary o-minimal structure with definable Skolem functions and prove that definably connected, locally definable manifolds are uniformly definably path connected, have an admissible cover by definably simply connected, open definable subsets and, definable paths and definable homotopies on such locally definable manifolds can be lifted to locally definable covering maps. These properties allow us to obtain the main properties of the general o-minimal fundamental group, including: invariance and comparison results; existence of universal locally (...) definable covering maps; monodromy equivalence for locally constant o-minimal sheaves – from which one obtains, as in algebraic topology, classification results for locally definable covering maps, o-minimal Hurewicz and Seifert–van Kampen theorems. (shrink)

La "riforma" della dialettica hegeliana e la "circolazione" del pensiero europeo scandirono il progetto culturale del filosofo e politico Bertrando Spaventa. Ma la sua biografia intellettuale - dalla giovinezza alle ultime riflessioni sul realismo e sulla metafisica - mostra una ricchezza per tanti versi inesplorata: la lettura dei grandi autori del Rinascimento, a cominciare da Giordano Bruno, il confronto con i filosofi italiani contemporanei, il contributo alla vita civile, costituiscono momenti essenziali per lo sviluppo del suo pensiero. In occasione (...) del bicentenario della nascita (Bomba, 26 giugno 1817), alcuni dei suoi maggiori interpreti propongono con questo libro una ricostruzione dell'intero itinerario filosofico e civile di Spaventa. (shrink)

Technology is always limited to the realm of means, while morality is supposed to deal with ends. In this theoretical article about comparing those two regimes of enunciation, it is argued that technology is on the contrary characterized by the `ends of means' that is the impossibility of being limited to tools; technical artefacts are never tools if what is meant by this is a transmission of function in a mastered way. Once this modification of the meaning of technology is (...) accepted, then it is possible to relate technology, in a totally different way, to morality which is not about values, but about the exploration of ends. (shrink)

In his interesting commentary, Joshua Shepherd raises two points—one related to epistemology, the other to ethics—about our article on human cerebral organoids.1 2 From the epistemological standpoint, he calls into question the need for a theory of consciousness. A theory of consciousness, for him, is not necessary because of the lack of consensus about the very nature of consciousness. Shepherd suggests that ‘given widespread disagreement, applying a theory of consciousness may not be helpful when attempting to diagnose the presence of (...) consciousness in cerebral organoids’. In Shepherd’s view, it would be better to transfer ‘concepts already under development in work on the presence and structure of consciousness in difficult marginal cases involving traumatic brain injury’.2 We could not agree more on this last point; detecting a minimal capacity for consciousness in the brain of comatose patients is a very similar challenge to inferring the presence of consciousness in cerebral organoids. Every day, as a by-product of saving many lives, intensive care medicine artificially produces thousands of brains that may remain isolated, split or fragmented; in the worst case, cortical islands, or an archipelago of islands, may survive while being disconnected from the outside world. Can these islands host some form of consciousness? That is, does it feel like anything to be a large piece of human cortex? Addressing this difficult question requires the development of general, objective brain-based indices of consciousness that are independent of sensory processing, executive functions and motor outputs.3 Consider, for example, a patient showing reflexive spontaneous behaviour, no response to command and no ability to communicate. In her brain, afferent pathways are damaged, thereby impairing the recruitment of cortical areas in response to sensory stimulation; basal ganglia, as well as other frontal structures supporting executive functions, are impaired. However, resting metabolism and significant electroencephalography …. (shrink)

Eye movements during mental imagery are not epiphenomenal but assist the process of image generation. Commands to the eyes for each fixation are stored along with the visual representation and are used as spatial index in a motor‐based coordinate system for the proper arrangement of parts of an image. In two experiments, subjects viewed an irregular checkerboard or color pictures of fish and were subsequently asked to form mental images of these stimuli while keeping their eyes open. During the perceptual (...) phase, a group of subjects was requested to maintain fixation onto the screen's center, whereas another group was free to inspect the stimuli. During the imagery phase, all of these subjects were free to move their eyes. A third group of subjects (in Experiment 2) was free to explore the pattern but was requested to maintain central fixation during imagery. For subjects free to explore the pattern, the percentage of time spent fixating a specific location during perception was highly correlated with the time spent on the same (empty) locations during imagery. The order of scanning of these locations during imagery was correlated to the original order during perception. The strength of relatedness of these scanpaths and the vividness of each image predicted performance accuracy. Subjects who fixed their gaze centrally during perception did the same spontaneously during imagery. Subjects free to explore during perception, but maintaining central fixation during imagery, showed decreased ability to recall the pattern. We conclude that the eye scanpaths during visual imagery reenact those of perception of the same visual scene and that they play a functional role. (shrink)

In his 1841-2 Berlin lectures, Schelling critiques German idealism’s negative method of regressing from existence to its first principle, which is supposed to be intelligible without remainder. He sees existence as precisely its remainder since there could be nothing that exists. To solve this, Schelling enlists the positive method of progressing from the fact of existence to a proof of this principle’s reality. Since this proof faces the absurdity that there is anything rather than nothing, he concludes that this fact’s (...) constitution and this principle’s proof are mutually dependent, non-dischargeable tasks. I trace this reciprocal relation to one Kant establishes between the constitutive categories of experience and the experience that proves their applicability and argue that it adheres to Kant’s threefold criterion of proof. I do so by uncovering the Maimonian skeptical motivation—specifically, the need to answer what I call the question quid indicii—behind the qualified return to Kant on which Schelling’s critique of idealism relies. (shrink)

In this article we question the utility of the distinction between conceptual and nonconceptual content in cognitive science, and in particular, in the empirical study of visual perception. First, we individuate some difficulties in characterizing the notion of “concept” itself both in the philosophy of mind and cognitive science. Then we stress the heterogeneous nature of the notion of nonconceptual content and outline the complex and ambiguous relations that exist between the conceptual/nonconceptual duality and other pairs of notions, such as (...) top–down/bottom-up and modular/nonmodular. Finally we look in greater detail at the proposal developed by Jacob and Jeannerod (Ways of seeing. The scopes and limits of visual cognition. Oxford, UK: Oxford University Press, 2003 ), who apply the notion of nonconceptual content to empirical research on visual perception. After reconstructing their point of view on concepts, we try to reject their major arguments in support of the conceptual/nonconceptual distinction, i.e. the compositionality of thought and the fineness of grain of percepts. (shrink)

The author of the present paper argues that while trying to explain the institutional success of the science and its broad social impact, it is worth throwing aside the arguments concerning the universal traits of human nature, changes in the human mentality, or transformation of the culture and civilization, such as the development of capitalism or bureaucratic power. In the 16th century no new man emerged, and no mutants with overgrown brains work in modern laboratories. So one must also reject (...) the Great Divide between the cultures of the scientific and pre-scientific and replace it with multiple, uncertain and unexpected ‘not-so-great divides’, which can be described in meticulous anthropological studies. Although the achievements of science are certainly spectacular, and the gap between scientific practice and other areas of activity is so obvious, this does not mean that one must look for the \"great\" reasons behind this situation. One should rather focus on quite down-to-earth practices and tools used by scientists. A significant part of their activities can be described by referring to the craft of writing, reading and transforming of various types of inscriptions (records), and broadly understood visualization – their combining, performing, interpreting, confronting, comparing, shifting, shuffling etc. The important role of these tools and methods is especially visible in situations of scientific controversy. It is so because scientific controversies are won by the one able to muster on the spot the largest number of well aligned and faithful allies, and the technology of writing, printing and visualizing play a special role in mobilizing them. These are necessary to ensure that certain factors can be mobile – easy to move from place to place, and yet, immutable – not undergoing deformation as a result of the movement. This way, scientists are able to not only diffuse different types of factors relevant to the dispute and the process of constituting science, but also concentrate them in the centers of calculation, where, through accumulation, one can take actions not available elsewhere. (shrink)

Historien du « catholicisme au féminin », Claude Langlois a magistralement étudié par la voie quantitative l’essor des congrégations féminines dans la France du XIXe siècle. Mais restait à comprendre l’indicible. Qu’est ce qui pousse ces milliers de femmes à entrer dans les ordres? Quels sont les ressorts profonds d’une vocation religieuse féminine? Claude Langlois va chercher la réponse chez Thérèse de Lisieux, entrée au carmel à 15 ans et décédée de la tuberculose à 24 ans, devenue l’une...

When formulating the concept of the impulse-image, Deleuze never tires of asserting that these images are saturated with death and obsessed by degradation. They stand at a curious intersection in the taxonomy of images, a constitutively in-between space: they are formally inserted between affection-image and action-image in The Movement-Image, but produce a direct passage to the time-image. However, they do not reach the time-image due to obsession by the negative effects of time. This article introduces the concept of the impulse-image (...) in Deleuze's work on the impulse and death instinct, in his fundamental texts of the 1960s and 1970s, including his collaboration with Félix Guattari. The death instinct in the late 1960s was a transcendental principle that acquired the form of the groundless or crack-up essential for the production of difference. It is at this time that Deleuze publishes Zola and the Crack-up, an embryonic essay for what would later become the impulse-image. In the 1970s, Deleuze, along with Guattari, fought the need to include a groundless force in the mould of the death instinct. Speaking of cinema in the 1980s, which is when he returns to the impulse theme, one finds characteristics of both preceding periods, especially the structure conceived in the 1960s, associated with the criticism of the 1970s. However, Deleuze now stands apart, recognising a naturalistic image and admiring a practice of symptomatology, but pointing out that his own understanding of the world does not lie in it. With the impulse-images, Deleuze also plays a relevant role in studies of film naturalism, shaping a powerful concept for studies of contemporary naturalistic symptomatologies that emerge in situations of misery of civilisation. (shrink)

L'origine dell'anima umana secondo Dante.--La dottrina d'Alberto Magno sull'Inchoatio formae.--Alberto Magno e san Tommaso.--La posizione di Alberto Magno di fronte all'averroismo.--L'anima umana secondo Sigieri.--Anima e corpo nel pensiero di san Tommaso.--L'aristotelismo della scolastica e i francescani.--Individualità e immortalità nell'averroismo e nel tomismo.

La mission du juge est de trancher les litiges. Or, avant de d’appliquer une règle juridique, il est nécessaire de connaître précisément les faits de la cause. « Da mihi factum, dabo tibi jus ». L’expert est le spécialiste de l’analyse des faits dont le juge a besoin. Dans le domaine de la santé, l’expert est incontournable tant pour étudier la santé corporelle que la santé mentale. On note toutefois une évolution considérable qui tend à demander à l’expert, non plus (...) seulement d’observer une situation passée ou présente mais de prévenir l’avenir. (shrink)

Bernard Mandeville's poem "The Grumbling Hive: or, Knaves turn'd Honest" explores the subtle interplay between morality and business practices, particularly through the lens of the term "knave". This article examines Mandeville's use of "knave" in juxtaposition with the value of honesty portrayed in the poem's title. In contrast to the spiritual transformation depicted in the poem, in which all the bees in the hive become honest through divine intervention, Mandeville suggests a different kind of change in moral practice, one that (...) incorporates previously unacceptable behavior into the social fabric. Through a varied historical reconstruction of the uses and understandings of the term in question, the study explores Mandeville's concerns about the acceptance and normalization of dishonesty in various segments of society, as illustrated by the anecdote in Observation B, which shows how dishonesty permeates all aspects of commerce, involving buyers, sellers, merchants, traders, and dealers. By analyzing Mandeville's portrayal of dishonesty and its integration into social dynamics, this study aims to elucidate the underlying tensions between ethical standards and the pursuit of self-interest. (shrink)

The economic crisis happening across the world over the last few years describes a range of interdependencies and interactions,and has highlighted the fundamentalf laws of neoclassical economic theory: its unedifying focus on prediction and, above all, its inability to explain how the economy really works. As such, it is increasingly recognised that economic phenomena cannot be exclusively investigated as being derived from deterministic, predictable and mechanistic dynamics. Instead, a new approach is required by which history-dependence, organic and ever-evolving processes are (...) also accounted for. As this view implies new challenges and opportunities for policy, we will focus our attention on innovative components of Complexity Theory for the study of economics and the evaluation of public policies. (shrink)

Dans cet article, nous revenons sur le premier moment de l'appropriation de Nietzsche dans le parcours de Gilles Deleuze. Le livre Nietzsche et la philosophie (1962) s'inscrit de plein pied dans une phase inédite de légitimation institutionnelle du philosophe allemand comme en témoigne toute une série de stratégies de lecture et de prises de position stylistiques propres au travail de Deleuze visant à constituer pleinement Nietzsche en philosophe, mais aussi ces opérations de courts-circuits de différents champs de production culturelle (littéraire, (...) politique, « marginaux ») au sein desquels la lecture de Nietzsche était particulièrement vivante durant la première moitié du XXe siècle. Restituer cette légitimation philosophique de Nietzsche par le haut, c'est aussi se donner les moyens de comprendre la force et l'audace de ce « second moment » (au début des années 1970 notamment) où Nietzsche, à l'inverse, devient chez Deleuze le nom de ralliement d'un rapport hétérodoxe à la lecture des textes philosophiques. (shrink)

An Irishman’s heart is nothing but his imagination.G.B. Shaw, John Bull’s other Island 1. Il primo principio della conoscenza e la riflessione estetica Secondo il primo principio della conoscenza, esse est percipi, l’essere delle cose è il loro essere percepite. Anche quando nessun soggetto percepisce l’oggetto, questo continua a esistere perché Dio, causa unica della realtà, percependo tutte le idee, dalla creazione in poi, le mantiene in essere. In questo modo il processo percettivo si stru...

How are ideas about education and democracy configured and reconfigured as they travel? Democracy and the Intersection of Religion looks at the work of John Dewey, the renowned philosopher, psychologist, and educational reformer, and the ways in which his educational ideas and democratic ideals have been configured and reconfigured, adopted, and interpreted in different historical and cultural spaces.

SummaryMutations in human genes encoding transcription factors are often dominant because one active allele cannot ensure a normal phenotype (haploinsufficiency). In other instances, heterozygous mutations of two genes are required for a phenotype to appear (combined haploinsufficiency). Here, we explore with models (i) the basis of haploinsufficiency and combined haploinsufficiency owing to mutations in transcription activators, and (ii) how the effects of such mutations can be amplified or buffered by subsequent steps in a transcription cascade. We propose that the non‐linear (...) (sigmoidal) response of transcription to the concentration of activators can explain haploinsufficiency. We further show that the sigmoidal character of the output of a cascade increases with the number of steps involved, the settings of which will determine the buffering or enhancement of the effects of a decreased concentration of an upstream activator. This exploration provides insights into the bases of compensatory mutations and on interloci interactions underlying oligogenic inheritance patterns. (shrink)

Cet essai analyse le sens que donne Leo Strauss à l’argument de l’élection des juifs, et tente à partir de là de comprendre sa position à l’égard des différentes options qui s’offrent aux juifs modernes (le retour à la tradition, l’assimilation, le sionisme politique). Le sens politique que Strauss confère à l’élection dans son diagnostic de la modernité et de la place que les juifs y occupent n’exclut pas, mais au contraire éclaire d’une manière nouvelle l’acception théologique du terme. Ce (...) sens s’éclaire par la reprise de la formule talmudique « Si je ne me bats pas pour moi, que suis-je? ». La question finale est alors de savoir quelle signification peut revêtir cette formule dès lors que le juif moderne se voue à la philosophie. (shrink)