We report on the deliberations of an interdisciplinary group of experts in science, law, and philosophy who convened to discuss novel ethical and policy challenges in stem cell research. In this report we discuss the ethical and policy implications of safety concerns in the transition from basic laboratory research to clinical applications of cell-based therapies derived from stem cells. Although many features of this transition from lab to clinic are common to other therapies, three aspects of stem cell biology pose (...) unique challenges. First, tension regarding the use of human embryos may complicate the scientific development of safe and effective cell lines. Second, because human stem cells were not developed in the laboratory until 1998, few safety questions relating to human applications have been addressed in animal research. Third, preclinical and clinical testing of biologic agents, particularly those as inherently complex as mammalian cells, present formidable challenges, such as the need to develop suitable standardized assays and the difficulty of selecting appropriate patient populations for early phase trials. We recommend that scientists, policy makers, and the public discuss these issues responsibly, and further, that a national advisory committee to oversee human trials of cell therapies be established. **NB we did not reccommend a NAC, we think it might be appropriate**. (shrink)

The truth-conditional theory of sense holds that a theory of truth for a natural language can serve as a theory of sense: if knowledge of a theory of truth for a language L is sufficient for understanding utterance of L-sentences, the T-sentences of the theory 'show' the sense of the uttered object-language sentences. In this paper I aim to show that indexicals create a serious problem for this prima facie attractive theoretical option. The so-called 'instantiation problem' is that a truth-theory (...) for indexical languages needs to contain universal statements that show how the reference of indexicals depends on features of the utterance context. Now one can deduce from such statements T-sentences that do not show the sense of an indexical sentence on an occasion of use. I survey proposed solutions to the instantiation problem by Evans and Sainsbury and, unfortunately, find them all wanting. Perhaps there is nothing like the sense-giving truth-condition for an indexical sentence. (shrink)

The investigator seeks guidance related to a planned recruitment strategy of requiring participants to live within close proximity to the study site for the 32-week Phase II study examining the saf...

On September 8, 2015, the Department of Health and Human Services issued a Notice of Proposed Rule Making to revise the Federal Policy for the Protection of Human Subjects, widely known as the “Common Rule.” The NPRM proposes several changes to the current system, including a dramatic shift in the approach to secondary research using biospecimens and data. Under the current rules, it is relatively easy to use biospecimens and data for secondary research. This approach systematically facilitates secondary research with (...) biospecimens and data, maximizing the capacity for substantial public benefit. However, it has been criticized as insufficiently protective of the privacy and autonomy interests of biospecimen and data sources. Thus, the NPRM proposes a more restrictive regime, although more so for biospecimens than data. Both the status quo and the NPRM's proposal are critically flawed. (shrink)

Current methods of obtaining an informed consent leave much to be desired. Patients rarely read consent forms or understand all of the risks, benefits, or alternatives associated with their treatment. Evaluating the advantages and disadvantages of treatment options often presents a more significant challenge for patients with lower levels of health literacy. This article reviews the evidence of shortcomings in our informed consent system and then explores the potential for a new approach to engage patients at all levels of health (...) literacy in their treatment decisions. Specifically, the article will examine the potential of shared decision-making to bridge gaps in knowledge, increase patient adherence to treatment, and improve health outcomes in low health literacy patient populations. Leveling barriers to treatment information for disadvantaged populations should be a public health imperative, especially if it can be shown to improve health outcomes and reduce health disparities. (shrink)

If stem cell-based therapies are developed, we will likely confront a difficult problem of justice: for biological reasons alone, the new therapies might benefit only a limited range of patients. In fact, they might benefit primarily white Americans, thereby exacerbating long-standing differences in health and health care.

This article offers a reading of the “transcendental” character of Alain Badiou’s and Giorgio Agamben’s ontologies. While neither Badiou nor Agamben are “transcendental” philosophers in the Kantian sense, this article argues that their respective projects of ontology both recover aspects of the “classical” conception of the transcendentals. Not unlike how pre-modern philosophers conceived of oneness, truth and goodness as transcendental properties of all things, both Badiou’s and Agamben’s ontologies present various structures which can be universally predicated of all being. However, (...) as opposed to the essentialist or even theological tendencies of traditional metaphysics, Badiou’s and Agamben’s ontologies are committedly “inessential” and atheistic at their very core. By replacing the divine names of the one, the true and the good in traditional metaphysics with a new yet quasi-classical transcendental notion of “the void” as a universal predicate of all beings, Badiou’s and Agamben’s works may be regarded as projects that go beyond both the pre-Kantian “theological” and the post-Kantian “subjective” conceptions of transcendental philosophy, thereby marking a new development in the history of western metaphysics. (shrink)

Gods, Kings, and Merchants in Old Babylonian Mesopotamia. By Dominique Charpin. Publications de l’Institute de Proche-Orient Ancient du Collège de France. Leuven: Peeters, 2015. Pp. 223, illus, €41.

It is tempting to think that we have heard just about all we want or need to know about race. As the above quotes indicate, modern notions of race have always revolved around the faculty of vision, with supplementary contributions from other senses such as hearing, as Arendt notes in a tacit allusion to one mark of Jewish difference—the way they sounded when concentrated in urban settings. Yet two very recent works—Mark M. Smith's How Race Is Made and (...) Anne C. Rose's Psychology and Selfhood in the Segregated South —have much to teach us about how race has “worked”, particularly in the twentieth-century South but also, by implication, in the United States in general. Both works assume that, historically, race is no mere add-on to the self, a kind of externality that, once detected, can be relatively easily excised. Rather, it stands right at the heart of personal and group identity in a nation where race and ethnicity continue to assume surprising new shapes and forms. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

Technology is developing fast - so fast that it threatens to overwhelm the very species whose genius lies in its technological cunning: us. From the metaverse to genetic engineering and mood-altering pharmaceuticals, to cybersex and cyberwar and the widespread automation of work, new technologies are rewriting the terms of our existence, not in a neutral spirit of 'progress' but in line with the priorities of power and profit, and in ways that often work against the grain of our fundamental being.In (...) this timely, provocative book, Richard King argues that we need to evolve a more critical attitude to new technologies if we are to avoid a world in which humans are no different in kind from algorithmic machines. The stakes could not be higher. As science, technology and capitalism fuse into a single system, and activists and entrepreneurs talk of a 'post-human' future in which individuals will transform themselves using powerful computers and biotechnologies, we are entering unchartered territory - a territory marked with the mapmaker's warning, Here Be Dragons... Here Be Monsters. (shrink)

The paradigm case of power as ?power over? (not ?power to') betrays a concern (1) more with the capacity to dominate others than with the unqualified capacity to act as such; (2) more with the fact, than with the morality, of dominance ? underscoring the key analytical distinction between ?power? and ?authority'; and (3) more with compulsion than co?operation. The three moves to combine (1) ?power over? with ?power to?, (2) ?power? with ?authority?, and (3) ?power? with ?co?operation?, are all (...) seen as inflationary, diminishing the value of the paradigm case, and assisting in rendering power, in its actual operations, both more obscure and insidious. Tumbling down this slope, there is a further argument, to the same effect, but secured by deflating, rather than inflating, the paradigm case. This deflationary argument (4) views luck as an alternative to power. In a world of dizzying technological innovation, marked by a deepening gap between rich and poor in the cities, between advanced and dependent states, we confront an inclination in many quarters both to expand and to contract power, so that it is everything and everywhere, thus nothing and nowhere. In attempts to substitute luck for power, it becomes difficult to assign to power responsibility, as heretofore. This paper is the first of two parts, taking a critical look at the overwhelming of power by inflation. The second part of this paper will be published in a subsequent issue, and it critically inspects the argument for deflation. (shrink)

In this essay, Mark Jonas argues that there are three broadly held misconceptions of Plato's philosophy that work against his relevance for contemporary moral education. The first is that he is an intellectualist who is concerned only with the cognitive aspect of moral development and does not sufficiently emphasize the affective and conative aspects; the second is that he is an elitist who believes that only philosopher-kings can attain true knowledge of virtue and it is they who should govern (...) society; the third is that he affirms the realm of the Forms as a literal metaphysical reality and believes that for individuals to attain virtue they must access this realm through contemplation. The goal of this essay is to correct these misconceptions. The rehabilitation of Plato's reputation may enable future researchers in moral education to discover in his philosophy new avenues for exploring how best to cultivate virtues in students. (shrink)

Not man as the king of creation, but rather as the being who is in intimate contact with the profound life of all forms or all types of beings, who is responsible for even the stars and animal life, and who ceaselessly plugs an organ-machine into an energy-machine, a tree into his body, a breast into his mouth, the sun into his asshole: the eternal custodian of the machines of the universe. Deleuze and Guattari, Anti-Oedipus 4.

Though largely unknown today, “Ned Buntline” (Edward Zane Carroll Judson) was one of the most influential authors of 19th-century America. He published over 170 novels, edited multiple popular and political publications, and helped pioneer the seafaring adventure, city mystery and Western genres. It was his pirate tales that Tom Sawyer constantly reenacted, his “Bowery B’hoys” that came to define the distinctive slang and swagger of urban American characters, and his novels and plays that turned an unknown scout into Buffalo Bill, (...) King of the Border Men. But before “Ned Buntline” became a mainstay of the popular press, he had been on his way to becoming one of the nation’s highbrow literary elites. He was praised by the leading critics, edited an important literary journal, and his stories appeared in the era’s most prestigious publications. This study examines how and why “Ned Buntline” moved from prestigious to popular authorship and argues that the transformation was precipitated by one very specific event: in 1846, Edward Z. C. Judson was lynched. A close examination of Judson’s life, writing, and the coverage of him in the newspapers of the day (including the remarkable story of how he survived a lynching) demonstrates that the same issues that led to his lynching also led to his rebirth as a new kind of American author. (shrink)

Wilfrid Sellars charged that mediaeval philosophers confused the genuine intentionality of thinking with what he called the “pseudo-intentionality” of sensing. I argue that Sellars’s charge rests on importing a form of mind/body dualism that was foreign to the Middle Ages, but that he does touch on a genuine difficulty for mediaeval theories, namely whether they have the conceptual resources to distinguish between intentionality as a feature of consciousness and mere discriminative responses to the environment. In the end, it seems, intentionality (...) cannot be “the mark of the mental” as contemporary philosophy usually takes it. (shrink)

T'Challa, the Black Panther, wears many hats, both at home and abroad. He is the chieftain of the Panther Tribe, which makes him the spiritual leader of his people as well as the king of Wakanda and its head of state. One key aspect that separates virtue ethics from its rival moral theories, consequentialism and deontology, is its focus on character. Judgment, or what Aristotle called "practical wisdom", is the ability to decide how best to act on one's virtues (...) in a particular situation. When T'Challa believed that agents within the US government were helping to overthrow his own, he and the Dora Milaje drove a truck into a building and abducted a businessman involved in the operation. T'Challa's duties as an Avenger come into conflict with his role as king of Wakanda, but other conflicts result from his role as a spiritual leader, which he regards as more important. (shrink)

In this paper I provide support for the view that at least some forms of adversariality in argumentation are legitimate. The support comes from Aristotle’s theory of illegitimate adversarial argumentation in dialectical contexts: his theory of eristic in his work On Sophistical Refutations. Here Aristotle develops non-epistemic standards for evaluating the legitimacy of dialectical procedures, standards which I propose can be understood in terms of the pragmatic notion of context as common ground. Put briefly, Aristotle makes the answerer’s meaning in (...) giving assent in dialectical contexts the basis for further moves in the game of dialectic. Moves which subvert the answerer’s meaning or do not solicit the answerer’s consent are marked as eristic, i.e. adversarial in a problematic sense. I conclude with remarks on what Aristotle’s theory may teach us about how semantic features relate to the normative evaluation of argumentation. (shrink)

Emmanuel Levinas identifies Husserl’s lectures on the internal consciousness of time as of central phenomenological importance. However, Levinas gives two different readings of these lectures: the first argues that Husserl’s concept of the proto-impression is the receptivity of sensation that provides the basis for intentional constitution. The second reading, by contrast, argues that Husserl’s account is ultimately bound to the category of the Same, as whatever enters consciousness is not put into question. Most commentators either conflate the readings or interpret (...) them as an ambiguity in Levinas’s thought. I argue to the contrary that while Levinas sees Husserl’s account as an advance in the articulation of the otherness presented to us in the world of perception and how such otherness funds consciousness, he claims that Husserl’s presentation of internal time consciousness is unsuitable to account for the ethical relationship with the other person. Thus, Levinas’s two readings mark out how Husserl’s description of temporal consciousness can and cannot be used in articulating the ways in which the ego is decentered by otherness. (shrink)

This essay presents a construct of constitutionalism. This is to do with more than a ?constitution?, or a ?corporate organisation?, or ?majority rule?. Constitutionalism is marked by a particular type of corporate rule, featuring a persistent (continuing) popular sovereignty, in which all who are governed are members, have a duty of mutual respect, enjoy an equal share in the vote, and are equally subject to the law. Under constitutionalism, the sovereign is perceived as bound by rules (in law) which that (...) sovereign cannot rise above. Constitutionalism underscores a procedure of non?exclusion, public rationality, and transparency. It is assumed to supply the most suitable philosophical and legal framework for most ?multiculturalist? theses. The essay extracts from British constitutional practice what it locates as the ?despatch?box? regime, and argues for this as a key principle in the management of all constitutionalist entities, including the European Union. (shrink)

Power consists in the capacity of A to command B, even against B's wishes, whether directly or indirectly. Questions to do with who possesses it and in what degree are obscured by inflationary shifts of definition (as where power encompasses action as such, or right action, or co?operation). These misjudged moves are generally marked by the assumption that democracy displaces power. But if democracy ultimately persists as a voting procedure, its object is to create power?holders. Democracy may endorse three electoral (...) principles: (a) majority rule, or (b) enhanced majority rule, or (c) unanimity. Its commonest electoral device is (a), but its strongest moral defence for (a) implicitly is (c), which legitimates forms of (d) veto and forms of minority rule. If (d) is fair, this need not follow from (a). Nor is (a) right in virtue of superior power. Democracy is commonly a combination of (a) plus (e) defence of individual and corporate rights. But this combination, while apt and convenient, is not incontestably coherent. Despite growing support for deliberation over election, if democracy must be impelled by (a), thus far does it sustain, not topple, power. If power persists more stably under democracies than elsewhere, sustained caution in regard to its supposed ?circularization? is fully warranted. (shrink)

The self has been a consistently central theme in philosophy and the social sciences and, in the last decades of the 20th century, the fragmentation of the modern self has engendered extensive academic commentary. In order to contribute to current discussions about self, it is perhaps most effective to map the transformation of a single representation of the self in contemporary culture. As a cultural ‘flashpoint’, the serial killer could provide an apposite analytical focus. Drawing critically on Mark Seltzer's (...) work on serial killers this article interprets serial killing as a form of commodified transgression. In contrast to the modern self, established through state-institutionalized routines, serial killers establish their identities through ecstatic intercourse. These acts of bodily and ethical transgression are facilitated by the use of commodities. In this way, the serial killer represents a self which is consistent with the colonization of interpersonal relations by multinational capital. The serial killer signifies the appearance of a postmodern self. (shrink)

This article discusses the relationship of history, theology and mythmaking with reference to the myths of Glastonbury. These related to the legends associated with Joseph of Arimathea’ purported visit to England, the burial place of King Arthur, as well as the quest for the Holy Grail. It draws on the work of Joseph Armitage Robinson, one of the most important Biblical and patristic scholars of his generation who, after becoming Dean of Westminster and later Dean of Wells Cathedral in (...) Somerset, and close to Glastonbury, became a distinguished medievalist. After assessing the development of the Glastonbury legends and the use of early British history made in the earlier Anglican tradition, particularly in the work of Archbishop Matthew Parker, it goes on to discuss their revival in the nineteenth and early twentieth centuries especially under the local parish priest Lionel Smithett Lewis. It concludes by showing that while there might be no historical substance in the myths, that there is nevertheless an important history to devotion and piety which is as equally open to theological and historical investigation as the events of history. (shrink)

This contribution examines the relatively unresearched doctoral thesis of Hans Urs von Balthasar as a Germanist, particularly in relation to the role that the reading of the Russian religious philosopher Nikolai Berdyaev played in the development of Balthasar's earliest theological thought. The authors argue that Berdyaev provided the young Germanist with a markedly eschatological point of departure for his nascent theological reflections. Although Balthasar had to renounce certain aspects of Berdyaev's thought, this eschatological orientation received from Berdyaev nevertheless remained recognizable (...) through Balthasar's mature theological works. This study is dedicated to Fr. James K. Voiss, S.J., teacher, mentor, and friend. (shrink)

Reasons, it is often said, are king in contemporary normative theory. Some philosophers say not only that the vocabulary of reasons is useful, but that reasons play a fundamental explanatory role in normative theory—that many, most, or even all, other normative facts are grounded in facts about reasons. Even if reasons fundamentalism, the strongest version of this view, has only been wholeheartedly endorsed by a few philosophers, it has a kind of prominence in contemporary normative theory that suits it (...) to be described as orthodoxy by its critics. It is the purpose of this paper to make progress toward understanding what appeal Reasons Fundamentalism should have, and whether that appeal is deserved. I will do so by exploring and comparing two central motivations for Reasons Fundamentalism. (shrink)

Strategic nonviolent action has reasserted itself as a potent force in shaping public debate and forcing political change. Whether it is an explosive surge of protest calling for racial justice in the United States, a demand for democratic reform in Hong Kong or Mexico, a wave of uprisings against dictatorship in the Middle East, or a tent city on Wall Street that spreads throughout the country, when mass movements erupt onto our television screens, the media portrays them as being as (...) spontaneous and unpredictable. In This is an Uprising, political analysts Mark and Paul Engler uncover the organization and well-planned strategies behind such outbursts of protest, examining core principles that have been used to spark and guide moments of transformative unrest. This is an Uprising traces the evolution of civil resistance, providing new insights into the contributions of early experimenters such as Mohandas Gandhi and Martin Luther King Jr., groundbreaking theorists such as Gene Sharp and Frances Fox Piven, and contemporary practitioners who have toppled repressive regimes in countries such as South Africa, Serbia, and Egypt. Drawing from discussions with activists now working to defend human rights, challenge corporate corruption, and combat climate change, the Englers show how people with few resources and little influence in conventional politics can nevertheless engineer momentous upheavals. Although it continues to prove its importance in political life, the strategic use of nonviolent action is poorly understood. Nonviolence is usually studied as a philosophy or moral code, rather than as a method of political conflict, disruption, and escalation. This is an Uprising corrects this oversight. It argues that if we are always taken by surprise by dramatic outbreaks of revolt, and if we decline to incorporate them into our view of how societies progress, then we pass up the chance to fully grasp a critical phenomenon-and to harness its power to create lasting change. (shrink)

Opponents of the Affordable Care Act have attempted to topple it in court by challenging the legality of two of its three legs. Three years ago, in NFIB v. Sibelius, Chief Justice Roberts narrowly upheld the constitutionality of the individual mandate, in a 5-to-4 decision that characterized the mandate as an optional tax rather than as a regulatory command. This year, on June 25, the health policy community exhaled a giant sigh of relief when the Supreme Court upheld the subsidy (...) leg of the ACA structure. In King v. Burwell, Justice Roberts again wrote the majority opinion, ruling as a matter of statutory interpretation that subsidies for insurance premiums are available not just through state-based exchanges but also through the federal exchange. (shrink)

ABSTRACT The article examines Old English claims to catholic ‘liberty of conscience’ and the way in which this engendered a discussion of English liberties in Ireland. Old English representatives sought to ground their claims to ‘liberty of conscience’ in established practice, custom and law. Their claims to ‘liberty of conscience’ also brought into play the vocabulary of corporate and parliamentary liberty. In response, New English protestants turned to ideas of duty and citizenship, which were equally embedded in conceptions of English (...) liberties. They argued that a catholic ‘conscience’ sat in opposition to ideas of duty to the king and the commonwealth. In doing so, the New English questioned both the basis and extent of the liberties possessed by the Old English. Such an exchange, this article argues, is illustrative of the way in which an English pairing of liberties, with ideas of duty and active citizenship, opened up an area of dispute involving a shared set of political concepts and vocabulary. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Piety, Justice, and the Unity of VirtueMark L. McPherranNo doubt the Socrates of the Euthyphro would be delighted to encounter many of its readers, offering as they do an audience of piety-seeking interlocutors, eager to mend the dialogical breach created by Euthyphro’s sudden departure. Socrates’ enthusiasm for this pursuit is at least as intense and comprehensible as theirs. We are told, after all, that he will never abandon his (...) quest for knowledge of “what the pious is” (15c–16a), since not only is this enterprise both pious and “inconceivably happy” (cf. Ap. 41c3–4) in itself,1 but coming to understand piety would allow one to “live better the rest of one’s life,” (15e7–16a4), especially should its continuation be threatened by a charge of impiety (3b–d, 5a–c, 12e, 15e–16a).2 My own search here is no less happy and ambitious, since I wish to uncover Socrates’ own, implicit understanding of piety and its relation to his claim elsewhere that “the virtues are one.”3 The account of this I shall provide will also touch on Platonic piety, although this notion obviously rests on a tendentious distinction. Nevertheless, there do seem to be some interesting differences between the way piety is treated in elenctic dialogues such as the Euthyphro and Protagoras, and the more explicitly theory-laden, constructive works such as the Republic and Laws. I shall later characterize [End Page 299] these differences, primarily in terms of the more carefully articulated, internalist moral psychology of the Republic.42. SOCRATIC PIETYThe distinct phenomena the term “religion” popularly designates for us were for the Greeks seamlessly integrated into everyday life. Thus, it is natural that the term “piety”—εὐσέβεια—carried a wider sense than our English equivalent commonly does: it concerned not only one’s immediate relation to the gods—emphasizing proper religious conduct and carrying a sense of respect and fear towards divinity (concomitant with a grasp of one’s own mortal limits)—but also often designated appropriate behavior towards parents, native land, and the dead.5 It is to this rough, inclusive conception of piety that Euthyphro appeals when confronted by Socrates on the Porch of the King (2a–6a). Moreover, and despite his own shockingly irreverent attempt at father-bashing and the subsequent elenctic drubbing he then receives from Socrates, toward the close of the dialogue Euthyphro still manages to envision piety in the quasi-traditionalist fashion with which he began—as “a knowledge of how to ensure the preservation of families and states by gratifying the gods through proper prayer and sacrifice” (14b; cf. 14c–15c).6 It is, however, precisely [End Page 300] at this dramatic juncture (14a–c) that we find—arguably—the final elements of a Socratically-acceptable conception of piety; one that builds upon Euthyphro’s initial concession to Socrates that piety and “human justice” are to be distinguished from one another (11e–12e). This, in turn, is a move that in principle forces Euthyphro to disengage from those aspects of the traditional conception of piety which would—from Socrates’ perspective—conflate the two.7 Recent challenges to this reading, however, have seen in Euthyphro’s initial holism not the heterogeneous presumptions of popular thought, but a semi-sophisticated grasp of the Socratic unity of the virtues.8 And since it does appear that the character Euthyphro is designed to serve not only as a hubristically-inflated, Homeric “fundamentalist,” but as an odd and Sophistically-influenced doppelgänger of Socrates as well—a lesson, that is, in what Socrates both is and is not—it now seems worthwhile to reexamine the view that Socratic piety is but a part and not the whole of justice.9Turning to our text, then, we discover that following the failure of Euthyphro’s initial definitional attempts to specify the nature of pious action and the resulting aporetic interlude, Socrates is willing to offer Euthyphro renewed assistance (11e1–4). This he does by asking whether all the just is pious, or whether justice is broader than piety such that piety is then merely a “part” (μóϱιον) of justice (11e4–12e5). Subsequent to his explanation of these alternatives, Socrates... (shrink)