三島教授は、60年代末から70年代はじめの社会的思想的な激動期を挾んで、長年、法思想史・法哲学の研究と教育に携わって、わが国の法哲学界において思想的支柱を担う一人として活躍してこられた。カントをはじめ とするドイツ観念論の法思想、プラトンを中心とする古代ギリシャ法思想、現代自然法論の法思想などに関する一連の研究は、わが国の法思想史研究の画期をなすものであるのみならず、その背後にあって導いている「人間 存在の根源」への真摯な問は、教授の研究に接する者に絶えざる再考を促している。教授の退官を記念して、論集を編むこととなったのは、教授が研究してこられた学問分野と、教授の研究の背後にあるものへのあらたな関 心をよぶ機会としたいと願うからである。.

The famous Japanese novelist offers his personal interpretation of a classic work on samurai ethics, everyday life, and spiritual salvation.

McEntire (1984) proved that, for a portfolio problem with independent assets, the generalized harmonic mean plays the role of a risk-free threshold. Based upon this property, he developed a criterion for including or excluding assets in an optimal portfolio, and he proved an ordering theorem showing that an optimal portfolio always consists of positive amounts of the assets with the largest mean values. Also, some commonly used utility functions were shown to satisfy the property that the dominance of an asset (...) over another is unaffected by the addition of other assets. In this paper we extend these results to the case where assets are dependent. (shrink)

近代の哲学的思潮の中でニーチェへの再評価は目覚ましい。本書はドイツ現代思想の第一人者による本格的ニーチェ論であり、その影響力を今日に問い直す。.

唐招提寺、薬師寺、法隆寺から、世界の名建築を経めぐり、そして桂離宮へ――。知られざる和辻倫理学のもうひとつの思想的源泉!

歴史的人文学の来歴を剔抉し、その現場を問う。西欧人文学における歴史意識の諸側面を反省的に捉え、現代の知を挑発する著者の主要な思想史的論考を集成。.

IntroductionDeep brain stimulation is an effective treatment for advanced Parkinson’s disease with the targeting bilateral subthalamic nucleus or globus pallidus internus. So far, detailed studies on the efficacy of unilateral STN-DBS for motor symptoms have been reported, but few studies have been conducted on unilateral GPi-DBS.Materials and MethodsSeventeen patients with Parkinson’s disease who underwent unilateral GPi-DBS were selected. We conducted comparison analyses between scores obtained 6–42 months pre- and postoperatively using the following measurement tools: the Movement Disorder Society Unified Parkinson’s (...) Disease Rating Scale part III, the Hoehn and Yahr stage, the presence/absence of dyskinesia, Mini-Mental State Examination, Frontal Assessment Battery, Geriatric Depression Scale, levodopa equivalent dose, and cerebral blood flow by single photon emission computed tomography. Patient backgrounds were compared between four cohorts with favorable and unfavorable postoperative outcome.ResultsSignificant improvement was observed postoperatively in the following: total MDS-UPDRS Part III scores during the off period, contralateral scores, ipsilateral scores, and axial scores. Similarly, the Hoehn and Yahr stages during the off period, and GDS also showed significant decrease. In contrast, LED, MMSE, and FAB remained unchanged while the number of patients who scored positive for dyskinesia decreased by 40%. Abnormal cerebral blood flow preoperatively seen in the cerebral cortex had normalized in the total score-based good responder cohort. In the ipsilateral score-based good responder cohort, cerebral blood flow increased in the contralateral frontal lobe including in the premotor cortex, contralateral to the DBS. Compared to the poor responders, postoperative good responders demonstrated significantly higher preoperative MMSE scores.DiscussionUnilateral GPi-DBS therapy was effective in improving contralateral, ipsilateral, and axial motor symptoms of patients with advanced PD; in particular, it was found to be especially beneficial in PwPD whose cognitive function was unimpaired; the treatment efficacy rivaled that of bilateral counterparts up till at least 6 months postoperatively. Finally, normalization of preoperative abnormalities in cerebral blood flow and increased cerebral blood flow in the contralateral frontal lobe indicated the beneficial potential of this therapy on ipsilateral motor symptoms. (shrink)