Site‐specific phosphorylation of intermediate filament (IF) proteins on serine and threonine residues leads to alteration of the filament structure, in vitro and in vivo. Protein kinases involved in cell signaling and those activated in mitosis dynamically control spatial and temporal organization of intracellular IF phosphorylation. Thus, IF phosphorylation appears to be one of the most predominant strategies in coordinating intracellular organization of the IF network.

Comparative quantifiers, such as more than three books, cannot take scope over any quantifier in subject position if they occupy object position. This is clearly different from the behavior of other quantifiers (e.g., universal quantifiers). This paper argues that this scope puzzle is due to a more complex internal structure of comparative quantifiers than other quantifiers. In the decompositional approach that I pursue, comparative quantifiers are decomposed into two generalized quantifiers (i.e., in the case above, the comparative operator er than (...) three and the DP many books). In this approach, obligatory narrow scope of comparative quantifiers in object position is a consequence of the interplay of the independently motivated principles of grammar that also constrain other quantifiers. On the basis of the scope puzzle, I specifically argue for two constraints on Scope Shifting Operations (SSOs) a locality condition on SSOs and Scope Economy, proposed by Fox (2000), which prohibits SSOs that have no effect on semantic interpretation. Thus, I argue that the apparently peculiar facts of comparative quantifiers are, in fact, additional evidence for the core properties of SSOs. (shrink)

This paper engages with a specific problem concerning the relationship between descriptive and normative claims. Namely, if we understand that descriptive claims frequently contain normative assertions, and vice versa, how then do we interpret the traditionally rigid distinction that is made between the two, as ’Hume’s law’ or Moore’s ’naturalistic fallacy’ argument offered. In particular, Kripke’s interpretation of Wittgenstein’s ’rule-following paradox’ is specially focused upon in order to re-consider the rigid distinction. As such, the paper argues that if descriptive and (...) normative claims are not mutually exclusive, then we need a new framework with which to understand this relationship. In this regard, the paper borrows from concerns with vagueness, particularly using a degree-theoretic approach in terms of subjective probability, in an attempt to graphically figure out these differences. Consequently, the paper tentatively proposes the hyperbola model in which degrees of normativity and degrees of descriptivity could be expressed and measured. It is hoped, as a result, that this tentative proposal will contribute to deepening the debate on vagueness in general. (shrink)

自己決定概念は、患者の自律やインフォームド・コンセント、プライバシー概念等の基礎にあり、生命倫理において核となる重要な概念である。しかし、その歴史的由来について、またその概念の意味するところについて、 これまで本巻のように主題的に扱われることはほとんどなかった。ここでの諸論考は、「自己決定権」や「自律」概念の理解にも大いに役立つはずである。.

This paper discusses how to refine a given initial legal ontology using an existing MRD (Machine-Readable Dictionary). There are two hard issues in the refinement process. One is to find out those MRD concepts most related to given legal concepts. The other is to correct bugs in a given legal ontology, using the concepts extracted from an MRD. In order to resolve the issues, we present a method to find out the best MRD correspondences to given legal concepts, using two (...) match algorithms. Moreover, another method called a static analysis is given to refine a given legal ontology, based on the comparison between the initial legal ontology and the best MRD correspondences to given legal concepts. We have implemented a software environment to help a user refine a given legal ontology based on these methods. The empirical results have shown that the environment works well in the field of Contracts for the International Sale of Goods. (shrink)

Recently, agent technologies have attracted a lot of interest as an emerging programming paradigm. With such agent technologies, services are provided through collaboration among agents. At the same time, the spread of mobile technologies and communication infrastructures has made it possible to access the network anytime and from anywhere. Using agents and mobile technologies to realize ubiquitous computing systems, we propose a new framework based on KODAMA and VPC. KODAMA provides distributed management mechanisms by using the concept of community and (...) communication infrastructure to deliver messages among agents without agents being aware of the physical network. VPC provides a method of defining peer-to-peer services based on agent communication with policy packages. By merging the characteristics of both KODAMA and VPC functions, we propose a new framework for ubiquitous computing environments. It provides distributed management functions according to the concept of agent communities, agent communications which are abstracted from the physical environment, and agent collaboration with policy packages. Using our new framework, we conducted a large-scale experiment in shopping malls in Nagoya, which sent advertisement e-mails to users' cellular phones according to user location and attributes. The empirical results showed that our new framework worked effectively for sales in shopping malls. (shrink)

For most death discharge patients, hospitals in Japan offer seeing-off services, a practice characteristic of Japanese culture. When a patient dies, nurses usually perform after-death procedures before transferring the body to the mortuary, where the nurses and doctors gather to provide the seeing-off service. This study was carried out to determine differences between the nurses’ and bereaved families’ opinions and thoughts regarding the seeing-off service. Semi-structured interviews were conducted with 17 nurses and 6 bereaved families . The interviews assessed: the (...) reasons why nurses provided seeing-off services; thoughts during the seeing-off service; impressions of the mortuary rituals; and the necessity for the seeing-off service. The results indicated that nurses expressed their courtesy and sense of appreciation during the seeing-off service, which was recognised as an important nursing role. In contrast, bereaved families felt thankful but also doubtful, particularly as regards the mortuary rituals. In light of the differences in perspective between nurses and families, it may be that the level of satisfaction with the seeing-off service is largely affected by the relationship between the family and the medical professionals before the patient's death. Our study also notes that Japanese people respect the dead body and treat it with care, reflecting the unique culture and customs of Japan. (shrink)

In this study, we analyzed the relationship between confirmation bias, which causes people to preferentially view information that supports their opinions and beliefs, and web search behavior. In an online user study, we controlled confirmation bias by presenting prior information to participants that manipulated their impressions of health search topics and analyzed their behavioral logs during web search tasks. We found that web search users with poor health literacy and negative prior beliefs about the health search topic did not spend (...) time examining the list of web search results, and these users demonstrated bias in webpage selection. In contrast, web search users with high health literacy and negative prior beliefs about the search topic spent more time examining the list of web search results. In addition, these users attempted to browse webpages that present different opinions. No significant difference in web search behavior was observed between users with positive prior beliefs about the search topic and those with neutral belief. (shrink)

Since Japan adopted the concept of informed consent from the West, its inappropriate acquisition from patients in the Japanese clinical setting has continued, due in part to cultural aspects. Here, we discuss the current status of and contemporary issues surrounding informed consent in Japan, and how these are influenced by Japanese culture.

I aim to bring the idea of “degree of free will or freedom” into philosophical debates on free will by rejecting the formulation, ‘we are either free or not’. This idea is based upon my viewpoint of regarding freedom as a realistic phenomena actually occurring. First of all, I focus on the fact that it is vague whether an agent is free or not. This vagueness is interpreted as ontic vagueness, corresponding with the status of freedom as real. However, Evans’s (...) argument regarding ontic vagueness must be considered as, according to his argument, ontic vagueness about identity and objects are impossible. I indicate that this argument assumes the truth-value gap position in borderline cases, hence we can avoid Evans’s argument by adopting truth-value glut position. Of course, the truth-value glut approach has serious difficulties, but I conclude with sketching out a possibility to develop this approach in the free will debate via the introduction of probabilistic valuation. (shrink)

In recent years, a number of news stories were reported worldwide involving brain-dead pregnant women. Debates over providing life support to braindead pregnant women and delivery of their children have been around for some decades. Maintaining a woman’s life solely for fetal viability has become a major controversial social issue. Opposing opinions exist where one side supports the woman and her child should be left to die in dignity and the other side claims to protect the unborn child’s right to (...) live. Each group has strong beliefs. This paper addresses main aspects when considering the continuation of somatic support to the brain-dead pregnant woman for the purpose of fetus delivery including; human death, dignity of the woman, rights of the fetus, proportionality of acts, and the woman’s donor status, and independence of mother and fetus. Then, the authors present several diverse opinions and positions concerning the legitimacy of life support for brain-dead women based on them and critically evaluate them. We show that each and every claim can be ethically refuted. This paper also approaches to those claims from three different points of views, which are that of the brain-dead woman, her fetus and her family. We believe that the brain-dead woman’s wish and dignity, the child’s predicted wellbeing after birth, and the family’s beliefs and welfare should all be counted equally when making the final decision. In conclusion, we argue that the decision can be ethically justified only when the interests of all parties are appropriately taken into consideration and protected. (shrink)

プラトン以降の西欧哲学・思想史において、“すぐれた哲学・思想”と思われているものが、いかに擬似宗教化の危険性と隣り合わせにありそのことが哲学者・思想家によってどのように問題化され、論じられてきたのか。 本書では、現代思想に特に強い影響を与えたハイデガー、アーレント、デリダなどの論考をてがかりに、思想史の概観を試みる。新興宗教体験を持つ著者だからこそ、現代日本の思想業界に、“生き生きとしたラディカルな 思想”を中心とした「真の共同体」を求めるかのような、擬似宗教化の風潮が生じていることが分かるのである。.

In the context of the controversies surrounding »globalisation« and In the context of the controversies surrounding »globalisation« and »multiculturality« the comparative study of cultures has the task of aiding intercultural communication and of contributing to the success of intercultural understanding. The model of contrastive cultural comparison discussed here is claimed to have applacibility to every possible study of other countries (»Auslandswissenschaft«) and to be able to provide the Geisteswissenschaften with an intercultural orientation.

本书精辟阐述朝鲜朱子学集大成者-李退溪的主敬哲学的形成、发展过程,思想体系特点及其影响等。.

篤胤において死の問題は、死後の存在としての霊魂の問題となり、さらには霊魂の行き場所の問題となる。もし人が死後に霊魂となることが確実であり、霊魂の行き着く場所が特定されるのであれば、先に現在の私たちに即 して述べたような死の問題は、「解決」されるに違いない。篤胤はまさにそのことを『霊の真柱』において試み、「幽冥界」という観念を提示することになる。.

Fundamental notions Husserl introduced in Ideen I, such as epochè, reality, and empty X as substrate, might be useful for elucidating how mathematical physics concepts are produced. However, this is obscured in the context of Husserl’s phenomenology itself. For this possibility, the author modifies Husserl’s fundamental notions introduced for pure phenomenology, which found all sciences on the absolute Ego. Subsequently, the author displaces Husserl's phenomenological notions toward the notions operating inside scientific activities themselves and shows this using a case study (...) of the construction of noncommutative geometry. The perspective in Ideen I about geometry and mathematical physics includes points that are inappropriate to modern geometry and to modern physics, especially to noncommutative geometry and to quantum physics. The first point relates to the intuitive character of geometrical objects in Husserl. The second is linked to the notion of locality related to the notion of extension, by which Husserl characterizes the essence of physical things. The points show that the notion of empty X as a substrate, developed in “Phenomenology of Reason” in Ideen I, is helpful for considering the notions of physical reality and of geometrical space, especially reality in quantum physics and space in noncommutative geometry. The salient conclusions include the proposition that aphilosophical study of the relationship between the physical object X, which imparts a unity to what is given to sensibility, and the geometrical space X, which imparts a unity of sense to various mathematical operations, opens a reinterpretation of Husserl’s interpretation, supporting an epistemology of mathematical physics. (shrink)