BackgroundWith the emergence of Brain Computer Interfaces, clinicians have been facing a new group of patients with severe acquired brain injury who are unable to show any behavioral sign of consciousness but respond to active neuroimaging or electrophysiological paradigms. However, even though well documented, there is still no consensus regarding the nomenclature for this clinical entity.ObjectivesThis systematic review aims to 1) identify the terms used to indicate the presence of this entity through the years, and 2) promote an informed discussion (...) regarding the rationale for these names and the best candidates to name this fascinating disorder.MethodsThe Disorders of Consciousness Special Interest Group of the International Brain Injury Association launched a search on Pubmed and Google scholar following PRISMA guidelines to collect peer-reviewed articles and reviews on human adults published in English between 2006 and 2021.ResultsThe search launched in January 2021 identified 4,089 potentially relevant titles. After screening, 1,126 abstracts were found relevant. Finally, 161 manuscripts were included in our analyses. Only 58% of the manuscripts used a specific name to discuss this clinical entity, among which 32% used several names interchangeably throughout the text. We found 25 different names given to this entity. The five following names were the ones the most frequently used: covert awareness, cognitive motor dissociation, functional locked-in, non-behavioral MCS and higher-order cortex motor dissociation.ConclusionSince 2006, there has been no agreement regarding the taxonomy to use for unresponsive patients who are able to respond to active neuroimaging or electrophysiological paradigms. Developing a standard taxonomy is an important goal for future research studies and clinical translation. We recommend a Delphi study in order to build such a consensus. (shrink)

With the purpose of introducing a useful tool for researches concerning foundations of quantum mechanics and applications to quantum technologies, here we address three quantumness quantifiers for bipartite optical systems: one is based on sub-shot-noise correlations, one is related to antibunching and one springs from entanglement determination. The specific cases of parametric downconversion seeded by thermal, coherent and squeezed states are discussed in detail.

Formal series are associated with ascriptions of numbers. They are ordered by formal operations that, unlike negation and disjunction, are not truth-operations. In spite of this, they are required to build propositions involving generic reference to numbers, and are essential to the Tractarian version of the logicist project.

Les Remarques philosophiques sont la première tentative de mettre en oeuvre le programme qui découle de l’échec du projet du Tractatus Logico-Philosophicus. Le noyau de ce programme est donné par l’abandon de l’analyse des nombres avancée dans le Tractatus. Wittgenstein se rend compte que les nombres doivent se trouver à la base même du langage, dans la structure des propositions élémentaires. En même temps, il se rend compte qu’il est impossible de fournir la logique sousjacente au langage avant d’avoir procédé (...) à l’analyse. Le projet d’une investigation logique des phénomènes s’imposait, donc, même après l’abandon de l’idée d’un langage phénoménologique. The Philosophical Remarks is a first attempt at pursuing the philosophical agenda determined by the failure of the Tractarian project. The central point of this agenda is the abandonment of the analysis of number that had been given in the Tractatus. Wittgenstein realizes that numbers should be brought back to the basis of language, as part of the structure of the elementary propositions themselves. At the same time, he realizes that it is impossible to give the logic underlying our language before the process of logical analysis is carried out. He undertakes the project of a logical investigation of phenomena even after giving up the idea of a phenomenological language. (shrink)

As innovations in the field of vascular composite allotransplantation (VCA) progress, whole-eye transplantation (WET) is poised to transition from non-human mammalian models to living human recipients. Present treatment options for vision loss are generally considered suboptimal, and attendant concerns ranging from aesthetics and prosthesis maintenance to social stigma may be mitigated by WET. Potential benefits to WET recipients may also include partial vision restoration, psychosocial benefits related to identity and social integration, improvements in physical comfort and function, and reduced surgical (...) risk associated with a biologic eye compared to a prosthesis. Perioperative and postoperative risks of WET are expected to be comparable to those of facial transplantation (FT), and may be similarly mitigated by immunosuppressive protocols, adequate psychosocial support, and a thorough selection process for both the recipient and donor. To minimize the risks associated with immunosuppressive medications, the first attempts in human recipients will likely be performed in conjunction with a FT. If first-in-human attempts at combined FT-WET prove successful and the biologic eye survives, this opens the door for further advancement in the field of vision restoration by means of a viable surgical option. This analysis integrates recent innovations in WET research with the existing discourse on the ethics of surgical innovation and offers preliminary guidance to VCA programs considering undertaking WET in human recipients. (shrink)

Some enlightenment regarding the project to mechanise reason. The assembly line of machine learning: data, algorithm, model. The training dataset: the social origins of machine intelligence. The history of AI as the automation of perception. The learning algorithm: compressing the world into a statistical model. All models are wrong, but some are useful. World to vector: the society of classification and prediction bots. Faults of a statistical instrument: the undetection of the new. Adversarial intelligence vs. statistical intelligence: labour in the (...) age of AI. (shrink)

The paper offers a solution to the problem of specifying computational systems that behave in accordance with a given set of ethical principles. The proposed solution is based on the concepts of ethical requirements and ethical protocols. A new conceptual tool, called the Control Closure of an operation, is defined and used to translate ethical principles into ethical requirements and protocols. The concept of Generalised Informational Privacy (GIP) is used as a paradigmatic example of an ethical principle. GIP is defined (...) in such a way as to (i) discriminate specific cases in which an individual’s GIP can be infringed without accessing the individual’s data; (ii) separate unauthorised accesses to data that do not respect the right to GIP from access that do; and (iii) distinguish different degrees of GIP. Finally a camera phone is used to illustrate the proposed solution. (shrink)

Les Remarques philosophiques sont la première tentative de mettre en oeuvre le programme qui découle de l’échec du projet du Tractatus Logico-Philosophicus. Le noyau de ce programme est donné par l’abandon de l’analyse des nombres avancée dans le Tractatus. Wittgenstein se rend compte que les nombres doivent se trouver à la base même du langage, dans la structure des propositions élémentaires. En même temps, il se rend compte qu’il est impossible de fournir la logique sousjacente au langage avant d’avoir procédé (...) à l’analyse. Le projet d’une investigation logique des phénomènes s’imposait, donc, même après l’abandon de l’idée d’un langage phénoménologique. The Philosophical Remarks is a first attempt at pursuing the philosophical agenda determined by the failure of the Tractarian project. The central point of this agenda is the abandonment of the analysis of number that had been given in the Tractatus. Wittgenstein realizes that numbers should be brought back to the basis of language, as part of the structure of the elementary propositions themselves. At the same time, he realizes that it is impossible to give the logic underlying our language before the process of logical analysis is carried out. He undertakes the project of a logical investigation of phenomena even after giving up the idea of a phenomenological language. (shrink)

Some authors have argued that the human use of reproductive cloning and genetic engineering should be prohibited because these biotechnologies would undermine the autonomy of the resulting child. In this paper, two versions of this view are discussed. According to the first version, the autonomy of cloned and genetically engineered people would be undermined because knowledge of the method by which these people have been conceived would make them unable to assume full responsibility for their actions. According to the second (...) version, these biotechnologies would undermine autonomy by violating these people’s right to an open future. There is no evidence to show that people conceived through cloning and genetic engineering would inevitably or even in general be unable to assume responsibility for their actions; there is also no evidence for the claim that cloning and genetic engineering would inevitably or even in general rob the child of the possibility to choose from a sufficiently large array of life plans. (shrink)

In this paper, we develop an organizational account that defines biological functions as causal relations subject to closure in living systems, interpreted as the most typical example of organizationally closed and differentiated self-maintaining systems. We argue that this account adequately grounds the teleological and normative dimensions of functions in the current organization of a system, insofar as it provides an explanation for the existence of the function bearer and, at the same time, identifies in a non-arbitrary way the norms that (...) functions are supposed to obey. Accordingly, we suggest that the organizational account combines the etiological and dispositional perspectives in an integrated theoretical framework. IntroductionDispositional ApproachesEtiological TheoriesBiological Self-maintenance Closure, teleology, and normativityOrganizational differentiationFunctions C1: Contributing to the maintenance of the organization C2: Producing the functional trait Implications and Objections Functional versus useful Dysfunctions, side effects, and accidental contributionsProper functions and selected effectsReproductionRelation with other ‘unitarian’ approachesConclusions. (shrink)

According to the received view of evolution, only genes are inherited. From this view it follows that only genetically-caused phenotypic variation is selectable and, thereby, that all selection is at bottom genetic selection. This paper argues that the received view is wrong. In many species, there are intergenerationally-stable phenotypic differences due to environmental differences. Natural selection can act on these nongenetically-caused phenotypic differences in the same way it acts on genetically-caused phenotypic differences. Some selection is at bottom nongenetic selection. The (...) argument against the received view involves a reformulation of the concepts of inheritance and heritability. Inherited factors are all those developmental factors responsible for parent–offspring similarity; some inherited factors are genetic and some are not. Heritable variation is intergenerationally-stable phenotypic variation; some such variation is genetically-caused and some is not. The received view and its critics The possibility of nongenetic selection (the lucky butterfly) The reality of nongenetic selection 3.1 Imprinting mechanisms 3.2 Other learning mechanisms 3.3 Other nongenetic mechanisms Genetic and nongenetic inheritance mechanisms Genetic and nongenetic inherited factors Genetic and nongenetic heritability Conclusions + Current address: Dr Matteo Mameli, Research Fellow, King's College, Cambridge, CB2 1ST, United Kingdom, matteo.mameli{at}kings.cam.ac.uk' + u + '@' + d + ''//-->. (shrink)

This paper critically evaluates some arguments against metaphysics recently formulated by Bas Van Fraassen. A more positive view of the relationship between science and metaphysics is outlined.

Science and philosophy both express, and attempt to quench, the distinctively human thirst for knowledge. Today, their mutual relationship has become one of conflict or indifference rather than cooperation. At the same time, scientists and philosophers alike have moved away from at least some of our ordinary beliefs. But what can scientific and philosophical theories tell us about the world, in isolation from each other? And to what extent does a sophisticated investigation into the nature of things force us to (...) question commonsense beliefs? This book defends a form of naturalism which preserves the autonomy of metaphysics – the part of philosophy that aims to uncover the fundamental features of reality - while also keeping science centre stage. The proposed methodological perspective allows one to seek the right equilibrium between science, metaphysics and common sense. This is illustrated via three case studies, which provide a clear discussion of key philosophical issues. (shrink)

The paper investigates the ethics of information transparency (henceforth transparency). It argues that transparency is not an ethical principle in itself but a pro-ethical condition for enabling or impairing other ethical practices or principles. A new definition of transparency is offered in order to take into account the dynamics of information production and the differences between data and information. It is then argued that the proposed definition provides a better understanding of what sort of information should be disclosed and what (...) sort of information should be used in order to implement and make effective the ethical practices and principles to which an organisation is committed. The concepts of “heterogeneous organisation” and “autonomous computational artefact” are further defined in order to clarify the ethical implications of the technology used in implementing information transparency. It is argued that explicit ethical designs, which describe how ethical principles are embedded into the practice of software design, would represent valuable information that could be disclosed by organisations in order to support their ethical standing. (shrink)

Teller argued that violations of Bell’s inequalities are to be explained by interpreting quantum entangled systems according to ‘relational holism’, that is, by postulating that they exhibit irreducible (‘inherent’) relations. Teller also suggested a possible application of this idea to quantum statistics. However, the basic proposal was not explained in detail nor has the additional idea about statistics been articulated in further work. In this article, I reconsider relational holism, amending it and spelling it out as appears necessary for a (...) proper assessment, and application, of the position. †To contact the author, please write to: FB Philosophie‐Zukunftskolleg, University of Konstanz, Universitätstraße 10, 78464, Konstanz, Germany; e‐mail: matteo.morganti@uni ‐konstanz.de. (shrink)

This paper puts forward the hypothesis that the distinctive features of quantum statistics are exclusively determined by the nature of the properties it describes. In particular, all statistically relevant properties of identical quantum particles in many-particle systems are conjectured to be irreducible, ‘inherent’ properties only belonging to the whole system. This allows one to explain quantum statistics without endorsing the ‘Received View’ that particles are non-individuals, or postulating that quantum systems obey peculiar probability distributions, or assuming that there are primitive (...) restrictions on the range of states accessible to such systems. With this, the need for an unambiguously metaphysical explanation of certain physical facts is acknowledged and satisfied. (shrink)

Causal reductionism is the widespread assumption that there is no room for additional causes once we have accounted for all elementary mechanisms within a system. Due to its intuitive appeal, causal reductionism is prevalent in neuroscience: once all neurons have been caused to fire or not to fire, it seems that causally there is nothing left to be accounted for. Here, we argue that these reductionist intuitions are based on an implicit, unexamined notion of causation that conflates causation with prediction. (...) By means of a simple model organism, we demonstrate that causal reductionism cannot provide a complete and coherent account of ‘what caused what’. To that end, we outline an explicit, operational approach to analyzing causal structures. (shrink)

According to a growing trend in theoretical neuroscience, the human perceptual system is akin to a Bayesian machine. The aim of this article is to clearly articulate the claims that perception can be considered Bayesian inference and that the brain can be considered a Bayesian machine, some of the epistemological challenges to these claims; and some of the implications of these claims. We address two questions: (i) How are Bayesian models used in theoretical neuroscience? (ii) From the use of Bayesian (...) models in theoretical neuroscience, have we learned or can we hope to learn that perception is Bayesian inference or that the brain is a Bayesian machine? From actual practice in theoretical neuroscience, we argue for three claims. First, currently Bayesian models do not provide mechanistic explanations; instead they are useful devices for predicting and systematizing observational statements about people's performances in a variety of perceptual tasks. That is, currently we should have an instrumentalist attitude towards Bayesian models in neuroscience. Second, the inference typically drawn from Bayesian behavioural performance in a variety of perceptual tasks to underlying Bayesian mechanisms should be understood within the three-level framework laid out by David Marr ( [1982] ). Third, we can hope to learn that perception is Bayesian inference or that the brain is a Bayesian machine to the extent that Bayesian models will prove successful in yielding secure and informative predictions of both subjects' perceptual performance and features of the underlying neural mechanisms. (shrink)

The free-energy principle states that all systems that minimize their free energy resist a tendency to physical disintegration. Originally proposed to account for perception, learning, and action, the free-energy principle has been applied to the evolution, development, morphology, anatomy and function of the brain, and has been called a postulate, an unfalsifiable principle, a natural law, and an imperative. While it might afford a theoretical foundation for understanding the relationship between environment, life, and mind, its epistemic status is unclear. Also (...) unclear is how the free-energy principle relates to prominent theoretical approaches to life science phenomena, such as organicism and mechanism. This paper clarifies both issues, and identifies limits and prospects for the free-energy principle as a first principle in the life sciences. (shrink)

Can facts about subpersonal states and events be constitutively relevant to personal-level phenomena? And can knowledge of these facts inform explanations of personal-level phenomena? Some philosophers, like Jennifer Hornsby and John McDowell, argue for two negative answers whereby questions about persons and their behavior cannot be answered by using information from subpersonal psychology. Knowledge of subpersonal states and events cannot inform personal-level explanation such that they cast light on what constitutes persons? behaviors. In this paper I argue against this position. (...) After having distinguished between enabling and constitutive relevance, I defend the claim that at least some facts about subpersonal states and events are constitutively relevant to some personal-level phenomenon, and therefore can, and sometimes should, inform personal-level explanations. I draw some of the possible consequences of my claim for our understanding of personal-level behavior by focusing on the phenomenon of addiction. (shrink)

This paper argues that contemporary analytic philosophy of music has characterized historically informed performance practice as compliance-focused, impersonal, and work-centered. The first part of the paper gathers evidence in support of this claim from the works of Julian Dodd, Peter Kivy, James O. Young, Aron Edidin, and Stephen Davies. In the second part of the paper, I reject this received view. Evidence from actual performance practice, as well as from the practitioners’ reflection on their activity, belies the received view outlined (...) in the first part of the paper. I conclude by drawing three methodological lessons from the oversights I attempt to rectify. (shrink)

According to the free energy principle, life is an “inevitable and emergent property of any random dynamical system at non-equilibrium steady state that possesses a Markov blanket” :20130475, 2013). Formulating a principle for the life sciences in terms of concepts from statistical physics, such as random dynamical system, non-equilibrium steady state and ergodicity, places substantial constraints on the theoretical and empirical study of biological systems. Thus far, however, the physics foundations of the free energy principle have received hardly any attention. (...) Here, we start to fill this gap and analyse some of the challenges raised by applications of statistical physics for modelling biological targets. Based on our analysis, we conclude that model-building grounded in the free energy principle exacerbates a trade-off between generality and realism, because of a fundamental mismatch between its physics assumptions and the properties of actual biological targets. (shrink)

Despite the impressive amount of financial resources invested in carrying out large-scale brain simulations, it is controversial what the payoffs are of pursuing this project. The present paper argues that in some cases, from designing, building, and running a large-scale neural simulation, scientists acquire useful knowledge about the computational performance of the simulating system, rather than about the neurobiological system represented in the simulation. What this means, why it is not a trivial lesson, and how it advances the literature on (...) the epistemology of computer simulation are the three preoccupations addressed by the paper. (shrink)

This article aims to systematically deconstruct four distinct narratives derived from the case of Caster Semenya v. IAAF (Court of Arbitration for Sport).

This article aims at investigating the history of the institutionalization of experimental hygiene teaching in Italy during the second half of the nineteenth century. Looking to France as the pioneering country in the international hygiene movement, this contribution investigates the process of institutionalizing experimental hygiene in universities and para-university context as an indispensable prerequisite for the organization of public health. With hygiene becoming a matter of global interest due to its importance in preventing the deleterious effects of epidemic diseases, the (...) Italian case will be studied in comparison with developments in the field of hygiene sciences in the German context. With these premises in mind, the focus will be on Luigi Pagliani, who, holding institutional and academic roles in the cities of Rome and Turin, devoted his entire scientific career to the consolidation of experimental hygiene in Italy. (shrink)

Near the beginning of the Nicomachean Ethics, Aristotle claims that “our discussion will be adequate if its degree of clarity reflects the subject matter.” Those who seek to give a proper “theoretical” account of some enterprise, but who neglect this wise Aristotelian counsel, do so at their own peril. Aristotle is urging that sound theory should reflect and elucidate actual practice. When philosophical speculation loses touch with such practice, it tends to caricature what it ought to clarify. For example, Steven (...) Weinberg points out the disparity that often exists between the view of science one finds expounded by some contemporary “philosophers of science” and that presupposed by those really engaged in scientific research: “From time to time I have tried to read current work on the philosophy of science. (shrink)

Since the discovery of the double helical structure of DNA, the standard account of the inheritance of features has been in terms of DNA-copying and DNA-transmission. This theory is just a version of the old theory according to which the inheritance of features is explained by the transfer at conception of some developmentally privileged material from parents to offspring. This paper does the following things: (1) it explains what the inheritance of features is; (2) it explains how the DNA-centric theory (...) emerged; (3) it clarifies the relation between the DNA-centric theory and the ‘unfolding’ theory of development; (4) it argues that (given what we now know about developmental processes and genetic activity) the DNA-centric theory should be abandoned in favour of a pluralistic (but not holistic) theory of the inheritance of features. According to this pluralistic theory, the reliable reoccurrence of phenotypes must be explained by appealing not only to processes responsible for the reliable reoccurrence of genetic developmental factors but also to processes responsible for the reliable reoccurrence (or persistence) of nongenetic developmental factors. (shrink)

This paper argues that biological organisation can be legitimately conceived of as an intrinsically teleological causal regime. The core of the argument consists in establishing a connection between organisation and teleology through the concept of self-determination: biological organisation determines itself in the sense that the effects of its activity contribute to determine its own conditions of existence. We suggest that not any kind of circular regime realises self-determination, which should be specifically understood as self-constraint: in biological systems, in particular, self-constraint (...) takes the form of closure, i.e. a network of mutually dependent constitutive constraints. We then explore the occurrence of intrinsic teleology in the biological domain and beyond. On the one hand, the organisational account might possibly concede that supra-organismal biological systems could realise closure, and hence be teleological. On the other hand, the realisation of closure beyond the biological realm appears to be highly unlikely. In turn, the occurrence of simpler forms of self-determination remains a controversial issue, in particular with respect to the case of self-organising dissipative systems. (shrink)

In this paper, we advocate the idea that an adequate explanation of biological systems requires appealing to organizational closure as an emergent causal regime. We first develop a theoretical justification of emergence in terms of relatedness, by arguing that configurations, because of the relatedness among their constituents, possess ontologically irreducible properties, providing them with distinctive causal powers. We then focus on those emergent causal powers exerted as constraints, and we claim that biological systems crucially differ from other natural systems in (...) that they realize a closure of constraints, i.e. a second-order emergent regime of causation such that the constituents, each of them acting as a constraint, realize a mutual dependence among them, and are collectively able to self-maintain. Lastly, we claim that closure can be justifiably taken as an emergent regime of causation, without admitting that it inherently involves whole-parts causation, which would require to commit to stronger ontological and epistemological assumptions. (shrink)

Some naturalistic philosophers of mind subscribing to the predictive processing theory of mind have adopted a realist attitude towards the results of Bayesian cognitive science. In this paper, we argue that this realist attitude is unwarranted. The Bayesian research program in cognitive science does not possess special epistemic virtues over alternative approaches for explaining mental phenomena involving uncertainty. In particular, the Bayesian approach is not simpler, more unifying, or more rational than alternatives. It is also contentious that the Bayesian approach (...) is overall better supported by the empirical evidence. So, to develop philosophical theories of mind on the basis of a realist interpretation of results from Bayesian cognitive science is unwarranted. Naturalistic philosophers of mind should instead adopt an anti-realist attitude towards these results and remain agnostic as to whether Bayesian models are true. For continuing on with an exclusive focus and praise of Bayes within debates about the predictive processing theory will impede progress in philosophical understanding of scientific practice in computational cognitive science as well as of the architecture of the mind. (shrink)

In this work we provide an analysis of some issues arising with geometrical representations of a family of deontic and potestative relations that can be classified as Hohfeldian modalities, traditionally illustrated on two diagrams, the Hohfeldian squares. Our main target is the lack of symmetry to be found in various formal accounts by drawing analogies with the square of opposition for alethic modalities. We argue that one should rather rely on an analogy with the alethic hexagon of opposition and exploit (...) the notions of contingency and absoluteness in order to restore the symmetry of Hohfeldian modalities in accordance to the diagrams presented by Hohfeld. Interestingly, the investigation unveils three potestative squares defined at different levels of granularity (force, outcome and change) and allows us to further elaborate on the connections between deontic and potestative relations. (shrink)

We develop a conceptual framework that connects biological heredity and organization. We refer to heredity as the cross-generation conservation of functional elements, defined as constraints subject to organizational closure. While hereditary objects are functional constituents of biological systems, any other entity that is stable across generations—and possibly involved in the recurrence of phenotypes—belongs to their environment. The central outcome of the organizational perspective consists in extending the scope of heredity beyond the genetic domain without merging it with the broad category (...) of cross-generation stability. After discussing some implications, we conclude with a reflection on the relationship between stability and variation. 1Introduction2From Extended Heredity to Cross-generation Stability 2.1Extending the scope of heredity: A brief state of the art2.2Rethinking heredity: Conceptual challenges3Biological Heredity in Light of Organization 3.1Biological organization within organisms and beyond3.2Extending organization in time3.3What is biological heredity?4Implications and Objections 4.1Heredity as a specific kind of cross-generation stability4.2Heredity at various levels of description4.3Non-functional and dysfunctional objects5Conclusions: From Conservation to Variation. (shrink)

This open access book assesses the prospects of (re)adopting organization as a pivotal concept in biology. It shows how organization can nourish biological thinking and practice, by reconnecting with the idea of biology as the science of organized systems. The book provides a comprehensive state-of-the-art picture of the characterizations and uses of the concept of organization in both biological science and philosophy of biology. It also deals with a variety of themes – including evolution, organogenesis, heredity, cognition and ecology – (...) with respect to which the concept of organization can guide the elaboration of original models and new experimental protocols. It will be of interest to biologists and scholars working in philosophy of science alike. (shrink)